Expression patterns and immunological characterization of PANoptosis -related genes in gastric cancer DOI Creative Commons
Qing Xin, Junyi Jiang, Chunlei Yuan

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 18, 2023

Accumulative studies have demonstrated the close relationship between tumor immunity and pyroptosis, apoptosis, necroptosis. However, role of PANoptosis in gastric cancer (GC) is yet to be fully understood.This research attempted identify expression patterns regulators immune landscape GC by integrating GSE54129 GSE65801 datasets. We analyzed specimens established molecular clusters associated with PANoptosis-related genes (PRGs) corresponding characteristics. The differentially expressed were determined WGCNA method. Afterward, we employed four machine learning algorithms (Random Forest, Support Vector Machine, Generalized linear Model, eXtreme Gradient Boosting) select optimal model, which was validated using nomogram, calibration curve, decision curve analysis (DCA), two validation cohorts. Additionally, this study discussed infiltrating cells variables selected model.This identified dysregulated PRGs differential activities normal samples, further GC. These remarkable immunological heterogeneity, Cluster1 exhibiting abundant infiltration. Machine signature found best discriminative ability, a 5-gene-based SVM established. This model showed excellent performance external cohorts, DCA indicated its reliability predicting patterns. Further confirmed that 5 remarkably related immune-related pathways.Taken together, work demonstrates pattern has potential as stratification tool for patient risk assessment reflection microenvironment

Language: Английский

Death by TNF: a road to inflammation DOI Open Access
Geert Loo, Mathieu J.M. Bertrand

Nature reviews. Immunology, Journal Year: 2022, Volume and Issue: 23(5), P. 289 - 303

Published: Nov. 15, 2022

Language: Английский

Citations

513
Mitochondria in health, disease, and aging DOI
John S. Harrington, Stefan W. Ryter, Maria Plataki

et al.

Physiological Reviews, Journal Year: 2023, Volume and Issue: 103(4), P. 2349 - 2422

Published: April 6, 2023

Mitochondria are well known as organelles responsible for the maintenance of cellular bioenergetics through production ATP. Although oxidative phosphorylation may be their most important function, mitochondria also integral synthesis metabolic precursors, calcium regulation, reactive oxygen species, immune signaling, and apoptosis. Considering breadth responsibilities, fundamental metabolism homeostasis. Appreciating this significance, translational medicine has begun to investigate how mitochondrial dysfunction can represent a harbinger disease. In review, we provide detailed overview metabolism, bioenergetics, dynamics, autophagy, damage-associated molecular patterns, mitochondria-mediated cell death pathways, at any these levels is associated with disease pathogenesis. Mitochondria-dependent pathways thereby an attractive therapeutic target ameliorating human

Language: Английский

Citations

304
Macrophage polarization and metabolism in atherosclerosis DOI Creative Commons
Pengbo Hou, Jiankai Fang, Zhanhong Liu

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(10)

Published: Oct. 20, 2023

Abstract Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty deposits in inner walls vessels. These plaques restrict blood flow and lead to complications such as heart attack or stroke. The development atherosclerosis influenced variety factors, including age, genetics, lifestyle, underlying health conditions high pressure diabetes. Atherosclerotic stable form are slow growth, which leads luminal stenosis, with low embolic potential unstable form, contributes risk for thrombotic rapid clinical onset. In this complex scenario atherosclerosis, macrophages participate whole process, initiation, growth eventually rupture wound healing stages artery plaque formation. Macrophages exhibit heterogeneity plasticity, affect evolving microenvironment, e.g., leading excessive lipid accumulation, cytokine hyperactivation, hypoxia, apoptosis necroptosis. metabolic functional transitions response microenvironmental factors not only influence ongoing imminent responses within lesions but also directly dictate atherosclerotic progression regression. review, we discuss origin plaques, their phenotypic diversity, shifts, fate roles they play dynamic atherosclerosis. It describes how interact other cells, particularly T cells. Ultimately, targeting pathways involved macrophage polarization may innovative promising approaches precision medicine. Further insights into landscape biological features offer valuable information optimizing future treatment macrophages.

Language: Английский

Citations

124
Regulated cell death pathways in cardiomyopathy DOI

Shuyuan Sheng,

Jiamin Li, Xinyang Hu

et al.

Acta Pharmacologica Sinica, Journal Year: 2023, Volume and Issue: 44(8), P. 1521 - 1535

Published: March 13, 2023

Language: Английский

Citations

73
Cell death checkpoints in the TNF pathway DOI Open Access
Jon Huyghe, Dario Priem, Mathieu J.M. Bertrand

et al.

