Resveratrol as a privileged molecule with antioxidant activity

Food Chemistry Advances, Journal Year: 2023, Volume and Issue: 3, P. 100539 - 100539

Published: Nov. 21, 2023

Oxidative stress has a significant impact on the occurrence of many chronic diseases. Antioxidants have ability to prevent, postpone or treat effects free radicals. Resveratrol is polyphenol from class stilbenes. The importance this compound determined by its numerous biological properties. strong antioxidant potential special significance, because way it acts in prevention and treatment action direct, inhibiting production reactive species, indirect, influencing activity enzymes. In case analyzing known methods, was observed that RSV had higher capacity than standard used. Also, vitro vivo studies demonstrate neurodegenerative, cardiovascular renal addition, active preeclampsia infertility. An important aspect fact reduce counteract adverse some anticancer agents.

Language: Английский

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Tapping into Nature’s Arsenal: Harnessing the Potential of Natural Antioxidants for Human Health and Disease Prevention

Foods, Journal Year: 2024, Volume and Issue: 13(13), P. 1999 - 1999

Published: June 25, 2024

Numerous natural antioxidants commonly found in our daily diet have demonstrated significant benefits for human health and various diseases by counteracting the impact of reactive oxygen nitrogen species. Their chemical properties enable a range biological actions, including antihypertensive, antimicrobial, anti-inflammatory, anti-fibrotic, anticancer effects. Despite promising outcomes from preclinical studies, ongoing debate persists regarding their reproducibility clinical models. This controversy largely stems lack understanding pharmacokinetic these compounds, coupled with predominant focus on monotherapies research, neglecting potential synergistic effects arising combining different antioxidants. study aims to provide an updated overview antioxidants, operating under hypothesis that multitherapeutic approach surpasses monotherapy efficacy. Additionally, this underscores importance integrating into diet, as they prevent onset progression diseases. To reinforce perspective, findings pertaining treatment prevention non-alcoholic fatty liver disease conditions associated ischemia reperfusion phenomena, myocardial infarction, postoperative atrial fibrillation, stroke, are presented key references.

Language: Английский

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Bioactive Metal–Organic Frameworks as a Distinctive Platform to Diagnosis and Treat Vascular Diseases

Small, Journal Year: 2024, Volume and Issue: 20(27)

Published: Feb. 5, 2024

Vascular diseases (VDs) pose the leading threat worldwide due to high morbidity and mortality. The detection of VDs is commonly dependent on individual signs, which limits accuracy timeliness therapies, especially for asymptomatic patients in clinical management. Therefore, more effective early diagnosis lesion-targeted treatments remain a pressing need. Metal-organic frameworks (MOFs) are porous crystalline materials formed by coordination inorganic metal ions organic ligands. Due their unique specific surface area, structural flexibility, functional versatility, MOFs recognized as highly promising candidates diagnostic therapeutic applications field VDs. In this review, potential act biosensors, contrast agents, artificial nanozymes, multifunctional agents treatment from perspective, highlighting integration between methods with generalized. At same time, multidisciplinary cooperation chemistry, physics, biology, medicine promote substantial commercial transformation tackling called for.

Language: Английский

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Hypertension linked to Alzheimer’s disease via stroke: Mendelian randomization

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 7, 2023

This study aimed to investigate the relationship between hypertension and Alzheimer's disease (AD) demonstrate key role of stroke in this using mediating Mendelian randomization. AD, a neurodegenerative characterized by memory loss, cognitive impairment, behavioral abnormalities, severely affects quality life patients. Hypertension is an important risk factor for AD. However, precise mechanism underlying unclear. To we used mediated randomization method screened variables AD setting instrumental variables. The results analysis showed that stroke, as variable, plays causal Specifically, indirect effect value obtained multivariate MR was 54.9%. implies approximately 55% owing can be attributed stroke. suggest increased through finding not only sheds light on but also indicates novel methods prevention treatment By identifying critical link provides insights into potential interventions could mitigate impact help develop personalized treatments improve patients with who suffer from hypertension.

