Association Between Inflammatory Bowel Disease and Both Psoriasis and Psoriatic Arthritis

JAMA Dermatology, Journal Year: 2022, Volume and Issue: 158(11), P. 1262 - 1262

Published: Sept. 14, 2022

Importance Psoriasis, psoriatic arthritis, and inflammatory bowel disease, ie, Crohn disease ulcerative colitis, are chronic systemic immune-mediated disorders affecting an increasing proportion of adults children worldwide. Observational studies have suggested association between psoriasis vice versa. So far, however, it remains unclear whether in which direction causal relationships exist. Objective To investigate the particularly or arthritis. Design, Setting, Participants A bidirectional 2-sample mendelian randomization study was conducted using summary statistics from genome-wide including up to 463 372 European individuals. Total direct effects were derived performing iterative radial robust inverse-variance weighted method within univariable multivariable setting, respectively. Causal estimates verified a validation sample, series pleiotropy-robust methods, sensitivity analyses based on PhenoScanner search conjunction with network analysis. Data analysis performed April May 2022. Main Outcomes Measures Inflammatory psoriasis, arthritis used as both exposures outcomes. Results The samples included 12 882 cases 5621 psoriasis. women ranged 48% 56%. Genetically predicted associated higher risk (pooled odds ratio [OR], 1.10; 95% CI, 1.05-1.15; P < .001) OR, 1.04-1.18; = .003). In contrast subentity (OR, 1.16; 1.12-1.20; 1.13; 1.06-1.20; .001). Regarding reverse directions, no notable associations could be found. Conclusions Relevance Findings this support effect well but not It seems that especially colitis is responsible for These findings implications management clinical practice.

Language: Английский

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The Contribution of the Human Oral Microbiome to Oral Disease: A Review

Microorganisms, Journal Year: 2023, Volume and Issue: 11(2), P. 318 - 318

Published: Jan. 26, 2023

The oral microbiome is an emerging field that has been a topic of discussion since the development next generation sequencing and implementation human project. This article reviews current literature surrounding microbiome, briefly highlighting most recent methods characterization including cutting edge omics, databases for areas with gaps in knowledge. also describes reports on microorganisms contained which include viruses, archaea, fungi, bacteria, provides in-depth analysis their significant roles tissue homeostasis. Finally, we detail key bacteria involved disease, cancer, research role stimulation inflammatory cytokines, gingival crevicular fluid periodontal creation network interactions between microorganisms, influence planktonic cospecies biofilms, implications antibiotic resistance. paper comprehensive while identifying knowledge to enable future studies be conducted.

Language: Английский

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Gut-microbiome-brain axis: the crosstalk between the vagus nerve, alpha-synuclein and the brain in Parkinson’s disease

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 18(12), P. 2611 - 2614

Published: May 12, 2023

This critical review of the literature shows that there is a close link between microbiome, gut, and brain in Parkinson's disease. The vagus nerve, main component parasympathetic nervous system, involved regulation immune response, digestion, heart rate, control mood. It can detect microbiota metabolites through its afferents, transferring this gut information to central system. Preclinical clinical studies have shown important role played by microbiome gut-related factors disease development progression, as well treatment responses. These findings suggest may be valuable target for new therapeutic strategies More are needed better understand underlying biology how axis modulated patient's benefit.

Language: Английский

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Nanopore sequencing technology and its applications

MedComm, Journal Year: 2023, Volume and Issue: 4(4)

Published: July 10, 2023

Abstract Since the development of Sanger sequencing in 1977, technology has played a pivotal role molecular biology research by enabling interpretation biological genetic codes. Today, nanopore is one leading third‐generation technologies. With its long reads, portability, and low cost, widely used various scientific fields including epidemic prevention control, disease diagnosis, animal plant breeding. Despite initial concerns about high error rates, continuous innovation platforms algorithm analysis effectively addressed accuracy. During coronavirus (COVID‐19) pandemic, critical detecting severe acute respiratory syndrome coronavirus‐2 virus genome containing pandemic. However, lack understanding this may limit popularization application. Nanopore poised to become mainstream choice for preventing controlling COVID‐19 future epidemics while creating value other such as oncology botany. This work introduces contributions during pandemic promote public use emerging outbreaks worldwide. We discuss application microbial detection, cancer genomes, genomes summarize strategies improve

Language: Английский

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Classifying compounds as prebiotics — scientific perspectives and recommendations

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Language: Английский

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Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease—An Overview

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(11), P. 2600 - 2600

Published: Nov. 8, 2023

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, most known as ulcerative colitis (UC) and Crohn’s (CD), that affects the gastrointestinal tract (GIT), causing considerable symptoms to millions of people around world. Conventional therapeutic strategies have limitations side effects, prompting exploration innovative approaches. Probiotics, for their potential restore gut homeostasis, emerged promising candidates IBD management. Probiotics been shown minimize symptoms, particularly in patients affected by UC, opening important opportunities better treat this disease. However, they exhibit terms stability targeted delivery. As several studies demonstrate, encapsulation probiotics, well synthetic drug, into micro- nanoparticles organic materials offers great solve problem. They resist harsh conditions upper GIT portions and, thus, protect probiotic drug inside, allowing delivery adequate amounts directly colon. An overview UC CD, benefits use nanoencapsulation technologies improve treatment are presented. This review sheds light on remarkable nano- microparticles loaded with probiotics novel efficient strategy managing IBD. Nonetheless, further investigations clinical trials warranted validate long-term safety efficacy, paving way new era therapeutics.

