Composition and functional properties of propolis (bee glue): A review

Saudi Journal of Biological Sciences, Journal Year: 2018, Volume and Issue: 26(7), P. 1695 - 1703

Published: Aug. 17, 2018

Propolis is a natural substance collected by honey bees from various plants such as, poplar, palm, pine, conifer secretions, gums, resins, mucilage and leaf buds. It brought very painstakingly to be used for sealing cracks crevices occurring in their hives. Originally, it as an antiseptic meant preventing bee-hive microbial infections along with decomposition of intruders. Additionally, propolis has been folk medicine centuries. The biological characteristics depend upon its chemical composition, plant sources, geographical zone seasons. More than 300 compounds have identified phenolic compounds, aromatic acids, essential oils, waxes amino acids. Many scientific articles are published every year different international journals, several groups researchers focused attention on the activity propolis.

Language: Английский

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Biological Properties and Therapeutic Applications of Propolis

Phytotherapy Research, Journal Year: 2016, Volume and Issue: 30(6), P. 894 - 905

Published: March 14, 2016

Propolis is a resinous material collected by bees from bud and exudates of the plants, mixed with bee enzymes, pollen wax. In this review, biological properties propolis some therapeutic applications are discussed. The same activities have been investigated until today, using samples different geographic regions. Thus, study given sample should always be associated its chemical composition botanical source, representing particular area, exploring potential role constituents. Efforts carried out to explain propolis' mechanisms action in vivo vitro, but majority targets actions still unclear. number formulations containing patents increased, although extracts used deliberately recommendations, not mentioning composition, vegetal source methods extraction. Clinical studies will help obtain criterious recommendations view expected outcomes. Further investigation explore effects common compounds found all over world an attempt standardize research on new drugs. Copyright © 2016 John Wiley & Sons, Ltd.

Language: Английский

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Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

Frontiers in Pharmacology, Journal Year: 2017, Volume and Issue: 8

Published: June 28, 2017

Honeybees produce honey, royal jelly, propolis, bee venom, pollen, and beeswax, which potentially benefit to humans due the bioactives in them. Clinical standardization of these products is hindered by chemical variability depending on honeybee botanical sources, but different molecules have been isolated pharmacologically characterized. Major honey include phenolics, methylglyoxal, jelly proteins (MRJPs), oligosaccharides. In there are antimicrobial jelleins royalisin peptides, immunomodulatory MRJPs, hydroxy-decenoic acid derivatives, notably 10-hydroxy-2-decenoic (10-HDA), with antimicrobial, anti-inflammatory, immunomodulatory, neuromodulatory, metabolic syndrome preventing, antiaging activities. Propolis contains caffeic phenethyl ester (CAPE) artepillin C, specific Brazilian antiviral, anti-inflammatory anticancer effects. Bee venom consists toxic peptides like pain-inducing melittin, SK channel blocking apamin, allergenic phospholipase A2. pollen vitaminic, antioxidant plant as well antiatherosclerotic, antidiabetic, hypoglycemic flavonoids, unsaturated fatty acids, sterols. Beeswax widely used cosmetics makeup. Given importance drug discovery from natural this review aimed at providing an exhaustive screening bioactive compounds detected their curative or adverse biological

Language: Английский

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Propolis as a novel antibacterial agent

Saudi Journal of Biological Sciences, Journal Year: 2020, Volume and Issue: 27(11), P. 3079 - 3086

Published: Sept. 14, 2020

Propolis (bee glue) is a bee glue, sticky resinous material released from various plant sources such as bud exudates, flowers, and leaves modified by secretions wax propolis composed of resins, waxes, polyphenols, polysaccharides, volatile materials, secondary metabolites that are responsible for bioactivity antibacterial, anti-angiogenic, antiulcer, anti-inflammatory, antioxidant, anti-viral activities. The physico-chemical characteristics the natural properties kinds have been studied past decade. Novel active anti-microbial compounds identified in propolis. Those positively modulated antimicrobial resistance multidrug resistant bacteria. Published research has indicated its derivatives many with broad spectrum against different types bacteria it enhanced efficacy conventional antibiotics. Besides, combination other honey whereby, combinations synergistic effect bacterial strains Escherichia coli Staphylococcus aureus. activity very much dependent on seasonal regional factors, Middle Eastern shown best antibacterial efficacy. main flavonoids ingredients should not be overlooked evaluated clinical trials to better elucidate their potential application fields medicine. Clinical use new drugs biotechnological products conducted. This review aims at highlighting some recent scientific findings associated components.

