The Neurologist's Role in Promoting Brain Health DOI
Linda M. Selwa, Brenda Banwell, Meeryo Choe

et al.

Neurology, Journal Year: 2024, Volume and Issue: 104(1)

Published: Dec. 16, 2024

Neurologic conditions are a leading cause of morbidity and mortality within the United States worldwide. Brain health is global concern, American Academy Neurology's Health Initiative promises to drive progress in this field over next decades. Neurologists with detailed training insight into brain function uniquely positioned apply emerging preventive data promote healthy development maintain optimal throughout lifespan. The neurologist's role promoting also vital patients active neurologic disease, whom measures may reduce recurrence or slow progression disease enhance quality life overall function. In Emerging Issues Neurology article, we present factors that protect frame practical approach screening assessments interventions neurology clinicians consider improve at all stages.

Language: Английский

Immune Mechanisms in Hypertension DOI
David G. Harrison, David M. Patrick

Hypertension, Journal Year: 2024, Volume and Issue: 81(8), P. 1659 - 1674

Published: June 17, 2024

It is now apparent that immune mediators including complement, cytokines, and cells of the innate adaptive system contribute not only to blood pressure elevation but also target organ damage occurs in response stimuli like high salt, aldosterone, angiotensin II, sympathetic outflow. Alterations vascular hemodynamic factors, microvascular pulsatility shear forces, lead release affect myeloid become potent antigen-presenting promote T-cell activation. Research past 2 decades has defined specific biochemical molecular pathways are engaged by these an emerging paradigm activation, products cells, reactive oxygen species, metalloproteinases act on further raise a feed-forward fashion. In this review, we will discuss pathophysiological events clinical interventions might prove effective quelling inflammatory process hypertension related cardiovascular diseases.

Language: Английский

Citations

10
Recent advancements in targeting the immune system to treat hypertension DOI Creative Commons
Rikeish R. Muralitharan, Francine Z. Marques, Joanne A. O’Donnell

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 177008 - 177008

Published: Sept. 1, 2024

Language: Английский

Citations

4
Is there a link between the abundance of nitrate-reducing bacteria and arterial hypertension? A systematic review DOI
Esthela M. Puel,

Lillian F Taruhn,

Nailê Damé‐Teixeira

et al.

Nitric Oxide, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
A global analysis of the burden of ischemic heart disease attributable to diet low in fiber between 1990 and 2019 DOI Creative Commons
Nana Wei, Lichao Wang, Bi Tang

et al.

BMC Cardiovascular Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 14, 2024

Language: Английский

Citations

3
Metformin modulates microbiota and improves blood pressure and cardiac remodeling in a rat model of hypertension DOI Creative Commons
Moritz I. Wimmer, Hendrik Bartolomaeus, Harithaa Anandakumar

et al.

Acta Physiologica, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Abstract Aims Metformin has been attributed to cardiovascular protection even in the absence of diabetes. Recent observations suggest that metformin influences gut microbiome. We aimed investigate influence on microbiota and hypertensive target organ damage rats. Methods Male double transgenic rats overexpressing human renin angiotensinogen genes (dTGR), a model angiotensin II‐dependent hypertension, were treated with (300 mg/kg/day) or vehicle from 4 7 weeks age. assessed microbiome composition function using shotgun metagenomic sequencing measured blood pressure via radiotelemetry. Cardiac renal inflammation evaluated by echocardiography, histology, flow cytometry. Results treatment increased production short‐chain fatty acids (SCFA) acetate propionate feces without altering microbial diversity. It significantly reduced systolic diastolic improved cardiac function, as end‐diastolic volume, E/A, stroke volume despite hypertrophy. lowering macrophage infiltration shifting subpopulations towards less inflammatory phenotype. The observed improvements pressure, correlated fecal SCFA levels dTGR. In vitro, altered M1‐like gene expression macrophages, reinforcing anti‐inflammatory effects. did not affect microvascular structure. Conclusion modulated microbiome, production, ameliorated remodeling Our findings confirm protective effects diabetes, highlighting potential mediators.

