Cell Communication and Signaling,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Aug. 14, 2023
Acute
myocardial
infarction
has
long
been
the
leading
cause
of
death
in
coronary
heart
disease,
which
is
characterized
by
irreversible
cardiomyocyte
and
restricted
blood
supply.
Conventional
reperfusion
therapy
can
further
aggravate
injury.
Stem
cell
therapy,
especially
with
mesenchymal
stem
cells
(MSCs),
emerged
as
a
promising
approach
to
promote
cardiac
repair
improve
function.
MSCs
may
induce
these
effects
secreting
exosomes
containing
therapeutically
active
RNA,
proteins
lipids.
Notably,
normal
function
depends
on
intracardiac
paracrine
signaling
via
exosomes,
secreted
partially
reflect
changes
during
so
analyzing
vesicles
provide
valuable
insights
into
pathology
well
guide
development
new
treatments.
The
present
review
examines
how
produced
influence
injury
after
serve
therapies
against
such
Video
Abstract.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Jan. 12, 2024
Abstract
Although
stem
cell-based
therapy
has
demonstrated
considerable
potential
to
manage
certain
diseases
more
successfully
than
conventional
surgery,
it
nevertheless
comes
with
inescapable
drawbacks
that
might
limit
its
clinical
translation.
Compared
cells,
cell-derived
exosomes
possess
numerous
advantages,
such
as
non-immunogenicity,
non-infusion
toxicity,
easy
access,
effortless
preservation,
and
freedom
from
tumorigenic
ethical
issues.
Exosomes
can
inherit
similar
therapeutic
effects
their
parental
cells
embryonic
adult
through
vertical
delivery
of
pluripotency
or
multipotency.
After
a
thorough
search
meticulous
dissection
relevant
literature
the
last
five
years,
we
present
this
comprehensive,
up-to-date,
specialty-specific
disease-oriented
review
highlight
surgical
application
exosomes.
derived
(e.g.,
embryonic,
induced
pluripotent,
hematopoietic,
mesenchymal,
neural,
endothelial
cells)
are
capable
treating
encountered
in
orthopedic
neurosurgery,
plastic
general
cardiothoracic
urology,
head
neck
ophthalmology,
obstetrics
gynecology.
The
diverse
cells-derived
hierarchical
translation
tissue-specific
responses,
cell-specific
molecular
signaling
pathways.
In
review,
viable
potent
alternative
managing
various
conditions.
We
recommend
future
research
combines
wisdoms
surgeons,
nanomedicine
practitioners,
cell
researchers
intriguing
area.
Molecular Cancer,
Journal Year:
2022,
Volume and Issue:
21(1)
Published: Sept. 13, 2022
Abstract
Mesenchymal
stem
cells
(MSCs)
are
multipotent
stromal
that
can
be
obtained
from
various
human
tissues
and
organs.
They
differentiate
into
a
wide
range
of
cell
types,
including
osteoblasts,
adipocytes
chondrocytes,
thus
exhibiting
great
potential
in
regenerative
medicine.
Numerous
studies
have
indicated
MSCs
play
critical
roles
cancer
biology.
The
crosstalk
between
tumour
has
been
found
to
regulate
many
behaviours,
such
as
proliferation,
metastasis
epithelial-mesenchymal
transition
(EMT).
Multiple
lines
evidence
demonstrated
secrete
exosomes
modulate
the
microenvironment
important
development.
Notably,
very
recent
works
shown
mesenchymal
cell-derived
(MSC-derived
exosomes)
critically
involved
resistance
chemotherapy
agents,
targeted-therapy
drugs,
radiotherapy
immunotherapy.
In
this
review,
we
systematically
summarized
emerging
detailed
molecular
mechanisms
MSC-derived
mediating
therapy
resistance,
providing
novel
insights
clinical
applications
management.
Pharmacological Research,
Journal Year:
2023,
Volume and Issue:
190, P. 106733 - 106733
Published: March 15, 2023
Natural
compounds
are
widely
used
to
prevent
and
treat
various
diseases
due
their
antioxidant
anti-inflammatory
effects.
