Clinical and Biochemical Evaluation of the Use of Alb-PRF versus L-PRF in Mandibular Third Molar Extractions: A Split-Mouth Randomized Clinical Trial

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(10), P. 505 - 505

Published: Oct. 10, 2023

Bone tissue engineering seeks biomaterials that enable cell migration, angiogenesis, matrix deposition, and regeneration. Blood concentrates like platelet-rich fibrin (L-PRF) offer a cost-effective source of cells growth factors to enhance healing. The present study aimed evaluate heated serum albumin with liquid PRF (Alb-PRF) L-PRF clinically biochemically after placement in dental sockets following mandibular third molar extraction. In controlled, split-mouth involving 10 volunteers, 20 extracted molars were treated either Alb-PRF or L-PRF. Post-extraction, pain, trismus, infection presence, swelling measured. concentrations different analytes the surgical sites also examined. data statistically analyzed, significance defined at p < 0.05 (t-test). No significant difference was noted between groups for pain but showed reduction on day seven. group lower levels pro-inflammatory cytokines (GM-CSF, IL-1b, IL-6, IFNy, IL-8, IL-15, RANTES, MIP-1a) seven days, only higher expressions MIP-1b, MCP-1 found group. Differences observed release Alb-PRF, significantly reducing edema days. reduced edema, while increased inflammatory cytokines. When compared L-PRF, cytokines, suggesting promising effects socket healing underscoring role potential applications blood concentrates.

Language: Английский

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A novel concentrated growth factor (CGF) and bio-oss based strategy for second molar protection after impacted mandibular third molar extraction: a randomized controlled clinical study

BMC Oral Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: Oct. 12, 2023

Abstract Background The extraction of impacted mandibular third molars might cause large bone defects in the distal area second molars. A new strategy was innovatively employed here combining autologous bone, Bio-Oss, concentrated growth factors (CGF) gel and CGF membrane for repair, present study aimed at exploring safety as well short- long-term efficacy this protocol clinically. Materials methods total 66 participants were enrolled randomized single-blind clinical trial, randomly allocated to control group (only blood clots), test (autogenous Bio-Oss with barrier membrane) B membrane). postoperative outcomes including PoSSe scale, periodontal probing depth (PD), degree gingival recession computed tomography measurements assessed 3rd, 6th, 12th month. p-value < 0.05 considered statistically significant. Results In no significant difference observed except a alleviation early-stage pain perception (p 0.05). Also, exhibited better effect on healing reduction after 6 months Both two groups showed more formation than It is noteworthy that repair significantly 3rd 6th month 0.05), yet > Conclusion could achieve stable defect repair. use accelerate alleviate short-term surgery, reduce relieve economic cost patients. This worthy promoting by clinicians. Trial registration registered identification number ChiCTR2300068466 20/02/2023 Chinese Clinical Registry. it ethically approved from institutional ethics committee Tongren Hospital, Shanghai Jiao Tong University School Medicine, Shanghai, China (No:2023-010-01), has been conducted accordance guidelines declaration Helsinki. Written informed consent obtained all study.

Language: Английский

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Extraction Socket Augmentation with Autologous Platelet Rich Fibrin (PRF): Case Reports and the Rationale for PRF

Published: Sept. 7, 2023

Alveolar bone atrophy after tooth extraction presents significant difficulties when planning delayed-immediate implant treatment to replace a lost tooth. Socket augmentation is an effective therapy that limits the post volumetric changes and facilitates placement whilst reducing need for staged grafting. However, socket osteoconductive graft conversion slow process could take 4-6 months. PRF its variants have bio-enhancement effect on wound healing regeneration through release of platelet drived growth factors, bioactive substances, cytokines. Leukocytes in also play role enhancing tissue as part osteo-immune response. Use during highly site integration by angiogenesis, cell proliferation, recruitment, differentiation factors substances mediated platelets leukocytes. with SA recommended adjunct sole biomaterial or combination xenograft allograft substitutes enhance reduce risk infection, osteitis postoperative pain sockets

Language: Английский

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Volumetric evaluation of effects of platelet-rich fibrin and concentrated growth factor on early bone healing after endodontic microsurgery: a randomized controlled trial

BMC Oral Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: Oct. 29, 2023

Abstract Background This randomized controlled clinical trial compared the effects of platelet-rich fibrin (PRF) and concentrated growth factor (CGF) on early bone healing after endodontic microsurgery. Methods Eighteen patients with an isolated periapical lesion < 10 mm in maxillary anterior region were randomly assigned to three groups: control, PRF, or CGF. Endodontic microsurgery was performed PRF CGF membranes placed over defects experimental groups. The volume defect at postoperative one week, months, six months evaluated using cone-beam computed tomography Mimics software. results statistically analyzed Kruskal–Wallis test post-hoc Mann–Whitney U Bonferroni correction. Results At three-month follow-up, groups showed significantly greater control group (p > 0.05). However, no significant difference observed between six-month differences Conclusions These suggested that promote

Language: Английский

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In vitro studies support clinical trials showing platelet-rich fibrin-mediated local delivery of antibiotics improves outcomes in impacted mandibular third molar surgery

Journal of drug targeting, Journal Year: 2024, Volume and Issue: 33(1), P. 87 - 98

Published: Aug. 22, 2024

Our previous clinical observations showed that platelet rich fibrin (PRF) can be used to deliver antibiotics attenuate postoperative complications after unilaterally impacted mandibular third molar surgery (IMTMS). In order begin understanding the mechanism involved in beneficial vivo effects of PRF-mediated delivery antibiotics, vitro studies were performed, which PRF preparations containing amoxicillin/clavulanic acid or clindamycin significantly inhibited growth S. aureus bacteria. our study, comparisons made between control and treated groups. However, since variations among individual patients could possibly affect results, current study included with bilaterally symmetric molars, allowing us compare antibiotic treatment within each patient. The on IMTMS was tested 60 cases. Antibiotic-injected resulted reduced pain, less use analgesics, swelling trismus compared group (PRF without antibiotics) confirming results IMTMS. support hypothesis using produces therapeutic by attenuating bacterial infection inflammation.

Language: Английский

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