Translational Stroke Research, Journal Year: 2025, Volume and Issue: unknown
Published: March 22, 2025
Language: Английский
Translational Stroke Research, Journal Year: 2025, Volume and Issue: unknown
Published: March 22, 2025
Language: Английский
Hypertension, Journal Year: 2022, Volume and Issue: 80(1), P. 22 - 34
Published: Oct. 5, 2022
Hypertension affects a significant proportion of the adult and aging population represents an important risk factor for vascular cognitive impairment late-life dementia. Chronic high blood pressure continuously challenges structural functional integrity cerebral vasculature, leading to microvascular rarefaction dysfunction, neurovascular uncoupling that typically impairs supply. disrupts blood-brain barrier integrity, promotes neuroinflammation, may contribute amyloid deposition Alzheimer pathology. The mechanisms underlying these harmful effects are still focus investigation, but studies in animal models have provided molecular cellular mechanistic insights. Remaining questions relate whether adequate treatment hypertension prevent deterioration function, threshold treatment, most effective antihypertensive drugs. Recent advances biology, advanced brain imaging, detection subtle behavioral phenotypes begun provide insights into critical issues. Importantly, parallel analysis parameters humans is feasible, making it possible foster translational advancements. In this review, we evaluation evidence available experimental examine progress made identify remaining gaps knowledge.
Language: Английский
Citations
128Nature Neuroscience, Journal Year: 2023, Volume and Issue: 27(1), P. 63 - 77
Published: Dec. 4, 2023
Language: Английский
Citations
43Science Advances, Journal Year: 2025, Volume and Issue: 11(4)
Published: Jan. 22, 2025
Human health is being threatened by environmental microplastic (MP) pollution. MPs were detected in the bloodstream and multiple tissues of humans, disrupting regular physiological processes organs. Nanoscale plastics can breach blood-brain barrier, leading to neurotoxic effects. How cause brain functional irregularities remains unclear. This work uses high-depth imaging techniques investigate within vivo. We show that circulating are phagocytosed lead these cells obstruction capillaries cortex. These blockages as thrombus formation reduced blood flow neurological abnormalities mice. Our data reveal a mechanism which disrupt tissue function indirectly through regulation cell interference with local circulation, rather than direct penetration. revelation offers lens comprehend toxicological implications invade bloodstream.
Language: Английский
Citations
6Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14
Published: Feb. 17, 2023
Cellular aging is the most severe risk factor for neurodegenerative disease. Simultaneously, oxidative stress (OS) a critical in process, resulting from an imbalance between reactive oxygen and nitrogen species antioxidant defense system. Emerging evidence indicates that OS common cause of several age-related brain pathologies, including cerebrovascular diseases. Elevated disrupts endothelial functional ability by diminishing bioavailability nitric oxide (a vascular dilator), induces atherosclerosis, impairs vasculature, which are all characteristics In this review, we summarize supporting active role disease progression, focusing primarily on stroke pathogenesis. We briefly discuss hypertension, diabetes, heart disease, genetic factors often linked to considered associated influencing pathology. Finally, current pharmaceutics/therapeutics available treating
Language: Английский
Citations
28British Journal of Anaesthesia, Journal Year: 2024, Volume and Issue: 132(6), P. 1260 - 1273
Published: March 12, 2024
Language: Английский
Citations
12International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2169 - 2169
Published: Feb. 11, 2024
Degenerative diseases, encompassing a wide range of conditions affecting various organ systems, pose significant challenges to global healthcare systems. This comprehensive review explores the intricate interplay between vascular system and degenerative shedding light on underlying mechanisms profound implications for disease progression management. The pivotal role in maintaining tissue homeostasis is highlighted, as it serves conduit oxygen, nutrients, immune cells vital organs tissues. Due homeostasis, its dysfunction, characterized by impaired blood flow, endothelial inflammation, emerges common denominator diseases across multiple In nervous system, we explored influence factors neurodegenerative such Alzheimer’s Parkinson’s, emphasizing critical cerebral flow regulation blood–brain barrier. Within kidney relationship health chronic scrutinized, unraveling which hypertension other contribute renal dysfunction. Throughout this review, emphasize clinical significance understanding involvement potential therapeutic interventions targeting health, highlighting emerging treatments prevention strategies. conclusion, appreciation essential advancing our pathogenesis developing innovative approaches treatment. provides foundation researchers, clinicians, policymakers seeking address pursuit improved patient outcomes enhanced public health.
