GSH resistant, luminescent 2-(pyren-1-yl)-1H-imidazo[4,5-f][1,10]phenanthroline-based Ru(ii)/Ir(iii)/Re(i) complexes for phototoxicity in triple-negative breast cancer cells DOI

Rishav Das,

Priyankar Paira

Dalton Transactions, Journal Year: 2023, Volume and Issue: 52(42), P. 15365 - 15376

Published: Jan. 1, 2023

Selective chemotherapeutic strategies necessitate the emergence of a photosensitive scaffold to abate nuisance cancer. In current context, photo-activated chemotherapy (PACT) has, therefore, appeared be very effective vanquish vehemence triple-negative breast cancer (TNBC). Metal complexes have been identified act well against cell microenvironment (high GSH content, low pH, and hypoxia), thus they employed in treatment various types As TNBC is challenging treat owing its poor prognosis, lack specific target, high chance relapse, strong metastatic ability, herein we aspired design GSH-resistant phototoxic Ru(II)/Ir(III)/Re(I) based pyrene imidazophenathroline selectively avert The application complexes, [RuL], [IrL], [ReL] absence presence MDA-MB-231TNBC cells, has revealed that are active upon irradiation visible light compared dark due creation copious singlet oxygen (1O2) as reactive species (ROS). Among three synthesized [IrL] shown outstanding potency (IC50 = 3.70 IC50 3.90 GSH). Also, complex, capable interacting with DNA highest binding constant (Kb 0.023 × 106 M-1) along higher protein affinity (KBSA 0.0321 M-1). Here, it unveiled all entitled involve covalent interaction through available sites both adenine guanine bases.

Language: Английский

Riding the metal wave: A review of the latest developments in metal-based anticancer agents DOI

Sara Abdolmaleki,

Alireza Aliabadi, Samad Khaksar

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 501, P. 215579 - 215579

Published: Nov. 28, 2023

Language: Английский

Citations

58
Metal Complexes in Cancer Treatment: Journey So Far DOI
Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh

et al.

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 20(4)

Published: Feb. 24, 2023

Abstract Metal complexes in cancer therapy have attracted much interest mainly because metals exhibit unique characteristics, such as redox activity, metal‐ligand interaction, structure and bonding, Lewis acid properties etc . In 1965, Barnett Rosenberg serendipitously discovered the metal‐based compound cisplatin, an outstanding breakthrough history of anticancer led to a new area drug discovery. Many compounds been studied for their potential properties. Some these FDA approval clinical use, while others are now undergoing trials detection. present study, we highlighted primary mode action metallic all FDA‐approved/under trial drugs with reference treatment. This review also focuses on recent progress platinum, ruthenium, iron, activities.

Language: Английский

Citations

43
Applications of metal complexes in analytical chemistry: A review article DOI
Rehab H. Elattar, Samah F. El‐Malla, Amira H. Kamal

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 501, P. 215568 - 215568

Published: Nov. 24, 2023

Language: Английский

Citations

31
Innovation of Fe(III), Ni(II), and Pd(II) complexes derived from benzothiazole imidazolidin‐4‐ol ligand: Geometrical elucidation, theoretical calculation, and pharmaceutical studies DOI Open Access
Ahmed M. Abu‐Dief, Musa A. Said, Omar M. Elhady

et al.

Applied Organometallic Chemistry, Journal Year: 2023, Volume and Issue: 37(8)

