Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 3, 2024
Background
Gowing
number
of
studies
have
demonstrated
the
association
between
gut
microbiome
and
T2DM
microvascular
complications,
however
causal
relationship
remains
unclear.
Therefore,
we
using
Mendelian
randomization
(MR)
approach
to
investigate
this
relation.
Methods
Using
data
from
International
MiBioGen
Consortium
genome-wide
study
(GWAS)
complications
FinnGen
GWAS
perform
MR
analyses.
Single
nucleotide
polymorphisms
(SNPs)
were
selected
as
instrumental
variables
(IVs),
inverse
variance
weighting
(IVW)
method
was
used
primary
analysis
method,
results
tested
for
heterogeneity
horizontal
pleiotropy.
Results
Our
research
identified
that
there
are
5
known
microbial
species
2
unknown
in
causally
related
retinopathy.
Besides,
three
seven
relationships
neuropathy
nephropathy,
respectively.
Conclusions
methods,
T2DM,
providing
a
new
strategy
prevention
treatment
it.
Apmis,
Journal Year:
2022,
Volume and Issue:
130(12), P. 690 - 705
Published: April 8, 2022
This
narrative
review
seeks
to
examine
the
relationships
between
bacterial
microbiomes
and
infectious
disease.
is
achieved
by
detailing
how
different
human
host
develop
function,
from
earliest
infant
acquisitions
of
maternal
environmental
species
through
full
development
adulthood.
Communication
or
communities
within
outside
microbiome
a
factor
in
both
maintenance
homeostasis
management
threats
external
environment.
Dysbiosis
this
key
understanding
disease
states.
Several
microbiota
are
used
as
prime
examples
changes
composition,
particularly
at
phylum
level,
leads
such
diverse
conditions
inflammatory
bowel
(IBD),
type
2
diabetes,
psoriasis,
Parkinson's
disease,
reflux
oesophagitis
others.
The
examines
spatial
understand
dysbiosis
gut
particular
can
influence
diseases
distant
sites
via
routes
gut-lung,
gut-skin
gut-brain
axes.
Microbiome
interaction
with
processes
adaptive
immunity
increasingly
identified
critical
developing
capacity
immune
system
react
pathogens.
essential
bacteria
involved
modification
substrates
bile
acid
components
result
Crohn's
small
intestine
overgrowth,
hepatic
cancer
obesity.
Interactions
distantly
located
being
identified,
resulting
'whole
body'
effect
combined
microbiome.
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: June 17, 2022
Background
Emerging
evidence
indicates
that
gut
dysbiosis
is
involved
in
the
occurrence
and
development
of
diabetic
kidney
diseases
(DKD).
However,
key
microbial
taxa
closely
related
to
DKD
have
not
been
determined.
Methods
PubMed,
Web
Science,
Cochrane,
Chinese
Biomedical
Databases,
China
National
Knowledge
Internet,
Embase
were
searched
for
case-control
or
cross-sectional
studies
comparing
microbiota
patients
with
healthy
controls
(HC)
from
inception
February
8,
2022,
random/fixed-effects
meta-analysis
on
standardized
mean
difference
(SMD)
performed
alpha
diversity
indexes
between
HC,
beta
relative
abundance
extracted
summarized
qualitatively.
Results
A
total
16
(578
444
HC)
included.
Compared
bacterial
richness
was
significantly
decreased,
decreased
but
statistically,
companying
a
distinct
diversity.
The
phylum
Proteobacteria
,
Actinobacteria
Bacteroidetes
family
Coriobacteriaceae
Enterobacteriaceae
Veillonellaceae
genus
Enterococcus
Citrobacter
Escherichia
Klebsiella
Akkermansia
Sutterella
Acinetobacter
species
E.
coli
enriched
while
Firmicutes
Lachnospiraceae
Roseburia
Prevotella
Bifidobacterium
depleted
DKD.
Conclusions
may
possess
specific
features
characterized
by
expansion
depletion
which
contribute
most
alterations
their
corresponding
taxa,
as
well
composition.
These
be
serve
promising
targets
management
Systematic
Review
Registration
https://www.crd.york.ac.uk/prospero/
identifier
CRD42021289863.
