APOPTOSIS, Journal Year: 2022, Volume and Issue: 27(5-6), P. 297 - 310
Published: March 21, 2022
Language: Английский
Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 310, P. 120721 - 120721
Published: Feb. 20, 2023
Language: Английский
Citations
49
Cancer Letters, Journal Year: 2023, Volume and Issue: 558, P. 216093 - 216093
Published: Feb. 22, 2023
Exosomes are small phospholipid bilayer vesicles that naturally produced by all living cells, both prokaryotes and eukaryotes. The exosomes due to their unique size, reduced immunogenicity, ability mimic synthetic liposomes in carrying various anticancer drugs have been tested as drug delivery vehicles for cancer treatment. An added advantage of developing a carrier is the ease manipulating intraluminal content surface modification achieve tumor-targeted delivery. In past ten-years, there has an exponential increase number exosome-related studies cancer. Preclinical demonstrate exosomes-mediated chemotherapeutics, biologicals natural products produce potent activity both, vitro vivo. contrast, exosome-based clinical trials few challenges manufacturing scalability related large-scale production storage stability. Herein, we discuss recent advances treatment preclinical conclude with be overcome translating larger therapies into clinic.
Language: Английский
Citations
49
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(8), P. 672 - 672
Published: April 12, 2024
Curcumin, an organic phenolic molecule that is extracted from the rhizomes of Curcuma longa Linn, has undergone extensive evaluation for its diverse biological activities in both animals and humans. Despite favorable characteristics, curcumin encounters various formulation challenges stability issues can be effectively addressed through application nanotechnology. Nano-based techniques specifically focused on enhancing solubility, bioavailability, therapeutic efficacy while mitigating toxicity, have been explored curcumin. This review systematically presents information improvement curcumin’s beneficial properties when incorporated, either individually or conjunction with other drugs, into nanosystems such as liposomes, nanoemulsions, polymeric micelles, dendrimers, nanoparticles, solid-lipid nanostructured lipid carriers. Additionally, examines ongoing clinical trials recently granted patents, offering a thorough overview dynamic landscape delivery. Researchers are currently exploring nanocarriers crucial features surface modification, substantial loading capacity, biodegradability, compatibility, autonomous targeting specificity selectivity. Nevertheless, utilization delivery still initial phases, regulatory approval pending persistent safety concerns surrounding their use.
Language: Английский
Citations
24
Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 7, 2025
Exosomes are small extracellular vesicles of endocytic origin released by various cell types. They consist lipid bilayers containing macromolecules such as lipids, proteins, microRNAs, growth factors, cytokines, and carbohydrates. play a critical role in the diagnosis treatment diseases. For instance, exosome contents have been utilized biomarkers body fluids (urine, saliva, serum) to identify cancers, autoimmune diseases, inflammatory conditions sepsis. Due their size ability reach tumor microenvironments, exosomes also used carriers for chemotherapeutic drugs drug delivery systems. Furthermore, evidence indicates that malignant cells release into microenvironment, influencing immune paracrine manner. Additionally, cell-derived exosomes, those from Natural Killer (NK) or cytotoxic T lymphocytes (CTLs), show potential therapeutic agents treating malignancies like leukemia. This review discusses diagnostic hematological explores these
Language: Английский
Citations
3
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 263 - 263
Published: Feb. 17, 2025
Background: Thyroid cancer (TC) is the most prevalent endocrine malignancy, and categorized into well-differentiated aggressive anaplastic types. Novel therapeutic modalities are needed for TC. Nanomedicine a promising strategy development of precision medicine. In this context, we investigated use nanogels (NGs) to deliver agents with different physicochemical properties, specifically hydrophilic agent doxorubicin (DOX) hydrophobic compound curcumin (CUR), in TC cell lines. Methods: Nα-9-fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) peptide-based NGs loaded DOX CUR were formulated using solvent-switch method. DOX-loaded previously characterized. CUR-loaded characterized through rheology, scanning electron microscopy (SEM), dynamic light scattering (DLS), nanoparticle tracking analysis (NTA), Fourier transform infrared (FT-IR) spectroscopy. Confocal microscopy, q-RT-PCR, ATP lite assays performed evaluate uptake delivery DOX- on Results: exhibited mean diameter approximately 204.3 nm zeta potential -34.6 mV, indicative good stability. vitro release studies revealed sustained profile over 72 h. Functional analyses demonstrated that Fmoc-FF-loaded internalized They primarily localized cytoplasm rather than early endosomes, thereby ensuring intracellular Furthermore, Fmoc-FF reduced nuclear kinetics cells, suggesting reduction dose-limiting toxicity. Comparative similar internalization delayed uptake, highlighting efficacy delivering agents. Conclusions: Overall, data suggest represent diverse properties TC, enhancing their safety warranting further investigation.
