Redox Biology,
Journal Year:
2021,
Volume and Issue:
41, P. 101916 - 101916
Published: Feb. 24, 2021
Zinc
and
cellular
oxidants
such
as
reactive
oxygen
species
(ROS)
each
participate
in
a
multitude
of
physiological
functions.
There
is
considerable
overlap
between
the
affected
events,
including
signal
transduction.
While
there
no
obvious
direct
connection
zinc
ROS,
mainly
because
bivalent
cation
does
not
change
its
oxidation
state
biological
systems,
these
are
linked
by
their
interaction
with
sulfur,
forming
remarkable
triad
zinc,
protein
thiols.
First,
binds
to
reduced
thiols
can
be
released
upon
oxidation.
Thereby,
redox
signals
translated
into
changes
free
concentration,
which
act
signals.
Second,
affects
several
ways,
directly
well
indirectly.
A
incorporating
many
interactions
metallothionein
(MT),
rich
cysteine
capable
binding
up
seven
ions
fully
state.
diminished
after
(partial)
oxidation,
while
show
increased
reactivity
absence
bound
metal
ions.
Adding
still
more
complexity,
MT
promoter
controlled
(via
regulatory
transcription
factor
1
(MTF-1))
nuclear
erythroid
2-related
2
(NRF2)).
Many
signaling
cascades
that
important
for
cell
proliferation
or
apoptosis
contain
thiols,
acting
centers
crosstalk
zinc-
redox-signaling.
prominent
example
shared
molecular
targets
ROS
active
site
tyrosine
phosphatases
(PTP),
activity
being
downregulated
binding.
Because
also
protects
PTP
form
irreversible
multi-faceted
reciprocal
interaction,
illustrating
redox-signaling
intricately
on
multiple
levels.
Nutrients,
Journal Year:
2017,
Volume and Issue:
10(1), P. 16 - 16
Published: Dec. 24, 2017
Wound
care
is
a
major
healthcare
expenditure.
Treatment
of
burns,
surgical
and
trauma
wounds,
diabetic
lower
limb
ulcers
skin
wounds
medical
challenge
with
current
therapies
largely
focused
on
supportive
measures.
Successful
wound
repair
requires
series
tightly
coordinated
steps
including
coagulation,
inflammation,
angiogenesis,
new
tissue
formation
extracellular
matrix
remodelling.
Zinc
an
essential
trace
element
(micronutrient)
which
plays
important
roles
in
human
physiology.
cofactor
for
many
metalloenzymes
required
cell
membrane
repair,
proliferation,
growth
immune
system
function.
The
pathological
effects
zinc
deficiency
include
the
occurrence
lesions,
retardation,
impaired
function
compromised
would
healing.
Here,
we
discuss
investigations
cellular
molecular
mechanisms
modulating
healing
process.
Knowledge
gained
from
this
body
research
will
help
to
translate
these
findings
into
future
clinical
management
The Journal of Physiological Sciences,
Journal Year:
2017,
Volume and Issue:
67(2), P. 283 - 301
Published: Jan. 27, 2017
Zinc
(Zn)
is
an
essential
trace
mineral
that
regulates
the
expression
and
activation
of
biological
molecules
such
as
transcription
factors,
enzymes,
adapters,
channels,
growth
along
with
their
receptors.
Zn
deficiency
or
excessive
absorption
disrupts
homeostasis
affects
growth,
morphogenesis,
immune
response,
well
neurosensory
endocrine
functions.
levels
must
be
adjusted
properly
to
maintain
cellular
processes
responses
necessary
for
life.
transporters
regulate
by
controlling
influx
efflux
between
extracellular
intracellular
compartments,
thus,
modulating
concentration
distribution.
Although
physiological
functions
remain
clarified,
there
growing
evidence
are
related
human
diseases,
transporter-mediated
ion
acts
a
signaling
factor,
called
"Zinc
signal".
Here
we
describe
critical
roles
in
body
contribution
at
molecular,
biochemical,
genetic
levels,
review
recently
reported
disease-related
mutations
transporter
genes.
International Journal of Molecular Sciences,
Journal Year:
2016,
Volume and Issue:
17(3), P. 336 - 336
Published: March 4, 2016
Around
3000
proteins
are
thought
to
bind
zinc
in
vivo,
which
corresponds
~10%
of
the
human
proteome.
Zinc
plays
a
pivotal
role
as
structural,
catalytic,
and
signaling
component
that
functions
numerous
physiological
processes.
It
is
more
widely
used
structural
element
than
any
other
transition
metal
ion,
catalytic
many
enzymes,
acts
cellular
mediator.
Thus,
it
expected
metabolism
homeostasis
have
sophisticated
regulation,
elucidating
underlying
molecular
basis
this
essential
understanding
physiology
pathogenesis.
In
recent
decades,
an
increasing
amount
evidence
has
uncovered
critical
roles
number
through
influxing,
chelating,
sequestrating,
coordinating,
releasing,
effluxing
zinc.
Metallothioneins
(MT)
Zrt-
Irt-like
(ZIP)
Zn
transporters
(ZnT)
primarily
involved
these
processes,
their
malfunction
been
implicated
inherited
diseases
such
acrodermatitis
enteropathica.
The
present
review
updates
our
current
biological
MTs
ZIP
ZnT
from
several
new
perspectives.
International Journal of Molecular Sciences,
Journal Year:
2017,
Volume and Issue:
18(11), P. 2285 - 2285
Published: Oct. 31, 2017
In
the
last
decade,
we
witnessed
discoveries
that
established
Zn2+
as
a
second
major
signalling
metal
ion
in
transmission
of
information
within
cells
and
communication
between
cells.
Together
with
Ca2+
Mg2+,
covers
biological
regulation
redox-inert
ions
over
many
orders
magnitude
concentrations.
The
regulatory
functions
zinc
ions,
together
their
cofactor
about
three
thousand
metalloproteins,
impact
virtually
all
aspects
cell
biology.
This
article
attempts
to
define
focuses
on
nature
signals
pathways
where
are
either
extracellular
stimuli
or
intracellular
messengers.
These
interact
Ca2+,
redox,
phosphorylation
signalling.
require
complex
system
precise
homeostatic
control
for
transients,
subcellular
distribution
traffic,
organellar
homeostasis,
vesicular
storage
exocytosis
ions.
