Fitness, physical activity, and exercise in multiple sclerosis: a systematic review on current evidence for interactions with disease activity and progression

Journal of Neurology, Journal Year: 2022, Volume and Issue: 269(6), P. 2922 - 2940

Published: Jan. 27, 2022

Abstract Background A moderate to high level of physical activity, including regular exercise, represents an established behavioral and rehabilitative approach for persons with multiple sclerosis (pwMS). Although being increasingly proposed limit disease activity progression, high-quality evidence is lacking. Objective The objective the study provide valuable information MS clinicians researchers by systematically evaluating current state (i) whether exercise interventions affect clinical measures progression in pwMS (i.e., EDSS, relapse rate, lesion load, brain volume, MSFC) (ii) how fitness interact these measures. Methods Literature search was conducted MEDLINE, EMBASE, CINAHL, SPORTDiscus. Evaluation quality done based on standards published American Academy Neurology. Results It likely that improves MSFC score, whereas EDSS volume are remain unchanged over intervention period. possible decreases rate. from cross-sectional studies indicate beneficial effects a or which, however, not corroborated quality. Conclusions (supportive) disease-modifying effect cannot be concluded. rather low existing RCTs underlines need conduct more well-designed assessing different as primary end points. major limitation short duration which limits meaningful exercise-induced most disability Findings difficult contextualize regarding importance due their solely associative character PROSPERO registration number CRD42020188774.

Language: Английский

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Sarcopenia and nervous system disorders

Journal of Neurology, Journal Year: 2022, Volume and Issue: 269(11), P. 5787 - 5797

Published: July 13, 2022

Language: Английский

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Machine Learning Algorithms Introduce Evoked Potentials As Alternative Biomarkers for the Expanded Disability Status Scale Prognosis of Multiple Sclerosis Patients

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Machine learning (ML) has witnessed a notable increase in significance within the medical field, primarily due to increasing availability of health-related data and progressive enhancements ML algorithms. Thus, can be utilized formulate predictive models that aid disease diagnosis, anticipate progression, tailor treatment fulfill individual patient needs, improve operational efficiency healthcare systems. Timely detection contributes effective symptom management guarantees appropriate is provided. In multiple sclerosis (MS), evoked potentials (EPs) show strong correlation with Expanded Disability Status Scale (EDSS), suggesting their potential as reliable predictors disability progression. The aim present study apply artificial intelligence (AI) techniques identify linked progression MS assessed by index (EDSS). It essential clarify role EPs prognostication MS. We conducted an analysis empirical obtained from database consisting 125 records. Our primary objective construct expert AI system capable predicting EDSS through application advanced knowledge-mining have developed intelligent systems predict utilizing algorithms, specifically decision trees neural networks. our experimental evaluation, trees, networks, Bayes for achieved accuracies 88.9%, 92.9%, 88.2% respectively, which are comparable MRI 88.2%, 96.0%, 85.0%. established efficacy analogous findings. Further investigation necessary validate EPs, significantly less expensive, portable, simpler administer than MRI, equally imaging or biochemical methods functioning biomarkers

Language: Английский

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Exercise Training for Multiple Sclerosis: A Narrative Review of History, Benefits, Safety, Guidelines, and Promotion

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(24), P. 13245 - 13245

Published: Dec. 16, 2021

Background: There have been significant advances in the medical treatment and management of multiple sclerosis pathogenesis, relapse disease progression over past 30 years. advancements symptomatic sclerosis, including secondary expressions such as walking, cognitive dysfunction, fatigue depression. Scientific evidence expert opinion suggest that exercise may be single most effective non-pharmacological for sclerosis. This article presents historical context training within multidisciplinary We guide neurologists healthcare providers on recommended prescription practical, theoretical methods to overcome barriers exercise. Method: undertook a critical search current literature regarding from viewpoint promotion by care team. Results: highlight ever-strengthening body research indicating is safe improving symptoms Further, necessary reducing progression. Conclusion: seek encourage specialists teams prescribe promote at diagnosis across all stages trajectory using prescriptive guidelines part comprehensive MS care. Available tools include clinical education dispel any myths related behaviour change theory patients

Language: Английский

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Exercise-induced increase in blood-based brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis: A systematic review and meta-analysis of exercise intervention trials

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(3), P. e0264557 - e0264557

Published: March 3, 2022

Background Exercise training may affect the blood levels of brain-derived neurotrophic factor (BDNF), but meta-analyses have not yet been performed comparing pre- and post-intervention BDNF concentrations in patients with multiple sclerosis (PwMS). Objective To perform a meta-analysis to study influence exercise on define components that modulate them across clinical trials adults living (MS). Method Five databases (PubMed, EMBASE, Cochrane Library, PEDro database, CINAHL) were searched up June 2021. According Preferred Reporting Items for Systematic Reviews Meta-Analyses, we included 13 articles meta-analysis, including 271 subjects. investigate sources heterogeneity, subgroup analysis, meta-regression, sensitivity analysis conducted. We compare post-exercise peripheral PwMS. Results Post-exercise serum significantly higher than pre-intervention (Standardized Mean Difference (SMD): 0.33, 95% CI: [0.04; 0.61], p-value = 0.02). Meta-regression indicated quality studies based assessment tool might be source while no significant effect was found chronological age disease severity according expanded disability status scale. Conclusion This systematic review shows physical activity increases More research different modes PwMS is warranted.

