A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives DOI Creative Commons
Nida Zahra, Javed Iqbal, Muhammad Arif

et al.

Chinese Medicine, Journal Year: 2023, Volume and Issue: 18(1)

Published: March 2, 2023

Abstract Paeonia emodi Wall. ex Royle is commonly known as Himalayan paeony has great importance a food and medicine. The practice of very ancient it conventionally used for wide range illnesses in the folk system medicine because its beneficial phytochemical profile. main purpose current review was synthesis recent data on botany, ethnopharmacology, phytochemistry potential pharmacological mechanisms action Royle, thus offering new prospects development adjuvant natural therapies. Using scientific databases such PubMed/MedLine, Scopus, Web Science, ScienceDirect, Google Scholar, Springer, Wiley, comprehensive literature search performed Royle. For searching, we next MeSH terms: “Biological Product/isolation purification”, Products/pharmacology”, “Drug Discovery/methods”, “Ethnopharmacology, Medicine”, “Traditional/methods”, “Paeonia/chemistry”, “Plant Extracts/pharmacology”, “Phytochemicals/chemistry”, “Phytochemicals/pharmacology”, “Plants, Medicinal”. results most studies were analyzed important summarized tables figures. Phytochemical research led to isolation triterpenes, monoterpenes, phenolic acids, fatty organic compounds, steroids, free radicals some other classes primary metabolites. In addition, diverse activities like antibacterial, antifungal, anticoagulant, airway relaxant lipoxygenase beta-glucuronidase inhibiting activity, radical scavenging phytotoxic insecticidal have been reported Different bioactive compounds proven their therapeutic modern biomedical cure numerous gastrointestinal nervous disorders. future, further vitro vivo are required identify action, pharmacokinetics studies, pharmaceutical formulations target transport possible interaction with allopathic drugs. Also, regarding quality evaluation, toxicity safety humans needed.

Language: Английский

Recent advances and limitations of mTOR inhibitors in the treatment of cancer DOI Creative Commons
Eunüs S. Ali, Kangkana Mitra, Shamima Akter

et al.

Cancer Cell International, Journal Year: 2022, Volume and Issue: 22(1)

Published: Sept. 15, 2022

Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR) signaling pathway is important in a variety biological activities, including cellular proliferation, survival, metabolism, autophagy, and immunity. Abnormal PI3K-Akt-mTOR signalling activation can promote transformation by creating environment conducive to it. Deregulation such system terms genetic mutations amplification has been related several human cancers. Consequently, mTOR recognized as key for treatment cancer, especially treating cancers with elevated due or metabolic disorders. In vitro vivo, which an immunosuppressant agent actively suppresses activity reduces cancer cell growth. As result, various sirolimus-derived compounds have now established therapies these medications are being investigated clinical studies. this updated review, we discuss usage other drugs preclinical studies well explain some challenges involved targeting

Language: Английский

Citations

102
Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications DOI Creative Commons

Shumaila Ijaz,

Javed Iqbal, Banzeer Ahsan Abbasi

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114687 - 114687

Published: April 14, 2023

Cancer is still the leading cause of death worldwide, burdening global medical system. Rosmarinic acid (RA) among first secondary metabolites discovered and it a bioactive compound identified in plants such as Boraginaceae Nepetoideae subfamilies Lamiaceae family, including Thymus masticmasti chinaythia koreana, Ocimum sanctum, Hyptis pectinate. This updated review to highlight chemopreventive chemotherapeutic effects RA its derivatives, thus providing valuable clues for potential development some complementary drugs treatment cancers. Relevant information about RA's derivatives were collected from electronic scientific databases, PubMed/Medline, Scopus, TRIP database, Web Science, Science Direct. The results studies showed numerous significant biological antiviral, antibacterial, anti-inflammatory, anti-tumour, antioxidant antiangiogenic effects. Most on anticancer with corresponding mechanisms are experimental preclinical stage missing evidence clinical trials support research. To open new therapeutic perspectives future must elucidate molecular targets action more detail, human toxic adverse

Language: Английский

Citations

63
Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy DOI Creative Commons
Javad Sharifi‐Rad, Véronique Seidel,

Michalak Izabela

et al.

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: May 1, 2023

Abstract Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has crucial role in cytoprotective response against stress, including cancer growth progression therapy resistance. For this reason, inhibitors are new targets to be studied. Traditional plant-based remedies rich phytochemicals have been used human cancers phenolic compounds known for their chemopreventive properties. This comprehensive review offers updated the as anticancer agents due action on inhibition. In addition, naturally-occurring bioactive covered clinical applications polyphenols inhibitors.

Language: Английский

Citations

53
Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae DOI
Benneth Ben‐Azu, Emuesiri Goodies Moke, LE Chris-Ozoko

et al.