International Journal of Biological Macromolecules,
Journal Year:
2023,
Volume and Issue:
257, P. 128588 - 128588
Published: Dec. 2, 2023
This
study
focuses
on
the
characterization
and
regulation
of
glycolipid
metabolism
polysaccharides
derived
from
biomass
Phyllostachys
nigra
(Lodd.
ex
Lindl.)
root
(PNr).
The
extracts
dilute
hydrochloric
acid,
hot
water,
2
%
sodium
hydroxide
solution
were
characterized
through
molecular
weight,
gel
permeation
chromatography,
monosaccharides,
Fourier
transform
infrared,
nuclear
magnetic
resonance
spectroscopy
analyses.
Polysaccharide
alkali
extraction
sieve
purification
(named
as:
PNS2A)
exhibited
optimal
inhibitory
3T3-L1
cellular
differentiation
lowered
insulin
resistance.
PNS2A
is
made
a
hemicellulose-like
main
chain
→4)-β-D-Xylp-(1→
that
was
connected
by
branches
4-O-Me-α-GlcAp-(1→,
T-α-D-Galp-(1→,
T-α-L-Araf-(1→,
→2)-α-L-Araf-(1→,
as
well
β-D-Glcp-(1→4-β-D-Glcp-(1→
fragments.
Oral
delivery
in
diabetes
mice
brought
down
blood
glucose
cholesterol
levels
regulated
lipid
metabolism.
alleviated
symptoms
body
weight
protected
liver
kidney
function
model
animals
altering
gut
microbiome.
Polysaccharides
can
be
new
approach
to
develop
bamboo
resources.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(12), P. 1870 - 1870
Published: June 14, 2024
Type
2
diabetes
mellitus
(T2DM)
is
a
chronic
metabolic
disease
which
seriously
affects
public
health.
Gut
microbiota
remains
dynamic
balance
state
in
healthy
individuals,
and
its
disorder
may
affect
health
status
even
results
diseases.
Quercetin,
natural
flavonoid,
has
been
shown
to
have
biological
activities
that
can
be
used
the
prevention
treatment
of
This
study
aimed
explore
mechanism
quercetin
alleviating
T2DM
based
on
gut
microbiota.
db/db
mice
were
adopted
as
model
for
this
study.
After
10
weeks
administration,
could
significantly
decrease
levels
body
weight,
fasting
blood
glucose
(FBG),
serum
insulin
(INS),
homeostasis
assessment
resistance
(HOMA-IR),
monocyte
chemoattractant
protein-1
(MCP-1),
D-lactic
acid
(D-LA),
lipopolysaccharide
(LPS)
mice.
16S
rRNA
gene
sequencing
untargeted
metabolomics
analysis
performed
compare
differences
metabolites
among
groups.
The
demonstrated
decreased
abundance
Proteobacteria,
Bacteroides,
Escherichia-Shigella
Escherichia_coli.
Moreover,
showed
L-Dopa
S-Adenosyl-L-methionine
(SAM)
increased,
but
3-Methoxytyramine
(3-MET),
L-Aspartic
acid,
L-Glutamic
Androstenedione
under
intervention.
Taken
together,
exert
hypoglycemic
effect,
alleviate
resistance,
repair
intestinal
barrier,
remodel
microbiota,
alter
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 17, 2025
The
gut
microbiota
play
crucial
roles
in
the
digestion
and
degradation
of
nutrients,
synthesis
biological
agents,
development
immune
system,
maintenance
gastrointestinal
integrity.
Gut
dysbiosis
is
thought
to
be
associated
with
type
2
diabetes
mellitus
(T2DM),
one
world's
fastest
growing
diseases.
aim
this
systematic
review
identify
differences
composition
diversity
individuals
T2DM.
A
search
was
conducted
studies
reporting
on
difference
between
T2DM
healthy
controls.
Relevant
were
evaluated,
their
characteristics
results
extracted
using
a
standardized
data
extraction
form.
assessed
for
risk
bias
findings
reported
narratively.
58
observational
published
2010
2024
included.
Beta
commonly
different
individuals.
