Military Medical Research,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: June 9, 2023
Abstract
Spinal
cord
injury
(SCI)
is
a
devastating
and
disabling
medical
condition
generally
caused
by
traumatic
event
(primary
injury).
This
initial
trauma
accompanied
set
of
biological
mechanisms
directed
to
ameliorate
neural
damage
but
also
exacerbate
(secondary
The
alterations
that
occur
in
the
spinal
have
not
only
local
systemic
consequences
virtually
all
organs
tissues
body
incur
important
changes
after
SCI,
explaining
progression
detrimental
related
this
condition.
Psychoneuroimmunoendocrinology
(PNIE)
growing
area
research
aiming
integrate
explore
interactions
among
different
systems
compose
human
organism,
considering
mind
as
whole.
consequent
neurological
disruption
trigger
immune,
endocrine,
multisystem
dysfunction,
which
turn
affect
patient’s
psyche
well-being.
In
present
review,
we
will
most
SCI
from
PNIE
perspective,
defining
occurring
each
system
how
these
are
interconnected.
Finally,
potential
clinical
approaches
derived
knowledge
be
collectively
presented
with
aim
develop
integrative
therapies
maximize
management
patients.
Journal of Personalized Medicine,
Journal Year:
2023,
Volume and Issue:
13(4), P. 626 - 626
Published: April 2, 2023
Oxidative
stress
is
a
major
signature
of
spinal
cord
injury
(SCI).
The
altered
levels
various
oxidative
markers
have
been
demonstrated
in
acute
and
chronic
SCI.
However,
the
variation
these
patients
with
SCI
depending
on
time
since
initial
has
not
explored
yet.Our
aim
was
to
measure
plasma
malondialdehyde
(MDA),
marker
lipid
peroxidation
stratified
different
periods
suffering
(0-5
years,
5-10
more
than
10
years).This
cross-sectional
study
enrolled
(N
=
105)
from
lesion
healthy
control
(HC)
subjects
38):
short
period
(SCI
SP,
N
31,
evolution
less
5
years);
early
ECP,
32,
5-15
late
LCP,
42,
15
years).
MDA
were
measured
using
commercially
available
colorimetric
assay.Patients
had
significantly
higher
HC
subjects.
Receiver
operating
characteristic
(ROC)
curve
analysis
for
areas
under
(AUC)
1
(HC
vs.
SCI-SP);
0.998
SCI-ECP);
0.964
SCI-LCP).
Additionally,
three
ROC
curves
used
compare
concentrations
between
subgroups
SCI,
resulting
AUCs
were:
0.896
(SCI-SP
0.840
(SCI-ECP
SCI-LCP);
0.979
SCI-LCP).Plasma
concentration
can
be
considered
as
an
biomarker
assess
prognosis
stages.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: Nov. 7, 2022
Central
nervous
system
(CNS)
disorders
and
diseases
are
expected
to
rise
sharply
in
the
coming
years,
partly
because
of
world’s
aging
population.
Medicines
for
treatment
CNS
have
not
been
successfully
made.
Inadequate
knowledge
about
brain,
pharmacokinetic
dynamic
errors
preclinical
studies,
challenges
with
clinical
trial
design,
complexity
variety
human
brain
illnesses,
variations
species
some
potential
scenarios.
Neurodegenerative
(NDDs)
multifaceted
lack
identifiable
etiological
components,
drugs
developed
treat
them
did
meet
requirements
those
who
anticipated
treatments.
Therefore,
there
is
a
great
demand
safe
effective
natural
therapeutic
adjuvants.
For
NDDs
other
memory-related
problems,
many
herbal
items
used
Ayurvedic
medical
system.
Anxiety,
depression,
Parkinson’s,
Alzheimer’s
(AD),
as
well
plethora
neuropsychiatric
disorders,
may
benefit
from
use
plant
food-derived
chemicals
that
antidepressant
or
antiepileptic
properties.
We
summarized
present
level
products
based
on
topological
evidence,
bioinformatics
analysis,
translational
research
this
review.
also
highlighted
investigation
will
help
us
select
neurological
conditions.
In
review,
we
explored
efficacy
phytoconstituents
against
diseases.
Various
evidence-based
studies
extensive
recent
investigations
included,
which
pharmacologists
reduce
progression
neuronal
disease.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
176, P. 116938 - 116938
Published: June 14, 2024
Spinal
cord
injury
(SCI)
is
a
serious
and
disabling
central
nervous
system
injury.