Language: Английский

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Potential role of propolis in wound healing: Biological properties and therapeutic activities

Biomedicine & Pharmacotherapy, Journal Year: 2017, Volume and Issue: 98, P. 469 - 483

Published: Dec. 27, 2017

Language: Английский

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Advances in keratinocyte delivery in burn wound care

Advanced Drug Delivery Reviews, Journal Year: 2017, Volume and Issue: 123, P. 18 - 32

Published: June 28, 2017

This review gives an updated overview on keratinocyte transplantation in burn wounds concentrating application methods and future therapeutic cell delivery options with a special interest hydrogels spray devices for delivery. To achieve faster re-epithelialisation of wounds, the original autologous culture technique was introduced over 3 decades ago. Application types keratinocytes have improved from sheets to single-cell solutions delivered system. However, further enhancement culture, viability function vivo, carrier systems remain themes interest. Hydrogels such as chitosan, alginate, fibrin collagen are frequently used wound care advantageous characteristics carriers. Future approaches involve devices, but optimisation type is necessary.

Language: Английский

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A Novel Bilayer Wound Dressing Composed of a Dense Polyurethane/Propolis Membrane and a Biodegradable Polycaprolactone/Gelatin Nanofibrous Scaffold

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: Feb. 20, 2020

One-layer wound dressings cannot meet all the clinical needs due to their individual characteristics and shortcomings. Therefore, bilayer which are composed of two layers with different properties have gained lots attention. In present study, polycaprolactone/gelatin (PCL/Gel) scaffold was electrospun on a dense membrane polyurethane ethanolic extract propolis (PU/EEP). The PU/EEP used as top layer protect area from external contamination dehydration, while PCL/Gel sublayer facilitate cells' adhesion proliferation. dressing investigated regarding its microstructure, mechanical properties, surface wettability, anti-bacterial activity, biodegradability, biocompatibility, efficacy in animal model histopathological analyzes. Scanning electron micrographs exhibited uniform morphology bead-free structure average fibers' diameter 237.3 ± 65.1 nm. Significant activity observed against Staphylococcal aureus (5.4 0.3 mm), Escherichia coli (1.9 0.4 mm) Staphylococcus epidermidis (1.0 0.2 according inhibition zone test. high hydrophilicity (51.1 4.9°), biocompatibility. could significantly accelerate closure collagen deposition Wistar rats' skin model. Taking together, PU/EEP-PCL/Gel can be potential candidate for biomedical applications remarkable antibacterial features, healing activities.

Language: Английский

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Propolis: An update on its chemistry and pharmacological applications

Chinese Medicine, Journal Year: 2022, Volume and Issue: 17(1)

Published: Aug. 26, 2022

Propolis, a resinous substance produced by honeybees from various plant sources, has been used for thousands of years in traditional medicine several purposes all over the world. The precise composition propolis varies according to source, seasons harvesting, geography, type bee flora, climate changes, and honeybee species at site collection. This apiary product broad clinical applications such as antioxidant, anti-inflammatory, antimicrobial, anticancer, analgesic, antidepressant, anxiolytic well asimmunomodulatory effects. It is also known uses treating purulent disorders, improving wound healing, alleviating many related discomforts. Even if its use was already widespread since ancient times, after First Second World War, it grown even more studies identify chemical pharmacological features, allowing discriminate qualities terms profile relative biological activity based on geographic place origin. Recently, vitro vivo have carried out new insights into pharmaceutical prospects this management different highlighted. Specifically, available literature confirms efficacy bioactive compounds reduction cancer progression, inhibition bacterial viral infections mitigation parasitic-related symptoms, paving way an alternative approach improve human health. However, conscious standardized extracts are needed substantiate these health claims.

Language: Английский

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Recent advances in 3D printing for wound healing: A systematic review

Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 74, P. 103564 - 103564

Published: July 6, 2022

The advances in additive manufacturing over the past decade have led to development of innovative strategies several healthcare sectors. treatment and healing chronic wounds remains a major clinical challenge due insufficient healing, increasing number patients financial burden systems. use novel natural or synthetic biomaterials design cell-laden bioinks combined with drug substances has paved way for effective wound management including engineering skin substitutes regeneration. advantages printing technologies encompass combination unlimited bioactive molecules cells polymers, fabrication complex scaffold designs, accelerated times personalised dressings. This review highlights principles processes used technological processing limitations. We also provide current trends improvements focusing on materials antimicrobial, antioxidant properties incorporation peptides wounds. Finally, we present approaches tissue regeneration based 3D printing.

Language: Английский

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3D Bioprinted Chitosan-Based Hydrogel Scaffolds in Tissue Engineering and Localised Drug Delivery

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(9), P. 1978 - 1978

Published: Sept. 19, 2022

Bioprinting is an emerging technology with various applications in developing functional tissue constructs for the replacement of harmed or damaged tissues and simultaneously controlled drug delivery systems (DDSs) administration several active substances, such as growth factors, proteins, molecules. It a novel approach that provides high reproducibility precise control over fabricated automated way. An ideal bioink should possess proper mechanical, rheological, biological properties essential to ensure function. Chitosan promising natural-derived polysaccharide be used ink because its attractive properties, biodegradability, biocompatibility, low cost, non-immunogenicity. This review focuses on 3D bioprinting preparation chitosan-based hydrogel scaffolds regeneration delivering either cells substances promote restoration.

Language: Английский

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