Genera
Lactobacillus,
Escherichia-Shigella,
Enterococcus,
Subdoligranulum
Fusobacteria
found
positively
associated;
while
Akkermansia,
Bifidobacterium,
Bacteroides,
Roseburia,
Faecalibacteirum
Prevotella
negatively
This
demonstrates
strong
association
dysbiosis,
as
evidenced
by
differential
microbial
abundances
altered
indices.
Among
these
taxa,
Escherichia-Shigella
consistently
T2DM,
whereas
Faecalibacterium
prausnitzii
appears
offer
protective
effect
against
However,
heterogeneity
nature
preclude
establishment
causative
relationships.
Future
research
should
incorporate
age,
diet
medication-matched
controls,
include
functional
analysis
microbes.
https://www.crd.york.ac.uk/prospero/,
identifier
CRD42023459937.
Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
9
Published: Oct. 15, 2021
Recent
evidence
suggests
there
is
a
link
between
metabolic
diseases
and
gut
microbiota.
To
investigate
the
microbiota
composition
fecal
phenotype
in
diabetic
retinopathy
(DR)
patients.
DNA
was
extracted
from
50
samples
(21
individuals
with
type
2
diabetes
mellitus-associated
(DR),
14
mellitus
but
without
(DM)
15
sex-
age-matched
healthy
controls)
then
sequenced
by
high-throughput
16S
rDNA
analysis.
Liquid
chromatography
mass
spectrometry
(LC-MS)-based
metabolomics
simultaneously
performed
on
samples.
A
significant
difference
observed
DR
groups
DM
groups.
At
genus
level,
Faecalibacterium
,
Roseburia
Lachnospira
Romboutsia
were
enriched
patients
compared
to
individuals,
while
Akkermansia
depleted.
Compared
those
patient
group,
five
genera,
including
Prevotella
enriched,
Bacillus
Veillonella
Pantoea
depleted
Fecal
metabolites
significantly
differed
population
The
levels
of
carnosine,
succinate,
nicotinic
acid
niacinamide
lower
than
controls.
patients,
nine
six
KEGG
annotation
revealed
17
pathways
differentially
abundant
controls,
only
two
identified
namely,
arginine-proline
α-linolenic
pathways.
In
correlation
analysis,
armillaramide
found
be
negatively
associated
Subdoligranulum
positively
.
Traumatic
correlated
Our
study
differential
compositions
characteristic
phenotypes
Additionally,
relevant.
We
speculated
that
may
cause
alterations
metabolites,
which
contribute
disease
progression,
providing
new
direction
for
understanding
DR.
Scientific Reports,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: Dec. 23, 2022
Abstract
The
association
between
gut
microbiome
and
chronic
metabolic
disease
including
polycystic
ovary
syndrome
(PCOS),
is
well
documented,
however,
the
relationship
microbiota
serum
metabolites
remains
unknown.
In
this
study,
untargeted
metabolomics
together
with
a
16S
rRNA
gene
sequencing
tool
was
used
to
detect
small
molecule
microbiome.
We
identified
15
differential
PCOS
patients
healthy
control.
Lysophosphatidylcholine
(LPC)
(18:2,
20:3,
18:1,
P-16:0,
17:0,
15:0,
18:3,
20:4),
phosphatidylcholine(PC),
ganglioside
GA2
(d18:1/16:0)
1-linoleoylglycerophosphocholine
were
increased
in
group,
concentrations
of
phosphoniodidous
acid,
bilirubin,
nicotinate
beta-
d
-ribonucleotide
citric
acid
decreased
suggesting
lipid
metabolism
energy
disorder
patients.
diversity
group
lower
than
that
controls.
Escherichia/Shigella
,
Alistipes
an
unnamed
strain
0319_6G20
belonging
Proteobacteria
important
distinguishing
genera
(LDA
>
3.5)
PCOS.
Prevotella_9
positively
correlated
concentrations,
negatively
concentration
LPC
(20:3)
1-linoleoylglycerophosphocholine;
Roseburia
(20:4),
while
characteristic
genus
(COR
0.45).
SF-36
significantly
control
(HC)
which
associated
presence
Escherichia-Shigella
.
Our
finding
demonstrated
correlation
PCOS,
therefore
may
play
role
insulin
resistance
mood
changes
