Corchorus olitorius extract exhibit anti-hyperglycemic and anti-inflammatory properties in rodent models of obesity and diabetes mellitus DOI Creative Commons
Kabelo Mokgalaboni, Wendy N. Phoswa

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: April 5, 2023

Obesity and type 2 diabetes (T2D) are chronic conditions with detrimental impacts on the overall health of individuals. Presently, use pharmacological agents in obesity T2D offers limited benefits pose side effects. This warrant studies remedies that less toxic inexpensive while effective ameliorating secondary complications T2D. Plant-based have been explored increasingly due to their remarkable properties safety profile. We searched for pre-clinical evidence published from inception until 2023 PubMed, Scopus, Google, Semantic scholar Corchorus olitorius ( C. ) both Our focus was understand beneficial impact this plant-based remedy basic glycemic, lipid, inflammatory, biomarkers oxidative stress. The gathered review suggests treatment may significantly reduce blood glucose, body weight, total cholesterol, triglycerides, low-density lipoprotein (LDL) concomitant increasing high-density lipoprotein-cholesterol (HDL-c) rodent models Interestingly, effect consistent reduction malonaldehyde, superoxide dismutase catalases, tumor necrosis factor-alpha, interleukins, leptin. Some mechanisms by which reduces glucose levels is through stimulation insulin secretion, β-cell proliferation, thus promoting sensitivity; process mediated ascorbic acid present plant. anti-hyperlipidemia attributable content ferulic found plant, inhibits 3-Hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors results reduced synthesis cholesterol increased hepatic LDL-c receptor expression, respectively. provides extensive knowledge further highlights potential metabolic parameters, lipid profile, inflammation, stress

Language: Английский

Oxidative Stress in Type 2 Diabetes: Impacts from Pathogenesis to Lifestyle Modifications DOI Creative Commons
Alfredo Caturano,

Margherita D’Angelo,

Andrea Mormone

et al.

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(8), P. 6651 - 6666

Published: Aug. 12, 2023

Oxidative stress is a critical factor in the pathogenesis and progression of diabetes its associated complications. The imbalance between reactive oxygen species (ROS) production body’s antioxidant defence mechanisms leads to cellular damage dysfunction. In diabetes, chronic hyperglycaemia mitochondrial dysfunction contribute increased ROS production, further exacerbating oxidative stress. This burden adversely affects various aspects including impaired beta-cell function insulin resistance, leading disrupted glucose regulation. Additionally, stress-induced blood vessels endothelial development diabetic vascular complications such as retinopathy, nephropathy, cardiovascular diseases. Moreover, organs tissues throughout body, kidneys, nerves, eyes, are vulnerable stress, resulting neuropathy, retinopathy. Strategies mitigate include therapy, lifestyle modifications, effective management hyperglycaemia. However, research necessary comprehensively understand underlying evaluate efficacy interventions preventing treating By addressing it might be possible alleviate improve patient outcomes.

Language: Английский

Citations

198
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence DOI Creative Commons
Angelica Varesi, Salvatore Chirumbolo, Lucrezia Irene Maria Campagnoli

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(7), P. 1224 - 1224

Published: June 22, 2022

Cellular senescence is an irreversible state of cell cycle arrest occurring in response to stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and oncogenic proteins. Although beneficial protective several physiological processes, excessive senescent burden has been involved various pathological conditions including aging, tissue dysfunction chronic diseases. Oxidative stress (OS) can drive due a loss balance between pro-oxidant stimuli antioxidant defences. Therefore, the identification characterization compounds capable preventing or counteracting phenotype major interest. However, despite considerable number studies, comprehensive overview main molecules OS-induced still lacking. Here, besides brief description molecular mechanisms implicated OS-mediated we review discuss role enzymes, mitochondria-targeting compounds, vitamins, carotenoids, organosulfur nitrogen non-protein molecules, minerals, flavonoids, non-flavonoids with anti-aging potential, therefore offering insights into innovative lifespan-extending approaches.

Language: Английский

Citations

89
Anti-Inflammatory, Antioxidant, and Other Health Effects of Dragon Fruit and Potential Delivery Systems for Its Bioactive Compounds DOI Creative Commons

Daniela Franceschi Nishikito,

Ana Claudia Abdalla Borges,

Lucas Fornari Laurindo

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 159 - 159

Published: Jan. 3, 2023

Dragon fruit (

Language: Английский

Citations

63
The role of dietary antioxidants in type 2 diabetes and neurodegenerative disorders: An assessment of the benefit profile DOI Creative Commons
Munazza Fatima, Ajaz A. Bhat, Sabah Nisar

et al.