Trends in Immunology, Journal Year: 2023, Volume and Issue: 44(8), P. 628 - 643

Published: June 24, 2023

Language: Английский

Citations

64
Role of necroptosis in kidney health and disease DOI
Benedikt Kolbrink, Friedrich Alexander von Samson‐Himmelstjerna, James M. Murphy

et al.

Nature Reviews Nephrology, Journal Year: 2023, Volume and Issue: 19(5), P. 300 - 314

Published: Jan. 3, 2023

Language: Английский

Citations

50
Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer DOI Creative Commons
Chunmei Zhang, Ning Liu

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: July 25, 2022

Ovarian cancer (OC) is one of the most common malignancies that causes death in women and a heterogeneous disease with complex molecular genetic changes. Because relatively high recurrence rate OC, it crucial to understand associated mechanisms drug resistance discover potential target for rational targeted therapy. Cell genetically determined process. Active orderly cell prevalent during development living organisms plays critical role regulating life homeostasis. Ferroptosis, novel type discovered recent years, distinct from apoptosis necrosis mainly caused by imbalance between production degradation intracellular lipid reactive oxygen species triggered increased iron content. Necroptosis regulated non-cysteine protease–dependent programmed necrosis, morphologically exhibiting same features as occurring via unique mechanism different apoptotic signaling pathway. Pyroptosis form characterized formation membrane pores subsequent lysis well release pro-inflammatory contents mediated abscisin family. Studies have shown ferroptosis, necroptosis, pyroptosis are involved progression variety diseases, including tumors. In this review, we summarized advances occurrence, development, therapeutic OC.

Language: Английский

Citations

59
Pyroptosis Provides New Strategies for the Treatment of Cancer DOI Creative Commons

Yuming Jia,

Xin Wang,

Yan-li Deng

et al.

Journal of Cancer, Journal Year: 2023, Volume and Issue: 14(1), P. 140 - 151

Published: Jan. 1, 2023

Cancer is an important cause of death worldwide.The main types cancer treatment are still surgery, chemotherapy and radiotherapy, immunotherapy becoming treatment.Pyroptosis a type programmed cell that accompanies inflammatory response.This paper reviews the recent research progress in pyroptosis tumors.Pyroptosis has been observed since 1986 until recently recognized as mediated by GSDM family proteins.The molecular pathway depends on inflammasome-mediated caspase-1/GSDMD pathway, which canonical caspase-4/5/11/GSDMD noncanonical pathway.Other pathways include caspase3/GSDME.Pyroptosis double-edged sword closely related to tumor immune microenvironment.On one hand, produces chronic environment, promotes transition normal cells cells, helps achieve escape, growth metastasis.On other some treatments can induce pyroptosis, nonapoptotic form death.Additionally, releases molecules promote lymphocyte recruitment enhance system's ability kill cells.With advent immunotherapy, shown antitumor efficacy checkpoint inhibitors.Some antineoplastic agents, such chemotherapeutic also exert effects through pathway.Pyroptosis, mode, focus years, relationship between tumors immunity attracted attention, but there questions be answered regarding specific mechanism.Further study would aid developing new therapies great clinical prospects.

Language: Английский

Citations

43
Defective efferocytosis by aged macrophages promotes STING signaling mediated inflammatory liver injury DOI Creative Commons

Haoran Hu,

Xuyu Cheng,

Fei Li

et al.

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: July 8, 2023

Aged livers have shown aggravated liver ischemia and reperfusion (IR) injury. Timely efferocytosis of apoptotic cells is a key mechanism for avoiding excessive inflammation tissue Here, we investigated the alteration by aged macrophages its role in regulating macrophage STING (stimulator interferon genes) signaling IR young mice were subjected to partial model. Liver injury measured. Efferocytosis underlying regulatory analyzed as well. exhibited impaired with decreased MerTK (c-mer proto-oncogene tyrosine kinase) activation, which was reversed treatment CRISPR activation plasmid. Increased cleavage ADAM17 (a disintegrin metalloproteinase 17) due enhanced ROS (reactive oxygen species) levels contributed defective macrophages. suppressing or improved efferocytosis, leading reduced inflammatory Moreover, increased hepatocytes, DNA accumulation, observed ischemic livers. Improvement via suppressed Our study demonstrates that aging suppresses MerTK- mediated promote injury, suggesting new potential therapy resolution

Language: Английский

Citations

40
Non-lethal outcomes of engaging regulated cell death pathways in cancer DOI
Halime Kalkavan, Sebastian Rühl, Jeremy J.P. Shaw

et al.

Nature Cancer, Journal Year: 2023, Volume and Issue: 4(6), P. 795 - 806

Published: June 5, 2023

Language: Английский

Citations

28