Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(2), P. 444 - 444
Published: Feb. 16, 2024
Sepsis
is
a
syndrome
of
organ
dysfunction
caused
by
an
uncontrolled
inflammatory
response,
which
can
seriously
endanger
life.
Currently,
there
still
shortage
specific
therapeutic
drugs.
Quercetin
and
its
natural
derivatives
have
received
lot
attention
recently
for
their
potential
in
treating
sepsis.
Here,
we
provide
comprehensive
summary
the
recent
research
progress
on
quercetin
derivatives,
with
focus
mechanisms
antioxidation
anti-inflammation.
To
obtain
necessary
information,
conducted
search
PubMed,
Web
Science,
EBSCO,
Cochrane
library
databases
using
keywords
sepsis,
anti-inflammatory,
antioxidant,
anti-infection,
quercetin,
to
identify
relevant
from
6315
articles
published
last
five
years.
At
present,
11
been
intensively
studied.
They
primarily
exert
anti-inflammation
effects
through
PI3K/AKT/NF-κB,
Nrf2/ARE,
MAPK
pathways.
The
feasibility
these
compounds
experimental
models
clinical
application
were
also
discussed.
In
conclusion,
good
treatment
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Oct. 14, 2024
Iron,
an
essential
mineral
in
the
body,
is
involved
numerous
physiological
processes,
making
maintenance
of
iron
homeostasis
crucial
for
overall
health.
Both
overload
and
deficiency
can
cause
various
disorders
human
diseases.
Ferroptosis,
a
form
cell
death
dependent
on
iron,
characterized
by
extensive
peroxidation
lipids.
Unlike
other
kinds
classical
unprogrammed
death,
ferroptosis
primarily
linked
to
disruptions
metabolism,
lipid
peroxidation,
antioxidant
system
imbalance.
Ferroptosis
regulated
through
transcription,
translation,
post-translational
modifications,
which
affect
cellular
sensitivity
ferroptosis.
Over
past
decade
or
so,
diseases
have
been
as
part
their
etiology,
including
cancers,
metabolic
disorders,
autoimmune
diseases,
central
nervous
cardiovascular
musculoskeletal
Ferroptosis-related
proteins
become
attractive
targets
many
major
that
are
currently
incurable,
some
regulators
shown
therapeutic
effects
clinical
trials
although
further
validation
potential
needed.
Therefore,
in-depth
analysis
its
molecular
mechanisms
may
offer
additional
strategies
prevention
treatment.
In
this
review,
we
discuss
significance
contribution
etiology
development
along
with
evidence
supporting
targeting
approach.
Importantly,
evaluate
recent
promising
interventions,
providing
guidance
future
targeted
treatment
therapies
against
Food Reviews International,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 50
Published: Jan. 4, 2025
Cancer
is
the
world's
second
most
common
cause
of
death,
with
colon
cancer
(CC)
ranking
third
in
prevalence
and
cancer-related
fatalities.
CC
originates
or
rectum
influenced
by
genetic
mutations,
lifestyle,
diet.
Although
chemotherapy,
especially
5-fluorouracil
(5-FU),
fundamental
to
treatment
has
improved
patient
survival,
its
benefits
are
often
limited
significant
side
effects
emerging
drug
resistance.
Recently,
plant-based
foods
have
drawn
interest
research
for
their
natural
bioactive
compounds
relatively
low
toxicity.
Certain
plant
not
only
exhibit
anti-cancer
activity
but
may
also
boost
effectiveness
5-FU
while
reducing
adverse
effects.
Despite
evidence
suggesting
a
synergistic
effect
between
5-FU,
this
area
remains
fragmented.
This
review
consolidates
current
on
including
fruits,
vegetables,
legumes,
tea
bioactives
treatment.
Besides,
it
explores
mechanisms
through
which
these
enhance
efficacy
reduce
effects,
evaluates
clinical
application
prospects,
identifies
challenges
future
directions.
comprehensive
analysis
aims
provide
scientific
foundation
integrated
CC,
highlighting
potential
enhancing
chemotherapy
associated
toxicities.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: July 11, 2022
Moringa
oleifera
is
one
of
the
popular
plants
that
have
shown
significant
health
benefits.
Certainly,
preclinical
evidence
(predominantly
from
animal
models)
summarized
in
current
review
supports
beneficial
effects
leaf
extracts
combating
prominent
characteristic
features
diabetes
mellitus.
This
includes
effective
control
blood
glucose
or
insulin
levels,
enhancement
tissue
sensitivity,
improvement
lipid
profiles,
and
protecting
against
organ
damage
under
sustained
conditions
hyperglycemia.
Interestingly,
as
major
complications
implicated
progression
diabetes,
including
damage,
seed
could
efficiently
block
detrimental
oxidative
stress
inflammation
these
models.
Notably,
(especially
extracts)
showed
enhanced
strengthening
intracellular
antioxidant
defences
like
catalase,
superoxide
dismutase,
glutathione
to
lower
peroxidation
products
reduce
pro-inflammatory
markers
such
tumor
necrosis
factor-α,
interleukin
(1L)-β,
IL-6,
monocyte
chemoattractant
protein-1
nitric
oxide
synthase.
From
models
common
dose
was
100–300
mg/kg,
within
treatment
duration
2–8
weeks.
Whereas
supplementation
with
approximately
20
g
powder
for
at
least
2
weeks
improve
postprandial
subjects
prediabetes
diabetes.
Although
limited
clinical
studies
been
conducted
on
antidiabetic
properties
,
findings
provide
an
important
platform
future
research
directed
developing
this
plant
a
functional
food
manage
diabetic
complications.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 26, 2024
.,
commonly
known
as
Chinese
prickly
ash,
is
a
well-known
spice
and
traditional
medicine
ingredient
with
rich
history
of
use
in
treating
inflammatory
conditions.
This
review
provides
comprehensive
overview
the
botanical
classification,
applications,
anti-inflammatory
effects
Analytical Methods,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1480 - 1488
Published: Jan. 1, 2024
Rutin
(RUT),
a
natural
flavonoid
with
various
beneficial
pharmacological
actions
such
as
cardioprotective,
antioxidant,
anti-inflammatory,
neuroprotective,
etc.
,
is
found
in
the
content
of
many
plants
that
are
consumed
daily.
Foods,
Journal Year:
2025,
Volume and Issue:
14(4), P. 619 - 619
Published: Feb. 13, 2025
The
consumption
of
wampee
has
traditionally
been
utilized
to
alleviate
gastrointestinal
inflammation
and
associated
disorders;
however,
its
exact
mechanism
remained
unknown.
aim
this
study
was
elucidate
the
therapeutic
efficacy
underlying
polyphenol
extract
(WPE)
in
dextran
sulfate
sodium
(DSS)-induced
ulcerative
colitis
(UC).
findings
revealed
that
WPE
alleviated
diverse
symptoms
UC,
regulated
various
inflammatory
cytokines,
effectively
protected
colon
tissue
structure
barrier
integrity,
thereby
inhibiting
LPS
translocation.
Moreover,
restored
richness
diversity
gut
microbiota
optimized
at
phylum
genus
levels,
causing
a
notable
improvement
short-
chain
fatty
acid
(SCFA)
metabolism,
particularly
acetic
acid,
propionic
butyric
acid.
Consequently,
demonstrated
suppress
LPS-induced
TLR4-p38
MAPK/NF-κB
signaling
pathway
by
modulating
SCFA
metabolism.
These
provided
theoretical
basis
for
use
as
potential
functional
natural
food
UC.
