Journal of Craniofacial Surgery,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 4, 2024
Meningeal
lymphatic
vessels
(mLVs),
located
around
the
dural
sinuses,
are
considered
significant
participants
in
cerebrospinal
fluid
(CSF)
circulation.
not
only
drain
fluids
and
metabolic
waste
from
brain
into
deep
cervical
lymph
nodes
(dCLNs)
but
also
transport
immune
cells
to
dCLNs,
thus
regulating
interaction
between
central
peripheral
systems.
These
play
a
crucial
role
maintaining
normal
physiological
functions
of
nervous
system
(CNS).
involved
pathophysiological
processes
various
CNS
diseases,
including
neurodegenerative
cerebrovascular
tumors.
In
aging
damage
dysfunction
mLVs
have
been
observed,
leading
abnormal
accumulation
toxic
substances
exacerbating
neural
damage.
By
transporting
antigen-presenting
that
taken
up
antigens
within
modulate
activation
their
migration
infiltration
lesions.
Certain
drug
interventions
or
physical
therapies
can
drainage
function
mLVs,
effectively
improving
prognosis
diseases.
This
review
provides
detailed
introduction
anatomic
structure,
roles,
research
advances
addition,
we
propose
new
strategies
for
targeting
treatment
It
is
unknown
how
the
brain
orchestrates
coordination
of
global
neural
and
vascular
dynamics.
We
sought
to
uncover
role
a
sparse
but
unusual
population
genetically-distinct
interneurons
known
as
type-I
nNOS
neurons,
using
novel
pharmacological
strategic
unilaterally
ablate
these
neurons
from
somatosensory
cortex
mice.
Region-specific
ablation
produced
changes
in
both
activity
dynamics,
decreased
power
delta-band
local
field
potential,
reduced
sustained
responses
prolonged
sensory
stimulation,
abolished
post-stimulus
undershoot
cerebral
blood
volume.
Coherence
between
left
right
gamma-band
envelope
volume
at
ultra-low
frequencies
was
decreased,
suggesting
type-1
integrate
long-range
signals.
Lastly,
we
observed
decreases
amplitude
resting-state
oscillations
vasomotion
following
neurons.
This
demonstrates
that
small
nNOS-positive
are
indispensable
for
regulating
dynamics
whole
implicates
disruption
diseases
ranging
neurodegeneration
sleep
disturbances.
Ageing and Neurodegenerative Diseases,
Journal Year:
2025,
Volume and Issue:
5(2)
Published: April 28, 2025
The
incidence
of
neurodegenerative
diseases
is
increasing
exponentially,
with
Alzheimer’s
disease
(AD)
being
a
notorious
example.
AD
progressive,
aging-related,
multifactorial
disease,
and
no
uniform
theory
exists
regarding
its
etiology.
One
hypothesis
implicates
defects
in
the
organism’s
mechanosensing
mechanotransduction
mechanisms.
deleterious
effects
mechanical
stress
neurodegeneration
have
been
proven
through
multiple
studies
observations,
but
pathways
linking
inputs
to
progression
remain
unclear.
It
has
proposed
that
nervous
tissue
primarily
responds
sources
astrocytes
microglia,
activation
Piezo1
TRPV4
ion
channels.
An
area
current
research
examining
might
be
involved
elevated
oxidative
dysregulated
apoptotic
pathways.
We
summarized
understanding
related
AD.
Our
review
indicated
relationship
between
crucial
Hippo
pathway
(MST1
humans)
KCNN4
worth
following
up
future
studies.
noted
G3BP1
G3BP2
FlnA-mediated
are
linked
ceramide
production,
along
their
interaction
granules
-
key
element
for
onset
apoptosis,
which
assembled,
among
others,
response
stress.
This
sheds
light
on
how
input
disrupts
what
implications
also
identifies
potential
targets
focus.
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: May 4, 2025
Abstract
In
recent
years,
increasing
evidence
has
suggested
that
meningeal
lymphatic
drainage
plays
a
significant
role
in
central
nervous
system
(CNS)
diseases.
