Composition and functional properties of propolis (bee glue): A review

Saudi Journal of Biological Sciences, Journal Year: 2018, Volume and Issue: 26(7), P. 1695 - 1703

Published: Aug. 17, 2018

Propolis is a natural substance collected by honey bees from various plants such as, poplar, palm, pine, conifer secretions, gums, resins, mucilage and leaf buds. It brought very painstakingly to be used for sealing cracks crevices occurring in their hives. Originally, it as an antiseptic meant preventing bee-hive microbial infections along with decomposition of intruders. Additionally, propolis has been folk medicine centuries. The biological characteristics depend upon its chemical composition, plant sources, geographical zone seasons. More than 300 compounds have identified phenolic compounds, aromatic acids, essential oils, waxes amino acids. Many scientific articles are published every year different international journals, several groups researchers focused attention on the activity propolis.

Language: Английский

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Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 131, P. 110622 - 110622

Published: Aug. 17, 2020

Propolis, a resinous material produced by honey bees from plant exudates, has long been used in traditional herbal medicine and is widely consumed as health aid immune system booster. The COVID-19 pandemic renewed interest propolis products worldwide; fortunately, various aspects of the SARS-CoV-2 infection mechanism are potential targets for compounds. entry into host cells characterized viral spike protein interaction with cellular angiotensin-converting enzyme 2 (ACE2) serine protease TMPRSS2. This involves PAK1 overexpression, which kinase that mediates coronavirus-induced lung inflammation, fibrosis, suppression. Propolis components have inhibitory effects on ACE2, TMPRSS2 signaling pathways; addition, antiviral activity proven vitro vivo. In pre-clinical studies, promoted immunoregulation pro-inflammatory cytokines, including reduction IL-6, IL-1 beta TNF-α. monocytes macrophages, well Jak2/STAT3, NF-kB, inflammasome pathways, reducing risk cytokine storm syndrome, major mortality factor advanced disease. also shown promise an treatment comorbidities particularly dangerous patients, respiratory diseases, hypertension, diabetes, cancer. Standardized consistent bioactive properties now available. Given current emergency caused limited therapeutic options, presented promising relevant option safe, easy to administrate orally readily available natural supplement functional food.

Language: Английский

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Potential role of propolis in wound healing: Biological properties and therapeutic activities

Biomedicine & Pharmacotherapy, Journal Year: 2017, Volume and Issue: 98, P. 469 - 483

Published: Dec. 27, 2017

Language: Английский

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Propolis: a new frontier for wound healing?

Burns & Trauma, Journal Year: 2015, Volume and Issue: 3

Published: Jan. 1, 2015

Abstract Propolis is a resin produced by honeybees mixing wax, pollen, salivary secretions, and collected natural resins. The precise composition of propolis varies with the source, over 300 chemical components belonging to flavonoids, terpenes, phenolic acids have been identified in propolis. Moreover, its subjected geographical location, botanical origin, bee species. compounds focus many works due their antimicrobial anti-inflammatory activity; however, it now recognized that also possesses regenerative properties. There an increasing interest healing potential products, considering availability low cost these products. contains huge number explicate some biological effects speeds up process widely used folk remedies. This review aims condense results on mechanism activity compounds.

Language: Английский

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Kaempferol: Antimicrobial Properties, Sources, Clinical, and Traditional Applications

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(23), P. 15054 - 15054

Published: Nov. 30, 2022

Flavonoids are a category of plant-derived compounds which exhibit large number health-related effects. One the most well-known and studied flavonoids is kaempferol, can be found in wide variety herbs plant families. Apart from their anticarcinogenic anti-inflammatory effects, kaempferol its associated also antibacterial, antifungal, antiprotozoal activities. The development drugs treatment schemes based on these becoming increasingly important face emerging resistance numerous pathogens as well complex molecular interactions between various drug therapies. In addition, many kaempferol-containing plants used traditional systems all over world for centuries to treat conditions. Due sources compounds, some mechanisms antimicrobial activity known while others still under analysis. This paper thoroughly documents vegetal food recent significant studies regarding applications.

Language: Английский

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Phytochemical Constituents, Antioxidant, Cytotoxic, and Antimicrobial Activities of the Ethanolic Extract of Mexican Brown Propolis

Antioxidants, Journal Year: 2020, Volume and Issue: 9(1), P. 70 - 70

Published: Jan. 13, 2020

Propolis is a complex mixture of natural sticky and resinous components produced by honeybees from living plant exudates. Globally, research has been dedicated to studying the biological properties chemical composition propolis various geographical climatic regions. However, data Mexican brown are scant. The antioxidant activity ethanolic extract (EEP) sample collected in México isolated compounds described. Cytotoxic was evaluated central nervous system cervical cancer cell lines. Cytotoxicity EEP C6 line (HeLa, SiHa, CasKi) measured 3-(3,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium (MTT) assay. antibacterial tested using minimum inhibitory concentration (MIC) Twelve known were identified nuclear magnetic resonance spectroscopy (NMR). Additionally, forty volatile means headspace-solid phase microextraction with gas chromatography mass spectrometry time flight analysis (HS-SPME/GC-MS-TOF). main detected include nonanal (18.82%), α-pinene (12.45%), neryl alcohol (10.13%), (8.04%). showed an anti-proliferative effect on glioma cells better than temozolomide, also decreased proliferation viability cells, but its effectiveness lower compared cisplatin.