As
a
kind
of
promising
natural
compound,
plant-derived
exosome-like
nanoparticles
(PELNs)
extracted
from
multivesicular
bodies
edible
plants,
including
vegetables,
foods,
fruits,
mainly
regulate
the
cellular
immune
response
pathogen
attacks.
Moreover,
PELNs
could
remarkably
interfere
with
dynamic
imbalance
between
pro-inflammatory
effects,
facilitating
maintain
homeostasis
microenvironment.
may
serve
as
better
alternative
animal-derived
exosomes
(ADEs)
owing
widespread
sources,
cost-effectiveness,
easy
accessibility.
can
mediate
interspecies
communication
by
transferring
cargoes
such
proteins,
lipids,
nucleic
acids
plant
cells
mammalian
cells.
This
review
summarizes
biogenesis,
composition,
classification
exosomes;
common
separation,
purification,
characterization
methods
PELNs,
potential
advantages
over
ADEs;
immunomodulatory
functions
in
colitis,
cancer,
inflammation-associated
metabolic
diseases.
Additionally,
future
perspectives
challenges
associated
clinical
application
discussed.
Acta Pharmaceutica Sinica B,
Journal Year:
2022,
Volume and Issue:
12(10), P. 3822 - 3842
Published: May 11, 2022
Extracellular
vesicles
(EVs)
are
secreted
by
both
eukaryotes
and
prokaryotes,
present
in
all
biological
fluids
of
vertebrates,
where
they
transfer
DNA,
RNA,
proteins,
lipids,
metabolites
from
donor
to
recipient
cells
cell-to-cell
communication.
Some
EV
components
can
also
indicate
the
type
status
their
parent
serve
as
diagnostic
targets
for
liquid
biopsy.
EVs
natively
carry
or
be
modified
contain
therapeutic
agents
(e.g.,
nucleic
acids,
polysaccharides,
small
molecules)
physical,
chemical,
bioengineering
strategies.
Due
excellent
biocompatibility
stability,
ideal
nanocarriers
bioactive
ingredients
induce
signal
transduction,
immunoregulation,
other
effects,
which
targeted
specific
cell
types.
Herein,
we
review
classification,
intercellular
communication,
isolation,
characterization
strategies
apply
therapeutics.
This
focuses
on
recent
advances
applications
carriers
vitro
research
towards
vivo
animal
models
early
clinical
applications,
using
representative
examples
fields
cancer
chemotherapeutic
drug,
vaccine,
infectious
disease
vaccines,
regenerative
medicine
gene
therapy.
Finally,
discuss
current
challenges
therapeutics
future
development.
Medicinal Research Reviews,
Journal Year:
2022,
Volume and Issue:
42(6), P. 2102 - 2125
Published: June 27, 2022
Abstract
Extracellular
vesicles
are
membranous
particles,
ranging
from
30
nm
to
10
µm
in
diameter,
which
released
by
nearly
all
cell
types
aid
intercellular
communication.
These
complex
carry
a
multitude
of
signaling
moieties
their
origin,
such
as
proteins,
lipids,
surface
receptors,
enzymes,
cytokines,
metabolites,
and
nucleic
acids.
A
growing
body
evidence
suggests
that
addition
delivering
cargos
into
target
cells
facilitate
communication,
extracellular
may
also
play
roles
processes
differentiation
proliferation,
angiogenesis,
stress
response,
immune
signaling.
As
these
have
natural
biocompatibility,
stability
circulation,
low
toxicity,
immunogenicity,
serve
efficient
carriers
molecular
cargos,
nanoparticles
ideal
therapeutic
candidates
for
regenerative
medicine.
Exploring
identifying
the
homeostatic
functions
development
new
therapies.
In
this
review,
we
summarize
wound
healing
process,
difficulties
stem
therapies
medicine,
applications
mesenchymal
stromal
cell‐derived
improving
accelerating
process.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(49)
Published: Oct. 4, 2022
Mitochondrial
dysfunction
is
a
fundamental
pathological
feature
of
Alzheimer's
disease
(AD).
