ELLAGIC ACID: A REVIEW ON NATURAL SOURCES AND MEDICINAL IMPORTANCE DOI Open Access

Ana Maria Stoenescu,

Ion Trandafir

Annals of the University of Craiova Series Biology Horticulture Food products processing technology Environmental engineering, Journal Year: 2023, Volume and Issue: 28(64)

Published: Dec. 19, 2023

Ellagic acid is a phenolic compound present in different plant species mainly fruits and vegetables (and other parts such as leaves, root, bark, kernel) but also processed foods (jams, alcoholic non-alcoholic beverages) with role protecting the body against numerous conditions due to its antioxidant capacity. The amount of ellagic depending on species, type sample, temperature extraction method, respectively method analysis. This paper proposes an analysis specialized literature regarding importance for human body, studied high content acid, therapeutic medicinal potential compound.

Language: Английский

Exercise training improves diabetic renal injury by reducing fetuin-A, oxidative stress and inflammation in type 2 diabetic rats DOI Creative Commons
Shadan Saberi, Majid Askaripour, Mohammad Khaksari

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e27749 - e27749

Published: March 1, 2024

BackgroundDiabetic kidney disease (DKD) stands as a primary contributor to end-stage renal disease, associated with heightened mortality in cardiovascular diseases. This study aimed explore the impact of an eight-week high-intensity interval training (HIIT) on injury diabetic rats.Methods.Twenty-eight male Wistar rats were randomly allocated into four groups: healthy control (CTL), (DC), exercise (EX), and diabetes-exercise (D + EX). Induction diabetes DC D EX groups occurred through two-month high-fat diet followed by single dose 35 mg/kg streptozotocin (STZ). Rats underwent 4–10 intervals HIIT (80–100% Vmax) over 8 weeks. Subsequently, pathological biochemical parameters assessed serum tissue experimental groups.Results.In group, led elevated damage, glomerulosclerosis, fasting blood glucose (FBG), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index, animal weight, dysfunction, albuminuria, glomerular filtration rate. Additionally, levels fetuin-A increased, along KIM-1. Mechanistically, induction resulted inflammation elevating tumor necrosis factor-alpha (TNF-α), transforming growth factor beta (TGF-β), interleukin 6 (IL-6), while reducing IL-10 increasing IL-6/IL-10 ratio. Furthermore, triggered oxidative stress, evidenced increased Malondialdehyde (MDA) decreased glutathione peroxidase (GPx), catalase, superoxide dismutase (SOD). mitigated adverse effects group compared group.Conclusion.Our findings suggest that ameliorates type 2 (T2D)-induced damage mitigating inflammation, lowering fetuin-A, bolstering antioxidant defenses. highlights potential time-efficient intervention nephropathy.

Language: Английский

Citations

12
Interaction of estradiol and renin–angiotensin system with microRNAs-21 and -29 in renal fibrosis: focus on TGF-β/smad signaling pathway DOI
Soodeh Rajabi, Shadan Saberi, Hamid Najafipour

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Jan. 18, 2024

Language: Английский

Citations

11
Targeting epigenetic and post-translational modifications of NRF2: key regulatory factors in disease treatment DOI Creative Commons
Xinyi Yang, Yingchao Liu, Jie Cao

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 21, 2025

Abstract Nuclear factor erythroid 2-related 2 (NRF2) is a key transcription involved in regulating cellular antioxidant defense and detoxification mechanisms. It mitigates oxidative stress xenobiotic-induced damage by inducing the expression of cytoprotective enzymes, including HO-1 NQO1. NRF2 also modulates inflammatory responses inhibiting pro-inflammatory genes mediates cell death pathways, apoptosis ferroptosis. Targeting offers potential therapeutic avenues for treating various diseases. regulated through two principal mechanisms: post-translational modifications (PTMs) epigenetic alterations. PTMs, phosphorylation, ubiquitination, acetylation, play pivotal role modulating NRF2’s stability, activity, subcellular localization, thereby precisely controlling its function response. For instance, ubiquitination can lead to degradation reduced while deubiquitination enhances stability function. Epigenetic modifications, such as DNA methylation, histone interactions with non-coding RNAs (e.g., MALAT1, PVT1, MIR4435-2HG, TUG1), are essential chromatin architecture gene accessibility. This paper systematically summarizes molecular mechanisms which PTMs alterations regulate NRF2, elucidates critical disease. By analyzing impact well RNA on expression, study reveals complex protection network mediated NRF2. Furthermore, explores how these regulatory affect roles stress, inflammation, death, identifying novel targets strategies. provides new insights into treatment NRF2-related diseases, cancer, neurodegenerative disorders, metabolic syndrome. research deepens our understanding homeostasis lays foundation development NRF2-targeted therapies.

Language: Английский

Citations

1
ATP releasing channels and the ameliorative effects of high intensity interval training on diabetic heart: a multifaceted analysis DOI Creative Commons
Siyavash Joukar, Mohammad Amin Rajizadeh, Mohammad Abbas Bejeshk

