Golden Tomato Juice Enhances Hepatic PPAR-α Expression, Mitigates Metabolic Dysfunctions and Influences Redox Balance in a High-Fat-Diet Rat Model DOI Creative Commons
Danila Di Majo,

Nicolò Ricciardi,

Alessandra Moncada

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1324 - 1324

Published: Oct. 30, 2024

Golden tomato (GT), harvested at the veraison stage, has gained attention due to its rich content of bioactive compounds and potential health benefits. Previous studies have highlighted GT's antioxidant properties positive effects on metabolic syndrome (MetS), a condition characterized by obesity, dyslipidemia, oxidative stress. This study investigates for first time derivative from GT, i.e., juice (GTJ), which could be candidate development as functional food. We GT juice, identifying 9-oxo-10(E),12(E)-octadecadienoic (9-oxo-10(E),12(E)-ODA) fatty acid, known peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, using High-Performance Liquid Chromatography (HPLC)-mass spectrometry. Then, high-fat-diet (HFD) rat model, we assessed impact daily supplementation in addressing MetS. outlined that GTJ improved body weight leptin-mediated food intake. Moreover, it ameliorated glucose tolerance, lipid profile, systemic redox homeostasis, hepatic stress, steatosis HFD rats. Furthermore, enhances transcription PPAR-α, thus putatively promoting acid oxidation metabolism. These findings suggest mitigates lipidic accumulation halters species level through PPAR-α activation. Our underscores protective against MetS, highlighting future nutraceutical improving dysmetabolism associated alterations.

Language: Английский

Correlation of Metabolic Syndrome with Redox Homeostasis Biomarkers: Evidence from High-Fat Diet Model in Wistar Rats DOI Creative Commons
Danila Di Majo, Pierangelo Sardo, Giuseppe Giglia

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 12(1), P. 89 - 89

Published: Dec. 30, 2022

Metabolic Syndrome (MetS) is an extremely complex disease. A non-balanced diet such as high-fat (HFD) induces metabolic dysfunction that could modify redox homeostasis. We here aimed at exploring homeostasis in male Wistar rats, following 8 weeks of HFD, correlating the eventual modification selected biomarkers be associated with clinical manifestations MetS. Therefore, we parameters relative to both glucose tolerance and lipid altered metabolism, but also oxidative pattern. assessed some stress i.e., thiols balance, peroxidation antioxidant barriers, via use specific biochemical assays, individuating cross correlation MetS through a Principal Component Analysis (PCA). The present study shows HFD induce altering increasing visceral adipose tissue, impairing physiological responses not counteract condition. Crucially, cross-correlation analysis suggested assessment reported can provide information comparable more widely acquired Mets tolerance. Lastly, hepatic steatosis association condition was highlighted by histological analysis. This research will elucidate fundamental impact these on induced rat model, tracing paths for developing prevention approaches.

Language: Английский

Citations

20
Early-life gut mycobiome core species modulate metabolic health in mice DOI Creative Commons
Mackenzie W. Gutierrez, Erik van Tilburg Bernardes,

Ellen Ren

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 8, 2025

The gut microbiome causally contributes to obesity; however, the role of fungi remains understudied. We previously identified three core species infant mycobiome (Rhodotorula mucilaginosa, Malassezia restricta and Candida albicans) that correlated with body mass index, however their causal contributions obesity development are unknown. Here we show effects early-life colonization by these fungal on metabolic health in gnotobiotic mice fed standard (SD) or high-fat-high-sucrose (HFHS) diets. Each resulted bacterial compositional functional differences. R. mucilaginosa M. increased adiposity SD, while only exacerbated disease. In contrast, C. albicans leanness resistance diet-induced obesity. Intestinal nutrient transporter expression was unaffected presence jejunal enteroids, yet immune landscape white adipose tissue distinctly impacted each species, suggesting phenotypes may be a result regulation. This work revealed common colonizers have distinct influences inflammation justifies consideration research host metabolism. Here, authors use human exert modulatory tissue, increasing exacerbating disease,

Language: Английский

Citations

0
“Golden” Tomato Consumption Ameliorates Metabolic Syndrome: A Focus on the Redox Balance in the High-Fat-Diet-Fed Rat DOI Creative Commons
Giuditta Gambino, Giuseppe Giglia, Mario Allegra

