Aerobic exercise increases irisin serum levels and improves depression and fatigue in patients with relapsing remitting multiple sclerosis: A randomized controlled trial

Multiple Sclerosis and Related Disorders, Journal Year: 2022, Volume and Issue: 61, P. 103742 - 103742

Published: March 15, 2022

Language: Английский

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Impact of the COVID-19 Pandemic on Physical Activity and Associated Technology Use in Persons With Multiple Sclerosis: An International RIMS-SIG Mobility Survey Study

Archives of Physical Medicine and Rehabilitation, Journal Year: 2022, Volume and Issue: 103(10), P. 2009 - 2015

Published: June 26, 2022

Language: Английский

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Home-Based Exercise Training in Multiple Sclerosis: A Systematic Review with Implications for Future Research

Multiple Sclerosis and Related Disorders, Journal Year: 2021, Volume and Issue: 55, P. 103177 - 103177

Published: July 27, 2021

Language: Английский

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The Role of Nutritional Lifestyle and Physical Activity in Multiple Sclerosis Pathogenesis and Management: A Narrative Review

Nutrients, Journal Year: 2021, Volume and Issue: 13(11), P. 3774 - 3774

Published: Oct. 25, 2021

Studies on the role of nutritional factors and physical activity (PA) in pathogenesis multiple sclerosis (MS) go back a long time. Despite intrinsic difficulty studying their positive or negative MS, interest researchers these topics increased during last few decades, since diet has been investigated with perspective association disease-modifying drugs (DMD). The DMD, diets, PA might have an additive effect modifying disease severity. Among various diets (low-carbohydrate, gluten-free, Mediterranean, low-fat, fasting-mimicking, Western diets) only low-carbohydrate, fast-mimicking shown both animal models humans MS course patient-reported outcomes (PROs). However, Mediterranean is easier to be maintained compared low-carbohydrate which may lead detrimental side effects requiring careful clinical monitoring. Conversely, diet, characterized by high intake highly saturated fats carbohydrates, activation pro-inflammatory immune pathways therefore not recommended. showed as well PROs humans. Training combined exercises considered more effective approach.

Language: Английский

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Efficacy of Transcranial Direct Current Stimulation (tDCS) on Balance and Gait in Multiple Sclerosis Patients: A Machine Learning Approach

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(12), P. 3505 - 3505

Published: June 17, 2022

Transcranial direct current stimulation (tDCS) has emerged as an appealing rehabilitative approach to improve brain function, with promising data on gait and balance in people multiple sclerosis (MS). However, single variable weights have not yet been adequately assessed. Hence, the aim of this pilot randomized controlled trial was evaluate tDCS effects patients MS through a machine learning approach. In (RCT), we included relapsing−remitting Expanded Disability Status Scale >1 <5 that were randomly allocated two groups—a study group, undergoing 10-session anodal motor cortex tDCS, control sham treatment. Both groups underwent specific program. We assessed outcome measures Berg Balance (BBS), Fall Risk Index timed up-and-go 6-min-walking tests at baseline (T0), end intervention (T1) 4 (T2) 6 weeks after (T3) inertial motion unit. At each time point, performed factor analysis allow influence variables, grouping participants based results. Seventeen (aged 40.6 ± 14.4 years), 9 group 8 included. reported significant repeated difference between for distances covered (6MWT (meters), p < 0.03). T1, showed increase distance (m) mean (MD) 37.0 [−59.0, 17.0] (p = 0.003), BBS MD 2.0 [−4.0, 3.0] T2, these improvements did seem be significantly maintained; however, considering analysis, Silhouette 0.34, low cluster overlap trend, confirmed possible short-term (T2), even weeks. Therefore, RCT may provide non-sustained patients. scenario, could suggest evidence prolonged beneficial effects.

Language: Английский

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Updated Systematic Review and Quantitative Synthesis of Physical Activity Levels in Multiple Sclerosis

American Journal of Physical Medicine & Rehabilitation, Journal Year: 2023, Volume and Issue: 103(4), P. 284 - 292

Published: July 6, 2023

Objective This article provided an updated quantitative synthesis of physical activity levels in persons with multiple sclerosis compared controls and other clinical populations. Design A systematic search through PubMed, Scopus, PsycINFO was conducted for articles published between August 2016 July 2022. Articles that included a group comparison at least one measurement adults or populations were the meta-analysis. Results Twenty-four studies met inclusion criteria yielded total 119 comparisons. There moderate difference (effect size = −0.56, P < 0.01), but no significant 0.01, 0.90). The pooled effect sizes comparing ( Q 104 457.9, 0.01) as well 13 108.4, heterogeneous. Moderating variables sex, disability status, method, outcome, intensity, application sclerosis–specific cut-point. Conclusions Physical remain significantly lower controls, magnitude has become smaller over past decade. is need continued development effective programs can reach greater community sclerosis.

Language: Английский

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The MoXFo initiative – adherence: Exercise adherence, compliance and sustainability among people with multiple sclerosis: An overview and roadmap for research

Multiple Sclerosis Journal, Journal Year: 2023, Volume and Issue: 29(13), P. 1595 - 1603

Published: Oct. 26, 2023

We know very little about exercise adherence, compliance and sustainability in multiple sclerosis (MS), yet adherence is seemingly important for yielding immediate sustained health benefits. This paper focused on the context of informing research practice involving MS. focus critical clarifying terminology future providing a roadmap guiding clinical practice. Our objective was accomplished through narrative summary literature by panel experts from Moving Exercise Research Multiple Sclerosis Forward (MoXFo) initiative concluding state directions. The identified three overall themes (Background Importance; Understanding Promoting Adherence, Compliance Sustainability Challenges to Sustainability) that represented categorization nine subthemes. These subthemes formed basis our recommendations regarding broadly Overall, there limited evidence rates determinants MS, known techniques interventions long-term behaviour change.

Language: Английский

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Cardiorespiratory fitness (V̇O2peak) across the adult lifespan in persons with multiple sclerosis and matched healthy controls

Journal of science and medicine in sport, Journal Year: 2023, Volume and Issue: 27(1), P. 10 - 15

Published: Oct. 18, 2023

Language: Английский

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Exploring the Major Barriers to Physical Activity in Persons With Multiple Sclerosis: Observational Longitudinal Study

JMIR Rehabilitation and Assistive Technologies, Journal Year: 2024, Volume and Issue: 11, P. e52733 - e52733

Published: Feb. 2, 2024

Physical activity (PA) represents a low-cost and readily available means of mitigating multiple sclerosis (MS) symptoms alleviating the disease course. Nevertheless, persons with MS engage in lower levels PA than general population.

Language: Английский

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Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: 131(8), P. 871 - 899

Published: May 18, 2024

Language: Английский

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