Journal of Controlled Release,
Journal Year:
2025,
Volume and Issue:
379, P. 202 - 220
Published: Jan. 10, 2025
Intracerebral
hemorrhage
(ICH)
is
associated
with
high
rates
of
mortality
and
disability,
underscoring
an
urgent
need
for
effective
therapeutic
interventions.
The
clinical
prognosis
ICH
remains
limited,
primarily
due
to
the
absence
targeted,
precise
options.
Advances
in
novel
drug
delivery
platforms,
including
nanotechnology,
gel-based
systems,
exosome-mediated
therapies,
have
shown
potential
enhancing
management.
This
review
delves
into
pathophysiological
mechanisms
provides
a
thorough
analysis
existing
treatment
strategies,
emphasis
on
innovative
approaches
designed
address
critical
pathological
pathways.
We
assess
benefits
limitations
these
offering
insights
future
directions
research
highlighting
transformative
next-generation
systems
improving
patient
outcomes.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
171, P. 116203 - 116203
Published: Jan. 26, 2024
Tumor
immunotherapy,
an
innovative
anti-cancer
therapy,
has
showcased
encouraging
outcomes
across
diverse
tumor
types.
Among
these,
the
PD-1/PD-L1
signaling
pathway
is
a
well-known
immunological
checkpoint,
which
significant
in
regulation
of
immune
evasion
by
tumors.
Nevertheless,
considerable
number
patients
develop
resistance
to
anti-PD-1/PD-L1
rendering
it
ineffective
long
run.
This
research
focuses
on
exploring
factors
PD-1/PD-L1-mediated
immunotherapy.
Initially,
characterized
its
role
facilitating
evasion,
emphasizing
autoimmune
homeostasis.
Next,
primary
mechanisms
PD-1/PD-L1-based
immunotherapy
are
analyzed,
including
antigen
deletion,
T
cell
dysfunction,
increased
immunosuppressive
cells,
and
alterations
expression
PD-L1
within
cells.
The
possible
ramifications
altered
metabolism,
microbiota,
DNA
methylation
also
described.
Finally,
resolution
strategies
for
dealing
with
discussed,
placing
particular
emphasis
personalized
therapeutic
approaches
exploration
more
potent
regimens.
Biomolecules and Biomedicine,
Journal Year:
2024,
Volume and Issue:
24(4), P. 897 - 911
Published: Feb. 23, 2024
Understanding
the
intricate
relationship
between
prognosis,
immune
function,
and
molecular
markers
in
bladder
cancer
(BC)
demands
sophisticated
analytical
methods.
To
identify
novel
biomarkers
for
predicting
prognosis
function
BC
patients,
we
combined
weighted
gene
co-expression
network
analysis
(WGCNA)
least
absolute
shrinkage
selection
operator
(LASSO)
regression
analysis.
This
was
conducted
using
data
from
The
Cancer
Genome
Atlas
(TCGA)
Gene
Expression
Omnibus
(GEO)
databases.
Ultimately,
screened
junctional
adhesion
molecule
3
(JAM3)
as
an
independent
risk
factor
BC.
High
levels
of
JAM3
were
linked
to
adverse
clinical
parameters,
such
higher
T
N
stages.
Additionally,
a
JAM3-based
nomogram
model
accurately
predicted
1-,
3-
5-year
survival
rates
indicating
potential
utility.
Functional
enrichment
revealed
that
high
expression
activated
calcium
signaling
pathway,
extracellular
matrix
(ECM)-receptor
interaction,
PI3K-Akt
positively
correlated
with
genes
associated
epithelial–mesenchymal
transition
(EMT).
Subsequently,
found
overexpression
promoted
migration
invasion
abilities
cells,
regulating
N-cadherin,
metallopeptidase
2
(MMP2),
Claudin-1
thereby
promoting
EMT
levels.
showed
negatively
anti-tumor
cells
CD8+
while
pro-tumor
M2
macrophages,
suggesting
its
involvement
cell
infiltration.
checkpoint
CD200
also
positive
correlation
JAM3.
