Effective protective mechanisms of HO-1 in diabetic complications: a narrative review

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Oct. 10, 2024

Diabetes mellitus is a metabolic disorder with persistent hyperglycemia caused by variety of underlying factors. Chronic can lead to diverse serious consequences and diversified complications, which pose threat patients. Among the major complications are cardiovascular disease, kidney diabetic foot ulcers, retinopathy, neurological disorders. Heme oxygenase 1 (HO-1) protective enzyme antioxidant, anti-inflammatory anti-apoptotic effects, has been intensively studied plays an important role in complications. By inducing expression activity HO-1, it enhance anti-inflammatory, capacity tissues, thus reduce degree damage The present study aims review relationship between HO-1 pathogenesis diabetes its involved regulation macrophage polarization promotes M1 state (pro-inflammatory) towards M2 (anti-inflammatory). Induction dendritic cells inhibits them maturation secretion pro-inflammatory cytokines regulatory T cell (T

Language: Английский

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Anti-Diabetic Effects of Pomegranate Peel Extract and L-Carnitine on Streptozotocin Induced Diabetes In Rats

Biomedical & Pharmacology Journal, Journal Year: 2023, Volume and Issue: 16(3), P. 1827 - 1835

Published: Sept. 30, 2023

Type 2 diabetes mellitus is a far reaching ongoing metabolic problem portrayed by hyperglycemia and related with few intricacies like hyperlipidemia. The current study aimed to the anti-diabetic efficacy of pomegranate peel extract L-carnitine on streptozotocin-induced in rats. A total 70 male rats were divided into 7 groups (normal treated L-carnitine; given high-fat diet cause hyperlipidemia, this low-dose intraperitoneal streptozotocin injections type II diabetes; diabetic PPE orally every day for 12 weeks. Measurements body mass, blood sugar, lipid profile antioxidant enzyme activity made.Results: treatment group that received + showed significant decrease weight, glucose, cholesterol, triglycerides low-density lipoprotein significantly reduced, while high-density levels increased. Superoxide dismutase increased, catalase Nuclear Factor Erythroid-derived (Nfe2) L-carnitine, Malondialdehyde decreased significantly. According results study, had anti-hyperglycemic, hypolipidemic, benefits after weeks

Language: Английский

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Assessing intention to use mobile phone–based self-management support among adults with type 2 diabetes in Saudi Arabia: A cross-sectional study

Digital Health, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 1, 2025

The use of mobile phone technology for chronic illness self-management is growing, and it may help people with type 2 diabetes mellitus (T2DM). Innovative methods are needed to improve patient involvement disease management in the Kingdom Saudi Arabia due high incidence T2DM. purpose this study was explore how T2DM patients KSA utilizes their phones self-management. A cross-sectional conducted between April June 2025 among who were attending endocrinologists Northern Border region (Rafha Arar) Central (Riyadh) using a validated questionnaire. This included total 267 participants Nearly all (99.3%) possess cellphone, 94.8% having daily internet access. majority reported have an intention managing diabetes, 78.3% dietary planning, 79.4% physical activity 78.7% text messages as reminders. Factors such female (p = 0.008), younger age 0.001), duration <0.001) significantly associated apps diabetes. demonstrates higher inclination toward vs. face-to-face consultations. These findings highlight promising role enhancing patients, thus highlighting need targeted interventions.

Language: Английский

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Dietary Supplements as Modulators of the Nrf2 Pathway to Enhance Intracellular Antioxidant Responses and Protect Against Dyslipidemia-Associated Cardiovascular Complications

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 29

Published: Jan. 23, 2025

The market for dietary supplements has significantly grown due to their envisaged health benefits. These bioactive compounds are actively explored therapeutic benefits against vast metabolic complications abundant antioxidant properties. Nuclear factor erythroid 2-related 2 (Nrf2) modulation as a cytoprotective mechanism oxidative stress-induced stress garnered interest, particularly through its regulation by many supplements. This review aims evaluate and critically discuss the available evidence on potential effects of supplements, including prominently used nutraceuticals dyslipidemia-associated cardiovascular complications. Notably, this highlights these modulate Nrf2 pathway, enhancing intracellular antioxidants providing protection Beyond value preclinical ability regulate pathway counteract damage, also incorporates clinical supporting in dyslipidemia-related conditions. Fundamental pharmacological aspects such bioavailability relevant biological properties discussed inform further development diseases.

Language: Английский

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Integrated meta-analysis and network pharmacology analysis: evaluation of Zhigancao decoction as treatment for diabetic cardiomyopathy

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 14, 2025

Zhigancao Decoction (ZGCD) is derived from "Treatise on Febrile Diseases" and traditionally prescribed for treating a variety of cardiovascular conditions. As now, there are no data to support its use as treatment diabetic cardiomyopathy (DCM) the mechanism behind effect unclear well. In present study, clinical evidence efficacy ZGCD in patients with DCM was examined using meta-analysis underlying anti-DCM molecular mechanisms were explored via network pharmacology. The current study utilized an extensive search strategy encompassing various domestic foreign databases retrieve pertinent articles published up June 2024. light this, thorough evaluation benefits safety decoction conducted this RevMan Stata. Subsequently, number active compounds target genes gathered TCMSP BATMAN-TCM databases, while main targets obtained such GenCards, OMIM, TTD, DrugBank. To select core genes, protein-protein interaction networks generated STRING platform, enrichment analyses completed Metascape platform. Meta-analysis results ultimately 9 studies involving 661 total. comparison WM therapy alone, pooled showed that significantly enhanced overall effectiveness. Additionally, utilization leading reduction LVEDV, LVESV LVDD, also greater increase LVEF. Meanwhile, during intervention more effective reducing SBP, DBP. addition, potential occurrence adverse events. context pharmacology, five constituents ZGCD-namely lysine, quercetin, gamma-aminobutyric acid, stigmasterol, beta-sitosterol-are posited exert anti-diabetic (anti-DCM) effects through interactions ASS1, SERPINE1, CACNA2D1, AVP, APOB, ICAM1, EGFR, TNNC1, F2, F10, IGF1, TNNI2, CAV1, INSR, INS. primary by which may achieve likely mediated AGEs/RAGE signaling pathway, well pathways related lipid metabolism atherosclerosis. demonstrates management DCM. not only reduces blood pressure, but enhances cardiac function producing fewer effects. therapeutic can be ascribed capacity modulate AGEs-RAGE enhancing mitigating identifier (INPLASY202430133).

