Sedentary lifestyle and precocious puberty in girls during the COVID-19 pandemic: an Italian experience

Endocrine Connections, Journal Year: 2022, Volume and Issue: 11(2)

Published: Jan. 14, 2022

This retrospective study aimed to evaluate children observed for suspected precocious puberty in five Italian centers of Pediatric Endocrinology during the first wave coronavirus disease 2019 pandemic (March-September 2020), compared subjects same period previous year.The population (490 children) was divided according year observation and final diagnosis: transient thelarche, non-progressive puberty, central (CPP), or early puberty.Between March September 2020, 338 were referred 152 (+122%). The increase girls (328 2020 vs 140 2019, P < 0.05), especially second half considered (92 from May 236 June September); while no difference boys (10 12 2019). percentage with confirmed CPP higher (135/328 (41%) 37/140 (26%), 0.01). Anthropometric hormonal parameters not different; showed more prolonged use electronic devices a sedentary lifestyle both before pandemic, rest population.The present findings corroborate recently reported association between complex changes related lockdown incidence girls.

Language: Английский

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Clinical and epidemiological insights into early puberty in Thai girls: a 5-year study

Annals of Pediatric Endocrinology & Metabolism, Journal Year: 2025, Volume and Issue: 30(1), P. 17 - 24

Published: Feb. 26, 2025

There is growing global concern about the shift to earlier onset of puberty among girls; however, prevalences precocious and normal variant Thai girls are uncertain. We conducted a study at King Chulalongkorn Memorial Hospital in Bangkok from 2018 2022 (amid coronavirus disease 2019 pandemic) investigate prevalence, characteristics, treatment early large cohort girls. The medical records 583 who had been evaluated for were reviewed. Demographic clinical approaches analyzed. analyses found significant annual increase evaluations signs (P-value trend 0.04). majority (71.2%) cases categorized as gonadotropin-releasing-hormone (GnRH)-dependent or central (CPP), with 16 showing abnormal brain magnetic resonance imaging findings. Among puberty, was most common category (10.5%), followed by premature thelarche (9.5%), slow-progressive (6.6%), adrenarche (2.2%). Median age presentation, basal luteinizing hormone (LH) follicle-stimulating (FSH), bone differed significantly groups. Importantly, 97% CPP received GnRH agonists. Girls exhibited higher body mass index z-scores LH FSH compared those puberty. Our highlighted impact obesity on pubertal timing. findings underscore need preventive weight management country-specific guideline updates enhance healthcare strategies young

Language: Английский

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Obesity and menstrual disorders

Best Practice & Research Clinical Obstetrics & Gynaecology, Journal Year: 2023, Volume and Issue: 89, P. 102343 - 102343

Published: May 11, 2023

Obesity is a growing public health concern and associated with range of menstrual disorders, including heavy bleeding, oligomenorrhea, dysmenorrhea, endometrial pathology. Investigations may be more logistically challenging in those the population obesity, because heightened risk malignancy, there should low threshold for biopsy to exclude hyperplasia. Although treatment modalities women obesity are broadly similar normal BMI, additional consideration must given risks estrogen obesity. Outpatient management bleeding developing field outpatient preferable avoid morbidity anesthetics.

Language: Английский

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IGF-1 and IGF-2 as Molecules Linked to Causes and Consequences of Obesity from Fetal Life to Adulthood: A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3966 - 3966

Published: April 2, 2024

This study examines the impact of insulin-like growth factor 1 (IGF-1) and 2 (IGF-2) on various aspects children's health-from realms puberty to nuanced characteristics metabolic syndrome, diabetes, liver pathology, carcinogenic potential, cardiovascular disorders. A comprehensive literature review was conducted using PubMed, with a Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) method employing specific keywords related child health, obesity, factors. reveals associations between birth weight, early growth, adiposity. Moreover, factors play pivotal role in regulating bone development height during childhood, potential implications onset. research uncovers as biomarkers therapeutic targets dysfunction-associated disease hepatocellular carcinoma, it also highlights association (IGFs) cancer. Additionally, this explores noting their cardiomyocyte hypertrophy. Insulin-like vital roles human physiology, influencing from fetal stages adulthood. The maternal obesity IGF levels is complex, carrying consequences. Imbalances are linked range health conditions (e.g., insulin resistance, glucose intolerance, diabetes), prompting researchers seek novel therapies preventive strategies, offering challenges opportunities healthcare.