Heliyon, Journal Year: 2022, Volume and Issue: 9(1), P. e12698 - e12698

Published: Dec. 31, 2022

Healthy diet is vital to cellular health. The human body succumbs numerous diseases which afflict severe economic and psychological burdens on the patient family. Oxidative stress a possible crucial regulator of various pathologies, including type 2 diabetes neurodegenerative diseases. It generates reactive oxygen species (ROS) that trigger dysregulation essential functions, ultimately affecting health homeostasis. However, lower levels ROS can be advantageous are implicated in variety signaling pathways. Due this dichotomy, terms oxidative "eustress," refers good event, "distress," hazardous, have developed. affects multiple pathways, leading compromised insulin secretion, resistance, β-cell dysfunction diabetes. also associated with increased mitochondrial neuroinflammation, aggravating conditions body, particularly age. Treatment includes drugs/therapies often dependence, side effects non-selectivity, toxicity, long run. imperative explore alternative medicines as an adjunct therapy, utilizing natural remedies/resources avoid all harms. Antioxidants components our fight disease by reducing or nullifying excess toxic free radicals produced under pathological conditions. In review, we focus antioxidant dietary foods such tea, coffee, wine, oils, honey role mechanism action these antioxidants alleviating disorders. We aim provide information about alternatives drug treatments used alone combined reduce intake encourage consumption ingredients at doses adequate promote combat pathologies while unwanted risks effects.

Language: Английский

Citations

43
The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene DOI Open Access
Anna Kulawik, Judyta Cielecka‐Piontek, Przemysław Zalewski

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(17), P. 3821 - 3821

Published: Aug. 31, 2023

Lycopene is a compound of colored origin that shows strong antioxidant activity. The positive effect lycopene the result its pleiotropic effect. ability to neutralize free radicals via one foundations pro-health effect, including inhibit development many civilization diseases. Therefore, this study focuses on importance in inhibiting diseases such as cardiovascular diseases, within nervous system, diabetes, liver and ulcerative colitis. According research mentioned, supplementation has significant promise for treatment illnesses marked by chronic inflammation oxidative stress. However, majority supporting data lycopene′s health benefits comes from experimental research, whereas evidence clinical studies both scarcer less certain any benefits. Research humans still required establish effectiveness.

Language: Английский

Citations

29
Lycopene: A Potent Antioxidant with Multiple Health Benefits DOI Creative Commons
Mercy Omoye Shafe,

Nontobeko Myllet Gumede,

Trevor Tapiwa Nyakudya

et al.

Journal of Nutrition and Metabolism, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Lycopene is a naturally occurring carotenoid predominantly found in tomatoes and tomato‐based products. Like other phytochemicals, it exhibits health beneficial biological activities that can be exploited when used as dietary supplement. In vitro vivo , lycopene has been demonstrated to mitigate oxidative stress‐induced metabolic dysfunctions diseases including inflammation, obesity, diabetes mellitus. shown alleviate affect the bone, eye, kidney, liver, lungs, heart, nervous system. This review presents state of art regarding lycopene’s benefits its potential applications system delivery. Furthermore, protective effects against toxins, safety use, possible toxicity are explored.

Language: Английский

Citations

13
Nutritional Benefits of Lycopene and Beta‐Carotene: A Comprehensive Overview DOI Creative Commons
Tabussam Tufail,

Huma Bader Ul Ain,

Sana Noreen

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(11), P. 8715 - 8741

Published: Oct. 16, 2024

Certain carotene components, such as lycopene and beta-carotene, are found in tomatoes, carrots, sweet potatoes, etc. good for human health. It gives plants their distinctive red color. A class of lipid-soluble natural pigments known carotenoids is the precursor vitamin vital antioxidant defense against peroxides cells tissues. This review provides an overview current state knowledge research on sources, structures, physiochemical properties, absorption metabolism, functional advantages, prevention many diseases associated with beta-carotene. These antioxidants have been linked to a lower risk cardiovascular disease cancer, they also help draw pollinators flowers. Carrots potatoes rich sources which strengthens immune system improves eye The vivid color reproductive organs, including flowers fruits, caused by carotenoid, secondary metabolite that produced plastids. other health advantages attributed lycopene. When ingested through food or supplements, beta-carotene manage prevent number diseases, metabolic, inflammatory, cardiovascular, hepatic, ophthalmic, skeletal, infertility disorders. main point toxicity uncommon, these generally accepted be safe at different doses. Including nutrients your diet can improve general provide illness prevention.