Studies
have
indicated
CNS
diseases
and
conditions
associated
with
dysfunction
include
neurodegenerative
diseases,
stroke,
infections,
traumatic
brain
injury,
tumors,
functional
cranial
disorders,
hydrocephalus.
However,
the
understanding
of
regulatory
damage
mechanisms
lymphatics
under
physiological
pathological
is
currently
limited.
Given
importance
profound
interplay
between
this
review
covers
seven
key
aspects:
development
structure
vessels,
methods
for
observing
lymphatics,
function
molecular
relationships
vessels
potential
conclusions
outstanding
questions.
We
will
explore
relationship
development,
structure,
current
both
animal
models
humans,
identify
unresolved
points
research.
The
aim
to
provide
new
directions
future
research
therapeutic
strategies
targeting
by
critically
analyzing
advancements
field,
identifying
gaps
knowledge,
proposing
innovative
approaches
address
these
gaps.
Fluids and Barriers of the CNS,
Journal Year:
2025,
Volume and Issue:
22(1)
Published: May 8, 2025
Abstract
Background
The
perivascular
conduct
pathway
that
connects
the
cerebrospinal
fluid
spaces
with
interstitial
in
parenchyma
are
of
importance
for
solute
clearance
from
brain.
In
this
pathway,
relatively
wide
space
(PVS)
surrounding
pial
arteries
provides
a
low-resistant
passage
while
around
perforating
arteries,
movement
is
along
basement
membrane
(BM),
prevents
free
exchange
fluids
and
solutes.
We
hypothesize
selectivity
involves
specific
components
vascular
BM,
which
mainly
composed
type
IV
collagen
(Col
IV)
laminin
networks
interconnected
by
nidogens
heparan
sulphate
proteoglycans
(HSPGs).
Perlecan
major
HSPG
BM
binds
to
Col
via
glycosaminoglycan
(GAG)
chains
form
molecular
sieve.
GAGs
may
also
provide
charge
required
filtration,
scaffold
amyloid-β
(Aβ)
aggregation.
purpose
study
was
functional
characterization
transport
brain
mice
lacking
perlecan
GAG
chains.
Methods
generated
novel
mouse
line
(
Hspg2
∆3∆91
)
side
investigated
flow
these
using
intravital
multiphoton
fluorescence
recovery
after
photobleaching
techniques,
assays
various
tracers.
Potentially
deleterious
effects
on
homeostasis
were
transcriptomic,
proteomic
immunohistochemical
methods.
crossed
5xFAD
examine
Aβ
Results
observed
delayed
inflow
CSF
tracer
into
no
changes
parenchymal
injected
Quantification
plaques
revealed
fewer
smaller
walls
at
six
months
age,
but
not
parenchyma.
Surprisingly,
deficiency
had
severe
transcriptomic
analyses.
Conclusions
Potential
mechanisms
dependent
through
special
ECM
structures.
known
its
barrier
function,
whereas
very
little
about
how
established.
This
shows
composition
affects
dynamics
deposition
periarterial
space.
Journal of Bone and Mineral Research,
Journal Year:
2024,
Volume and Issue:
39(5), P. 580 - 594
Published: March 3, 2024
Abstract
Healthy
alveolar
bone
is
the
cornerstone
of
oral
function
and
treatment.
Alveolar
highly
dynamic
during
entire
lifespan
affected
by
both
systemic
local
factors.
Importantly,
subjected
to
unique
occlusal
force
in
daily
life,
mechanical
a
powerful
trigger
remodeling,
but
effect
maintaining
mass
remains
ambiguous.
In
this
study,
Piezo1
channel
identified
as
an
sensor.
Activation
rescues
loss
caused
force.
Moreover,
we
identify
mediator
osteoblasts,
homeostasis
directly
promoting
osteogenesis
sequentially
regulating
catabolic
metabolism
through
Fas
ligand
(FasL)-induced
osteoclastic
apoptosis.
Interestingly,
activation
also
exhibits
remarkable
efficacy
treatment
osteoporosis
estrogen
deficiency,
which
prevalent
among
middle-aged
elderly
women.
Promisingly,
may
serve
not
only
target
for
loss-induced
potential
metabolic
loss,
especially
older
patients.