Psychopharmacology, Journal Year: 2024, Volume and Issue: 241(4), P. 785 - 803

Published: Feb. 5, 2024

Language: Английский

Citations

17
Bioactivities of morroniside: A comprehensive review of pharmacological properties and molecular mechanisms DOI
Md. Shimul Bhuia, Raihan Chowdhury, Iffat Ara

et al.

Fitoterapia, Journal Year: 2024, Volume and Issue: 175, P. 105896 - 105896

Published: March 11, 2024

Language: Английский

Citations

16
Myricetin: targeting signaling networks in cancer and its implication in chemotherapy DOI Creative Commons
Zeeshan Javed, Khushbukhat Khan, Jesús Herrera‐Bravo

et al.

Cancer Cell International, Journal Year: 2022, Volume and Issue: 22(1)

Published: July 28, 2022

Abstract The gaps between the complex nature of cancer and therapeutics have been narrowed down due to extensive research in molecular oncology. Despite gathering massive insight into mysteries tumor heterogeneity framework cells, therapy resistance adverse side effects current therapeutic remain major challenge. This has shifted attention towards with less toxicity high efficacy. Myricetin a natural flavonoid under spotlight for its anti-cancer, anti-oxidant, anti-inflammatory properties. cutting-edge techniques shed light on interplay myricetin dysregulated signaling cascades progression, invasion, metastasis. However, there are limited data available regarding nano-delivery platforms composed cancer. In this review, we provided comprehensive detail myricetin-mediated regulation different cellular pathways, implications prevention, preclinical clinical trials, nano-formulations treatment various cancers.

Language: Английский

Citations

64
Anticancer Potential and Other Pharmacological Properties of Prunus armeniaca L.: An Updated Overview DOI Creative Commons
Dušanka Kitić, Bojana Miladinović, Milica Randjelović

et al.

Plants, Journal Year: 2022, Volume and Issue: 11(14), P. 1885 - 1885

Published: July 20, 2022

L. (Rosaceae)-syn.

Language: Английский

Citations

62
Recent advances in the therapeutic potential of emodin for human health DOI Open Access
Javad Sharifi‐Rad, Jesús Herrera‐Bravo, Senem Kamiloğlu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 154, P. 113555 - 113555

Published: Aug. 23, 2022

Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a bioactive compound, natural anthraquinone aglycone, present mainly in herbaceous species of the families Fabaceae, Polygonaceae and Rhamnaceae, with physiological role protection against abiotic stress vegetative tissues. used traditional Chinese medicine to treat sore throats, carbuncles, sores, blood stasis, damp-heat jaundice. Pharmacological research last decade has revealed other potential therapeutic applications such as anticancer, neuroprotective, antidiabetic, antioxidant anti-inflammatory. The study aimed summarize recent studies on bioavailability, preclinical pharmacological effects evidence molecular mechanisms, clinical trials pitfalls, respectively limitations emodin. For this purpose, extensive searches were performed using PubMed/Medline, Scopus, Google scholar, TRIP database, Springer link, Wiley SciFinder databases search engines. vitro vivo included updated review highlighted signaling pathways mechanisms Because its bioavailability low, there are use. In conclusion, for an increase pharmacotherapeutic efficacy, future carrier molecules target, thus opening up new perspectives.

Language: Английский

Citations

57
Recent updates on anticancer mechanisms of polyphenols DOI Creative Commons
Eshita Sharma, Dharam Chand Attri,

Priyanka Sati

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 10

Published: Sept. 29, 2022

In today’s scenario, when cancer cases are increasing rapidly, anticancer herbal compounds become imperative. Studies on the molecular mechanisms of action polyphenols published in specialized databases such as Web Science, Pubmed/Medline, Google Scholar, and Science Direct were used sources information for this review. Natural provide established efficacy against chemically induced tumor growth with fewer side effects. They can sensitize cells to various therapies increase effectiveness biotherapy. Further pharmacological translational research clinical trials needed evaluate theirs vivo efficacy, possible effects toxicity. Polyphenols be design a potential treatment conjunction existing drug regimens chemotherapy radiotherapy.

Language: Английский

Citations

56
Artemisia spp.: An Update on Its Chemical Composition, Pharmacological and Toxicological Profiles DOI Creative Commons
Javad Sharifi‐Rad, Jesús Herrera‐Bravo, Prabhakar Semwal

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 23

Published: Sept. 5, 2022

plants are traditional and ethnopharmacologically used to treat several diseases in addition food, spices, beverages. The genus is widely distributed all continents except the Antarctica, medicine has been as antimalarial, antioxidant, anticancer, antinociceptive, anti-inflammatory, antiviral agents. This review aimed at systematizing scientific data on geographical distribution, chemical composition, pharmacological toxicological profiles of

Language: Английский

Citations

46