Crosstalk Between the Neuroendocrine System and Bone Homeostasis DOI Open Access
Yuhu Zhao, Xiaole Peng, Qing Wang

et al.

Endocrine Reviews, Journal Year: 2023, Volume and Issue: 45(1), P. 95 - 124

Published: July 17, 2023

Abstract The homeostasis of bone microenvironment is the foundation health and comprises 2 concerted events: formation by osteoblasts resorption osteoclasts. In early 21st century, leptin, an adipocytes-derived hormone, was found to affect through hypothalamic relay sympathetic nervous system, involving neurotransmitters like serotonin norepinephrine. This discovery has provided a new perspective regarding synergistic effects endocrine systems on skeletal homeostasis. Since then, more studies have been conducted, gradually uncovering complex neuroendocrine regulation underlying Intriguingly, also considered as organ that can produce regulatory factors in turn exert activities. After decades exploration into mechanisms, separate bioactive extensively investigated, whereas few systematically shown global view regulation. Therefore, we summarized previously studied patterns from system bone. review will provide readers with panoramic intimate relationship between bone, compensating for current understanding homeostasis, probably developing therapeutic strategies its related disorders.

Language: Английский

Emerging pharmaceutical therapies for osteoarthritis DOI
Augustin Latourte, M. Kloppenburg, Pascal Richette

et al.

Nature Reviews Rheumatology, Journal Year: 2020, Volume and Issue: 16(12), P. 673 - 688

Published: Oct. 29, 2020

Language: Английский

Citations

324
Functionalized 3D-printed silk-hydroxyapatite scaffolds for enhanced bone regeneration with innervation and vascularization DOI
Vincent Fitzpatrick, Zaira Martín‐Moldes, Anna Deck

et al.

Biomaterials, Journal Year: 2021, Volume and Issue: 276, P. 120995 - 120995

Published: July 1, 2021

Language: Английский

Citations

161
Crosstalk between Bone and Nerves within Bone DOI Creative Commons
Qianqian Wan, Wenpin Qin, Yuxuan Ma

et al.

Advanced Science, Journal Year: 2021, Volume and Issue: 8(7)

Published: Feb. 10, 2021

Abstract For the past two decades, function of intrabony nerves on bone has been a subject intense research, while is still hidden in corner. In present review, possible crosstalk between and peripheral will be comprehensively analyzed. Peripheral participate development repair via host signals generated through secretion neurotransmitters, neuropeptides, axon guidance factors neurotrophins, with additional contribution from nerve‐resident cells. return, contributes to this microenvironmental rendezvous by housing within its internal milieu provide mechanical support protective shelf. A large ensemble chemical, mechanical, electrical cues works harmony marrow stromal cells regulation nerves. The not limited physiological state, but also involved various diseases including osteoporosis, osteoarthritis, heterotopic ossification, psychological stress‐related abnormalities, related tumors. This may harnessed design tissue engineering scaffolds for defects or targeted treatment

Language: Английский

Citations

153
Photosensitive and Conductive Hydrogel Induced Innerved Bone Regeneration for Infected Bone Defect Repair DOI
Xirui Jing, Chao Xu, Weijie Su

et al.

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 12(3)

Published: Nov. 3, 2022

Repairing infected bone defects is a challenge in the field of orthopedics because limited self-healing capacity tissue and susceptibility refractory materials to bacterial activity. Innervation initiating factor for regeneration plays key regulatory role subsequent vascularization, ossification, mineralization processes. Infection leads necrosis local nerve fibers, impeding repair defects. Herein, biomaterial that can induce skeletal-associated neural network reconstruction with high antibacterial activity proposed treatment A photosensitive conductive hydrogel prepared by incorporating magnesium-modified black phosphorus (BP@Mg) into gelatin methacrylate (GelMA). The near-infrared irradiation-based photothermal photodynamic endows it strong activity, improving inflammatory microenvironment reducing bacteria-induced damage. nanosheets bioactive ions released from BP@Mg synergistically improve migration secretion Schwann cells, promote neurite outgrowth, facilitate innerved regeneration. In an skull defect model, GelMA-BP@Mg shows efficient promotes CGRP+ fiber phototherapy provides novel strategy based on innervation repair.

Language: Английский

Citations

99
Neurovascular coupling in bone regeneration DOI Creative Commons
Qizhi Qin, Seungyong Lee, Nirali M. Patel

et al.

Experimental & Molecular Medicine, Journal Year: 2022, Volume and Issue: 54(11), P. 1844 - 1849

Published: Nov. 29, 2022

Abstract The mammalian skeletal system is densely innervated by both neural and vascular networks. Peripheral nerves in the skeleton include sensory sympathetic nerves. crosstalk between tissues critical for development regeneration. cellular processes of osteogenesis angiogenesis are coupled physiological pathophysiological contexts. molecular regulation have yet to be fully defined. This review will provide a detailed characterization regulatory role blood vessels during bone Furthermore, given importance spatial relationship bone, we discuss neurovascular coupling pathological formation. A better understanding interactions inform future novel therapeutic targeting clinical repair

Language: Английский

Citations

89
Msx1+ stem cells recruited by bioactive tissue engineering graft for bone regeneration DOI Creative Commons
Xianzhu Zhang, Wei Jiang,