Language: Английский
Citations
2
Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12
Published: Nov. 15, 2021
Receptor tyrosine kinases (RTKs) are transmembrane cell-surface proteins that act as signal transducers. They regulate essential cellular processes like proliferation, apoptosis, differentiation and metabolism. RTK alteration occurs in a broad spectrum of cancers, emphasising its crucial role cancer progression suitable therapeutic target. The use small molecule inhibitors however, has been crippled by the emergence resistance, highlighting need for pleiotropic anti-cancer agent can replace or be used combination with existing pharmacological agents to enhance treatment efficacy. Curcumin is an attractive mainly due potent effects, extensive range targets minimal toxicity. Out numerous documented curcumin, RTKs appear one main nodes curcumin-mediated inhibition. Many studies have found curcumin influences activation their downstream signaling pathways resulting increased decreased proliferation migration both vitro vivo. This review focused on how exhibits effects through inhibition MAPK, PI3K/Akt, JAK/STAT, NF-κB pathways. Combination were also analysed emphasis common molecular targets.
Language: Английский
Citations
95
Advances in Colloid and Interface Science, Journal Year: 2021, Volume and Issue: 300, P. 102582 - 102582
Published: Dec. 14, 2021
Language: Английский
Citations
87
Biochemical Pharmacology, Journal Year: 2020, Volume and Issue: 184, P. 114364 - 114364
Published: Dec. 11, 2020
Language: Английский
Citations
82
Phytotherapy Research, Journal Year: 2021, Volume and Issue: 35(12), P. 6514 - 6529
Published: Aug. 4, 2021
The efficacy of chemotherapy in cancer therapy is limited due to resistance, treatment selectivity, and severe adverse effects. Immunotherapy, chemotherapy, targeted therapy, radiation, surgery are the most common therapeutic strategies for treatment, with being successful. Nonetheless, these treatments exhibit poor effectiveness toxicity resistance. Therefore, combination therapies natural products may be used as an effective novel strategy overcome such barriers. Cisplatin a platinum‐based agent, when administered alone, it can lead effects resistance mechanism resulting failure. Curcumin polyphenolic compound extracted from turmeric ( Curcuma longa ) exhibiting anticancer potential minimal curcumin cisplatin mitigate/attenuate cisplatin‐related improve barrier reducing unwanted However, there uncertainties on curcumin, more depth high‐quality studies needed. This review aims explain related individual delivery, positive outcome nano platform therapy.
Language: Английский
Citations
76
Molecules, Journal Year: 2021, Volume and Issue: 27(1), P. 236 - 236
Published: Dec. 31, 2021
Curcumin, the dietary polyphenol isolated from Curcuma longa (turmeric), is commonly used as an herb and spice worldwide. Because of its bio-pharmacological effects curcumin also called “spice life”, in fact it recognized that possesses important proprieties such anti-oxidant, anti-inflammatory, anti-microbial, antiproliferative, anti-tumoral, anti-aging. Neurodegenerative diseases Alzheimer’s Diseases, Parkinson’s Multiple Sclerosis are a group characterized by progressive loss brain structure function due to neuronal death; at present there no effective treatment cure these diseases. The protective effect against some neurodegenerative has been proven vivo vitro studies. current review highlights latest findings on neuroprotective curcumin, bioavailability, mechanism action possible application for prevention or disorders.
Language: Английский
Citations
74