Our
findings
elevated
are
predictive
poor
infiltration
patients
by
process.
iScience,
Journal Year:
2024,
Volume and Issue:
27(6), P. 109979 - 109979
Published: May 15, 2024
This
review
explores
the
hallmarks
of
cancer
resistance,
including
drug
efflux
mediated
by
ATP-binding
cassette
(ABC)
transporters,
metabolic
reprogramming
characterized
Warburg
effect,
and
dynamic
interplay
between
cells
mitochondria.
The
role
stem
(CSCs)
in
treatment
resistance
regulatory
influence
non-coding
RNAs,
such
as
long
RNAs
(lncRNAs),
microRNAs
(miRNAs),
circular
(circRNAs),
are
studied.
chapter
emphasizes
future
directions,
encompassing
advancements
immunotherapy,
strategies
to
counter
adaptive
integration
artificial
intelligence
for
predictive
modeling,
identification
biomarkers
personalized
treatment.
comprehensive
exploration
these
provides
a
foundation
innovative
therapeutic
approaches,
aiming
navigate
complex
landscape
enhance
patient
outcomes.
Journal of Hematology & Oncology,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Aug. 16, 2024
Cuproptosis
is
a
newly
identified
form
of
cell
death
induced
by
excessive
copper
(Cu)
accumulation
within
cells.
Mechanistically,
cuproptosis
results
from
Cu-induced
aggregation
dihydrolipoamide
S-acetyltransferase,
correlated
with
the
mitochondrial
tricarboxylic
acid
cycle
and
loss
iron–sulfur
cluster
proteins,
ultimately
resulting
in
proteotoxic
stress
triggering
death.
Recently,
has
garnered
significant
interest
tumor
research
due
to
its
potential
as
crucial
therapeutic
strategy
against
cancer.
In
this
review,
we
summarized
cellular
molecular
mechanisms
relationship
other
types
Additionally,
reviewed
current
drugs
or
strategies
available
induce
cells,
including
Cu
ionophores,
small
compounds,
nanomedicine.
Furthermore,
targeted
metabolism
specific
regulatory
genes
cancer
therapy
enhance
sensitivity
cuproptosis.
Finally,
discussed
feasibility
targeting
overcome
chemotherapy
immunotherapy
resistance
suggested
future
directions.
This
study
that
could
open
new
avenues
for
developing
therapy.
Journal of Hematology & Oncology,
Journal Year:
2025,
Volume and Issue:
18(1)
Published: Jan. 13, 2025
The
tumor
microenvironment
(TME)
is
integral
to
cancer
progression,
impacting
metastasis
and
treatment
response.
It
consists
of
diverse
cell
types,
extracellular
matrix
components,
signaling
molecules
that
interact
promote
growth
therapeutic
resistance.
Elucidating
the
intricate
interactions
between
cells
TME
crucial
in
understanding
progression
challenges.
A
critical
process
induced
by
epithelial-mesenchymal
transition
(EMT),
wherein
epithelial
acquire
mesenchymal
traits,
which
enhance
their
motility
invasiveness
progression.
By
targeting
various
components
TME,
novel
investigational
strategies
aim
disrupt
TME's
contribution
EMT,
thereby
improving
efficacy,
addressing
resistance,
offering
a
nuanced
approach
therapy.
This
review
scrutinizes
key
players
emphasizing
avenues
therapeutically
components.
Moreover,
article
discusses
implications
for
resistance
mechanisms
highlights
current
toward
modulation
along
with
potential
caveats.
Theranostics,
Journal Year:
2025,
Volume and Issue:
15(5), P. 1689 - 1714
Published: Jan. 2, 2025
In
recent
years,
nano-drug
delivery
systems
(Nano-DDS)
that
target
the
tumor
microenvironment
(TME)
to
overcome
multidrug
resistance
(MDR)
have
become
a
research
hotspot
in
field
of
cancer
therapy.
