The current applications of nano and biomaterials in drug delivery of dental implant

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 24, 2024

Abstract Background and aim Dental implantology has revolutionized oral rehabilitation, offering a sophisticated solution for restoring missing teeth. Despite advancements, issues like infection, inflammation, osseointegration persist. Nano biomaterials, with their unique properties, present promising opportunities enhancing dental implant therapies by improving drug delivery systems. This review discussed the current applications of nano biomaterials in implants. Method A literature examined recent studies advancements implantology. Various materials, including nanoparticles, biocompatible polymers, bioactive coatings, were reviewed efficacy controlled release, antimicrobial promotion osseointegration. Results exhibit considerable potential Nanostructured carriers demonstrate enhanced therapeutic efficacy, sustained release profiles, improved biocompatibility. Furthermore, coatings contribute to better reduced risks infections. Conclusion Integrating implants holds promise advancing clinical outcomes. Enhanced systems can mitigate complications associated procedures, infection control, optimized

Language: Английский

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Antibiotic-Loaded Platelet-Rich Fibrin (AL-PRF) as a New Carrier for Antimicrobials: A Systematic Review of In Vitro Studies

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2140 - 2140

Published: Feb. 27, 2025

Platelet-rich fibrin (PRF) has emerged as a promising scaffold for drug delivery, particularly in the context of antimicrobial therapies. This systematic review evaluates incorporation antibiotics into PRF to determine its efficacy localized delivery system compared plain without antibiotics. A was conducted according Preferred Reporting Items Systematic Reviews and Meta-Analyses (PRISMA) guidelines, including 13 vitro studies with moderate risk bias. Antibiotics were incorporated using different methodologies, systemic administration before blood collection, addition centrifugation, injection formed matrices. Outcomes analyzed regarding antibacterial efficacy, structural integrity PRF, release kinetics. Antibiotic-enhanced demonstrated significant activity against various bacterial strains. The enhanced dependent on type antibiotic, concentration, method. Encapsulation approaches facilitated sustained antibiotic release, while higher concentrations occasionally disrupted integrity. Systemic collection enriches effectively, producing inhibition zones. effects outperformed alternative carriers, such collagen sponges. Antibiotic-loaded is potent tool applications clinical settings. Further research needed standardize preparation protocols explore impact methods PRF's regenerative properties.

Language: Английский

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Autologous platelet concentrates as adjuvant in the surgical management of medication‐related osteonecrosis of the jaw

Periodontology 2000, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Abstract Medication‐related osteonecrosis of the jaw (MRONJ) is an infectious side effect associated with bisphosphonates and monoclonal antibodies (denosumab, immune modulators, antiangiogenic medications). Adjunctive therapies for surgical management MRONJ include autologous platelet concentrates (APCs). These APCs serve as a source various cells growth factors that aid tissue healing regeneration. This review evaluated use platelet‐rich plasma (PRP), plasma‐rich in (PRGF), leukocyte‐ fibrin (L‐PRF) adjuvant by conducting analyses on results 58 articles. Compared to treatment alone, application PRP L‐PRF after surgery appears increase patients MRONJ. No studies have reported unhealed lesions result PRGF or compared it alone. The overall this shown favorable rates managed treatment; however, significant methodological limitations may limit scientific evidence supporting their use. Further randomized controlled trials strict criteria are needed establish extent which can improve wound quality life requiring treatment.

Language: Английский

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Advanced Platelet-Rich Fibrin (A-PRF) as Antibiotics Delivery System: In-Vitro Proof-of-Concept Study

Materials, Journal Year: 2025, Volume and Issue: 18(3), P. 570 - 570

Published: Jan. 27, 2025

Autologous blood centrifugation produces various forms of platelet concentrates widely used in tissue regenerative therapies due to their high concentrations growth factors and abundance autologous cells. Advanced Platelet-Rich Fibrin (A-PRF), introduced as a low-speed product, contains an even higher concentration factors, greater number cells, looser fibrin clot structure compared previous Leukocyte (L-PRF). This study aims assess the potential A-PRF local delivery system for antibiotics. Different (0.5 mg/mL, 0.25 0.125 mg/mL) injectable amoxicillin (AMX) metronidazole (MTZ) were preliminarily tested impact on formation, with 0.5 mg/mL selected subsequent experiments. Blood samples from healthy volunteers supplemented antibiotics centrifuged form clots. Antibiotic-enriched clots immersed phosphate-buffered saline (1x PBS) analyzed at 24 h, 72 7 days, 14 days. AMX showed consistent release (mean: 19.9 ± 4.8 ng/mL h) over while MTZ demonstrated variability 12.8 4.5 h). remained constant 14-day period, no significant variations among patients. In contrast, displayed progressively lower time. Microbiological analysis revealed bacterial inhibition zones Fusobacterium nucleatum (AMX: 23 mm, MTZ: 28 mm) Prevotella intermedia 34 30 h. These findings suggest that can act effective antibiotic system, maintaining sustained antimicrobial activity potentially reducing need systemic

Language: Английский

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Application of sticky bone combined with concentrated growth factor (CGF) for horizontal alveolar ridge augmentation of anterior teeth: a randomized controlled clinical study

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: April 8, 2024

Abstract Objective This study was designed to estimate the effect of sticky bone combined with concentrated growth factor (CGF) on anterior alveolar horizontal augmentation during implantation. Methods Twenty-eight patients were randomly assigned either test group (Group 1, n = 14) or control 2, 14). Patients in Group 1 and 2 underwent GBR using CGF powders mixed saline, respectively. On postoperative Day 7, completed visual analogue scale (VAS). Three-dimensional models maxillary reconstructed from CBCT data at different periods, volume conversion rate calculated assistance a measurement marker guide. Labial thickness before after trauma closure density six months postoperatively also measured. Results The mean for (72.09 ± 12.18%) greater than that (57.47 9.62%, P 0.002). VAS score lower ( 0.032). At postoperatively, found those although difference not statistically significant > 0.05). change labial graft material smaller 0.025). Conclusion Sticky able achieve better conventional GBR. With excellent mechanical properties capacity release factors, is an ideal grafting. Trial registration registered Chinese Clinical Registry 10/04/2022 (Identification number: ChiCTR2200058500).

