Frontiers in Aging Neuroscience,
Journal Year:
2022,
Volume and Issue:
14
Published: Aug. 8, 2022
The
proportion
of
the
world's
elderly
population
continues
to
rise,
and
treatment
improvement
neurodegenerative
diseases
have
become
issue
public
health
importance
as
people
live
longer
many
countries
aging
populations.
This
systematic
review
aims
discuss
effects
dance
movement
therapy
(DMT)
on
motor
function,
cognitive
deficit,
mood,
quality
life
in
with
diseases,
such
Parkinson's
disease
(PD),
mild
impairment
(MCI),
Alzheimer's
(AD).Two
reviewers
independently
conducted
search
Cochrane
library,
PubMed
database,
Web
Science
Core
Collection
Physiotherapy
Evidence
database
until
February
1,
2022.
Only
analyses
randomized
controlled
trials
were
included
further
analyzed.Thirty-three
studies
PD,
16
MCI,
4
AD
obtained.
found
that
DMT
substantially
improved
global
memory,
executive
function
MCI.
Compared
non-dance
group,
remarkably
general
condition,
balance,
gait
for
individuals
PD.
evidence
efficacy
is
insufficient,
research
needed.DMT
can
effectively
improve
deficits
diseases.
Positive
mood
ND
patients
are
controversial
require
evidence.
Future
requires
scientific
design,
large
sample
size,
long-term
comprehensive
intervention,
clear
reporting
standards.www.osf.io/wktez,
identifier:
10.17605/OSF.IO/UYBKT.
Biomedicines,
Journal Year:
2020,
Volume and Issue:
8(7), P. 229 - 229
Published: July 21, 2020
Non-alcoholic
fatty
liver
disease
(NAFLD)
and
its
complication
non-alcoholic
steatohepatitis
(NASH)
are
important
causes
of
worldwide.
Recently,
a
significant
association
between
these
hepatic
diseases
different
central
nervous
system
(CNS)
disorders
has
been
observed
in
an
increasing
number
patients.
NAFLD-related
CNS
dysfunctions
include
cognitive
impairment,
hippocampal-dependent
memory
mood
imbalances
(in
particular,
depression
anxiety).
This
review
aims
at
summarizing
the
main
correlations
NAFLD
development
dysfunctions,
focusing
on
studies
investigating
mechanism(s)
involved
this
association.
Growing
evidences
point
cerebrovascular
alteration,
neuroinflammation,
brain
insulin
resistance
as
NAFLD/NASH-related
manifestations.
Since
pharmacological
options
available
for
management
conditions
still
limited,
further
needed
to
unravel
NAFLD/NASH
their
manifestations
identify
effective
targets.
IntechOpen eBooks,
Journal Year:
2022,
Volume and Issue:
unknown
Published: Oct. 6, 2022
Heterogeneity
of
symptoms
within
and
among
mild
cognitive
impairment
(MCI)
individuals
often
makes
it
challenging
to
document
cases
clinically.
Number
diagnostic
criteria
have
been
proposed
in
recent
decades.
MOCA
MMSE
are
two
tests
useful
for
the
assessment
MCI,
besides
neuroimaging
studies
with
MRI
PET
scan,
provided
promising
results
early
diagnosis
MCI.
Lifestyle
changes
training
found
be
more
effective
treatment
International Journal of Environmental Research and Public Health,
Journal Year:
2022,
Volume and Issue:
19(7), P. 4000 - 4000
Published: March 28, 2022
Older
adults
are
vulnerable
towards
cognitive
frailty
that
can
lead
to
adverse
health
outcomes
and
telerehabilitation
appears
be
a
potential
platform
reverse
among
older
adults.
The
aim
of
this
coping
review
is
identify
the
usage
its
common
delivery
with
mild
impairment
(MCI)
or
(CF).
Articles
published
from
January
2015
until
October
2020
were
selected.
Out
1738
articles
retrieved,
six
studies
identified.
Two
randomized
controlled
trials,
one
was
pilot
study
three
qualitative
studies.
outcome
suggests
may
improve
quality
life
participants
as
well
it
useful
supportive
digital
for
care.
Some
types
technologies
commonly
used
smartphones
telephones
internet,
television-based
assistive
integrated
technology,
mobile
application
videoconference.
Telerehabilitation
utilization
in
managing
still
limited
more
research
required
evaluate
feasibility
acceptability.
Although
implemented
MCI
CF,
some
social
support
adherence
effectiveness
telerehabilitation.
Future
should
focus
on
evaluation
acceptance
participants’
existing
knowledge
achieve
target.
Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring,
Journal Year:
2023,
Volume and Issue:
15(1)
Published: Jan. 1, 2023
Abstract
Introduction
We
conducted
a
systematic
review
and
meta‐analysis
to
the
relationship
between
midlife
dyslipidemia
lifetime
incident
dementia.