Published: June 6, 2023

The synthesis of a simple, highly tunable, and effective BSI ligand, 2‐(benzothiazol‐2‐ylimino)‐2,3‐dihydro‐1H‐imidazol‐4‐ol, was presented. Three new coordinating substances ligand were synthesized. Various spectroscopic analytical methods, including 1 H NMR 13 C NMR, infrared (IR), ultraviolet–visible (UV‐vis), thermal conduction, measures magnetism, used to clarify the structures these compounds. A further examination compounds revealed an octahedral‐coordinating environment surrounding Fe 3+ ion, ([Fe(BSI) 2 (NO 3 ) ](NO ·0.5H O)) Ni 2+ , ([Ni(BSI) ](H O) cations distorted square planner Pd ([Pd(BSI)(COOCH ]H cation. under investigation linked through nitrogen thiazole ring NH imidazole ring. formed complexes' deterioration behavior investigated. Calculated kinetic data for examined various phases supported their endothermic character. Using Gaussian 09 software at B3LYP/LANL2DZ level, equilibrium geometry ligands coordination complex has been studied by calculations using density functional theory (DFT). suggested DFT calculation are in good agreement with experimental data. antibacterial effectiveness molecules against different types bacteria fungus reveals that BSIPd (MIC = 2.25–4.75 μg/mL) greatest activity is most comparable standard. newly synthesized also tested several cell lines MTT assay. results given as IC 50 value, where Pd(II) values show potential anticancer properties compound. Moreover, inspected complexes showed significant growth inhibition (IC50 6.79–9.05 μg/mL), even higher than standard drugs; cisplatin (IC 18 versus breast carcinoma cells. This intriguing finding verified Swiss‐ADME pharmacophore query calculations. In accordance actual findings, silico free ligand's low increased when it complexed metal ions.

Language: Английский

Citations

27
Cytotoxicity and mechanism of action of metal complexes: An overview DOI

Sara Abdolmaleki,

Samad Khaksar, Alireza Aliabadi

et al.

Toxicology, Journal Year: 2023, Volume and Issue: 492, P. 153516 - 153516

Published: April 20, 2023

Language: Английский

Citations

23
Metal N-heterocyclic carbene complexes as potential metallodrugs in antitumor therapy DOI
Yifan Zhang,

Yi-Kui Yin,

Heng Zhang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 514, P. 215941 - 215941

Published: May 18, 2024

Language: Английский

Citations

16
Synthesis and Characterization of a New Neodymium Complex: DFT Insights and Potential Anticancer Applications DOI Open Access
Basma A.A. Balboul, Rania H. Taha,

Alaa Muqbil Alsirhani

et al.

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 18, 2025

ABSTRACT A new complex of type [Nd (HL) (NO 3 ) 2 ] has been synthesized with a Schiff base ligand H L derived from 2‐hydroxy‐3‐methoxybenzaldehyde and L‐histidine. The structure the was established using elemental analysis, molar conductivities, FT‐IR, 1 HNMR, SEM, x‐ray diffraction (XRD) spectroscopy. FT‐IR data revealed that acts as tetradentate through carboxylic acid, azomethine nitrogen, methoxy oxygen, hydroxyl groups. Based on electronic spectra, an octahedral configuration hypothesized for complex. TGA method employed to study thermal behavior its complex, thermodynamic parameters were determined Coats–Redfern equations. XRD analysis compounds possess nanoscale dimensions, their crystallinity significantly enhanced by coordination Nd(III) ion L. DFT calculations performed optimize geometry proposed structures, indicating improved stabilities. reduced HOMO–LUMO gap in further highlights remarkable conductive properties. surface morphology analyzed SEM investigate structural characteristics. images reveal variety particle shapes, including elongated, prismatic, irregular blocky particles sharp edges, suggesting crystalline nature. evaluated anticancer activity against prostate carcinoma, breast lung carcinoma cell lines. inhibition rate 92.81%, 93.25%, 94.58%, respectively. results demonstrated exhibited compared alone, likely due These findings suggest holds promise potent agent.

Language: Английский

Citations

1
Recent Advances in Bioconjugated Transition Metal Complexes for Cancer Therapy DOI Creative Commons
Enrica Bortolamiol, Fabiano Visentin, Thomas Scattolin

et al.