Language: Английский

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A comprehensive review on diabetic cardiomyopathy (DCM): histological spectrum, diagnosis, pathogenesis, and management with conventional treatments and natural compounds

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract Diabetic complications are among the most pressing health issues currently. Cardiovascular problems, particularly diabetic cardiomyopathy (DCM), responsible for almost 80% of deaths. Because increasing prevalence diabetes and increased threat death from its consequences, researchers searching new pharmaceutical targets to delay or cure it. Currently, there a few medicines available treatment DCM, some which have serious side effects. To address this issue, focusing on natural products. Thus, in review, we discuss prevalence, incidence, risk factors, histological spectrum, diagnosis, pathogenic pathways genetic epigenetic mechanisms involved current treatments, beneficial effects product–based therapeutics. Natural treatments range single doses continuous regimens lasting weeks months. Flavonoids largest class compounds reported DCM. may cover way strategies DCM being multi-target agents with ability play variety functions via distinct signaling pathways.

Language: Английский

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Non-coding RNAs modulate pyroptosis in diabetic cardiomyopathy: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142865 - 142865

Published: April 1, 2025

Language: Английский

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Fabric Functionalized with RGO and MWCNT-CuxO composites for flexible non-enzymatic glucose sensing applications

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113708 - 113708

Published: April 1, 2025

Language: Английский

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Cranberry Extract Ameliorates Diabetic Cognitive Impairment in Rats Via LncRNA GAS-5 Downregulation and Pyroptosis Pathway Inhibition

Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 21, 2025

Abstract The pathophysiology of diabetes-induced brain injury involves pyroptosis, an inflammatory programmed cell death. This study aimed to investigate the potential protective effect cranberry extract (CE) against injury. Type 1 diabetes was induced by intraperitoneal injection streptozotocin in rats. Brain tissue samples were investigated for biochemical determination reduced glutathione (GSH), superoxide dismutase (SOD), and malondialdehyde (MDA), quantitative RT-PCR gene expression glial cell-derived neurotrophic factor (GDNF), lncRNA GAS-5, pyroptosis markers. ELISA used determine caspase-1 level immunohistochemical staining assessing IL-1β. Prophylactic dosing CE diabetic rats improved cognitive behavior significantly suppressed MDA concentration, genes (gasdermin D caspase 1), GAS-5. In addition, elevated GSH SOD activity, GDNF markedly IL-1β positive stained cells score brain. Phytochemical characterization FT-IR UPLC-PDA-MS/MS revealed cyanidin arabinoside, procyanidins, quercetin, isorhamnetin as key components. protects dysfunction targeting redox-related signaling pathways inducing anti-inflammatory effect. LncRNA GAS-5 downregulation pathway inhibition may contribute its beneficial effects, suggesting therapeutic potential.

Language: Английский

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Quercetin is a Potential Therapy for Rheumatoid Arthritis via Targeting Caspase-8 Through Ferroptosis and Pyroptosis

Journal of Inflammation Research, Journal Year: 2023, Volume and Issue: Volume 16, P. 5729 - 5754

Published: Dec. 1, 2023

Background: Rheumatoid arthritis (RA) is one of the most common chronic inflammatory autoimmune diseases. However, underlying molecular mechanisms its pathogenesis are unknown. This study aimed to identify biomarkers ferroptosis and pyroptosis in RA screen potential drugs. Methods: The RA-related differentially expressed genes (DEGs) GSE55235 were screened by R software intersected with gene libraries obtain ferroptosis-related (DEFRGs) pyroptosis-related (DEPRGs). We performed Gene Ontology (GO), Kyoto Encyclopedia Genome (KEGG), ClueGO, Protein-Protein Interaction (PPI) analysis for DEFRGs DEPRGs validated them machine learning. microRNA/transcription factor (TF)-hub regulatory network was further constructed. key using GSE77298 validation set, cellular vitro experiments, immune infiltration CIBERSORT. Network pharmacology used find gene-targeting drugs, followed docking dynamics simulations analyze binding stability between small-molecule drugs large-molecule proteins. Results: Three hub (CASP8, PTGS2, JUN) via bioinformatics, (CASP8) obtained through diagnostic efficacy verified be excellent receiver operating characteristic (ROC) curves. phenotypes constructed fibroblast-like synoviocytes (FLS), caspase-8 detected as a biomarker RA, quercetin can reduce levels. Quercetin found target drug pharmacology, their simulations. Conclusion: Caspase-8 an important therapy targeting pyroptosis. Keywords: rheumatoid arthritis, ferroptosis, pyroptosis, caspase-8,

Language: Английский

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