Language: Английский

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Aesthetic Rehabilitation Medicine: Enhancing Wellbeing beyond Functional Recovery

Medicina, Journal Year: 2024, Volume and Issue: 60(4), P. 603 - 603

Published: April 5, 2024

Although rehabilitation medicine emphasizes a holistic health approach, there is still large gap of knowledge about potential interventions aimed at improving overall wellbeing through cosmetic interventions. Therefore, this narrative review investigates the role different rehabilitative techniques in enhancing aesthetics, quality life, and psychosocial for patients with disabilities. The study follows SANRA framework criteria review. Literature searches across PubMed/Medline, Web Science, Scopus identified articles focusing on strategies within aesthetic domain. evidence supporting injection procedures, such as Botulinum Toxin, Platelet-Rich Plasma, Hyaluronic Acid, Ozone, Carboxytherapy, assessing their applications several disabling disorders. Additionally, physical therapies like Extracorporeal Shock Wave Therapy, Laser Microcurrent Tecar exercises were explored impact cutaneous microcirculation, cellulite treatment, wound healing, scar appearance improvement. Lastly, manuscript underlines manual therapy addressing both discomfort concerns, discussing effectiveness adipose tissue therapy, mobilization, regional fat thickness reduction. Taken together, multidisciplinary aiming to provide valuable insights into benefits functional outcomes.

Language: Английский

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New biomaterials for modern dentistry

BMC Oral Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: Oct. 29, 2023

Whilst the appropriate assessment criteria for dental biomaterials is debated, there has been an increasing interest in use of oral rehabilitation. Consequently, a variety new have introduced dentistry. To address this issue, BMC Oral Health launched Collection on "New modern dentistry".

Language: Английский

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Platelet rich fibrin and MTA in the treatment of teeth with open apices

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 13, 2024

Abstract Background The present study aimed to evaluate the effectiveness of using platelet-rich fibrin (PRF) as apical matrix for placement MTA in nonsurgical endodontic therapy teeth with periapical lesions and open apices. Methods Twelve from eleven patients periodontitis apices were enrolled study. Nonsurgical was performed PRF used an barrier manipulated plug further thermoplasticized gutta percha remaining part root canal. Clinical signs digital radiographs recorded analyzed curing progress after periodical follow-ups 1, 3, 6 months. horizontal dimension lesion determined, changes dimensions each time. Friedman test statistical analysis, P < .05 serving threshold determining significance. Results All had no clinical symptoms first month treatment, a significant reduction appointments. Conclusions is effective when combined treatment

Language: Английский

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The preventive effect of photocrosslinked Hep/GelMA hydrogel loaded with PRF on MRONJ

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 29, 2024

Medication-related osteonecrosis of the Jaw (MRONJ) is a rare but severe side effect in patients treated with medications such as Bisphosphonates (BPs). Its pathophysiological mechanism needs to be more precise. Establishing preventive measures and treatment standards necessary. This study aimed develop composite hydrogel scaffold constituted by methacrylated gelatin (GelMA), heparin (HepMA) PRF, investigate its potential application value prevention MRONJ.

Language: Английский

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Modified minimally invasive surgical technique with clindamycin‐augmented or non‐augmented platelet‐rich fibrin in periodontal regeneration: A randomized clinical trial

Journal of Periodontal Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Abstract Aim Injectable platelet‐rich fibrin (I‐PRF), a second‐generation platelet concentrate, is widely used to enhance soft and hard tissue healing alone or in combination with biomaterials, relying on its harboring of various pivotal growth/differentiation factors. This randomized trial assessed the effect clindamycin (CLN) augmented injectable (I‐PRF) modified minimally invasive surgical technique (M‐MIST) versus I‐PRF M‐MIST clinical radiographic parameters management periodontal intra‐bony defects patients stage‐III grade B periodontitis. Methods 9‐month parallel‐grouped, two arm, double‐blinded, controlled (RCT) that included 28 ( n = 28) periodontitis, who were allocated randomly test‐ (CLN/I‐PRF + M‐MIST, 50 μL CLN per 1 mL I‐PRF; 14) control‐group (I‐PRF M‐MIST; 14). Clinical attachment level (CAL; primary outcome), probing depth (PD), gingival margin (GML), plaque index (PI), (GI) recorded at baseline, 3, 6, 9 months, whereas linear defect (RLDD), area (RDA) months. The release kinetics from further characterized. Results Compared both groups independently demonstrated significant improvements CAL, PD, GML, GI, PI, RLDD BDA 6 months p < .05). A reduction CAL measurements was noticeable CLN/I‐PRF group over time showed significantly lower than PRF after three as well Intergroup comparisons CAL‐gain non‐significant between > .05), GI PD‐reduction higher steadily released for up 48 h, peak concentration 24 which then gradually declined till seventh day. Conclusions provided improvement postoperatively CLN, applied duration, does not appear positively impact these observed effects.

Language: Английский

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