British Journal of Pharmacology,
Journal Year:
2024,
Volume and Issue:
181(23), P. 4714 - 4732
Published: Oct. 14, 2024
Abstract
PIEZO1
is
a
eukaryotic
membrane
protein
that
assembles
as
trimers
to
form
calcium‐permeable,
non‐selective
cation
channels
with
exquisite
capabilities
for
mechanical
force
sensing
and
transduction
of
into
effect
in
diverse
cell
types
include
blood
cells,
endothelial
epithelial
fibroblasts
stem
cells
systems
bone,
lymphatics
muscle.
The
channel
has
wide‐ranging
roles
considered
target
novel
therapeutics
ailments
spanning
cancers
cardiovascular,
dental,
gastrointestinal,
hepatobiliary,
infectious,
musculoskeletal,
nervous
system,
ocular,
pregnancy,
renal,
respiratory
urological
disorders.
identification
modulators
its
infancy
but
useful
experimental
tools
emerged
activating,
lesser
extent
inhibiting,
the
channels.
Elementary
structure–activity
relationships
are
known
Yoda
series
small
molecule
agonists,
which
show
potential
physicochemical
pharmacological
properties.
Intriguing
effects
Yoda1
stimulated
removal
excess
cerebrospinal
fluid.
Despite
PIEZO1's
broad
expression,
opportunities
suggested
selective
positive
or
negative
modulation
without
intolerable
adverse
effects.
Here
we
provide
focused,
non‐systematic,
narrative
review
progress
this
pharmacology
discuss
future
directions
research
area.
Aging and Disease,
Journal Year:
2024,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2024
Aging
is
interrelated
with
changes
in
red
blood
cell
parameters
and
functionality.
In
this
article,
we
focus
on
cells
(RBCs)
provide
a
review
of
the
known
associated
characterization
RBC
deformability
aging
related
pathologies.
The
biophysical
complement
commonly
used
biochemical
may
contribute
to
better
understanding
process.
power
measurement
approach
well
established
clinical
settings.
Measuring
RBCs'
has
advantage
relative
simplicity,
it
reflects
complex
effects
developing
erythrocytes
during
aging.
However,
pathological
conditions
also
promote
heterogeneity
features
have
certain
impact
variance
erythrocyte
properties.
possible
applications
as
an
early
biomarker
states
are
discussed,
modulating
PIEZO1
therapeutic
target
suggested.
shape
can
serve
proxy
for
evaluation,
leveraging
single-cell
analysis
imaging
flow
cytometry
artificial
intelligence
algorithms.
RBCs
progress
humans
will
dynamics
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 3, 2024
Introduction
(Abstract)
Impaired
clearance
of
the
byproducts
aging
and
neurologic
disease
from
brain
exacerbates
progression
severity.
We
have
developed
a
noninvasive,
low
intensity
transcranial
focused
ultrasound
protocol
that
facilitates
removal
pathogenic
substances
cerebrospinal
fluid
(CSF)
interstitium.
This
clears
neurofilament
light
chain
(NfL)
–
an
byproduct
in
aged
mice
red
blood
cells
(RBCs)
central
nervous
system
two
mouse
models
hemorrhagic
injury.
Cleared
RBCs
accumulate
cervical
lymph
nodes
both
CSF
interstitial
compartments,
indicating
through
meningeal
lymphatics.
Treating
these
injury
with
this
reduced
neuroinflammatory
neurocytotoxic
profiles,
improved
behavioral
outcomes,
decreased
morbidity
and,
importantly,
increased
survival.
RBC
efficacy
was
blocked
by
mechanosensitive
channel
antagonism
effective
when
applied
anesthetized
subjects,
mediated
mechanism
does
not
depend
on
sensory
stimulation
or
specific
neural
activity
pattern.
Notably,
qualifies
for
FDA
non-significant
risk
designation
given
its
intensity,
making
it
readily
clinically
translatable.
Overall,
our
results
demonstrate
low-intensity
hemorrhage
other
harmful
via
lymphatic
system,
potentially
offering
novel
therapeutic
tool
varied
disorders.