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 26, 2024

Abstract Type 2 diabetes (T2D) can cause severe cardiac complications at functional, histologic and molecular levels. These pathological could be mediated by ATP-releasing channels such as Panx1 ATP receptors, in particular P2X7. The aim of our study was to investigate the effect high-intensity interval training (HIIT) on T2D-induced histopathological levels, with a focus channels. 48 male Wistar rats age 8 weeks were randomly allocated into four groups: control (Con), Diabetes (T2D), Training (TR), + (T2D TR). T2D induced high-fat diet plus low dose (35 mg/kg) STZ administration. Rats TR groups underwent an 8-weeks program involving intervals ranging from 80 100% their maximum running speed (Vmax), 4–10 per session. Protein expression Interleukin 1β (IL1β), 10 (IL-10), Pannexin 1 (Panx1), P2X7R (purinergic P2X receptor 7), NLRP1 (NLR Family Pyrin Domain Containing 1), BAX, Bcl2 measured heart tissue. Additionally, we assessed function, changes, well insulin resistance using homeostasis model assessment (HOMA-IR). In contrast group, HIIT led increased protein IL-10 heart. It also resulted improvements systolic diastolic blood pressures, rate, ± dp/dt (maximum minimum changes left ventricular pressure), while reducing IL-1β, Panx1, P2X7R, NLRP1, BAX levels Furthermore, pressure (LVDP) reduced ( P ≤ 0.05). Moreover, lesion scores but decreased HIIT, along reduction fibrosis percentage results this suggest that cardioprotective effects diabetic may modulation This lead inflammation apoptosis, improve attenuate injury fibrosis.

Language: Английский

Citations

8
Effects of voluntary, and forced exercises on neurotrophic factors and cognitive function in animal models of Parkinson's disease DOI
Forouzan Rafie, Mohammad Amin Rajizadeh, Mehdi Shahbazi

et al.

Neuropeptides, Journal Year: 2023, Volume and Issue: 101, P. 102357 - 102357

Published: June 26, 2023

Language: Английский

Citations

14
Kidney Aging and Chronic Kidney Disease DOI Open Access
Yingying Zhang, Yu Chen, Xiaogang Li

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6585 - 6585

Published: June 14, 2024

The process of aging inevitably leads to an increase in age-related comorbidities, including chronic kidney disease (CKD). In many aspects, CKD can be considered a state accelerated and premature aging. Aging have numerous common characteristic features, ranging from pathological presentation clinical manifestation underlying mechanisms. shared mechanisms the development include cellular senescence, decrease autophagy, mitochondrial dysfunction, alterations epigenetic regulation, suggesting existence potential therapeutic targets that are applicable both conditions. this review, we provide comprehensive overview characteristics between CKD, encompassing morphological changes, functional alterations, recent advancements understanding Moreover, discuss strategies for targeting senescent cells CKD.

Language: Английский

Citations

6
Ellagic acid ameliorates arsenic-induced neuronal ferroptosis and cognitive impairment via Nrf2/GPX4 signaling pathway DOI Creative Commons
Xiyue Yang,

Fang Chu,

Zhe Jiao

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 283, P. 116833 - 116833

Published: Aug. 10, 2024

Language: Английский

Citations

6
An Updated Comprehensive Review of Plants and Herbal Compounds with Antiasthmatic Effect DOI Open Access
Mohammad Amin Rajizadeh, Hamid Najafipour, Mohammad Abbas Bejeshk

et al.

Evidence-based Complementary and Alternative Medicine, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 36

Published: Feb. 8, 2024

Background. Asthma is a common disease with rising prevalence worldwide, especially in industrialized countries. Current asthma therapy traditional medicines lacks satisfactory success, hence the patients’ search for alternative and complementary treatments their diseases. Researchers have conducted many studies on plants antiallergic antiasthmatic effects recent decades. Many of these are now used clinics, searching mechanism action may result creating new ideas producing more effective drugs. Purpose. The goal this review was to provide compilation findings active agents experimentally confirmed effects. Study Design Method. A literature from 1986 November 2023 Scopus, Springer Link, EMBASE, Science Direct, PubMed, Google Scholar, Web identify report accumulated knowledge herbs compounds that be treatment. Results. results revealed 58 32 herbal extracted had activity. Also, were shown anti-inflammatory antioxidative or act as bronchodilators potentially effects, which must investigated future studies. Conclusion. ability medicine improve symptoms has been by clinical preclinical studies, such source developing Moreover, suggests bioactive therapeutic potential against asthma.

Language: Английский

Citations

4
The Antiaging and Antioxidative Effects of a Combination of Resveratrol and High‐Intensity Interval Training on the Frontal Lobe in Aged Rats: The Role of SIRTS 4, SIRTS 5, SOD1, and SOD2 DOI Creative Commons
Amin Mehrabi, Reza Nouri, A A Gaeini

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Introduction: High‐intensity interval training (HIIT) is a form of exercise that enhances capacity and benefits well‐being. Resveratrol naturally occurring polyphenol prevalent in grapes red wine, demonstrating significant health effects on the body. This study sought to evaluate synergistic swimming HIIT resveratrol intake expression SIRTs 4, 5, superoxide dismutases (SOD1 SOD2) frontal lobe elderly rats. Materials Methods: Forty‐five male Wistar rats, aged 22 months, were categorized into five groups: control group (CTL), (Ex: Exercise), with (R + Ex), (R), solvent (vehicle). The R Ex engaged high‐intensity ingested (10 mg/kg/day via gavage) for 6 weeks. During initial final sessions each week, blood samples from rats groups collected lactate analysis. proteins 4 as well SODs 1 2, quantified using western blot approach. Results: Integrating markedly enhanced SIRT4, SIRT5, antioxidant enzymes Conclusion: HIIT, particularly their effects, provide antiaging

Language: Английский

Citations

0
Various endurance training intensities improve GFR and Up-regulate AQP2/GSK3β in lithium-induced nephropathic rats DOI Creative Commons

Shadan Saberi,

Mohammad Amin Rajizadeh, Mohammad Khaksari

et al.

BMC Nephrology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 6, 2025

Language: Английский

Citations

0