Language: Английский

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The use of cellulose, chitosan and hyaluronic acid in transdermal therapeutic management of obesity: A review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 244, P. 125374 - 125374

Published: June 15, 2023

Language: Английский

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Height and Growth Velocity in Children and Adolescents Undergoing Obesity Treatment: A Prospective Cohort Study

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 109(1), P. e314 - e320

Published: July 13, 2023

Pediatric obesity affects endocrine conditions, which may alter growth.This work aimed to investigate the effect of severity and treatment outcome on prospective cohort study included children (aged 3-18 years) enrolled in Swedish Childhood Obesity Treatment Register (BORIS) (1998-2020). was categorized as class I II obesity. measured body mass index (BMI) z score changes into good (BMI reduction ≥0.25), intermediate, poor (increasing BMI score). Height for age score, final height, growth velocity were compared between Further, during 2-year follow-up assessed.A total 27 997 individuals (mean 10.2 ± 3.6 included. Individuals with average taller than those childhood. Among males, reduced spurt observed obesity, even absent Females exhibited a similar but less pronounced pattern. Good yielded lower at ages 3 9 years higher 10 13 outcome.Obesity is positively associated height A hampered puberty should be anticipated, particularly adolescents severe Therefore no difference expected. Successful does not harm, rather normalizes,

Language: Английский

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Physical activity may attenuate the association of early adolescent adiposity with PCOS assessed in later adolescence: findings from a prospective cohort, Project Viva

Journal of Pediatric and Adolescent Gynecology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Causal associations between childhood obesity and delayed puberty or height: a bidirectional two-sample Mendelian randomization study

Journal of Pediatric Endocrinology and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Abstract Objectives Childhood obesity is thought to influence pubertal development, according observational studies. However, the exact causal relationship remains unclear due complexity of factors affecting development. Methods To explore association between exposure (childhood obesity) and outcome (delayed puberty, height), we utilized various methods, including inverse-variance weighted (IVW), median, mode, MR Egger regression. Additionally, sensitivity analyses were conducted using MR-Egger, MR-PRESSO, Cochran’s Q, leave-one-out techniques ensure robustness results. reverse analysis was potential causation. Results The IVW revealed no significant genetic link childhood delayed puberty or height (all P>0.05). In analysis, had a with (OR=0.85, 95 % CI=0.76–0.96). Q test highlighted heterogeneity in results concerning (p<0.05). But MR-Egger intercept MR-PRESSO confirmed impact pleiotropic bias, supported by analysis. Conclusions Our study found height. causally associated obesity. Future research should utilize advanced analytical methods better understand determinants

Language: Английский

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Research on Body Composition and Lifestyle Behaviors During Pubertal Development in 6–12-Year-Old Children with Obesity

Healthcare, Journal Year: 2025, Volume and Issue: 13(6), P. 607 - 607

Published: March 11, 2025

Objective: The objective of this study was to investigate the pubertal development in school-age children with obesity and explore body composition lifestyle behaviors influencing its onset. Method: We enrolled 217 children, aged 6–12 years, who visited Pediatrics Department at Beijing Jishuitan Hospital, Capital Medical University. All participants underwent a series examinations. These assessments included analysis, measurement blood glucose fasting insulin levels, evaluation secondary sexual characteristics. Statistical analysis conducted using R4.0.3 software. Results: Of 152 male participants, 83 (54.6%) were adolescent-undeveloped group, 69 (45.4%) adolescent-developed group. 119 female students, 30 (25.2%) 89 (74.8%) In comparative those adolescent group exhibited significantly higher values for age, height, weight, mass index (BMI), BMI-z score, fat, muscle mass, fat-free index, waist/hip ratio compared (p < 0.05). Additionally, resistance also statistical significance observed. BMI emerged as an independent factor affecting girls Among boys consumption sugary drinks fried food than undeveloped moderate-intensity exercise lower, girls, reported longer daily sitting times intakes foods these differences being statistically significant positively correlated identified Conclusions: A high (BMI) intake both genders are strong predictors early puberty children.

Language: Английский

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A Cross-sectional Approach in Unveiling the Prevalence, Anthropometric Measurements, and Risk Factors of Eating Disorders among Bengalee Adolescent Females

Anthropological Review, Journal Year: 2025, Volume and Issue: 88(1), P. 13 - 31

Published: April 2, 2025

Background: The crucial adolescent period demands greater nutritional needs along with physical maturity where overweight can lead to sensitivity towards body image. Excessive appearance concern results in faulty eating habits and complementary behavioral approaches known as disorders (ED). Aim: Due inconsistencies prior information regarding ED on Bengalee females, the cross-sectional study was conducted school females of rural urban areas North 24 Parganas district insights prevalence, anthropometric parameters risk factors ED. Method: design consisted self-reported surveys using standardized questionnaires (Eating disorder examination questionnaire-28; Body shape questionnaire-34) determine ED, dissatisfaction (BD), meal skipping (MS) objective assessments 396 students aged 13–19 years. Statistical analysis interpret findings. Result: 14.39% 44.95% BD cases were found this community significantly high BMI-for-age (BAZ), hip circumference subscale values questionnaire among participants. After chi-square binary logistic regression regular MS be strongest predictor accounting for 14% likelihood followed by fear-of-weight-gain (4.48%) excessive exercise (3.88%). Conclusion: findings highlight a complex interplay psychological social contributing Regular emerged reflecting an unhealthy coping strategy driven stressors such fear weight gain, BD. Influence cultural norms image cannot avoided. Our will help healthcare practitioners designing identification treatment procedures diet plans holistic way during further investigation

Language: Английский

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