Immunopharmacological Activities of Luteolin in Chronic Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2136 - 2136

Published: Jan. 21, 2023

Flavonoids have been shown to anti-oxidative effects, as well other health benefits (e.g., anti-inflammatory and anti-tumor functions). Luteolin (3′, 4′, 5,7-tetrahydroxyflavone) is a flavonoid found in vegetables, fruits, flowers, herbs, including celery, broccoli, green pepper, navel oranges, dandelion, peppermint, rosemary. has multiple useful especially regulating inflammation-related symptoms diseases. In this paper, we summarize the studies about immunopharmacological activity of luteolin on anti-inflammatory, anti-cardiovascular, anti-cancerous, anti-neurodegenerative diseases published since 2018 available PubMed or Google Scholar. review, also introduce some additional formulations improve its solubility bioavailability.

Language: Английский

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Recent advances in anti-inflammation via AMPK activation

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33670 - e33670

Published: June 26, 2024

Inflammation is a complex physiological phenomenon, which the body's defensive response, but abnormal inflammation can have adverse effects, and many diseases are related to inflammatory response. AMPK, as key sensor of cellular energy status, plays crucial role in regulating homeostasis glycolipid metabolism. In recent years, anti-inflammation effect AMPK signalling cascade has begun enter everyone's field vision – not least impact on metabolic diseases. A great number studies shown that anti-inflammatory drugs work through pathways.Herein, this article summarises advances compounds show effects by activating attempts comment them.

Language: Английский

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Phillygenin inhibits inflammation in chondrocytes via the Nrf2/NF-κB axis and ameliorates osteoarthritis in mice

Journal of Orthopaedic Translation, Journal Year: 2023, Volume and Issue: 41, P. 1 - 11

Published: May 4, 2023

Osteoarthritis (OA), widely seen in the elderly, is featured by cartilage degradation, subchondral bone remolding, and synovium inflammation. Currently, there no cure for OA development. Phillygenin (PHI), an active ingredient from Forsythiae Fructus, possesses many biological properties, such as anti-inflammation anti-oxidative stress several diseases. However, potential effects underlying mechanisms of PHI on remain unclear.Western blotting, RT-PCR, ELISA tissue staining were employed to explore which exerted a protective effect IL-1β-induced production pro-inflammation cytokines extracellular matrix (ECM) degradation primary murine chondrocytes destabilization medial meniscus (DMM) mouse models.In this study, we found that inhibited ECM induced IL-1β chondrocytes. Mechanically, NF-κB pathway via activating nuclear factor (erythrluteolind-derived 2)-like 2 (Nrf2). In vivo experiments also confirmed chondroprotection DMM models.PHI alleviated inflammation Nrf2 inhibiting pathway.This study provides rationale use candidate treatment.

Language: Английский

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Injectable Inflammation‐Responsive Hydrogels for Microenvironmental Regulation of Intervertebral Disc Degeneration

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: April 22, 2024

Chronic local inflammation and excessive cell apoptosis in nucleus pulposus (NP) tissue are the main causes of intervertebral disc degeneration (IDD). Stimuli-responsive hydrogels have great potential treatment IDD by facilitating localized controlled drug delivery. Herein, an injectable drug-loaded dual stimuli-responsive adhesive hydrogel for microenvironmental regulation IDD, is developed. The gelatin methacryloyl functionalized with phenylboronic acid groups to enhance loading capacity enable behavior, while incorporation oxidized hyaluronic further improves properties. prepared exhibits enhanced diol-containing drugs, pH- reactive oxygen species (ROS)-responsive behaviors, excellent radical scavenging efficiency, potent antibacterial activity, favorable biocompatibility. Furthermore, shows a beneficial protective efficacy on NP cells within vitro oxidative stress microenvironment. vivo results demonstrate hydrogel's therapeutic effect treating maintaining water retention, restoring height, promoting regeneration, indicating that this holds as promising approach regulating microenvironment alleviating progression IDD.