Chang Xie

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 5, 2022

Abstract Critical-sized bone defects often lead to non-union and full-thickness of the calvarium specifically still present reconstructive challenges. In this study, we show that neurotrophic supplements induce robust in vitro expansion mesenchymal stromal cells, situ transplantation supplements-incorporated 3D-printed hydrogel grafts promote regeneration critical-sized defects. Single-cell RNA sequencing analysis reveals a unique atlas stem/progenitor cells is generated during calvarial healing vivo. Notably, find local resident Msx1+ skeletal stem after cell culture system. Moreover, enhanced accompanied by an increased endochondral ossification closely correlates cells. Our findings illustrate time-saving regenerative efficacy systems targeting major subpopulations vivo for rapid tissue regeneration.

Language: Английский

Citations

79
Hallmarks of peripheral nerve function in bone regeneration DOI Creative Commons
Ranyang Tao, Bobin Mi, Yiqiang Hu

et al.

Bone Research, Journal Year: 2023, Volume and Issue: 11(1)

Published: Jan. 5, 2023

Abstract Skeletal tissue is highly innervated. Although different types of nerves have been recently identified in the bone, crosstalk between bone and remains unclear. In this review, we outline role peripheral nervous system (PNS) regeneration following injury. We first introduce conserved species ranging from amphibians to mammals. then present distribution PNS skeletal under physiological conditions, fractures, or regeneration. Furthermore, summarize ways which communicates with bone-lineage cells, vasculature, immune cells microenvironment. Based on comprehensive timely conclude that regulates through neuropeptides neurotransmitters nerves. An in-depth understanding roles will inform development new strategies based bone-nerve promoting repair

Language: Английский

Citations

61
Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges DOI Creative Commons
Wenzhe Sun, Bing Ye, Siyue Chen

et al.

Bone Research, Journal Year: 2023, Volume and Issue: 11(1)

Published: Dec. 20, 2023

The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal cells. Peripheral endings release neurogenic factors and sense signals, mediate bone metabolism pain. In recent years, tissue engineering has increasingly focused on the effects of nervous system regeneration. Simultaneous regeneration nerves through use materials or by enhancement endogenous repair signals been proven to promote functional Additionally, emerging information mechanisms interoception central regulation homeostasis provide an opportunity for advancing biomaterials. However, comprehensive reviews this topic are lacking. Therefore, review provides overview relationship between regeneration, focusing applications. We discuss novel regulatory explore innovative approaches based nerve-bone interactions Finally, challenges future prospects field briefly discussed.

Language: Английский

Citations

46
Nerve Growth Factor-Preconditioned Mesenchymal Stem Cell-Derived Exosome-Functionalized 3D-Printed Hierarchical Porous Scaffolds with Neuro-Promotive Properties for Enhancing Innervated Bone Regeneration DOI

Meifei Lian,

Zhiguang Qiao, Shichong Qiao

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(10), P. 7504 - 7520

Published: Feb. 27, 2024

The essential role of the neural network in enhancing bone regeneration has often been overlooked biomaterial design, leading to delayed or compromised healing. Engineered mesenchymal stem cells (MSCs)-derived exosomes are becoming increasingly recognized as potent cell-free agents for manipulating cellular behavior and improving therapeutic effectiveness. Herein, MSCs stimulated with nerve growth factor (NGF) regulate exosomal cargoes improve neuro-promotive potential facilitate innervated regeneration. In vitro cell experiments showed that NGF-stimulated MSCs-derived (N-Exos) obviously improved function neurotrophic effects cells, consequently, osteogenic osteo-reparative cells. Bioinformatic analysis by miRNA sequencing pathway enrichment revealed beneficial N-Exos may partly be ascribed NGF-elicited multicomponent miRNAs subsequent regulation activation MAPK PI3K-Akt signaling pathways. On this basis, were delivered on micropores 3D-printed hierarchical porous scaffold accomplish sustained release profile extended bioavailability. a rat model distal femoral defect, N-Exos-functionalized significantly induced neurovascular structure formation This study provided feasible strategy modulate functional acquire desirable potential. Furthermore, developed represent promising neurovascular-promotive reparative clinical translation.

Language: Английский

Citations

23
Nerve growth factor receptor limits inflammation to promote remodeling and repair of osteoarthritic joints DOI Creative Commons
Lan Zhao, Yumei Lai, Hongli Jiao

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 15, 2024

Abstract Osteoarthritis (OA) is a painful, incurable disease affecting over 500 million people. Recent clinical trials of the nerve growth factor (NGF) inhibitors in OA patients have suggested adverse effects NGF inhibition on joint structure. Here we report that receptor (NGFR) upregulated skeletal cells during and plays an essential role remodeling repair osteoarthritic joints. Specifically, NGFR expressed osteochondral but not progenitor induced by TNFα to attenuate NF-κB activation, maintaining proper BMP-SMAD1 signaling suppressing RANKL expression mice. deficiency hyper-activates murine joints, which impairs bone formation enhances resorption as exemplified reduction subchondral osteophytes. In human cartilage, also negatively associated with activation. Together, this study suggests limiting inflammation for diseased tissues.

Language: Английский

Citations

21