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(9), P. 5561 - 5561

Published: April 29, 2023

The introduction of biologically relevant organic moieties in the coordination sphere transition metal complexes has recently become a well-established strategy to increase selectivity and biocompatibility metallodrugs. In this review, major advances achieved area research last three years are described detail. Particular attention is given bearing main biomolecules life: carbohydrates, lipids, nucleotides, proteins vitamins. Each paragraph summarizes synthetic employed obtain interest as well most interesting biological results obtained with these potential Moreover, structure–activity relationships observed by different groups discussed, goal suggesting reader ligand/metal centre combinations that provide promising fight against cancer. Some compounds examined review other bioconjugated published recent decades exhibit towards cancer cells over normal ones specific mode action. These latter aspects basis what commonly known anticancer target therapy.

Language: Английский

Citations

22
Synthesis, Structural Determination, DFT Calculation and Biological Evaluation Supported by Molecular Docking Approach of Some New Complexes Incorporating (E)‐N'‐(3,5‐di‐Tert‐Butyl‐2‐Hydroxybenzylidene) Isonicotino Hydrazide Ligand DOI
Eida S. Al‐Farraj, Hamza A. Qasem, Mohamed Reda Aouad

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 39(1)

Published: Sept. 29, 2024

ABSTRACT The synthesis and structural analysis of complexes derived from (E)‐N′‐(3,5‐di‐ tert ‐butyl‐2‐hydroxybenzylidene) isonicotino hydrazide ( ITB ligand) were examined using multiple analytical techniques. These techniques included TGA, decomposition point determination, elemental (CHN), spectroscopic (IR, NMR, mass spectrometry) analysis, magnetic susceptibility, conductivity, as well UV–Vis spectrum along with theoretical studies. Molar conductance values indicated that the Cd (II), Co Cu Ni Zn (II) are non‐electrolytes in fresh DMSO solutions, ranging 8.5 to 14.35 Ω −1 cm 2 mol . IR spectra suggested which ligand coordinates through metal ions a tridentate fashion, utilizing (N & O) donor sites (CN CO CO) groups hydroxybenzylidene moiety. Analytical data solution complexation, job's method 1:1 (metal:ligand) molar ratio. stability order was determined ITBCo > ITBCu ITBNi ITBZn ITBCd, consistent constant (K f ) values. pH profile studied exhibit upon wide scale, typically between (pH = 4:10). Magnetic electronic spectral analyses helped deduce coordination abilities geometric structures complexes. In vitro (antimicrobial anticancer) performances tested versus various (microbial strains cancer cell lines), revealing higher activity chelates assessed free ligand. antioxidant potential also DPPH assay. Finally, molecular docking performed toward estimate binding efficiency protein receptors compounds, results aligning biological investigations.

Language: Английский

Citations

7
Evaluation of the role of ionic liquid as a modifier for carbon paste electrodes in the detection of anthracyclines and purine-pyrimidine-based anticancer agents DOI Creative Commons
Isha Soni,

Amisha Kumari,

Gururaj Kudur Jayaprakash

et al.

Materials Research Express, Journal Year: 2024, Volume and Issue: 11(1), P. 012005 - 012005

Published: Jan. 1, 2024

Abstract Ionic liquid has become a very fascinating modifier in the past few years. With help of an ionic liquid-modified carbon paste electrode (CPE), electrochemistry great way to find different drugs with lower detection limit and high sensitivity selectivity. The circulation electrons ring cationic part enables lowering electron resistance further enhancing electrical conductivity. combination liquids various kinds materials such as Nobel metals, metal oxides, graphene nanotubes (CNT), etc improved its catalytic activity enabling faster transfer. Additionally, ability dissolve other chemicals allows for incorporation electrolytes redo-active species into electrode, performance. Anti-cancer are life-saving but have lot side effects, one biggest is cardiotoxicity, which important saving patients’ lives. So figuring out what these big task scientists all over world. Therefore, current review enlightens path using anthracycline purine-pyrimidine-based anti-cancer drugs.

Language: Английский

Citations

5