Anti-Obesity Effect and Signaling Mechanism of Potassium Poly-γ-Glutamate Produced by Bacillus subtilis Chungkookjang in High-Fat Diet-Induced Obese Mice DOI Open Access

Seung-Hyeon Lee,

Jiwon Choi,

Jae Young Park

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 809 - 809

Published: March 12, 2024

The purpose of this work was to examine the effects potassium poly-γ-glutamate (PGA-K) on mice fed a high-fat diet consisting 60% total calories for 12 weeks. PGA-K administration reduced increase in body weight, epididymal fat, and liver weight caused by compared obese group. triglyceride, low-density lipoprotein cholesterol high-density levels, which are blood lipid indicators, were significantly increased group but decreased PGA-K-treated resulted significant inhibition pro-inflammatory cytokines, including tumor necrosis factor α interleukin 6. Moreover, levels leptin insulin, insulin resistance These results suggest that exhibits protective effect against obesity induced diet, underscoring its potential as candidate treatment.

Language: Английский

Biological functions of compounds from Bacillus subtilis and its subspecies, Bacillus subtilis natto DOI Creative Commons
Taiki Miyazawa, Chizumi Abe,

Maharshi Bhaswant

et al.

Food Bioengineering, Journal Year: 2022, Volume and Issue: 1(3-4), P. 241 - 251

Published: Dec. 1, 2022

Abstract Natto, fermented food produced by Bacillus subtilis natto ( B. natto), is widely consumed around the world, and its potential health functions are attracting attention. Natto has been reported to have a variety of bioactive compounds such as levan, menaquinone‐7, nattokinase, others. Such deeply involved in function natto, because they consequently contained natto. This review summarizes (1) subspecies, (2) Overall, natural source expected be applied functional foods.

Language: Английский

Citations

9

Effects of dietary fermented soybean meal with Thua nao starter on the growth performance, body composition, and disease resistance against Aeromonas hydrophila of Nile tilapia (Oreochromis niloticus) DOI Creative Commons

Mahattanee Phinyo,

Soraya Pumma,

Phattharamat Thinjan

et al.

Aquaculture Reports, Journal Year: 2023, Volume and Issue: 34, P. 101890 - 101890

Published: Dec. 23, 2023

The purpose of this study was to evaluate the improvement nutritional value soybean meal by using Thua nao starter as a dietary supplement for tilapia culture. covered five different experimental diets, each containing fermented (FSBM): FSBM0 (0 g/kg), FSBM75 (75 FSBM150 (150 FSBM225 (225 and FSBM300 (300 g/kg) 10 weeks. results fermentation process revealed that FSBM exhibited an abundance Bacillus Kosakonia, along with notable enzyme activities such protease, filter paper cellulase, carboxymethyl cellulase. Furthermore, protein content increased from 42% 44%. When feed supplemented FSBM, it observed supplementation amounts below had no significant impact on fish growth. Conversely, diet detrimental effect Fish receiving diets demonstrated elevated white blood cells, particularly in those fed FSBM150, FSBM225, FSBM300, increase neutrophils FSBM300. whole-body composition changes crude ash, but there reduction lipid content. Notably, positive disease resistance Aeromonas hydrophila, group showing lowest mortality rate at 23.8%. These findings indicate inclusion concentration 225 g/kg does not negatively affect growth improves survival rates when exposed A. hydrophila. This indicates can be considered valuable resist bacterial infection farming.

Language: Английский

Citations

5

Nutritional improvement in soybean (Glycine max (L.) Merrill) through plant breeding and biotechnological interventions DOI

Vedna Kumari,

R. C. Thakur, Jyoti Kumari

et al.

Crop and Pasture Science, Journal Year: 2023, Volume and Issue: 75(1)

Published: Dec. 20, 2023

Soybean has been grown as an important protein and oil crop for thousands of years. Additionally, it also a high content iso-flavonoids, folic acid saponins, exhibiting various biological activities. It contains several antioxidants, anti-diabetic, anti-proliferative, anti-obesity anti-inflammatory properties. However, soybean antinutritional factors such trypsin inhibitor, agglutinin, lectins, phytic tannins, which reduce nutrient utilisation. Attempts have made to improve the nutritional quality through conventional breeding, but anticipated outcomes could not be met these efforts primarily resulted in agronomically undesirable traits. development cutting-edge tools technologies including throughput genotyping, phenotyping, DNA sequencing techniques genome editing great progress improving functional qualities soybean.

Language: Английский

Citations

4

Anti-Obesity Effect and Signaling Mechanism of Potassium Poly-γ-Glutamate Produced by Bacillus subtilis Chungkookjang in a High-Fat Diet-Induced Obese Mice DOI Open Access

Seung-Hyeon Lee,

Jiwon Choi,

Jae Young Park

et al.

Published: Feb. 8, 2024

This study aimed to investigate the effect of potassium poly-γ-glutamate (PGA-K) on mice fed a high-fat diet consisting 60% total calories for duration 12 weeks. PGA-K administration reduced increase in body weight, epididymal fat, and liver weight caused by compared obese group. The triglyceride, low-density lipoprotein cholesterol high-density levels, which are blood lipid indicators, were significantly increased group but decreased PGA-K-treated resulted significant inhibition pro-inflammatory cytokines, including tumor necrosis factor α interleukin 6. Moreover, levels leptin insulin, insulin resistance These results suggest that exhibits protective against obesity induced diet, underscoring its potential as candidate treatment.

Language: Английский

Citations

1

Anti-Obesity Effect and Signaling Mechanism of Potassium Poly-γ-Glutamate Produced by Bacillus subtilis Chungkookjang in High-Fat Diet-Induced Obese Mice DOI Open Access

Seung-Hyeon Lee,

Jiwon Choi,

Jae Young Park

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 809 - 809

Published: March 12, 2024

The purpose of this work was to examine the effects potassium poly-γ-glutamate (PGA-K) on mice fed a high-fat diet consisting 60% total calories for 12 weeks. PGA-K administration reduced increase in body weight, epididymal fat, and liver weight caused by compared obese group. triglyceride, low-density lipoprotein cholesterol high-density levels, which are blood lipid indicators, were significantly increased group but decreased PGA-K-treated resulted significant inhibition pro-inflammatory cytokines, including tumor necrosis factor α interleukin 6. Moreover, levels leptin insulin, insulin resistance These results suggest that exhibits protective effect against obesity induced diet, underscoring its potential as candidate treatment.

Language: Английский

Citations

1