circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Jan. 12, 2021

Abstract Circular RNAs (circRNA) are a class of covalently closed single-stranded that have been implicated in cancer progression. Here we identify circNDUFB2 to be downregulated non-small cell lung (NSCLC) tissues, and negatively correlate with NSCLC malignant features. Elevated inhibits growth metastasis cells. Mechanistically, functions as scaffold enhance the interaction between TRIM25 IGF2BPs, positive regulator tumor progression metastasis. This TRIM25/circNDUFB2/IGF2BPs ternary complex facilitates ubiquitination degradation this effect enhanced by N 6 -methyladenosine (m A) modification . Moreover, is also recognized RIG-I activate RIG-I-MAVS signaling cascades recruit immune cells into microenvironment (TME). Our data thus provide evidences participates IGF2BPs activation anti-tumor immunity during via modulation both protein degradation, well cellular responses.

Language: Английский

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Whole-Genome Duplication and Plant Macroevolution

Trends in Plant Science, Journal Year: 2018, Volume and Issue: 23(10), P. 933 - 945

Published: Aug. 17, 2018

Language: Английский

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Evolution of neuropeptide signalling systems

Journal of Experimental Biology, Journal Year: 2018, Volume and Issue: 221(3)

Published: Feb. 1, 2018

ABSTRACT Neuropeptides are a diverse class of neuronal signalling molecules that regulate physiological processes and behaviour in animals. However, determining the relationships evolutionary origins heterogeneous assemblage neuropeptides identified range phyla has presented huge challenge for comparative physiologists. Here, we review revolutionary insights into evolution neuropeptide have been obtained recently through analysis genome/transcriptome sequence data by ‘deorphanisation’ receptors. The at least 30 systems traced to common ancestor protostomes deuterostomes. Furthermore, two rounds genome duplication gave rise an expanded repertoire vertebrate lineage, enabling neofunctionalisation and/or subfunctionalisation, but with lineage-specific gene loss additional or duplications generating complex patterns phylogenetic distribution paralogous systems. We entering new era research where it become feasible compare roles orthologous wide phyla. Moreover, ambitious mission reconstruct function animal kingdom now represents tangible future.

Language: Английский

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The multifaceted roles of macrophages in bone regeneration: A story of polarization, activation and time

Acta Biomaterialia, Journal Year: 2021, Volume and Issue: 133, P. 46 - 57

Published: May 8, 2021

Language: Английский

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A chromosome-level genome of the spider Trichonephila antipodiana reveals the genetic basis of its polyphagy and evidence of an ancient whole-genome duplication event

GigaScience, Journal Year: 2021, Volume and Issue: 10(3)

Published: March 1, 2021

Abstract Background The spider Trichonephila antipodiana (Araneidae), commonly known as the batik golden web spider, preys on arthropods with body sizes ranging from ∼2 mm in length to insects larger than itself (>20‒50 mm), indicating its polyphagy and strong dietary detoxification abilities. Although it has been reported that an ancient whole-genome duplication event occurred spiders, lack of a high-quality genome limited characterization this event. Results We present chromosome-level T. constructed basis PacBio Hi-C sequencing. assembled is 2.29 Gb size scaffold N50 172.89 Mb. scaffolding assigned 98.5% bases 13 pseudo-chromosomes, BUSCO completeness analysis revealed assembly included 94.8% complete arthropod universal single-copy orthologs (n = 1,066). Repetitive elements account for 59.21% genome. predicted 19,001 protein-coding genes, which 96.78% were supported by transcriptome-based evidence 96.32% matched protein records UniProt database. also shows substantial expansions several detoxification-associated gene families, including cytochrome P450 mono-oxygenases, carboxyl/cholinesterases, glutathione-S-transferases, ATP-binding cassette transporters, reflecting possible genomic polyphagy. Further architecture reveals event, based 2 lines evidence: (i) large-scale duplications inter-chromosome synteny (ii) duplicated clusters Hox genes. Conclusions represents valuable resource research provides insights into species’ adaptation environment.

Language: Английский

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The Phylogeny and Evolutionary History of Arthropods

Current Biology, Journal Year: 2019, Volume and Issue: 29(12), P. R592 - R602

Published: June 1, 2019

Language: Английский

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Gene content evolution in the arthropods

Genome biology, Journal Year: 2020, Volume and Issue: 21(1)

Published: Jan. 23, 2020

Abstract Background Arthropods comprise the largest and most diverse phylum on Earth play vital roles in nearly every ecosystem. Their diversity stems part from variations a conserved body plan, resulting recorded adaptive changes genome. Dissection of genomic record sequence change enables broad questions regarding genome evolution to be addressed, even across hyper-diverse taxa within arthropods. Results Using 76 whole sequences representing 21 orders spanning more than 500 million years arthropod evolution, we document gene protein domain content provide temporal phylogenetic context for interpreting these innovations. We identify many novel families that arose early arthropods during diversification insects into modern orders. reveal unexpected variation patterns DNA methylation examples family coincident with appearance notable phenotypic physiological adaptations such as flight, metamorphosis, sociality, chemoperception. Conclusions These analyses demonstrate how large-scale comparative genomics can new insights genotype phenotype map generate testable hypotheses about animal diversity.

Language: Английский

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Interconnection between circadian clocks and thyroid function

Nature Reviews Endocrinology, Journal Year: 2019, Volume and Issue: 15(10), P. 590 - 600

Published: Aug. 12, 2019

Language: Английский

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Diversity and evolution of the P450 family in arthropods

Insect Biochemistry and Molecular Biology, Journal Year: 2020, Volume and Issue: 127, P. 103490 - 103490

Published: Oct. 23, 2020

The P450 family (CYP genes) of arthropods encodes diverse enzymes involved in the metabolism foreign compounds and essential endocrine or ecophysiological functions. sequences (CYPome) from 40 arthropod species were manually curated, including 31 complete CYPomes, a maximum likelihood phylogeny nearly 3000 is presented. Arthropod CYPomes are assembled members six CYP clans variable size, CYP2, CYP3, CYP4 mitochondrial clans, as well CYP20 CYP16 that not found Neoptera. CYPome sizes vary two dozen genes some parasitic to over 200 collembolans ticks. comprised few families with many genes, this distribution result dynamic birth death processes. Lineage-specific expansions blooms throughout often genomic clusters appear form reservoir catalytic diversity maintained heritable units. Among P450s physiological functions, ecdysteroid metabolism. However, five so-called Halloween universally represented do constitute unique pathway biosynthesis. has only partially been uncovered date functions regulating synthesis degradation endogenous signal molecules (including ecdysteroids) semiochemicals pheromones defense chemicals) remain be discovered. Sequence extreme, lacking conserved Cys ligand heme have evolved several times. A better understanding evolution needed discern relative contributions stochastic processes adaptive shaping size CYPomes.

Language: Английский

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Chitosan/Hyaluronic acid/Alginate and an assorted polymers loaded with honey, plant, and marine compounds for progressive wound healing—Know-how

International Journal of Biological Macromolecules, Journal Year: 2021, Volume and Issue: 186, P. 656 - 685

Published: July 14, 2021

Language: Английский

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