Language: Английский

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Antiviral, Antibacterial, Antifungal, and Antiparasitic Properties of Propolis: A Review

Foods, Journal Year: 2021, Volume and Issue: 10(6), P. 1360 - 1360

Published: June 11, 2021

Propolis is a complex phytocompound made from resinous and balsamic material harvested by bees flowers, branches, pollen, tree exudates. Humans have used propolis therapeutically for centuries. The aim of this article to provide comprehensive review the antiviral, antibacterial, antifungal, antiparasitic properties propolis. mechanisms action are discussed. There two distinct impacts with regards antimicrobial anti-parasitic propolis, on pathogens host. With pathogens, acts disrupting ability invade host cells forming physical barrier inhibiting enzymes proteins needed invasion into cells. also inhibits replication process pathogens. Moreover, metabolic processes cellular organelles components responsible energy production. regard host, functions as an immunomodulator. It upregulates innate immunity modulates inflammatory signaling pathways. helps maintain host’s antioxidant status. More importantly, small number human clinical trials demonstrated efficacy safety adjuvant therapy pathogenic infections.

Language: Английский

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Bee Products: An Emblematic Example of Underutilized Sources of Bioactive Compounds

Journal of Agricultural and Food Chemistry, Journal Year: 2022, Volume and Issue: 70(23), P. 6833 - 6848

Published: Jan. 2, 2022

Beside honey, honeybees (Apis mellifera L.) are able to produce many byproducts, including bee pollen, propolis, bread, royal jelly, and beeswax. Even if the medicinal properties of these byproducts have been recognized for thousands years by ancient civilizations, in modern era, they a limited use, essentially as nutritional supplements or health products. However, natural products excellent sources bioactive compounds, macro- micronutrients, that, synergistic way, confer multiple biological activities such as, example, antimicrobial, antioxidant, anti-inflammatory properties. This work aims update chemical phytochemical composition beeswax summarize main effects exerted on human health, from anticancer immune-modulatory antidiabetic, hypolipidemic, hypotensive, anti-allergic

Language: Английский

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The Honey Bee Apis mellifera: An Insect at the Interface between Human and Ecosystem Health

Biology, Journal Year: 2022, Volume and Issue: 11(2), P. 233 - 233

Published: Feb. 1, 2022

The concept of ecosystem services is widely understood as the and benefits thatecosystems provide to humans, they have been categorised into provisioning, regulating, supporting, cultural services. This article aims an updated overview that honey bee Apis mellifera provides humans well ecosystems. We revised role bees pollinators in natural ecosystems preserve restore local biodiversity wild plants; agro-ecosystems, this species used enhance crop yield quality, meeting increasing food demand. Beekeeping activity not only with high-quality but also substances raw materials pharmaceuticals, polluted areas, convey valuable information on environmental presence pollutants their impact human health. Finally, symbolic tradition, mysticism, values habitats are presented. Overall, we suggest value most important played by insect species, it may help revitalise strengthen intimate reciprocal relationship between world, avoiding inaccuracy considering mere providers humans.

Language: Английский

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Propolis: Its Role and Efficacy in Human Health and Diseases

Molecules, Journal Year: 2022, Volume and Issue: 27(18), P. 6120 - 6120

Published: Sept. 19, 2022

With technological advancements in the medicinal and pharmaceutical industries, numerous research studies have focused on propolis produced by stingless bees (Meliponini tribe) Apis mellifera honeybees as alternative complementary medicines for potential treatment of various acute chronic diseases. Propolis can be found tropical subtropical forests throughout world. The composition phytochemical constituents varies depending bee species, geographical location, botanical source, environmental conditions. Typically, contains lipid, beeswax, essential oils, pollen, organic components. latter include flavonoids, phenolic compounds, polyphenols, terpenes, terpenoids, coumarins, steroids, amino acids, aromatic acids. biologically active propolis, which countless compounds such artepillin C, caffeic acid, acid phenethyl ester, apigenin, chrysin, galangin, kaempferol, luteolin, genistein, naringin, pinocembrin, coumaric quercetin, a broad spectrum biological therapeutic properties antidiabetic, anti-inflammatory, antioxidant, anticancer, rheumatoid arthritis, obstruct pulmonary disorders, cardiovascular diseases, respiratory tract-related gastrointestinal well neuroprotective, immunomodulatory, immuno-inflammatory agents. Therefore, this review aims to provide summary recent role its constituents, their efficacy

Language: Английский

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