However,
toxicity
and
poor
brain
enrichment
existing
mitophagy
inducers
limit
their
further
applications.
In
this
study,
platform
for
AD
therapy
developed
using
nanosized
mesenchymal-stem-cells-derived
extracellular
vesicles
with
tyrosine
phosphatase-2
(SHP2)
high-expression
(MSC-EVs-SHP2).
The
high
blood-brain
barrier
penetration
ability
MSC-EVs-SHP2
demonstrated
in
AD-mice,
facilitating
SHP2
delivery
to
the
brain.
addition,
significantly
induces
neuronal
cells,
which
alleviates
mitochondrial
damage-mediated
apoptosis
NLRP3
inflammasome
activation.
Mitophagy
diminishes
cells
neuroinflammation,
culminating
rescued
synaptic
loss
cognitive
decline
an
mouse
model.
EV-engineering
technology
provides
potential
effective
by
inducing
mitophagy.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(4)
Published: June 17, 2023
Abstract
Regeneration
is
a
complex
process
affected
by
many
elements
independent
or
combined,
including
inflammation,
proliferation,
and
tissue
remodeling.
Stem
cells
class
of
primitive
with
the
potentiality
differentiation,
regenerate
self‐replication,
multidirectional
immunomodulatory
functions.
their
cytokines
not
only
inextricably
linked
to
regeneration
ectodermal
skin
tissues,
but
also
can
be
used
for
treatment
variety
chronic
wounds.
produce
exosomes
in
paracrine
manner.
cell
play
an
important
role
regeneration,
repair,
accelerated
wound
healing,
biological
properties
which
are
similar
stem
cells,
while
safer
more
effective.
Skin
bone
tissues
critical
organs
body,
essential
sustaining
life
activities.
The
weak
repairing
ability
leads
pronounced
impact
on
quality
patients,
could
alleviated
treatment.
However,
there
obstacles
that
trough
improved
bioavailability.
This
paper
summarizes
applications
mechanisms
healing.
We
propose
new
ways
utilizing
through
different
nanoformulations,
liposomes
nanoliposomes,
polymer
micelles,
microspheres,
hydrogels,
scaffold
microneedles,
improve
use
healing
regeneration.
General Psychiatry,
Journal Year:
2023,
Volume and Issue:
36(5), P. e101143 - e101143
Published: Oct. 1, 2023
There
have
been
no
effective
treatments
for
slowing
or
reversing
Alzheimer's
disease
(AD)
until
now.
Growing
preclinical
evidence,
including
this
study,
suggests
that
mesenchymal
stem
cells-secreted
exosomes
(MSCs-Exos)
the
potential
to
cure
AD.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Sept. 16, 2023
Abstract
Extracellular
vesicles
(EVs)
are
30–150
nm
membrane-bound
naturally
secreted
by
cells
and
play
important
roles
in
intercellular
communication
delivering
regulatory
molecules
such
as
proteins,
lipids,
nucleic
acids
metabolites
to
recipient
cells.
As
natural
nano-carriers,
EVs
possess
desirable
properties
high
biocompatibility,
biological
barrier
permeability,
low
toxicity,
immunogenicity,
making
them
potential
therapeutic
delivery
vehicles.
derived
from
specific
have
inherent
targeting
capacity
towards
cell
types,
which
is
yet
not
satisfactory
enough
for
targeted
therapy
development
needs
be
improved.
Surface
modifications
endow
with
abilities,
significantly
improving
their
efficiency.
Herein,
we
first
briefly
introduce
the
biogenesis,
composition,
uptake
function
of
EVs,
review
cargo
loading
approaches
EVs.
Then,
summarize
recent
advances
surface
engineering
strategies
focusing
on
applications
engineered
therapy.
Altogether,
hold
great
promise
various
cargos,
show
promising
effects
multiple
diseases.
Graphical