Language: Английский

Citations

12
Lycopene as a Therapeutic Agent against Aflatoxin B1-Related Toxicity: Mechanistic Insights and Future Directions DOI Creative Commons
Meng Li, Shusheng Tang,

Xinyan Peng

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 452 - 452

Published: April 11, 2024

Aflatoxin (AFT) contamination poses a significant global public health and safety concern, prompting widespread apprehension. Of the various AFTs, aflatoxin B1 (AFB1) stands out for its pronounced toxicity association with spectrum of chronic ailments, including cardiovascular disease, neurodegenerative disorders, cancer. Lycopene, lipid-soluble natural carotenoid, has emerged as potential mitigator deleterious effects induced by AFB1 exposure, spanning cardiac injury, hepatotoxicity, nephrotoxicity, intestinal damage, reproductive impairment. This protective mechanism operates reducing oxidative stress, inflammation, lipid peroxidation, activating mitochondrial apoptotic pathway, facilitating activation biogenesis, endogenous antioxidant system, nuclear factor erythroid 2-related 2 (Nrf2)/kelch-like ECH-associated protein 1 (KEAP1) peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) pathways, well regulating activities cytochrome P450 (CYP450) enzymes. review provides an overview lycopene against exposure-induced underlying molecular mechanisms. Furthermore, it explores profile clinical applications lycopene. The present underscores lycopene’s promising detoxification agent intent to stimulate further research practical utilization in this domain.

Language: Английский

Citations

9
A Narrative Review: The Effect and Importance of Carotenoids on Aging and Aging-Related Diseases DOI Open Access

Elif Rabia Bakac,

Ece Percin,

Ayşe Güneş Bayır

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15199 - 15199

Published: Oct. 15, 2023

Aging is generally defined as a time-dependent functional decline that affects most living organisms. The positive increase in life expectancy has brought along aging-related diseases. Oxidative stress caused by the imbalance between pro-oxidants and antioxidants can be given one of causes aging. At same time, oxidative reactive oxygen species (ROS) main reason for diseases such cardiovascular, neurodegenerative, liver, skin, eye diabetes. Carotenoids, natural compound, used to change course aging diseases, thanks their highly effective oxygen-quenching ROS-scavenging properties. Therefore, this narrative review, conducted using PubMed, ScienceDirect, Google Scholar databases complying with Scale Assessment Narrative Review Articles (SANRA) guidelines, effects carotenoids on were analyzed. Carotenoids are fat-soluble, unsaturated pigments occur naturally plants, fungi, algae, photosynthetic bacteria. A large number works have been relation Animal human studies found significantly reduce obesity fatty lower blood sugar, improve liver fibrosis cirrhosis, well risk cardiovascular disease erythema formation, while also lowering glycated hemoglobin fasting plasma glucose levels. Carotenoid supplementation may preventing delaying treating fatigue dry disease, improving macular function. These stop, delay, or treat due powerful antioxidant, restorative, anti-proliferative, anti-inflammatory, anti-aging As an increasingly population emerges globally, review could provide important prospective contribution public health.

Language: Английский

Citations

20
Effects of Dietary Lycopene on the Growth Performance, Antioxidant Capacity, Meat Quality, Intestine Histomorphology, and Cecal Microbiota in Broiler Chickens DOI Creative Commons
Hongzhi Wu, Sibo Wang, Jiajun Xie

et al.

Animals, Journal Year: 2024, Volume and Issue: 14(2), P. 203 - 203

Published: Jan. 8, 2024

The experiment aimed to investigate the effects of dietary lycopene on growth performance, antioxidant capacity, meat quality, intestine histomorphology, and cecal microbiota in broiler chickens. We randomly divided five hundred seventy-six one-day-old male broilers into four groups each with six replicates 24 chickens replicate. control group (CG) was fed basal diet, other were given powder 10, 20, 30 mg/kg (LP10, LP20, LP30, respectively). Compared group, (1) increased (p = 0.001) average daily gain decreased 0.033) feed conversion ratio experimental groups; (2) glutathione peroxidase enzyme contents LP20 higher =< myocardium; (3) crude protein 0.007) treated lycopene; (4) jejunum villous height 0.040) LP20; (5) Unclassified-f-Ruminococcaceae relative abundance significantly 0.043) LP20. In this study, adding 20 chickens’ diets improved

Language: Английский

Citations

6