Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease DOI Creative Commons
Debra A. Kendall, Guillermo A. Yudowski

Frontiers in Cellular Neuroscience, Journal Year: 2017, Volume and Issue: 10

Published: Jan. 3, 2017

The identification and cloning of the two major cannabinoid (CB¬1 CB2) receptors together with discovery their endogenous ligands in late 80s early 90s, resulted a effort aimed at understanding mechanisms physiological roles endocannabinoid system (ECS). Due to its expression localization central nervous (CNS), CB1 receptor (endocannabinoids) enzymes involved synthesis degradation, has been implicated multiple pathophysiological events ranging from memory deficits neurodegenerative disorders among others. In this review, we will provide general overview emphasis on health disease. We describe our current complex aspects signaling trafficking, including non-canonical pathways such as those mediated by β-arrestins within context functional selectivity ligand bias. Finally, highlight some which have implicated. Significant knowledge achieved over last 30 years. However, much more research is still needed fully understand system, particularly vivo, unlock true potential source therapeutic targets.

Language: Английский

Acute toxicity due to the confirmed consumption of synthetic cannabinoids: clinical and laboratory findings DOI

Maren Hermanns‐Clausen,

Stefan Kneisel,

Béla Szabó

et al.

Addiction, Journal Year: 2012, Volume and Issue: 108(3), P. 534 - 544

Published: Sept. 13, 2012

Recently, several synthetic cannabinoids were identified in herbal mixtures consumed as recreational drugs alternative to cannabis products. The aim was characterize the acute toxicity of experienced by emergency patients.This a retrospective study targeting patients seeking treatment after use cannabinoids.Patients selected from database Poisons Information Center Freiburg between September 2008 and February 2011. inclusion criteria were: hospitalization, available clinical reports analytical verification cannabinoid uptake. In total, 29 included (age 14-30 years, median 19; 25 males, four females).Clinical evaluated other determined analytically.CP-47,497-C8 (one), JWH-015 JWH-018 (eight), JWH-073 JWH-081 (seven), JWH-122 (11), JWH-210 JWH-250 (four) AM 694 (one) quantified blood samples. most common 2008-9, 2010, Tachycardia, agitation, hallucination, hypertension, minor elevation glucose, hypokalaemia vomiting reported frequently. Chest pain, seizures, myoclonia psychosis also noted.There appears have been an increase extremely potent JWH-210. Acute toxic symptoms associated with their are intake high doses cannabis, but emesis seem be characteristic cannabinoids, which high-affinity high-efficacy agonists CB(1) receptor. Thus, these effects due probably strong receptor stimulation.

Language: Английский

Citations

468
Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD DOI Creative Commons
Jing Han,

Philip Kesner,

Mathilde Metna‐Laurent

et al.

Cell, Journal Year: 2012, Volume and Issue: 148(5), P. 1039 - 1050

Published: March 1, 2012

Language: Английский

Citations

466
Endocannabinoid Signaling and Long-Term Synaptic Plasticity DOI
Boris D. Heifets, Pablo E. Castillo

Annual Review of Physiology, Journal Year: 2009, Volume and Issue: 71(1), P. 283 - 306

Published: Feb. 13, 2009

Endocannabinoids (eCBs) are key activity-dependent signals regulating synaptic transmission throughout the central nervous system. Accordingly, eCBs involved in neural functions ranging from feeding homeostasis to cognition. There is great interest understanding how exogenous (e.g., cannabis) and endogenous cannabinoids affect behavior. Because behavioral adaptations widely considered rely on changes strength, prevalence of eCB-mediated long-term depression (eCB-LTD) at synapses brain merits close attention. The induction expression eCB-LTD, although remarkably similar various synapses, controlled by an array regulatory influences that we just beginning uncover. This complexity endows eCB-LTD with important computational properties, such as coincidence detection input specificity, critical for higher CNS like learning memory. In this article, review major molecular cellular mechanisms underlying well potential physiological relevance widespread form plasticity.

