Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise

ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(3), P. 408 - 446

Published: Jan. 12, 2024

Aging is typified by a gradual loss of physiological fitness and accumulation cellular damage, leading to deteriorated functions enhanced vulnerability diseases. Antiaging research has long history throughout civilization, with many efforts put forth understand prevent the effects aging. Multiple strategies aiming promote healthy aging extend lifespan have been developed including lifestyle adjustments, medical treatments, social programs. A multitude antiaging medicines remedies also explored. Here, we use data from CAS Content Collection analyze publication landscape recent related treatments. We review advances delineate trends in headway knowledge practice across time, geography, development pipelines. further assess state-of-the-art approaches explore their correlations age-related The drugs outlined Well-recognized novel, currently evaluated agents summarized. Finally, clinical applications products objective this summarize current on preventive treatment field aging, outline challenges evaluate growth opportunities, order solve problems that remain.

Language: Английский

---

The state of the art in anti-aging: plant-based phytochemicals for skin care

Immunity & Ageing, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 31, 2025

Phytochemicals help mitigate skin aging by scavenging free radicals, modulating key enzymatic pathways, and promoting the skin's structural integrity. Carotenoids, vitamins, essential fatty acids, phenolic compounds work acting as antioxidants, inhibiting enzymes like hyaluronidase, collagenase, elastase, which degrade structure, reducing levels of inflammatory markers (IL-6, IL-8, etc.) matrix metalloproteinases (MMP-1, MMP-2) linked to aging. Recent research highlights that plant-based phytochemicals can improve elasticity, reduce hyperpigmentation, prevent breakdown important proteins, support wound healing, making them valuable components for care treatments. This review explores multifaceted roles in maintaining improving health, highlighting their mechanisms action potential anti-aging innovations.

Language: Английский

---

Anti-Aging Activity and Modes of Action of Compounds from Natural Food Sources

Biomolecules, Journal Year: 2023, Volume and Issue: 13(11), P. 1600 - 1600

Published: Oct. 31, 2023

Aging is a natural and inescapable phenomenon characterized by progressive deterioration of physiological functions, leading to increased vulnerability chronic diseases death. With economic medical development, the elderly population gradually increasing, which poses great burden society, economy field. Thus, healthy aging has now become common aspiration among people over world. Accumulating evidence indicates that substances can mediate deteriorated processes are highly likely have potential prolong lifespan improve aging-associated diseases. Foods from sources full bioactive compounds, such as polysaccharides, polyphenols, carotenoids, sterols, terpenoids vitamins. These compounds their derivatives been shown be able delay and/or diseases, thereby prolonging lifespan, via regulation various processes. Here, we summarize current understanding anti-aging activities vitamins food sources, modes action in delaying improving This will certainly provide reference for further research on effects sources.

Language: Английский

---

SKP alleviates the ferroptosis in diabetic kidney disease through suppression of HIF-1α/HO-1 pathway based on network pharmacology analysis and experimental validation

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Feb. 25, 2024

Diabetic kidney disease (DKD) represents a microvascular complication of diabetes mellitus. Shenkang Pills (SKP), traditional Chinese medicine formula, has been widely used in the treatment DKD and obvious antioxidant effect. Ferroptosis, novel mode cell death due to iron overload, shown be associated with DKD. Nevertheless, precise effects underlying mechanisms SKP on ferroptosis diabetic remain unclear.

Language: Английский

---

Research on the anti-aging mechanisms of Panax ginseng extract in mice: a gut microbiome and metabolomics approach

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 20, 2024

Introduction: Aged-related brain damage and gut microbiome disruption are common. Research affirms that modulating the microbiota-gut-brain axis can help reduce age-related damage. Methods: Ginseng, esteemed in traditional Chinese medicine, is recognized for its anti-aging capabilities. However, previous Ginseng studies have largely focused on diseased animal models. To this end, efforts were hereby made to explore potential neuroprotective effects of fecal microbiota transplantation (FMT) from Ginseng-supplemented aged mice those pre-treated with antibiotics. Results: As a result, FMT specific modifications natural aging improved weight gain, extended telomere length, anti-oxidative stress tissue, regulated serum levels cytokine, balanced proportion Treg cells. Besides, increased abundance beneficial bacteria Lachnospiraceae , Dubosiella Bacteroides etc. decreased pathogenic Helicobacter Lachnoclostridium samples mice. This revealed remarkably reshaped microbiome. Additionally, FMT-treated showed metabolites Ursolic acid, β-carotene, S-Adenosylmethionine, Spermidine, Guanosine, Celecoxib, Linoleic etc., which significantly positively correlated critical above. these identified mainly enriched pathways Amino acid metabolism, Lipid Nucleotide Furthermore, downregulated p53/p21/Rb signaling upregulated p16/p14, ATM/synapsin I/synaptophysin/PSD95, CREB/ERK/AKT following aging. Discussion: Overall, study demonstrates reprogramming by impedes process, possibly through regulation axis.