Methods
The
databases
Medline,
Embase,
Scopus,
Web
of
Science,
Cochrane
were
searched
from
inception
February
20,
2022.
Longitudinal
studies
examining
lipid
levels
on
dementia,
dementia
subtypes,
and/or
cognitive
impairment
pooled
using
inverse‐variance
weighted
random‐effects
meta‐analysis.
Results
Seventeen
(1.2
million
participants)
included.
Midlife
hypercholesterolemia
was
associated
with
increased
incidence
mild
(effect
size
[ES]
=
2.01;
95%
confidence
interval
[CI]
1.19
2.84;
I
2
0.0%)
all‐cause
(ES
1.14;
CI:
1.07
1.21;
0.0%).
Each
1
mmol/L
increase
in
low‐density
lipoprotein
an
8%
1.08,
1.03
0.3%)
Discussion
is
risk
later
life.
Journal of the American Heart Association,
Journal Year:
2024,
Volume and Issue:
13(4)
Published: Feb. 14, 2024
As
the
older
adult
population
expands,
an
increasing
number
of
patients
affected
by
geriatric
syndromes
are
seen
cardiovascular
clinicians.
One
such
syndrome
that
has
been
associated
with
poor
outcomes
is
cognitive
frailty:
simultaneous
presence
impairment,
without
evidence
dementia,
and
physical
frailty,
which
results
in
decreased
reserve.
Driven
common
pathophysiologic
underpinnings
(eg,
inflammation
neurohormonal
dysregulation),
disease,
frailty
also
share
following
risk
factors:
hypertension,
diabetes,
obesity,
sedentary
behavior,
tobacco
use.
Cardiovascular
disease
onset
progression
may
be
reversible
early
stages,
making
it
essential
for
clinicians
to
diagnose
condition
a
timely
manner
prescribe
appropriate
interventions.
Additional
research
required
elucidate
mechanisms
underlying
development
establish
preventive
therapeutic
strategies
address
needs
at
ultimately
facilitate
targeted
intervention
studies.
Medical Science Monitor,
Journal Year:
2024,
Volume and Issue:
30
Published: Jan. 16, 2024
Metabolic
dysfunction-associated
fatty
liver
disease
or
metabolic
steatotic
(MAFLD/MASLD),
is
a
common
chronic
condition
affecting
substantial
global
population.
Beyond
its
primary
impact
on
function,
MAFLD/MASLD
associated
with
myriad
of
extrahepatic
manifestations,
including
cognitive
impairment.
The
scope
impairment
within
the
realm
matter
escalating
concern.
Positioned
as
an
intermediate
stage
between
normal
aging
process
and
onset
dementia,
manifests
challenge
this
condition.
Insights
from
studies
underscore
presence
compromised
executive
function
decline
in
capabilities
among
individuals
identified
being
at
risk
progressing
to
fibrosis.
Importantly,
transcends
mere
association
factors,
delving
deep
into
intricate
pathophysiology
characterizing
MAFLD/MASLD.
multifaceted
nature
context
underlined
by
spectrum
prominently
featuring
insulin
resistance,
lipotoxicity,
systemic
inflammation
pivotal
contributors.
These
factors
interplay
landscape
MAFLD/MASLD,
fostering
nuanced
understanding
links
hepatic
health
function.
By
synthesizing
available
evidence,
exploring
potential
mechanisms,
assessing
clinical
implications,
overarching
aim
review
contribute
more
complete
Molecular Psychiatry,
Journal Year:
2024,
Volume and Issue:
29(10), P. 3064 - 3075
Published: April 25, 2024
Depression
in
older
adults
with
cognitive
impairment
increases
progression
to
dementia.
Microbiota
is
associated
current
mood
and
cognition,
but
the
extent
which
it
predicts
future
symptoms
unknown.
In
this
work,
we
identified
microbial
features
that
reflect
predict
depressive
symptoms.
Clinical
assessments
stool
samples
were
collected
from
268
participants
varying
Seventy
underwent
2-year
follow-up.
Microbial
community
diversity,
structure,
composition
assessed
using
high-resolution
16
S
rRNA
marker
gene
sequencing.
We
implemented
linear
regression
characterize
relationship
between
microbiome
composition,
impairment,
leveraged
elastic
net
discover
or
function
Greater
diversity
lower
cognition
whole
sample,
greater
depression
not
on
antidepressants.
Poor
relative
abundance
of
Bifidobacterium,
while
GABA
degradation
severity.
Future
decline
function,
Intestinibacter,
glutamate
degradation,
higher
baseline
histamine
synthesis.
increase
anxiety,
diabetes,
Bacteroidota,
degradation.
Our
results
suggest
dysfunction
are
unique
states
an
overall
biological
effect
detectable
through
gut
microbiota.
The
may
present
a
noninvasive
readout
prognostic
tool
for
psychiatric
states.