Its
complex
pathological
mechanism
can
lead
to
sensory
motor
dysfunction.
It
has
been
reported
that
signaling
pathway
plays
key
role
in
the
process
neuronal
recovery
of
SCI.
Such
as
PI3K/Akt,
MAPK,
NF-κB,
Wnt/β-catenin
pathways.
According
reports,
various
stimuli
cytokines
activate
these
pathways
related
SCI
pathology,
thereby
participating
regulation
processes
such
inflammation
response,
cell
apoptosis,
oxidative
stress,
glial
scar
formation
after
Activation
or
inhibition
relevant
delay
inflammatory
reduce
prevent
formation,
improve
microenvironment
SCI,
promote
neural
function
recovery.
Based
on
they
may
be
potential
targets
for
treatment
Therefore,
understanding
its
inhibitors
beneficial
development
therapeutic
new
drugs.
This
paper
mainly
summarizes
pathophysiological
involved
pathogenesis,
specific
inhibitors/activators
treatment.
In
addition,
this
review
also
discusses
deficiencies
defects
research.
hoped
study
provide
reference
future
research
pathogenesis
theoretical
basis
biotherapy.
ACS Biomaterials Science & Engineering,
Journal Year:
2023,
Volume and Issue:
9(10), P. 5709 - 5723
Published: Sept. 15, 2023
Spinal
cord
injury
is
an
impact-induced
disabling
condition.
A
series
of
pathological
changes
after
spinal
(SCI)
are
usually
associated
with
oxidative
stress,
inflammation,
and
apoptosis.
These
eventually
lead
to
paralysis.
The
short
half-life
low
bioavailability
many
drugs
also
limit
the
use
in
SCI.
In
this
study,
we
designed
nanovesicles
derived
from
macrophages
encapsulating
selenium
nanoparticles
(SeNPs)
metformin
(SeNPs-Met-MVs)
be
used
treatment
can
cross
blood–spinal
barrier
(BSCB)
deliver
SeNPs
Met
site
exert
anti-inflammatory
reactive
oxygen
species
scavenging
effects.
Transmission
electron
microscopy
(TEM)
images
showed
that
SeNPs-Met-MVs
particle
size
was
approximately
125
±
5
nm.
Drug
release
assays
exhibited
sustained
encapsulation
by
macrophage
cell
membrane.
cumulative
80%
over
36
h.
vitro
cellular
experiments
vivo
animal
demonstrated
decreased
(ROS)
malondialdehyde
(MDA)
levels,
increased
superoxide
dismutase
(SOD)
glutathione
peroxidase
(GSH-Px)
activities,
reduced
expression
inflammatory
(TNF-α,
IL-1β,
IL-6)
apoptotic
(cleaved
caspase-3)
cytokines
tissue
addition,
motor
function
mice
significantly
improved
treatment.
Therefore,
have
a
promising
future
Nutritional Neuroscience,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 14
Published: Feb. 28, 2025
Spinal
cord
injury
(SCI)
is
a
major
challenge
in
the
medical
community
because
of
its
difficulty
treatment
and
poor
prognosis.
Extract
ginkgo
biloba
(EGb)
has
been
widely
used
prevention
age-related
neurosensory
disease,
which
considered
to
have
effect
neuroprotection.
We
performed
systematic
review
evaluate
neurobiological
roles
EGb
for
treating
SCI
rats.
Pubmed,
Embase,
Sinomed
China
National
knowledge
Infrastructure
were
searched
from
their
inception
dates
April
2024,
30
articles
included.
The
quality
score
included
studies
ranged
4
7
out
10
points,
all
them
randomization.
It
was
shown
that
after
SCI,
administration
could
significantly
improve
motor
function
(WMD
=
2.09
[1.59,
2.59],
p
<
0.00001).
Subgroup
analysis
concluded
at
doses
10-50
mg/kg
improved
greatest
extent.
In
comparison
with
control
group,
reduce
lipid
peroxidation
inhibit
inflammation
(MDA:
SMD
-1.43
[-5.05,2.20],
0.00001;
iNOS:
WMD
-22.17
[-35.45,
-8.90],
addition,
this
suggested
can
antagonize
inflammation,
oxidative
stress
resistance
apoptosis,
promote
nerve
growth
myelin
loss
on
SCI.
Preclinical
grade
suggests
that,
collectively,
may
be
promising
natural
neuroprotective
agent
unique
advantages
mechanisms
action.
More
clinical
randomized,
blind
controlled
trials
are
also
needed
confirm