Language: Английский
Citations
11Machine Learning and Knowledge Extraction, Journal Year: 2024, Volume and Issue: 6(2), P. 827 - 841
Published: April 15, 2024
Dataset imbalances pose a significant challenge to predictive modeling in both medical and financial domains, where conventional strategies, including resampling algorithmic modifications, often fail adequately address minority class underrepresentation. This study theoretically practically investigates how the inherent nature of data affects classification classes. It employs ten machine deep learning classifiers, ranging from ensemble learners cost-sensitive algorithms, across comparably sized datasets. Despite these efforts, none classifiers achieved effective dataset, with sensitivity below 5.0% area under curve (AUC) 57.0%. In contrast, similar applied dataset demonstrated strong discriminative power, overall accuracy exceeding 95.0%, over 73.0%, AUC above 96.0%. disparity underscores unpredictable variability data, as exemplified by dispersed homogeneous distribution among other classes principal component analysis (PCA) graphs. The application synthetic oversampling technique (SMOTE) introduced 62 patients based on merely 20 original cases, casting doubt its clinical validity representation real-world patient variability. Furthermore, post-SMOTE feature importance analysis, utilizing SHapley Additive exPlanations (SHAP) tree-based methods, contradicted established cerebral stroke parameters, further questioning coherence augmentation. These findings call into question SMOTE underscore urgent need for advanced techniques innovations predicting minority-class outcomes datasets without depending strategies. approach developing methods that are not only robust but also clinically relevant applicable scenarios. Consequently, this future research efforts bridge gap between theoretical advancements practical, applications models like healthcare.
Language: Английский
Citations
9Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: 568, P. 120154 - 120154
Published: Jan. 22, 2025
Language: Английский
Citations
1Stroke, Journal Year: 2022, Volume and Issue: 53(4), P. 1104 - 1113
Published: March 10, 2022
High blood pressure (BP) is detrimental to brain health. BP contributes cognitive impairment and dementia through pathways independent of clinical stroke. Emerging evidence shows that the deleterious effect high on cognition occurs across life span, increasing risk for early-onset late-life dementia. The term vascular includes disorders associated with cerebrovascular disease, regardless pathogenesis. This focused report a narrative review aims summarize epidemiology impairment, including differences by sex, race, ethnicity, as well management reversibility impairment. It also discusses knowledge gaps future directions.
Language: Английский
Citations
34Hypertension, Journal Year: 2023, Volume and Issue: 80(3), P. 580 - 589
Published: Jan. 23, 2023
The potential benefits or harms of intensive systolic blood pressure (BP) control on cognitive function and cerebral flow in individuals with low diastolic (DBP) remain unclear.We conducted a post hoc analysis the SPRINT MIND (Systolic Blood Pressure Intervention Trial Memory Cognition Decreased Hypertension) that randomly assigned hypertensive participants to an (<120 mm Hg; n=4278) standard (<140 n=4385) target. We evaluated effects BP intervention outcomes across baseline DBP quartiles.Participants group had lower incidence rate probable dementia mild impairment than those group, regardless quartiles. hazard ratio versus target for was 0.91 (95% CI, 0.73-1.12) lowest quartile 0.70 0.48-1.02) highest quartile, respectively, interaction P value 0.24. Similar results were found (interaction P=0.06) P=0.80). effect treatment not modified by either P=0.25). Even among within resulted increasing trend annualized change (+0.26 [95% -0.72 1.24] mL/[100 g·min]).Intensive did appear have detrimental perfusion patients DBP.URL: https://www.gov; Unique identifier: NCT01206062.
Language: Английский
Citations
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