Language: Английский

Citations

2
Sex Differences in Gut Microbiota, Hypertension, and Cardiovascular Risk DOI
Anish Sharma,

Sahil K. Kapur,

Priyal Kancharla

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 177183 - 177183

Published: Dec. 1, 2024

Language: Английский

Citations

2
Faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patients DOI Creative Commons
Chaoran Yang, Letícia Camargo Tavares, Han-Chung Lee

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 17(1)

Published: Dec. 22, 2024

The gut microbiota is a crucial link between diet and cardiovascular disease (CVD). Using fecal metaproteomics, method that concurrently captures human microbiome proteins, we determined the crosstalk microbiome, diet, health, CVD. Traditional CVD risk factors (age, BMI, sex, blood pressure) explained < 10% of proteome variance. However, unsupervised protein-based clustering analysis revealed two distinct clusters (low-risk high-risk) with different pressure (by 9 mmHg) sex-dependent dietary potassium fiber intake. In proteome, low-risk group had lower angiotensin-converting enzymes, inflammatory proteins associated neutrophil extracellular trap formation auto-immune diseases. microbial higher expression phosphate acetyltransferase produces SCFAs, particularly in fiber-fermenting bacteria. This model identified severity across phenotypes heart failure patients long-term events large population-based cohort. These findings underscore multifactorial gut-to-host mechanisms may underlie for

Language: Английский

Citations

2
Dietary fiber intake impacts gut bacterial and viral populations in a hypertensive mouse model DOI Creative Commons
Laura Avellaneda-Franco, Liang Xie, Michael Nakai

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Sept. 28, 2024

The gut microbiome is an emerging factor in preventing hypertension, yet the influence of bacteriophages, viruses infecting bacteria, on this condition remains unclear. Bacteriophage-bacteria interactions, which impact microbiome, are influenced differentially by temperate and virulent bacteriophages. However, standard technique for studying viral populations, viral-like particles (VLPs)-metagenomes, often overlook prophages, intracellular stage creating a knowledge gap. To address this, we investigated alterations extracellular alongside bacterial angiotensin II-hypertension model. We sequenced VLPs bulk DNA from cecal-colonic samples collected male C57BL/6J mice implanted with minipumps containing saline or II. assembled 106 816 genomes found that populations remained stable between hypertensive normotensive mice. A higher number were observed across all treatments. Although outnumbered viruses, sequencing both revealed virions more abundant murine gut. then evaluated low- high-fiber intake composition II Fiber significantly hypertension development. Mice receiving had lower blood pressure, bacterial-encoded carbohydrate-associated enzyme, total relative abundance than those low-fiber. Our findings suggest phages not associated development they support complex diet-bacteria/phage interaction may be involved pressure regulation.

Language: Английский

Citations

1
Effect of chia seeds or concentrated fish oil on cardiometabolic risk markers in subjects with hypertriglyceridaemia: a parallel clinical trial DOI

Mohammad Reza Shahparvari,

Javad Nasrollahzadeh

Journal of Human Nutrition and Dietetics, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Abstract Background The beneficial effects of n‐3 polyunsaturated fatty acids (PUFA) in reducing high blood triglyceride (TG) levels have been well demonstrated. This study aimed to investigate the effect chia seeds on TG and its associated cardiometabolic factors hypertriglyceridaemic individuals. Methods three‐group randomised controlled trial compared a low‐calorie diet ( n = 22), with (30 g/day, 22) or concentrated fish oil (1.8 g/day long‐chain PUFAs, patients hypertriglyceridaemia. Anthropometrics, fasting lipids, proprotein convertase subtilisin/kexin type 9, insulin, adiponectin, leptin interleukin‐6 were measured. Results After 8 weeks, mean reduction weight exhibited by three groups was not statistically different (2.0, 2.7 2.8 kg, respectively, for control, seed groups). plasma decreased both comparison control group p 0.001). However, no significant difference observed between (change from baseline mean: 145.2 136.7 mg/dL groups, respectively). consumption diastolic pressure 8.4 mmHg) other two groups. No alterations biochemical Conclusions In people moderate hypertriglyceridaemia, 30 g supplements containing 1.8 PUFAs has similar levels, whereas it higher pressure–lowering effect.

Language: Английский

Citations

1
The Neurologist's Role in Promoting Brain Health DOI
Linda M. Selwa, Brenda Banwell, Meeryo Choe

et al.

Neurology, Journal Year: 2024, Volume and Issue: 104(1)

Published: Dec. 16, 2024

Neurologic conditions are a leading cause of morbidity and mortality within the United States worldwide. Brain health is global concern, American Academy Neurology's Health Initiative promises to drive progress in this field over next decades. Neurologists with detailed training insight into brain function uniquely positioned apply emerging preventive data promote healthy development maintain optimal throughout lifespan. The neurologist's role promoting also vital patients active neurologic disease, whom measures may reduce recurrence or slow progression disease enhance quality life overall function. In Emerging Issues Neurology article, we present factors that protect frame practical approach screening assessments interventions neurology clinicians consider improve at all stages.

Language: Английский

Citations

0