Language: Английский

---

Astrocyte senescence-like response related to peripheral nerve injury-induced neuropathic pain

Cellular & Molecular Biology Letters, Journal Year: 2023, Volume and Issue: 28(1)

Published: Aug. 15, 2023

Peripheral nerve damage causes neuroinflammation, which plays a critical role in establishing and maintaining neuropathic pain (NeP). The mechanisms contributing to neuroinflammation remain poorly elucidated, pharmacological strategies for NeP are limited. Thus, this study, we planned explore the possible link between astrocyte senescence disorders following chronic sciatic injury.An animal model was established by inducing constrictive injury (CCI) adult rats. A senolytic drug combination of dasatinib quercetin gavaged daily from first postoperative day until end study. Paw mechanical withdrawal threshold (PMWT) paw thermal latency (PTWL) were evaluated assess behaviors response experimental Senescence-associated β-galactosidase staining, western blot analysis, immunofluorescence applied examine levels proinflammatory factors severity senescence-like spinal cord. Lipopolysaccharide (LPS) administered induce astrocytes primary cultures vitro, potential impacts on secretion factors. Furthermore, single-cell RNA sequencing (scRNA-seq) conducted identify senescence-related molecular responses under pain.Following CCI, rats exhibited reduced PMWT PTWL, increased factors, an enhanced degree astrocytes. Treatment with effectively attenuated mitigated hypersensitivities subjected CCI. Mechanistically, dasatinib-quercetin reversed LPS-stimulated cultured decreased scRNA-seq data revealed four genes population, expression clusterin (CLU) protein validated via vitro experiments.The findings indicate peripheral injury, suggest that targeting CLU activation might provide novel therapeutic strategy treat NeP.

Language: Английский

---

Antioxidants for improved skin appearance: Intracellular mechanism, challenges and future strategies

International Journal of Cosmetic Science, Journal Year: 2023, Volume and Issue: 45(3), P. 299 - 314

Published: Feb. 16, 2023

Recent advances in molecular and biochemical processes relevant to the skincare field have led development of novel ingredients based on antioxidants that can improve skin health youthfulness. Considering plethora such many implications for skin's appearance, this review focuses describing critical aspects antioxidants, including cosmetic functions, intracellular mechanisms challenges. In particular, specialized substances are suggested treatment each condition, as ageing, dehydration hyperpigmentation, which treatments maximize effectiveness avoid side effects during care processes. addition, proposes advanced strategies either already exists market or should be developed optimize cosmetic' beneficial effects.

Language: Английский

---

Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies

Biology Direct, Journal Year: 2023, Volume and Issue: 18(1)

Published: July 18, 2023

Abstract Natural ageing of organisms and corresponding age-related diseases result mainly from stem cell “inflammaging”. Mesenchymal cells (MSCs) exhibit very high immune-regulating capacity are promising candidates for immune-related disease treatment. However, the effect MSC application is not satisfactory some patients, especially in elderly individuals. With ageing, MSCs undergo many changes, including altered population reduction differentiation ability, reduced migratory homing and, most important, defective immunosuppression. It necessary to explore relationship between “inflammaging” aged prevent increase therapeutic effects MSCs. In this review, we discuss changes naturally an inflammation perspective propose ideas rejuvenating future treatments.

Language: Английский

---

Application of Response Surface Methodology for the Extraction of Phytochemicals from Upcycled Kale (Brassica oleracea var. acephala)

Nutraceuticals, Journal Year: 2025, Volume and Issue: 5(1), P. 2 - 2

Published: Jan. 6, 2025

Kale (Brassica oleracea) is recognized as a ‘superfood’ among leafy vegetables due to its high carotenoid content and potential health benefits. This study aims optimize ultrasound-assisted extraction (UAE) enhance the recovery of carotenoids other phytochemicals from upcycled kale using response surface methodology. The optimized parameters for carotenoids, i.e., aqueous ethanol solvent, temperature, time at fixed solid-to-solvent ratio, were established central composite design. method was compared with reported methods total phenolic (TPC) antioxidant capacity (ferric reducing power (FRAP) 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging). Ultra-high-performance liquid chromatography–electrospray ionization–mass spectrometry (UPLC-ESI-MS) analysis also performed. Under UAE conditions 100% 57 °C 30 min, 392 µg/g dry weight (DW) observed, though predicted 550 DW. these conditions, TPC, FRAP, DPPH 10.5 mg gallic acid equivalents/g DW, 13.9 µmole Trolox equivalence/g scavenging activity IC50 2.04 ± 0.31 mg/mL, respectively. UPLC-ESI-MS showed highest recovered through microwave-assisted extraction, followed by UAE, tested methods. In conclusion, process significantly enhanced yield quality kale.

Language: Английский

---

Dietary carotenoid intakes and biological aging among US adults, NHANES 1999–2018

Nutrition Journal, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 16, 2025

Language: Английский

---