Language: Английский

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Nrf2-mediated therapeutic effects of dietary flavones in different diseases

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 12, 2023

Oxidative stress (OS) is a pathological status that occurs when the body’s balance between oxidants and antioxidant defense systems broken, which can promote development of many diseases. Nrf2, redox-sensitive transcription encoded by NFE2L2, master regulator phase II enzymes cytoprotective genes. In this context, Nrf2/ARE signaling be compelling target against OS-induced Recently, natural regulators like dietary flavones have shown therapeutic potential in various acute chronic diseases such as diabetes, neurodegenerative diseases, ischemia-reperfusion injury, cancer. review, we aim to summarize nrf2-mediated protective effects different conditions. Firstly, retrospected mechanisms how regulate pathway introduced mediator role Nrf2 plays inflammation apoptosis. Then review evidence modulated prevent experimental models. Based on these literature, found could expression below: 1) dissociating binding Keap1 via PKC-mediated phosphorylation P62-mediated autophagic degradation; 2) regulating nuclear translocation kinases AMPK, MAPKs, Fyn; 3) decreasing ubiquitination degradation activating sirt1 PI3K/AKT-mediated GSK3 inhibition; 4) epigenetic alternation demethylation at promoter region histone acetylation. conclusion, targeting promising agents for OS-related disorders. However, there lack investigations human subjects, new drug delivery improve flavones’ treatment efficiency still need developed.

Language: Английский

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Inflammatory signaling pathways in the treatment of Alzheimer's disease with inhibitors, natural products and metabolites (Review)

International Journal of Molecular Medicine, Journal Year: 2023, Volume and Issue: 52(5)

Published: Oct. 4, 2023

The intricate nature of Alzheimer's disease (AD) pathogenesis poses a persistent obstacle to drug development. In recent times, neuroinflammation has emerged as crucial pathogenic mechanism AD, and the targeting inflammation become viable approach for prevention management AD. present study conducted comprehensive review literature between October 2012 2022, identifying total 96 references, encompassing 91 distinct pharmaceuticals that have been investigated their potential impact on AD by inhibiting neuroinflammation. Research shown ameliorate reducing mainly through regulating inflammatory signaling pathways such NF‑κB, MAPK, NLRP3, PPARs, STAT3, CREB, PI3K/Akt, Nrf2 respective pathways. Among them, tanshinone IIA extensively studied its anti‑inflammatory effects, which significant pharmacological properties can be applied clinically. Thus, it may hold promise an effective treatment elucidated therapeutic efficacy in elucidates underlying mechanisms. This underscores auspicious ameliorating impeding

Language: Английский

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Osteoarthritis in the Elderly Population: Preclinical Evidence of Nutrigenomic Activities of Flavonoids

Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 112 - 112

Published: Dec. 28, 2023

Osteoarthritis (OA) is a degenerative joint disease that age-related and progressive. It causes the destruction of articular cartilage underlying bone, often aggravated by inflammatory processes oxidative stresses. This pathology impairs quality life elderly, causing pain, reduced mobility, functional disabilities, especially in obese patients. Phytochemicals with anti-inflammatory antioxidant activities may be used for long-term treatment OA, either combination current anti-inflammatories painkillers, or as an alternative to other products such glucosamine chondroitin, which improve structure elasticity. The systematic review provides comprehensive understanding use flavonoids. highlights chondrocyte, cartilage, subchondral bone activities, particular focus on their nutrigenomic effects. molecular mechanisms these molecules demonstrate how they can prevention OA elderly population. However, clinical trials are still needed effective practice.

Language: Английский

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Harnessing Luteolin's therapeutic potential in human disorders: Medicinal significance, biological, clinical properties and analytical aspects

