Circadian rhythms and disorders of the timing of sleep

The Lancet, Journal Year: 2022, Volume and Issue: 400(10357), P. 1061 - 1078

Published: Sept. 1, 2022

Language: Английский

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The relevance of daylight for humans

Biochemical Pharmacology, Journal Year: 2020, Volume and Issue: 191, P. 114304 - 114304

Published: Oct. 28, 2020

Daylight is ubiquitous and crucial for mammalian vision as well non-visual input to the brain via intrinsically photosensitive retinal ganglion cells (ipRGCs) that express photopigment melanopsin. The ipRGCs project circadian clock in suprachiasmatic nuclei thereby ensure entrainment 24-hour day-night cycle, changes daylength trigger appropriate seasonal behaviours. also perihabenular nucleus surrounding regions modulate mood, stress learning animals humans. Given light has strong direct effects on cognition, alertness, performance, sleep, can be considered a "drug" treat many clinical conditions. Light therapy already established winter other depressions sleep disorders. Beyond visual retina, daylight contributes prevent myopia young by its impact eye development, important Vitamin D synthesis bone health skin. sun most powerful source and, dependent dose, ultraviolet radiance toxic living organisms used disinfectant. Most research involves laboratory-based electric light, without dynamic spectral undergoes moment moment. There gap between importance of human beings amount being done this subject. taken granted an environmental factor, enjoyed or avoided, according More awareness architecture urban design beyond aesthetic values comfort may lead higher quality work environments. Although we do not yet have factual basis assumption natural overall "better" than debate mandates serious consideration sunlight just solar power but biologically necessary sustainable healthy living.

Language: Английский

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The dim light melatonin onset across ages, methodologies, and sex and its relationship with morningness/eveningness

SLEEP, Journal Year: 2023, Volume and Issue: 46(5)

Published: Feb. 17, 2023

Abstract The onset of melatonin secretion, the dim light (DLMO), is a tool for determining phase circadian timing system. Although small studies have investigated impacts age and methods calculating DLMO, there no DLMO reference range. In current study, saliva from 3579 participants 121 published plasma 818 healthy controls 31 (aged 3–73 years) were analyzed. subset 53 papers (1749 participants), individual Morningness Eveningness Questionaire (MEQ) scores obtained authors or mined publications range was constructed. Saliva earliest in children to 10 years latest around 20 thereafter advanced with by 30 min oldest participants. Melatonin assay calculation had little effect on determination DLMO. correlated (p < 0.001) MEQ score; lower associated later increased age, reflecting tendency toward morningness. An evaluation 14 clinically diagnosed patients living delayed sleep–wake disorder (mean ages revealed mean within albeit at late extreme. Peak levels 179 high degree variability groups, but only decline between 50 lowest after 70 years.

Language: Английский

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The sleep–circadian interface: A window into mental disorders

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(9)

Published: Feb. 23, 2024

Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the quality, continuity, timing of sleep can precipitate or exacerbate psychiatric symptoms in susceptible individuals, while treatments that target sleep-circadian disturbances alleviate psychopathology. Conversely, poor disrupt clock-controlled processes. Despite progress elucidating underlying mechanisms, a cohesive approach integrates dynamic interactions between disorder with both processes is lacking. This review synthesizes recent evidence for dysfunction as transdiagnostic contributor range disorders, an emphasis on biological mechanisms. We highlight observations from adolescent young adults, who at greatest risk developing whom early detection intervention promise benefit. In particular, we aim a) integrate factors implicated pathophysiology treatment mood, anxiety, psychosis spectrum perspective; b) need reframe existing knowledge adopt integrated which recognizes interaction factors; c) identify important gaps opportunities further research.