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 1121 - 1121

Published: May 18, 2023

Tomato fruits defined as "golden" refer to a food product harvested at an incomplete ripening stage with respect red tomatoes full maturation. The aim of this study is explore the putative influence "golden tomato" (GT) on Metabolic Syndrome (MetS), especially focusing effects redox homeostasis. Firstly, differential chemical properties GT matrix were characterized in terms phytonutrient composition and antioxidant capacities tomato (RT). Later, we assessed biochemical, nutraceutical eventually disease-modifying potential vivo high-fat-diet rat model MetS. Our data revealed that oral supplementation able counterbalance MetS-induced biometric metabolic modifications. Noteworthy nutritional proved reduce plasma oxidant status improve endogenous barriers, by strong systemic biomarkers. Furthermore, consistently reduction hepatic reactive oxygen nitrogen species (RONS) levels, treatment markedly reduced HFD-induced increase lipid peroxidation steatosis. This research elucidates importance prevention management

Language: Английский

Citations

7
Metabolic Effects of Short-Term High-Fat Intake Vary Depending on Dietary Amino Acid Composition DOI Creative Commons
Hiroki Nishi,

Yuki Goda,

Ryosuke Okino

et al.

Current Developments in Nutrition, Journal Year: 2024, Volume and Issue: 8(6), P. 103768 - 103768

Published: May 8, 2024

Language: Английский

Citations

1
Gut mycobiome core species causally modulate metabolic health in mice DOI Creative Commons
Marie‐Claire Arrieta

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 19, 2024

Abstract The gut microbiome causally contributes to obesity; however, the role of fungi remains understudied. We previously identified three core species infant mycobiome ( Rhodotorula mucilaginosa , Malassezia restricta and Candida albicans ) that correlated with body mass index, however their causal contributions obesity development are unknown. In gnotobiotic mice, we evaluated effects early-life colonization by these fungal on metabolic health in mice fed standard (SD) or high-fat-high-sucrose (HFHS) diets. Each resulted bacterial compositional functional differences. R. M. increased adiposity SD, while only exacerbated disease. contrast, C. leanness resistance diet-induced obesity. This phenotype was accompanied enhanced white adipose tissue inflammation (type 1 type 17 responses). work revealed common colonizers have distinct influences justifies consideration research host metabolism.

Language: Английский

Citations

1
Effects of quercetin on hepatic fibroblast growth factor-21 (FGF-21) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) levels in rats fed with high fructose DOI
Kardelen Kocaman Kalkan, Serkan Şen, Belkıs Narlı

et al.

Molecular Biology Reports, Journal Year: 2023, Volume and Issue: 50(6), P. 4983 - 4997

Published: April 22, 2023

Language: Английский

Citations

3
Effects of Fructose and Palmitic Acid on Gene Expression in Drosophila melanogaster Larvae: Implications for Neurodegenerative Diseases DOI Open Access
Luis Felipe Santos-Cruz, Santiago C. Sigrist-Flores, Laura Castañeda-Partida

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10279 - 10279

Published: June 17, 2023

One of the largest health problems worldwide is development chronic noncommunicable diseases due to consumption hypercaloric diets. Among most common alterations are cardiovascular diseases, and a high correlation between overnutrition neurodegenerative has also been found. The urgency in study specific damage tissues such as brain intestine led us use Drosophila melanogaster metabolic effects caused by fructose palmitic acid tissues. Thus, third instar larvae (96 ± 4 h) wild Canton-S strain D. were used perform transcriptomic profiling midgut test for potential diet supplemented with acid. Our data infer that this can alter biosynthesis proteins at mRNA level participate synthesis amino acids, well fundamental enzymes dopaminergic GABAergic systems brain. These demonstrated flies may help explain various reported human associated humans. studies will not only better understand mechanisms which these alimentary products related neuronal but contribute prevention conditions.

Language: Английский

Citations

3
Alpha-ketoglutarate partially alleviates effects of high-fat high-fructose diet in mouse muscle. DOI
Myroslava Vatashchuk, Maria M. Bayliak, Viktoria Hurza

et al.