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 10, P. 100401 - 100401

Published: Feb. 22, 2024

Luteolin (3′,4′,5,7-tetrahydroxyflavone) is a common flavonoid in many fruits, vegetables, and medicinal herbs. Plants rich luteolin have been used Chinese traditional medicine for treating various diseases, such as hypertension, inflammatory disorders, cancer. Throughout history, herbal medicines employed to address range of health issues their associated complications. This review delves into the biological characteristics, pharmacological importance, clinical analytical aspects potential use. study explores properties relevance luteolin, drawing support from both applications scientific findings. The information on has curated reputable sources Science Direct, PubMed, Google Scholar, Google, Scopus. Additionally, this paper incorporates data books, journals, reports provide well-rounded understanding luteolin's properties. Scientific investigations underscored significance diverse luteolin. Research revealed efficacy exhibiting anti-inflammatory, antioxidant, anti-cancer, wound healing, antimicrobial, antiviral, COVID-19 related Furthermore, its effectiveness extends anti-aging, antiallergic, cardioprotective, arthritis, neuroprotective, periodontal disorder, renal hepatoprotective, eye obesity, cytotoxicity, genotoxicity. compounds versatility therapeutic agent accentuated by adept interaction with molecular targets, influencing crucial cellular pathways. article provides pertaining identification isolation samples, underscoring across spectrum health-related domains. present highlights importance showcasing applicability addressing human diseases mitigating side effects. ADAM, A disintegrin Metalloproteinase; AMPK, Adenosine monophosphate, Activated protein kinase; AOM, azoxymethane; AP, activator protein; ApoE, apolipoprotein E-deficient; AR, Androgen receptor; ASD, Autistic disorders; CCl4, Tetrachloromethane; ccRCC, Clear cell carcinoma; CIA, Collagen-induced arthritis; CK-MB, Creatine kinase-MB; COVID-19,Coronavirus disease 2019; COX-2, Cyclooxygenase-2; DEDD2, Death effector domain-containing 2; EGFR, Epidermal growth factor FZD6, Frizzled class receptor6; FZJDXJ, Fuzheng Jiedu Xiaoji formulation; GBM, Glioblastoma multiforme grade IV; H. pylori, Helicobacter pylori; HBV, Hepatitis B virus; HCC, Hepatocellular HGI, Hypertrophic factor; HIV, Human immunodeficiency HNF4α, Hepatocyte nuclear 4α; IgE, Immunoglobulin E; IL, Interleukin; iNOS, Inducible nitric oxide synthase; IRAK1, Inhibiting interleukin-1 receptor-associated JNK, Jun N terminal K. Ras, Kirsten rat sarcoma L7Gn, Luteolin-7-O-glucuronide; LDH, Lactate dehydrogenase; LIP, Labile iron pool; LPS, Lipopolysaccharide; LTL, Luteolin; MAPK, Mitogen-activated MDA, Malondialdehyde; MICs, Minimum inhibitory concentrations; MMP-1, Matrix metalloproteinase 1; MPTP, Mitochondrial permeability transition pores; MRSA, Methicillin-resistant staphylococcus aureus; MSH, Melanocyte-stimulating hormone; MTP, transmembrane potential; NAFLD, Non-alcoholic fatty liver disease; NF, NF-κB, Nuclear factor-kappa B; Nlrp3, NOD-like receptor family pyrin domain containing 3; NO, Nitric oxide; NRCMs, Neonatal cardiomyocytes; Nrf2, erythroid NSCLC, Non-small lung cancer; PARP, poly-ADP ribose polymerase; PC, Prostate PDEF, Prostate-derived Ets PEA, Palmitoylethanolamide; PFS, Progression-free survival; POD, Post-operative delirium; PSA, Prostate-specific antigen levels; qPCR, Quantitative Polymerase chain reaction; ROS, Reactive oxygen species; Rpt, Proteasome-regulated particles; RTPCR, Real-time reverse transcriptase-polymerase SARS-CoV-2, Severe acute respiratory syndrome coronavirus SOD, Superoxide dismutase; SREBP, Sterol regulatory element binding sT antigen, Soluble tumor antigen; STAT, Signal transducer transcription; Syk, Spleen Tyrosine Kinase; TACE, Transcatheter arterial chemoembolization; TCM, Traditional chinese medicines; TNF-α, Tumor necrosis factor-α; TRAIL, TNF apoptosis-inducing ligand; TXNIP, Thioredoxin interacting protein.

Language: Английский

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Luteolin restricts ASFV replication by regulating the NF-κB/STAT3/ATF6 signaling pathway

Veterinary Microbiology, Journal Year: 2022, Volume and Issue: 273, P. 109527 - 109527

Published: Aug. 4, 2022

Language: Английский

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Ginkgolide C slows the progression of osteoarthritis by activating Nrf2/HO-1 and blocking the NF-κB pathway

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 28, 2022

Osteoarthritis (OA) is driven by chronic low-grade inflammation and subsequent cartilage degradation. OA the most prevalent degenerative joint disease worldwide, its treatment remains a challenge. The aim of this study was to explore potential effects mechanism underlying anti-OA properties ginkgolide C (GC). Protective GC on hydrogen peroxide (H 2 O )-treated rat chondrocytes were evaluated using ELISA, qPCR, western blot analysis, flow cytometry, ROS detection immunofluorescence in vitro . Ameliorating degeneration rats through behavioral assays, microcomputed tomography, histopathological analysis ELISA vivo In , inhibited release pro-apoptotic factors induced H promoted anti-apoptotic proteins. addition, decreased expression matrix metalloproteinase (MMP3 MMP13), thrombospondin motifs 4 (ADAMTS4), inflammatory mediators inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2), SOX9 thereby inhibiting extracellular (ECM) Mechanistically, exerts anti-inflammatory upregulating oxidative stress signaling Nrf2/HO-1 pathway preventing p65 from binding DNA. Similarly, model with post-traumatic (PTOA) anterior cruciate ligament transection (ACLT), pain, destruction, abnormal bone remodeling subchondral bone. -induced chondrocyte apoptosis NF-κB axis, exerted effects, OA. Our findings advanced concept that may contribute metabolism identified therapeutic agent for

Language: Английский

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