Language: Английский

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GC-MS and HPTLC bioautography-based phytochemical profiling and evaluation of biological activity Neptunia prostrata Linn whole plant and leaves

Pharmacological Research - Natural Products, Journal Year: 2024, Volume and Issue: 2, P. 100013 - 100013

Published: Jan. 5, 2024

Language: Английский

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The role of Chinese herbal medicine in the regulation of oxidative stress in treating hypertension: from therapeutics to mechanisms

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Oct. 29, 2024

Language: Английский

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Investigation of Lipid Profile in Patients with Cerebrovascular Diseases: Systematic Review and Meta-Analysis

Advanced Biomedical Research, Journal Year: 2025, Volume and Issue: 14(1)

Published: Feb. 1, 2025

Cerebrovascular diseases are caused by issues in the brain’s blood vessels, resulting ischemic and hemorrhagic strokes. The association between serum lipid profile or stroke has shown conflicting results some studies. We conducted a comprehensive review meta-analysis to investigate potential link plasma cerebrovascular disease. Our study followed guidelines of PRISMA 2021 for systematic reviews meta-analysis, conducting thorough analysis. searched multiple databases, including Medline, Google Scholar, Scopus, Web Science, Embase, identify studies on profiles diseases. included published up June 2021. After searching various 24,346 were found. Finally, 36 meta-analysis. estimated odds ratio (95% CI) different total cholesterol levels be 1.12 (1.02–1.22). ratios LDL, HDL, triglyceride 1.02 (0.98–1.07), P < 0.001, 0.97 (0.93–1.02), 1.01 (0.97–1.04), respectively. According Egger’s test, no noteworthy publication bias was found (coefficient: −0.26, : 0.919). this risk increases with increase level. It discovered that there is notable correlation incidence varying triglycerides. Further research required validate these findings.

Language: Английский

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Advanced Insights of Oxidative Stress in Ischemic Stroke: Pathogenesis, Diagnosis and Treatment

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Ischemic stroke is one of the major causes disability and mortality in aged people. A better understanding pathology, mechanism, diagnosis treatment might have important practical implications for patient clinical management, especially patients. Affected by cerebral ischemia, neurons are not capable maintaining cellular respiration metabolism, leading to excitotoxicity calcium overload, which further induce oxidative stress. During stress process, reactive oxygen species massively produced, involved regulation diverse biological processes including lipid, DNA, protein signaling pathways. This review aimed provide a comprehensive overview ischemic stroke, particularly occurred elderly. Our topics included pathogenesis role plays occurrence development. Additionally, stress-related diagnostic methods antioxidant therapies use discussed. With focus perspective on patients, we expect our can contribute guide acknowledgment suggesting preventive toward antioxidant-based therapy as novel therapeutic alternative

Language: Английский

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Nutrition, cognition and chronic kidney disease: A comprehensive review of interactions and interventions

European Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Cognitive impairment is a prevalent complication in chronic kidney disease (CKD), ranging from mild deficits early stages to more severe conditions, such as cognitive and dementia advanced stages. CKD patients exhibit reduced performance memory, attention, language, visuospatial abilities executive functions. Contributing factors include uraemic toxins, structural brain changes, blood-brain barrier dysfunction, anaemia comorbidities like diabetes mellitus. Malnutrition, affecting nearly half of patients, exacerbates decline through inflammation, oxidative stress protein-energy wasting. Nutritional deficiencies, particularly protein, vitamin D, B vitamins, omega-3 fatty acids antioxidants, are linked impaired cognition. Emerging evidence highlights the role gut-brain axis, with gut-derived toxins microbiome alterations contributing dysfunction. Processed foods microplastics further compound risks by promoting inflammation neurotoxicity. Dialysis transplantation offer opportunities for recovery, though challenges remain, haemodialysis patients. interventions, including tailored protein intake, micronutrient supplementation dietary counselling, critical mitigating decline. Addressing comorbidities, targeted nutritional pharmacological strategies, improves outcomes. Integrating psychological social support enhances quality life, given high prevalence anxiety depression Future research should focus on personalized nutrition, gut microbiota modulation routine assessments optimise care. A holistic approach combining medical, psychosocial strategies essential improving overall health

Language: Английский

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CircXYLT1 suppresses oxidative stress and promotes vascular remodeling in aging mice carotid artery injury model of atherosclerosis via PTBP1

Experimental Gerontology, Journal Year: 2025, Volume and Issue: 201, P. 112690 - 112690

Published: Feb. 7, 2025

Atherosclerosis and aortic aneurysms are prevalent cardiovascular diseases in the elderly, characterized by chronic inflammation oxidative stress. This study explores role of CircXYLT1 regulating stress vascular remodeling age-related diseases. RNA sequencing revealed a significant upregulation tissues aged mice, highlighting its potential Using carotid artery wire injury model, we performed adeno-associated virus (AAV)-mediated knockdown overexpression CircXYLT1. Key markers, including reactive oxygen species (ROS) malondialdehyde (MDA), were measured. Knockdown increased reduced antioxidant protein expression (SOD, GPX), while led to decreased damage enhanced smooth muscle cell (VSMC) proliferation. Mechanistically, interacted with PTBP1, reducing nuclear localization modulating downstream chemokine signaling pathways. These findings suggest that plays critical regulation, offering as therapeutic target for managing aging populations.

Language: Английский

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