Language: Английский

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Physical Activity in Multiple Sclerosis: Meeting the Guidelines at the Time of the COVID-19 Pandemic

Journal of Neurologic Physical Therapy, Journal Year: 2023, Volume and Issue: 47(2), P. 112 - 121

Published: Jan. 31, 2023

Regular physical activity (PA) helps to reduce the severity of and mental symptoms improves quality life in people with multiple sclerosis (PwMS). Based on current evidence expert opinion, recent guidelines recommend at least 150 minutes/week PA. This study presents results a survey analyzing whether how PwMS met before during pandemic.We developed disseminated an international online between December 2020 July 2021, investigating changes self-reported PA type, duration, frequency, intensity due COVID-19 outbreak differing disability levels.Among respondents (n = 3810), 3725 were eligible. The proportion those who conducted one decreased increasing level both time points (pre during). Overall 60% pandemic (mild: 64.43%; moderate: 51.53%; severe: 39.34%; χ 2(2) 109.13, P < 0.01); reduction approximately 10% occurred all groups 54.76%; 42.47%; 29.48%; 109.67, 0.01). Respondents higher participated more therapy less walking, cycling, running points. Most reported practicing moderate points; frequency duration sessions as increased.The percentage meeting reduced pandemic. type varied widely across categories. Interventions accounting for are required enable reap benefits PA.Video Abstract available insights from authors (see Video, Supplemental Digital Content 1, http://links.lww.com/JNPT/A415 ).

Language: Английский

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Building a monitoring matrix for the management of multiple sclerosis

Autoimmunity Reviews, Journal Year: 2023, Volume and Issue: 22(8), P. 103358 - 103358

Published: May 12, 2023

Language: Английский

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Safety of exercise training in multiple sclerosis: An updated systematic review and meta-analysis

Multiple Sclerosis Journal, Journal Year: 2023, Volume and Issue: 29(13), P. 1604 - 1631

Published: Oct. 26, 2023

Background: A review of the safety profile exercise training in multiple sclerosis (MS) has not been conducted since 2013. Objective: We undertook a systematic and meta-analysis randomised controlled trials (RCTs) published 2013 quantified estimated population risks clinical relapse, adverse events (AE) serious event (SAE). Methods: Articles reporting outcomes from comparisons with non-exercise among persons MS were identified. The risk bias was established study’s internal validity assessed using Physiotherapy Evidence Database (PEDro). Rates mean relative (RRs; 95% confidence interval (CI)) calculated, random-effects RR. Results: Forty-six interventions 40 RCTs ( N = 1780) yielded 46, 39 effects for AE, SAE, respectively. RRs ((95% CI), p-value) AE SAE 0.95 ((0.61, 1.48), p 0.82), 1.40 ((0.90, 2.19), 0.14) 1.05 ((0.62, 1.80), 0.85), No significant heterogeneity is observed any outcome. Conclusion: In studies that reported outcomes, there no higher or than comparator. Exercise may be promoted as safe beneficial to MS.

Language: Английский

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MS care: integrating advanced therapies and holistic management

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 30, 2024

Lifestyle and environmental factors are key determinants in disease causality progression neurological conditions, including multiple sclerosis (MS). Lack of exercise, poor diet, tobacco smoking, excessive alcohol intake, social health, concomitant medications, sleep comorbidities can exacerbate MS pathological processes by impacting brain health depleting reserves, resulting more rapid worsening. In addition to using disease-modifying therapies alter the course, therapeutic strategies should aim preserve as much reserve possible promoting adoption a “brain-healthy” “metabolically-healthy” lifestyle. Here, we recommend self-regulated lifestyle modifications that have potential improve directly impact on outcomes people with MS. We emphasise importance self-management adopting multidisciplinary, collaborative person-centred approach care encompasses healthcare team, family members community support groups.

Language: Английский

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Drop-out, adherence, and compliance in randomized controlled trials of exercise training in multiple sclerosis: Short report

Multiple Sclerosis Journal, Journal Year: 2024, Volume and Issue: 30(4-5), P. 605 - 611

Published: Feb. 9, 2024

We documented reporting and rates of drop-out, adherence, compliance from 40 randomized controlled trials (RCTs) included in our meta-analysis on safety exercise training (ET) MS. adopted definitions metrics adherence provided by the MoXFo group. Drop-out was reported 100% RCTs approximated 10% for intervention control conditions. Adherence were approximately 50% RCTs, respectively, 80% 70%, respectively. Standardized are important future understanding impact outcomes translation research evidence into practice.

Language: Английский

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