By
precisely
targeting
TME
and
regulating
its
unique
pathological
features,
such
as
hypoxia,
weakly
acidic
pH,
abnormally
expressed
proteins,
etc.,
these
Nano-DDS
enable
effective
therapeutic
agents
reversal
MDR.
This
scientific
community
is
increasing
investment
development
diversified
exploring
their
anti-drug
potential.
Therefore,
it
particularly
important
conduct
comprehensive
review
progress
TME-targeted
years.
After
brief
introduction
MDR,
design
principle
structure
liposomes,
polymer
micelles
inorganic
nanocarriers
are
focused
on,
characteristics
described.
It
also
demonstrates
how
break
through
MDR
treatment
various
mechanisms,
discusses
synthetic
innovation,
results
overcoming
mechanisms.
The
was
concluded
with
deliberations
on
key
challenges
future
outlooks
Journal of Cancer Research and Clinical Oncology,
Journal Year:
2023,
Volume and Issue:
149(12), P. 10851 - 10865
Published: June 15, 2023
The
serine
protease
inhibitor
clade
E
member
1
(SERPINE1)
has
been
studied
as
a
potential
biomarker
in
variety
of
cancers,
but
poorly
gastric
cancer
(GC).
purpose
this
study
was
to
explore
the
prognostic
value
SERPINE1
GC
and
primarily
analyze
its
functions.We
analyzed
relationship
with
clinicopathologic
biomarkers
cancer.
expression
by
GEO
TCGA
databases.
Moreover,
we
validated
results
immunohistochemistry.
Next,
correlation
analysis
between
cuproptosis-related
genes
"Spearman"
method.
CIBERSORT
TIMER
algorithms
were
used
immune
infiltration.
Furthermore,
GO
KEGG
gene
enrichment
analyses
functions
pathways
that
might
be
involved
in.
Then,
drug
sensitivity
performed
using
CellMiner
database.
Finally,
cuproptosis-immune-related
model
constructed
related
cuproptosis,
verified
against
external
datasets.SERPINE1
up-regulated
tissues,
which
tends
toward
poor
prognosis.
Using
immunohistochemistry
experiment,
verified.
found
negatively
correlated
FDX1,
LIAS,
LIPT1,
PDHA1.
On
contrary,
positively
APOE.
This
indicates
effect
on
cuproptosis
process.
conducting
immune-related
analyses,
it
revealed
may
promote
inhibitory
microenvironment.
infiltration
level
resting
NK
cells,
neutrophils,
activated
mast
macrophages
M2
SERPINE1.
However,
B
cell
memory
plasma
cells
Functional
showed
closely
angiogenesis,
apoptosis,
ECM
degradation.
pathway
associated
P53,
Pi3k/Akt,
TGF-β,
other
signaling
pathways.
Drug
could
also
seen
treatment
target.
risk
based
co-expression
better
predict
survival
patients
than
alone.
We
score
is
highly
expressed
regulate
microenvironment
series
Therefore,
therapeutic
target
deserves
further
study.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 8, 2024
Cancer
stands
as
a
prominent
global
cause
of
death.
One
the
key
reasons
why
clinical
tumor
chemotherapy
fails
is
multidrug
resistance
(MDR).
In
recent
decades,
accumulated
studies
have
shown
how
Natural
Product-Derived
Compounds
can
reverse
MDR.
Discovering
novel
potential
modulators
to
reduce
MDR
by
has
become
popular
research
area
across
globe.
Numerous
mainly
focus
on
natural
products
including
flavonoids,
alkaloids,
terpenoids,
polyphenols
and
coumarins
for
their
modulatory
activity.
regulating
signaling
pathways
or
relevant
expressed
protein
gene.
Here
we
perform
deep
review
previous
achievements,
advances
in
development
treatment
This
aims
provide
some
insights
study
products.