Language: Английский

Citations

461
Endocannabinoids Potentiate Synaptic Transmission through Stimulation of Astrocytes DOI Creative Commons
Marta Navarrete, Alfonso Araque

Neuron, Journal Year: 2010, Volume and Issue: 68(1), P. 113 - 126

Published: Oct. 1, 2010

Language: Английский

Citations

454
The Endocannabinoid 2-Arachidonoylglycerol Produced by Diacylglycerol Lipase α Mediates Retrograde Suppression of Synaptic Transmission DOI Creative Commons
Asami Tanimura, Maya Yamazaki, Yuki Hashimotodani

et al.

Neuron, Journal Year: 2010, Volume and Issue: 65(3), P. 320 - 327

Published: Feb. 1, 2010

Language: Английский

Citations

451
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors DOI

William Marrs,

Jacqueline L. Blankman,

Eric A. Horne

et al.

Nature Neuroscience, Journal Year: 2010, Volume and Issue: 13(8), P. 951 - 957

Published: July 25, 2010

Language: Английский

Citations

419
From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology DOI Open Access
Alessia Ligresti, Luciano De Petrocellis, Vincenzo Di Marzo

et al.

Physiological Reviews, Journal Year: 2016, Volume and Issue: 96(4), P. 1593 - 1659

Published: Sept. 15, 2016

Apart from having been used and misused for at least four millennia for, among others, recreational medicinal purposes, the cannabis plant its most peculiar chemical components, cannabinoids (phytocannabinoids), have merit to led humanity discover one of intriguing pleiotropic endogenous signaling systems, endocannabinoid system (ECS). This review article aims describe critically discuss, in comprehensive possible manner, multifaceted aspects 1) pharmacology potential impact on mammalian physiology all major phytocannabinoids, not only famous Δ 9 -tetrahydrocannabinol, 2) adaptive pro-homeostatic physiological, or maladaptive pathological, roles ECS cells, tissues, organs. In doing so, we respected chronological order milestones millennial route medicinal/recreational beyond, as it is now clear that some early steps this long path, which were originally neglected, are becoming important again. The emerging picture rather complex, but still supports belief more discoveries human physiology, new therapies, might come future knowledge field.

Language: Английский

Citations

418
A cannabinoid link between mitochondria and memory DOI
Étienne Hébert-Chatelain, Tifany Desprez, Romàn Serrat

et al.

Nature, Journal Year: 2016, Volume and Issue: 539(7630), P. 555 - 559

Published: Nov. 1, 2016

Language: Английский

Citations

386
Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling DOI
Emma Puighermanal, Giovanni Marsicano, Arnau Busquets‐Garcia

et al.

Nature Neuroscience, Journal Year: 2009, Volume and Issue: 12(9), P. 1152 - 1158

Published: Aug. 2, 2009

Language: Английский

Citations

376
Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease DOI Creative Commons
Timothy J. Tracey, Frederik J. Steyn, Ernst J. Wolvetang

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2018, Volume and Issue: 11

Published: Jan. 23, 2018

Lipids are a fundamental class of organic molecules implicated in wide range biological processes related to their structural diversity, and based on this can be broadly classified into five categories; fatty acids, triacylglycerols (TAGs), phospholipids, sterol lipids sphingolipids. Different lipid classes play major roles neuronal cell populations; they used as energy substrates, act building blocks for cellular machinery, serve bioactive molecules, or combination each. In amyotrophic lateral sclerosis (ALS), dysfunctions metabolism function have been identified potential drivers pathogenesis. particular, aberrant is proposed underlie denervation neuromuscular junctions, mitochondrial dysfunction, excitotoxicity, impaired transport, cytoskeletal defects, inflammation reduced neurotransmitter release. Here we review current knowledge the CNS discuss how modulating these pathways may offer novel therapeutic options treating ALS.

Language: Английский

Citations

334