Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Nature Reviews Drug Discovery, Journal Year: 2020, Volume and Issue: 19(9), P. 609 - 633

Published: July 24, 2020

Language: Английский

---

Immunology of Aging: the Birth of Inflammaging

Clinical Reviews in Allergy & Immunology, Journal Year: 2021, Volume and Issue: 64(2), P. 109 - 122

Published: Sept. 18, 2021

Language: Английский

---

Severe COVID-19: NLRP3 Inflammasome Dysregulated

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: June 26, 2020

SARS-CoV-2 might directly activate NLRP3 inflammasome resulting in an endogenous adjuvant activity necessary to mount a proper adaptive immune response against the virus. Heterogeneous of COVID-19 patients could be attributed differences not being able properly downregulate activation. This relates fitness system individual challenged by Patients with reduced can demonstrate dysregulated severe tissue damage and cytokine storm. We sketch outlines five possible scenarios for medical practice provide potential treatment options targeting patients.

Language: Английский

---

A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis

JCI Insight, Journal Year: 2020, Volume and Issue: 5(9)

Published: April 17, 2020

Inflammation is a major risk factor of morbidity and mortality in older adults. Although its precise etiology unknown, low-grade inflammation adults commonly associated with increased intestinal epithelial permeability (leaky gut) abnormal (dysbiotic) gut microbiota. The increasing population lack treatments to reduce aging-related microbiota dysbiosis, leaky gut, culminates rise comorbidities, constituting significant public health concern. Here, we demonstrate that human-origin probiotic cocktail containing 5 Lactobacillus Enterococcus strains isolated from healthy infant prevented high-fat diet–induced (HFD-induced) inflammation, metabolic dysfunctions, physical function decline mice. Probiotic-modulated primarily reduced by tight junctions, which turn inflammation. Mechanistically, probiotics modulated way increase bile salt hydrolase activity, taurine abundance the stimulated junctions suppressed leakiness. Furthermore, Caenorhabditis elegans, life span, adiposity enhanced function. results suggest such therapies could prevent or treat elderly.

Language: Английский

---

Potential of Curcumin in Skin Disorders

Nutrients, Journal Year: 2019, Volume and Issue: 11(9), P. 2169 - 2169

Published: Sept. 10, 2019

Curcumin is a compound isolated from turmeric, plant known for its medicinal use. Recently, there growing interest in the medical community identifying novel, low-cost, safe molecules that may be used treatment of inflammatory and neoplastic diseases. An increasing amount evidence suggests curcumin represent an effective agent several skin conditions. We examined most relevant vitro vivo studies published to date regarding use inflammatory, neoplastic, infectious diseases, providing information on bioavailability safety profile. Moreover, we performed computational analysis about curcumin's interaction towards major enzymatic targets identified literature. Our results suggest well-tolerated, However, bypass limitations (low oral bioavailability, metabolism) essential order conduct larger clinical trials could confirm these observations. The possible combination with traditional drugs formulations novel delivery systems very promising field future applicative research.

Language: Английский

---

Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential?

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: May 18, 2020

Dietary odd-chain saturated fatty acids (OCFAs) are present in trace levels dairy fat and some fish plants. Higher circulating concentrations of OCFAs, pentadecanoic acid (C15:0) heptadecanoic (C17:0), associated with lower risks cardiometabolic diseases, higher dietary intake OCFAs is mortality. Population-wide OCFA levels, however, have been declining over recent years. Here, we show C15:0 as an active that attenuates inflammation, anemia, dyslipidemia, fibrosis vivo, potentially by binding to key metabolic regulators repairing mitochondrial function. This the first demonstration C15:0's direct role attenuating multiple comorbidities using relevant physiological mechanisms at established concentrations. Pairing our findings evidence (1) not readily made endogenously, (2) blood mortality a poorer state, (3) has demonstrated activities efficacy parallel health benefits humans, propose potential essential acid. Further studies needed evaluate impact decades reduced OCFA-containing foods contributors deficiencies susceptibilities chronic disease.

Language: Английский

---

The role of nutrition in inflammaging

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 77, P. 101596 - 101596

Published: Feb. 24, 2022

Language: Английский

---

Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 7910 - 7910

Published: April 26, 2023

Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from general pathology perspective, particularly with regard atherogenesis patterns in context both canonical and non-classical inflammation types. In review, we analyze various typical phenomena outcomes cellular pro-inflammatory stress atherosclerosis, as well role endothelial dysfunction local systemic manifestations low-grade inflammation. We also present features immune development productive stable unstable plaques, along their similarities differences compared There are numerous factors that act inducers inflammatory process including vascular endothelium aging, metabolic dysfunctions, autoimmune, some cases, infectious damage factors. Life-critical complications such cardiogenic shock severe strokes, associated acute hyperinflammation. Additionally, critical atherosclerotic ischemia lower extremities induces paracoagulation chronic Conversely, sepsis, other conditions, diseases contribute atherogenesis. summary, can be characterized an independent form inflammation, sharing but having fundamental variants (classic vasculitis).

Language: Английский

---

Immunosenescence, Inflammaging, and Frailty: Role of Myeloid Cells in Age-Related Diseases

Clinical Reviews in Allergy & Immunology, Journal Year: 2022, Volume and Issue: 64(2), P. 123 - 144

Published: Jan. 15, 2022

Language: Английский

---

Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on Modulation of the Gut Microbiota

Advances in Nutrition, Journal Year: 2022, Volume and Issue: 13(5), P. S1 - S26

Published: May 6, 2022

The immune system is key to host defense against pathogenic organisms. Aging associated with changes in the system, a decline protective components (immunosenescence), increasing susceptibility infectious disease, and chronic elevation low-grade inflammation (inflammaging), risk of multiple noncommunicable diseases. Nutrition determinant cell function gut microbiota. In turn, microbiota shapes controls inflammatory responses. Many older people show Age-related competence, inflammation, dysbiosis may be interlinked relate, at least part, age-related nutrition. A number micronutrients (vitamins C, D, E zinc selenium) play roles supporting many types. Some trials report that providing these as individual supplements can reverse deficits and/or those insufficient intakes. There inconsistent evidence this will reduce or severity infections including respiratory infections. Probiotic, prebiotic, synbiotic strategies modulate microbiota, especially by promoting colonization lactobacilli bifidobacteria, have been demonstrated some biomarkers and, cases, gastrointestinal infections, although, again, inconsistent. Further research well-designed well-powered at-risk populations required more certain about role modify microbiota-host relationship protecting infection, infection.

Language: Английский

---