Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
Mycotoxin
contamination
is
a
universal
agricultural
problem
and
critical
health
issue.
Fumonisin
B1
(FB1)
one
of
the
most
toxic
extensive
fumonisins
that
exist
in
various
agro-products
foods.
Lycopene
(LYC),
as
natural
carotenoid,
becoming
increasingly
favored
owing
to
its
oxidation
resistance.
Here,
we
aim
explore
mechanism
FB1-induced
hepatotoxicity
antagonism
LYC.
In
this
study,
our
findings
indicated
FB1
induced
mitochondrial
structure
damage
loss
function
chicken
hepatocytes.
Furthermore,
upregulated
expression
PANoptosis-related
signal
molecules.
also
reduced
levels
SIRT1
Ac-FOXO1
protein
expression,
which
then
inhibited
mitophagy.
However,
LYC
relieved
these
alterations.
Most
importantly,
knockdown
protective
effects
PANoptosis.
Our
study
provides
evidence
for
role
mycotoxin-induced
hepatocyte
injury
points
potential
target
liver
protection.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(4), P. 1957 - 1957
Published: Feb. 10, 2022
Cardiovascular
diseases
(CVDs)
are
the
leading
cause
of
human
mortality
worldwide.
Oxidative
stress
and
inflammation
pathophysiological
processes
involved
in
development
CVD.
That
is
why
bioactive
food
ingredients,
including
lycopene,
so
important
their
prevention,
which
seems
to
be
a
compound
increasingly
promoted
diet
people
with
cardiovascular
problems.
Lycopene
present
tomatoes
tomato
products
responsible
not
only
for
red
color
but
also
health-promoting
properties.
It
characterized
by
high
antioxidant
potential,
highest
among
carotenoid
pigments.
Mainly
this
reason,
epidemiological
studies
show
number
favorable
properties
between
consumption
lycopene
reduced
risk
disease.
While
there
some
controversy
research
into
its
protective
effects
on
system,
growing
evidence
supports
beneficial
role
heart,
endothelium,
blood
vessels,
health.
The
mechanisms
action
now
being
discovered
may
explain
contradictions
observed
literature.
This
review
aims
current
knowledge
recent
years
preventive
disorders.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(2), P. 232 - 232
Published: Jan. 26, 2022
Lycopene
is
a
bioactive
red
pigment
found
in
plants,
especially
fruits
and
vegetables,
including
tomato,
pink
guava,
papaya,
grapefruit,
watermelon.
Several
research
reports
have
advocated
its
positive
impact
on
human
health
physiology.
For
humans,
lycopene
an
essential
substance
obtained
from
dietary
sources
to
fulfil
the
body
requirements.
The
production
of
reactive
oxygen
species
(ROS)
causing
oxidative
stress
downstream
complications
include
one
major
concerns
worldwide.
In
recent
years,
counter
strategies
attracted
biomedical
order
manage
emerging
issues.
has
been
reported
directly
interact
with
ROS,
which
can
help
prevent
chronic
diseases,
diabetes
neurodegenerative
cardiovascular
diseases.
this
context,
present
review
article
was
written
provide
accumulative
account
protective
ameliorative
effects
coronary
artery
disease
(CAD)
hypertension,
are
leading
causes
death
potent
antioxidant
that
fights
ROS
and,
subsequently,
complications.
It
reduces
blood
pressure
via
inhibiting
angiotensin-converting
enzyme
regulating
nitrous
oxide
bioavailability.
plays
important
role
lowering
LDL
(low-density
lipoproteins)
improving
HDL
(high-density
levels
minimize
atherosclerosis,
protects
onset
hypertension.
Various
studies
exhibited
combating
competence
treatment
these
Owing
all
antioxidant,
anti-diabetic,
anti-hypertensive
properties,
provides
potential
nutraceutical
curing
ability
against
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(8), P. 1896 - 1896
Published: April 14, 2023
Phytochemicals
are
a
non-nutritive
substances
that
present
in
plants
and
contribute
significantly
to
their
flavor
color.
These
biologically
active
compounds
classified
into
five
major
groups,
namely
phenolics,
carotenoids,
organosulfur
compounds,
nitrogen-containing
alkaloids,
known
for
potential
health
benefits
the
prevention
of
various
diseases,
including
cancer.
The
purpose
this
review
article
is
explore
therapeutic
dietary
phytochemicals,
such
as
flavonoids,
phenolic
acids,
phytosterols,
stilbenes,
cancer
treatment
based
on
epidemiological
studies
clinical
trials.
Although
majority
report
significant
advantage
heightened
phytochemical
consumption
increased
serum
levels
these
linking
exposure
with
lower
risk
across
most
types,
effects
could
not
be
replicated
available
In
fact,
many
trials
were
withdrawn
early
due
lack
evidence
and/or
harm.
Despite
strong
anticancer
effect
well
proven
efficacy
multiple
studies,
there
still
great
need
human
trials,
caution
regarding
safety
measures.
This
provides
an
overview
supporting
chemopreventive
properties
focus
further
research
area.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(4), P. 860 - 860
Published: April 2, 2023
It
is
more
effective
to
maintain
good
health
than
regain
it
after
losing
it.
This
work
focuses
on
the
biochemical
defense
mechanisms
against
free
radicals
and
their
role
in
building
maintaining
antioxidant
shields,
aiming
show
how
balance,
as
much
possible,
situations
which
we
are
exposed
radicals.