Language: Английский

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Our current clinical understanding of Candida biofilms: where are we two decades on?

Apmis, Journal Year: 2023, Volume and Issue: 131(11), P. 636 - 653

Published: March 18, 2023

Clinically we have been aware of the concept Candida biofilms for many decades, though perhaps without formal designation. Just over 20 years ago subject emerged on back progress made from bacterial biofilms, and academic pace has continued to mirror biofilm community, albeit at a decreased volume. It is apparent that species considerable capacity colonize surfaces interfaces form tenacious structures, either alone or in mixed communities. From oral cavity, respiratory genitourinary tracts, wounds, around plethora biomedical devices, scope these infections vast. These are highly tolerant antifungal therapies measurable impact clinical management. This review aims provide comprehensive overight our current understanding where cause infections, discuss existing emerging strategies.

Language: Английский

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Entero-toxigenic Bacteroides fragilis contributes to intestinal barrier injury and colorectal cancer progression by mediating the BFT/STAT3/ZEB2 pathway

Cell Cycle, Journal Year: 2024, Volume and Issue: 23(1), P. 70 - 82

Published: Jan. 2, 2024

Our previous findings confirmed the high enrichment of Bacteroides fragilis (BF) in fecal samples from patients with colorectal cancer (CRC). The intestinal mucosal barrier is first defense organism against commensal flora and pathogens closely associated occurrence development CRC. Therefore, this study aimed to investigate molecular mechanisms through which BF mediates injury CRC progression. SW480 cells a Caco2 model were treated entero-toxigenic (ETBF), its enterotoxin (B. toxin, BFT), non-toxigenic (NTBF). Cell counting kit-8, flow cytometry, wound healing transwell assays performed analyze proliferation, apoptosis, migration, invasion cells. Transmission electron microscopy, FITC-dextran, transepithelial electrical resistance (TEER) used damage model. Azoxymethane/Dextran Sulfate Sodium (AOM/DSS) animal was established evaluate effect ETBF on progression vivo. BFT enhanced viability, ratio, invasion, EMT In addition, disrupted tight junctions villus structure model, resulting increased permeability reduced TEER. Similarly, expression barrier-related proteins (MUC2, Occludin Zo-1) restricted by BFT. Interestingly, STAT3/ZEB2 axis activated BFT, treatment Brevilin A (a STAT3 inhibitor) or knockdown ZEB2 limited promotional malignant phenotype. vivo experiments also that colonization accelerated tumor load, carcinogenesis, colorectum AOM/DSS alleviated these processes. ETBF-secreted activating axis. provide new insights perspectives for application treatment.

Language: Английский

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Probiotics in Allergy and Immunological Diseases: A Comprehensive Review

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: March 8, 2024

Allergy and immunological disorders like autoimmune diseases are vastly prevalent worldwide. These conditions account for a substantial amount of personal social burden. Such illnesses have lengthy, uncertain, spotted courses with unpredictable exacerbations. A definite tendency improving the overall quality life individuals suffering from such is crucial to tackling these diseases, especially through diet or lifestyle modification. Further, interventions microbiome-based therapeutics as prebiotics probiotics were explored. Changes in microbial population evident during flare-up allergic conditions. The realization that human microbiome central player hallmark its potential usefulness therapy illnesses. This review focuses on intricate symphony orchestra immune system. New therapeutic strategies involving appear be future personalized medicine. Through this review, we explore narrative reaffirm their use preventive agents disorders.

Language: Английский

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Factors Influencing Neonatal Gut Microbiome and Health with a Focus on Necrotizing Enterocolitis

Microorganisms, Journal Year: 2023, Volume and Issue: 11(10), P. 2528 - 2528

Published: Oct. 10, 2023

Maturational changes in the gut start utero and rapidly progress after birth, with some functions becoming fully developed several months or years post birth including acquisition of a full microbiome, which is made up trillions bacteria thousands species. Many factors influence normal development neonatal infantile resulting dysbiosis, associated various interventions used for morbidities survival. Extremely low gestational age neonates (<28 weeks’ gestation) frequently experience recurring arterial oxygen desaturations, apneas, during first few weeks life. Apnea, cessation breathing lasting 15–20 s more, occurs due to immature respiratory control commonly intermittent hypoxia (IH). Chronic IH induces radical diseases neonate, necrotizing enterocolitis (NEC), most common devastating gastrointestinal disease preterm infants. NEC an intestinal structure function involves dysbiosis inflammation, necrosis mucosal layer. This review describes that microbiome predispose infants NEC. Current future management therapies, avoidance use human milk diet, probiotics, prebiotics, synbiotics, restricted antibiotics, fecal transplantation, prevention promotion healthy are also reviewed. Interventions directed at boosting endogenous and/or exogenous antioxidant supplementation may not only help prevention, but lessen severity shorten course disease.

Language: Английский

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