Language: Английский

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Wearables in Chronomedicine and Interpretation of Circadian Health

Diagnostics, Journal Year: 2025, Volume and Issue: 15(3), P. 327 - 327

Published: Jan. 30, 2025

Wearable devices have gained increasing attention for use in multifunctional applications related to health monitoring, particularly research of the circadian rhythms cognitive functions and metabolic processes. In this comprehensive review, we encompass how wearables can be used study disease. We highlight importance these as markers well-being potential predictors outcomes. focus on wearable technologies sleep research, medicine, chronomedicine beyond domain emphasize actigraphy a validated tool monitoring sleep, activity, light exposure. discuss various mathematical methods currently analyze actigraphic data, such parametric non-parametric approaches, linear, non-linear, neural network-based applied quantify non-circadian variability. also introduce novel actigraphy-derived markers, which personalized proxies status, assisting discriminating between disease, offering insights into neurobehavioral status. lifestyle factors physical activity exposure modulate brain health. establishing reference standards measures further refine data interpretation improve clinical The review calls existing tools methods, deepen our understanding health, develop healthcare strategies.

Language: Английский

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Managing Travel Fatigue and Jet Lag in Athletes: A Review and Consensus Statement

Sports Medicine, Journal Year: 2021, Volume and Issue: 51(10), P. 2029 - 2050

Published: July 14, 2021

Language: Английский

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Circadian depression: A mood disorder phenotype

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 126, P. 79 - 101

Published: March 7, 2021

Language: Английский

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Workshop report. Circadian rhythm sleep–wake disorders: gaps and opportunities

SLEEP, Journal Year: 2021, Volume and Issue: 44(5)

Published: Feb. 14, 2021

Abstract This White Paper presents the results from a workshop cosponsored by Sleep Research Society (SRS) and for on Biological Rhythms (SRBR) whose goals were to bring together sleep clinicians circadian rhythm researchers identify existing gaps in diagnosis treatment areas of high-priority research sleep–wake disorders (CRSWD). CRSWD are distinct class caused alterations time-keeping system, its entrainment mechanisms, or misalignment endogenous external environment. In these disorders, timing primary episode is either earlier later than desired, irregular day-to-day, and/or occurs at wrong time. While there incomplete insufficient prevalence data, likely affect least 800,000 perhaps as many 3 million individuals United States, if Shift Work Disorder Jet Lag included, then millions more impacted. The SRS Advocacy Taskforce has identified which additional high-quality could have significant impact improve patient care. Participants selected their expertise assigned one three working groups: Phase Disorders, Entrainment Other. Each group presented summary current state science specific area, followed discussion all participants. outcome those presentations discussions here.

Language: Английский

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Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement

American Journal of Respiratory and Critical Care Medicine, Journal Year: 2023, Volume and Issue: 207(7), P. e49 - e68

Published: March 31, 2023

Section:ChooseTop of pageAbstract <

Language: Английский

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Fundamentals of sleep regulation: Model and benchmark values for fractal and oscillatory neurodynamics

Progress in Neurobiology, Journal Year: 2024, Volume and Issue: 234, P. 102589 - 102589

Published: March 1, 2024

Homeostatic, circadian and ultradian mechanisms play crucial roles in the regulation of sleep. Evidence suggests that ratios low-to-high frequency power electroencephalogram (EEG) spectrum indicate instantaneous level sleep pressure, influenced by factors such as individual sleep-wake history, current stage, age-related differences brain topography characteristics. These effects are well captured reflected spectral exponent, a composite measure constant ratio periodogram, which is scale-free exhibits lower interindividual variability compared to slow wave activity, potentially serving suitable standardization reference measure. Here we propose an index homeostasis based on reflecting membrane hyperpolarization and/or network bistability central nervous system humans. In addition, advance idea U-shaped overnight deceleration oscillatory fast spindle frequencies marks biological night, providing somnologists with EEG-index regulation. supporting this assertion comes from studies replacement, forced desynchrony protocols high-resolution analyses spindles. Finally, regulatory indicated recurrent, abrupt shifts dominant frequencies, ranges signifying non-rapid eye movement non-spindle oscillations – rapid phases cycles. Reconsidering indicators fundamental processes framework new Fractal Oscillatory Adjustment Model (FOAM) offers appealing opportunity bridge gap between two-process model clinical somnology.

Language: Английский

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