Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 11, 2024

Abstract The basolateral amygdala (BLA) contains discrete neuronal circuits that integrate positive or negative emotional information and drive the appropriate innate learned behaviors. Whether these consist of genetically-identifiable anatomically segregated neuron types, is poorly understood. Also, our understanding response patterns behavioral spectra BLA neurons limited. Here, we classified 11 glutamatergic cell clusters in mouse found several them were lateral versus basal amygdala, anterior posterior regions BLA. Two subpopulations innately responded to valence-specific, whereas one mixed - aversive social cues. Positive-valence promoted normal feeding, while selectivity fear learning interactions. These findings enhance type diversity spatial organization role distinct populations representing valence-specific stimuli.

Language: Английский

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Therapeutic potential of CBD in Autism Spectrum Disorder

International review of neurobiology, Journal Year: 2024, Volume and Issue: unknown, P. 149 - 203

Published: Jan. 1, 2024

Language: Английский

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Amygdala neural ensemble mediates mouse social investigation behaviors

National Science Review, Journal Year: 2022, Volume and Issue: 10(1)

Published: Aug. 30, 2022

Innate social investigation behaviors are critical for animal survival and regulated by both neural circuits neuroendocrine factors. Our understanding of how neuropeptides regulate interest, however, is incomplete at the current stage. In this study, we identified expression secretin (SCT) in a subpopulation excitatory neurons basolateral amygdala. With distinct molecular physiological features, BLASCT+ cells projected to medial prefrontal cortex were necessary sufficient promoting behaviors, whilst other amygdala anxiogenic antagonized behaviors. Moreover, exogenous application effectively promoted interest healthy autism spectrum disorder model mice. These results collectively demonstrate previously unrecognized group mediating suggest promising strategies deficits.

Language: Английский

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Sex Differences in the Activity of Basolateral Amygdalar Neurons That Project to the Bed Nucleus of the Stria Terminalis and Their Role in Anticipatory Anxiety

Journal of Neuroscience, Journal Year: 2022, Volume and Issue: 42(22), P. 4488 - 4504

Published: April 27, 2022

Abnormal fear and anxiety can manifest as psychiatric disorders. The bed nucleus of the stria terminalis (BNST) is implicated in sustained responding to, or anticipation of, an aversive event which be expressed anticipatory anxiety. BLA also active during sends projections to BNST. However, little known about role for neurons that project BNST (BLA-BNST) rodents. To address this, we tested whether chemogenetic inactivation BLA-BNST pathway attenuates conditioned responses produced by stimulus. For comparison, assessed social interaction, sensitive unlearned We found reduced freezing increased behaviors, but surprisingly, only males. determine sex differences neuronal activity contribute behavior, used vivo ex electrophysiological approaches. In males, projection were more excitable, coincided with a smaller after-hyperpolarization current ( I AHP ) compared other neurons; whereas females, less excitable had larger neurons. These findings demonstrate mediates anxiety-like behavior lack females this possibly because low excitability these neurons, highlights need caution when generalizing specific neurocircuits SIGNIFICANCE STATEMENT Anxiety disorders disproportionately affect women. This hints toward within neurocircuitry, yet most our understanding derived from male Furthermore, debilitating adverse events among severe symptoms, neurocircuitry. Here demonstrated required prolonged cue, Moreover, are hypoactive females. results uncover key component circuitry, cellular may explain sex-dependent circuit. Uncovering disparity provides evidence assumed basic circuitry might not readily transpose males

Language: Английский

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Role of 5-HT1A receptors in the basolateral amygdala on 3,4-methylenedioxymethamphetamine-induced prosocial effects in mice

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 946, P. 175653 - 175653

Published: March 10, 2023

Language: Английский

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