To
achieve
this
aim,
foods,
fruits,
marine
algae
with
a
high
content
should
constitute
basis
of
nutritional
elements,
since
natural
products
known
have
significantly
greater
assimilation
efficiency.
review
also
gives
perspective
use
antioxidants
can
extend
life
food
products,
by
protecting
them
from
damage
caused
oxidation
well
additives.
Food Chemistry Advances,
Journal Year:
2024,
Volume and Issue:
5, P. 100749 - 100749
Published: June 10, 2024
In
recent
years,
functional
foods
have
gained
attention
for
their
potential
health
benefits
beyond
basic
nutrition,
serving
as
rich
sources
of
proteins,
carbohydrates,
vitamins,
and
dietary
fiber.
Enriched
with
bioactive
compounds
such
polyphenols,
tannins,
flavonoids,
alkaloids,
these
shown
promise
in
inhibiting
cell
signaling
pathways
related
to
proliferation,
communication,
apoptosis.
Key
components
offer
benefits.
Omega-3
fatty
acids
scavenge
free
radicals,
reducing
the
risk
chronic
diseases
like
heart
disease
cancer.
Antioxidants
sesame
seed
oil
promote
cardiovascular
anti-inflammatory
effects.
Curcumin
inhibits
cancer
by
suppressing
inflammatory
cytokines.
Understanding
mechanisms
action
is
crucial
realizing
therapeutic
However,
identifying
suitable
substances
comprehending
role
prevention
are
challenging.
As
we
enter
food
era,
this
review
aims
present
current
state
nutraceuticals,
exploring
applications
human
wellness.
Recognizing
nutrition's
individualized
nature
nutrition
a
central
theme,
emphasizing
importance
tailored
recommendations
based
on
diverse
responses
elements,
ensuring
that
personalized
approaches
aligned
individual
goals.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1098 - 1098
Published: Jan. 27, 2025
This
article
reviews
the
synergistic
effects
of
antioxidant-enriched
functional
foods
and
exercise
in
improving
metabolic
health,
focusing
on
underlying
molecular
mechanisms.
The
review
incorporates
evidence
from
PubMed,
SCOPUS,
Web
Science,
PsycINFO,
reference
lists
relevant
up
to
20
December
2024,
highlighting
central
role
Nrf2
pathway.
As
a
critical
regulator
oxidative
stress
adaptation,
mediates
benefits
these
interventions.
presents
an
innovative
approach
understanding
regulation
inflammation,
its
potential
prevention
treatment
various
diseases,
including
cancer,
neurodegenerative
disorders,
cardiovascular
pulmonary
diabetes,
inflammatory
conditions,
ageing,
infections
such
as
COVID-19.
novelty
this
study
is
investigate
bioactive
compounds
found
(such
polyphenols,
flavonoids,
vitamins)
exercise-induced
activation
combined
reveals
their
improve
insulin
sensitivity
lipid
metabolism
reduce
offering
promising
strategy
for
management
chronic
diseases.
However,
there
are
significant
gaps
current
research,
particularly
regarding
mechanisms
interaction
between
diet,
physical
activity,
activation,
well
long-term
different
populations,
those
with
In
addition,
interactions
other
signalling
pathways,
AMPK,
NF-κB,
PI3K/Akt,
collective
contributions
health
explored.
Furthermore,
novel
biomarkers
presented
assess
impact
strategies,
NAD+/NADH
ratio,
GSH
markers
mitochondrial
health.
findings
provide
valuable
insights
into
how
integration
antioxidant-rich
diet
regular
can
by
activating
related
pathways
represent
strategies
disorders.
Further
studies
needed
fully
understand
therapeutic
interventions
diseases
stress,
disease,
cancer.
Heliyon,
Journal Year:
2022,
Volume and Issue:
8(11), P. e11505 - e11505
Published: Nov. 1, 2022
Biotechnologically
useful
yeast
strains
have
been
receiving
important
attention
worldwide
for
the
demand
of
a
wide
range
industries.
Rhodotorula
mucilaginosa
is
recognized
as
biotechnologically
that
has
gained
great
interest
promising
platform
strain,
owing
to
diverse
substrate
appetites,
robust
stress
resistance,
and
other
gratifying
features.
Due
its
attractive
properties,
R.
regarded
an
excellent
candidate
biorefinery
carotenoids,
lipids,
enzymes,
functional
bioproducts
by
utilizing
low-cost
agricultural
waste
materials
substrates.
These
compounds
aroused
potential
alternative
sources
health-promoting
food
products,
substrates
so-called
third-generation
biodiesel,
dyes
or
ingredients
cosmetics.
Furthermore,
use
rapidly
increased
result
advancements
in
fermentation
enhanced
production
these
valuable
bioactive
compounds.
This
review
focuses
on
summarizes
prospects
natural
bioproducts.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(7), P. 2335 - 2335
Published: April 4, 2022
Nutrition
is
of
utmost
importance
in
chronic
disease
management
and
has
often
been
described
as
the
cornerstone
a
variety
non-communicable
diseases.
In
particular,
type
II
diabetes
mellitus
(T2DM)
represents
prevalent
global
public
health
crisis.
Lycopene,
bright
red
carotenoid
hydrocarbon
found
tomatoes
other
fruits
vegetables,
extensively
studied
for
its
biological
activities
treatment
efficiency
care.
Epidemiological
investigations
indicate
that
lycopene
potential
antioxidant
properties,
capable
scavenging
reactive
species,
alleviates
oxidative
stress
T2DM
patients.
This
review
aims
to
summarize
characteristics
mechanisms
action
potent
T2DM.
addition,
evidence
demonstrating
effects
on
glycemic
control
biomarkers
are
also
highlighted
using
animal
human
studies
literature
approach.
