Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 29 - 42
Published: Feb. 13, 2025
Language: Английский
Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(9), P. 701 - 719
Published: April 30, 2024
Language: Английский
Citations
117
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(7), P. 4124 - 4257
Published: March 21, 2024
Hydrogen sulfide (H2S) is not only a well-established toxic gas but also an important small molecule bioregulator in all kingdoms of life. In contemporary biology, H2S often classified as "gasotransmitter," meaning that it endogenously produced membrane permeable carries out essential cellular processes. Fluorescent probes for and related reactive sulfur species (RSS) detection provide cornerstone investigating the multifaceted roles these molecules complex biological systems. A now common approach to develop such tools "activity-based probes" couple specific H2S-mediated chemical reaction fluorescent output. This Review covers different types highlights mechanisms by which each probe type activated RSS. Common examples include reduction oxidized nitrogen motifs, disulfide exchange, electrophilic reactions, metal precipitation, coordination. addition, we outline complementary activity-based imaging reductant-labile sulfane species, including persulfides polysulfides. For highlighted this Review, focus on systems with demonstrated compatibility or applications. Building from breadth reported strategies application, highlight key unmet challenges future opportunities advancing
Language: Английский
Citations
65
Redox Biology, Journal Year: 2023, Volume and Issue: 59, P. 102601 - 102601
Published: Jan. 7, 2023
Hydrogen sulfide (H2S) is an important signaling molecule in colorectal cancer (CRC). It produced the colon by catalytic synthesis of colonocytes' enzymatic systems and release intestinal microbes, oxidatively metabolized mitochondria. Both endogenous H2S colonic epithelial cells exogenous lumen contribute to onset progression CRC. The up-regulation synthetases thought be cause elevated levels CRC cells. Different diagnostic probes combination therapies, as well tumor treatment approaches through modulation, have been developed recent years become active area investigation for diagnosis In this review, we focus on specific mechanisms production oxidative metabolism function occurrence, progression, diagnosis, We also discuss present challenges provide insights into future research burgeoning field.
Language: Английский
Citations
64
Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 13
Published: Jan. 4, 2023
Arterial occlusive disease is the leading cause of death in Western countries. Core contemporary therapies for this include angioplasties, stents, endarterectomies and bypass surgery. However, these treatments suffer from high failure rates due to re-occlusive vascular wall adaptations restenosis. Restenosis following surgery largely intimal hyperplasia. Intimal hyperplasia develops response vessel injury, inflammation, smooth muscle cells dedifferentiation, migration, proliferation secretion extra-cellular matrix into vessel’s innermost layer or intima. In review, we describe current state knowledge on origin mechanisms underlying dysregulated hyperplasia, present new avenues research targeting VSMC phenotype proliferation.
Language: Английский
Citations
53
Computers in Biology and Medicine, Journal Year: 2023, Volume and Issue: 165, P. 107408 - 107408
Published: Aug. 29, 2023
Language: Английский
Citations
47
Acta Physiologica, Journal Year: 2024, Volume and Issue: 240(3)
Published: Jan. 25, 2024
Abstract Our aim is to present an updated overview of the erythrocyte metabolism highlighting its richness and complexity. We have manually collected connected available biochemical pathways integrated them into a functional metabolic map. The focus this map on main consisting glycolysis, pentose phosphate pathway, redox metabolism, oxygen purine/nucleoside membrane transport. Other recently emerging are also curated, like methionine salvage glyoxalase system, carnitine lands cycle, as well remnants carboxylic acid metabolism. An additional goal review dynamics providing key numbers used perform basic quantitative analyses. By synthesizing experimental computational data, we conclude that foundations Additionally, can sense levels oxidative stress adjusting mechanics, function. In conclusion, fine‐tuning controls one most important biological processes, is, loading, transport, delivery.
Language: Английский
Citations
34
Nitric Oxide, Journal Year: 2024, Volume and Issue: 144, P. 20 - 28
Published: Jan. 17, 2024
Language: Английский
Citations
23
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 12, 2024
Abstract Background Spinal cord ischemia‒reperfusion injury (SCIRI) can lead to paraplegia, which leads permanent motor function loss. It is a disastrous complication of surgery and causes tremendous socioeconomic burden. However, effective treatments for SCIRI are still lacking. PANoptosis consists three kinds programmed cell death, pyroptosis, apoptosis, necroptosis, may contribute ischemia‒reperfusion-induced neuron death. Previous studies have demonstrated that hydrogen sulfide (H 2 S) exerts neuroprotective effect in many neurodegenerative diseases. whether H S anti-PANoptosis the progression acute remains unclear. Thus, this study we aimed explore role its underlying mechanisms. Methods Measurements lower limb function, neuronal activity, microglia/macrophage histopathological examinations, biochemical levels were performed examine efficacy further demonstrate mechanism treatment SCIRI. Results The results showed GYY4137 (a slow-releasing donor) attenuated loss Nissl bodies after improved BBB score. Additionally, number TUNEL-positive cleaved caspase-3-positive cells was decreased, upregulation expression caspase-8, caspase-3, Bax, Bad downregulation Bcl-2 reversed administration. Meanwhile, both activation p-MLKL, p-RIP1, p-RIP3, along with PI-positive RIP3-positive neurons, decreased GYY4137-treated rats. Furthermore, administration reduced NLRP3, caspase-1 GSDMD, colocalization NeuN/NLRP3 Iba1/interleukin-1β-expressing cells, inhibited proinflammatory factors polarization. Conclusions ameliorated spinal loss, prevented dysfunction SCIRI, exerted via inhibition overactivated microglia-mediated neuroinflammation
Language: Английский
Citations
17
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: March 28, 2024
Abstract CRISPR/Cas9 gene editing systems are widely studied in cancer therapy, however, it is still challenging to improve the efficiency and enhance anticancer efficacy. Herein, a novel self‐assembled manganese sulfide nanourchin with hybrid membrane encapsulation (MCRT) developed highlight synergistic mechanism of hydrogen (H 2 S) therapy. The special structure cationic surface nanourchins facilitate loading large size erythrocyte‐tumor cell membrane, endowing nanoplatform long circulation precise tumor targeting. MCRT pH‐response can effectively decompose into H S Mn 2+ , release acidic microenvironment. up‐regulate intracellular peroxide level by inhibiting activity catalase, which enables self‐enhanced chemodynamic therapy (CDT) . In addition, synergize released CRISPR/Cas9, co‐downregulating anti‐apoptotic protein survivin, achieving Furthermore, systemic delivery displays significantly magnetic resonance imaging (MRI) contrast enhancement. Importantly, S‐enhanced CDT‐gene simultaneously induces immunogenic death triggered robust anti‐tumor immune response. Thus, has potential application for targeted MRI CDT‐gene‐immune
Language: Английский
Citations
17
Microbiological Research, Journal Year: 2024, Volume and Issue: 284, P. 127725 - 127725
Published: April 12, 2024
Language: Английский
Citations
16