PubMed, Journal Year: 2023, Volume and Issue: 22, P. 1264 - 1277

Published: Jan. 1, 2023

Consumption of high-calorie diets leads to excessive accumulation storage lipids in adipose tissue. Metabolic changes occur not only tissue but other tissues, too, such as liver, heart, muscle, and brain. This study aimed explore the effects high-fat high-fructose diet (HFFD) alone combination with alpha-ketoglutarate (AKG), a well-known cellular metabolite, on energy metabolism skeletal muscle C57BL/6J mice. Five-month-old male mice were divided into four groups - control one fed standard (10 % kcal fat), HFFD group (45 fat, 15 fructose), AKG 1 sodium drinking water, + water AKG. The dietary regimens lasted 8 weeks. Mice had higher levels triacylglycerides, lower glycogen, total water-soluble protein, activities key glycolytic enzymes, namely hexokinase, phosphofructokinase, pyruvate kinase, compared group. results suggest that muscles may suffer from lipotoxicity. In mice, metabolites enzymes did differ respective values group, except for activity which was significantly control. Thus, metabolic mouse muscles, caused by HFFD, alleviated AKG, indicating protective role regarding

Language: Английский

Citations

3
Phytoconstituent Profiles Associated with Relevant Antioxidant Potential and Variable Nutritive Effects of the Olive, Sweet Almond, and Black Mulberry Gemmotherapy Extracts DOI Creative Commons

Amina Aleya,

E.A. Mihok,

Bence Pecsenye

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(9), P. 1717 - 1717

Published: Sept. 4, 2023

The extracts of whole plants or specific organs from different plant species are gaining increasing attention for their phytotherapy applications. Accordingly, we prepared standardized gemmotherapy (GTEs) young shoots/buds olive (Olea europaea), sweet almond (Prunus amygdalus), and black mulberry (Morus nigra), analyzed the corresponding phytonutrient profiles. We identified 42, 103, 109 phytonutrients in olive, almond, GTEs, respectively, containing amino acids, vitamins, polyphenols, flavonoids, coumarins, alkaloids, iridoids, carboxylic lignans, terpenoids, others. In order to assess physiological effects generated by developed a translational nutrition model based on Drosophila melanogaster Cyprinus carpio. results indicate that GTEs could influence, variable extent, viability ATP synthesis, even though both dependent carbohydrate load applied diet acid polyphenol pools provided GTEs. It seems, therefore, likely complex chemical composition offers nutritional properties cannot be separated health-promoting mechanisms ultimately increase survival. Such an approach sets paves way genomic descriptions regarding GTE-associated effects.

Language: Английский

Citations

2
Correlation of silent brain infarcts and leukoaraiosis in middle-aged ischemic stroke patients: a retrospective study DOI Creative Commons

Mohammad Fathi Abdulsalam,

Nour Shaheen, Ahmed Shaheen

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 21, 2024

Background Cerebrovascular diseases of the brain are usually defined by transient ischemic attacks and strokes. However, they can also cause injuries without neurological events. Silent infarcts (SBI) leukoaraiosis symptoms both vascular abnormalities. This study aims to investigate association between SBI, leukoaraiosis, middle-aged patients with stroke. Methods A single-center retrospective 50 middle-aged, stroke were studied from November 2022 May 2023. The divided into two groups based on presence or absence leukoaraiosis. History taking, physical examination, CT scan, MRI all part diagnostic process. Metabolic syndrome (MetS) was assessed through various factors. statistical analysis included descriptive statistics, logistic regression analysis, chi-square test. Results Out cohort comprising patients, characterized a mean age 52.26 years (SD 5.29), 32 male, constituting 64% sample. Among these 26 individuals exhibited 17 them (65.4%) presenting SBI. Moreover, within this cohort, 22 diagnosed MetS, representing 84.6% those affected. Multivariate showed strong independent Individuals nearly five times more likely have SBI compared Conclusion highlights as significant risk factor for alongside MetS. Advanced imaging techniques facilitated their detection, revealing higher prevalence among particularly associated hypertension. Further research is needed fully understand complex relationship develop better management strategies cerebrovascular diseases, ultimately improving patient outcomes.

Language: Английский

Citations

0