Interacting and joint effects of triglyceride-glucose index (TyG) and body mass index on stroke risk and the mediating role of TyG in middle-aged and older Chinese adults: a nationwide prospective cohort study

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Jan. 13, 2024

Abstract Background Individuals who are overweight or obese often develop insulin resistance, mediation of the association between body mass index (BMI) and stroke risk through triglyceride-glucose (TyG) seems plausible but has not been investigated. This study aims to examine whether TyG mediates associations BMI with extent interaction joint relations outcome. Methods The China Health Retirement Longitudinal Study, initiated in 2011, is a nationally representative, ongoing prospective cohort involving 8 231 middle-aged older Chinese adults without history at baseline. Exposures examined include TyG, latter being logarithmized product fasting triglyceride glucose concentrations. primary outcome incidence, as determined self-reports, follow-up period extending from June 1, 30, 2018. Results Of participants, 3 815 (46.3%) were men; mean (SD) age was 59.23 (9.32) years. During median 7.1 years, 585 (7.1%) participants developed stroke. found mediate incident stroke, proportions mediated 16.3% for 24.0–27.9 kg/m 2 group 53.8% ≥ 28.0 group. No significant multiplicative additive interactions on (Additive: RERI = 1.78, 95% CI − 1.29–4.86; Multiplicative, HR 1.40, 0.86–2.27). HRs individuals quartile 4 compared those < 24.0 1 2.05 (95% 1.37–3.06) Combining enhanced predictive performance when their individual (AUC BMI+TyG vs AUC , 0.602 0.581 0.583). Conclusions appeared be associated more than 50% total adults. Public health efforts aiming reduction weight might decrease due resistance burden

Language: Английский

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Joint association of triglyceride glucose index (TyG) and a body shape index (ABSI) with stroke incidence: a nationwide prospective cohort study

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 6, 2025

Triglyceride glucose index(TyG) and a body shape index(ABSI) are both independent predictor of stroke incidence or adverse prognosis but these two indicators seldom were combined to predict. The purpose this study is evaluate whether the combination TyG ABSI better predict stroke. Based on China Health Retirement Longitudinal Study(CHARLS), 8,257 people aged 45 years older without enrolled followed up 9 years. Sociodemographic information, health status, physical examination blood data collected retrospectively. Cox regressions determine relationship between different groups incidence, using receiver operating characteristic curves diagnostic value. Meanwhile, subgroup analysis was performed investigate prediction performance among population. 672(8.14%) participants had during In adjusted multivariate cox regression model, still predictors HR 1.25(95%CI: 1.06-1.47) 1.33(95%CI: 1.06-1.68). Restricted cubic spline showed associations highest efficacy(AUC: 0.579, 95%CI: 0.553-0.597), compared TyG(AUC:0.566, 0.544-0.587) ABSI(AUC:0.533, 0.524-0.597). Kaplan-Meier that cumulative with high ABSI(TyG ≥ 8.5742, 0.0852; P < 0.0001), which incidence(HR:1.64, 95%CI:1.2-2.24). higher clinical value enabled earlier detection in general population, could be monitored intervened reduce overall burden

Language: Английский

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Long-term survival in stroke patients: insights into triglyceride-glucose body mass index from ICU data

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 25, 2024

Abstract Background The Triglyceride Glucose-Body Mass Index (TyG-BMI) has been established as a robust indicator of insulin resistance (IR), reflecting metabolic health across various populations. In general, lower TyG-BMI values are often associated with better outcomes and reduced risk adverse events in non-critically ill Previous studies have highlighted significant negative association between all-cause mortality (ACM) among critically atrial fibrillation patients. Given the high prevalence severe stroke, understanding how at time ICU admission correlates ACM stroke patients becomes imperative. This study aims to assess correlation this specific patient cohort, exploring traditional associations may differ context acute, life-threatening illness. Methods Patient data were retrieved by accessing Medical Information Mart for Intensive Care IV (MIMIC-IV 2.2) database, categorizing into three groups on basis tertiles. evaluated both primary secondary outcomes: included 90-day, 180-day, 1-year ACM, while encompassed ICU, in-hospital, 30-day ACM. Our employed Kaplan–Meier (K–M) curve method outcome comparison utilizing multivariate Cox proportional-hazards regression models restricted cubic splines (RCS) explore these outcomes. Additionally, interaction subgroup analyses performed, focusing different points. Results Among cohort 1707 individuals diagnosed average age was 68 years (interquartile range [IQR]: 58–78 years), 946 (55.42%) participants being male. analysis K-M curves suggested that having level faced heightened long-term whereas short-term exhibited no statistically differences groups. Furthermore, validated increased belonging lowest tertile. RCS results demonstrated L-shaped correlations index short- These findings underscore predictive value patients, highlighting nuanced relationship varies over frames. revealed interactions stratified variables, exception age. Conclusion our study, levels significantly related higher within United States. finding suggests potential marker stratifying population. However, it's crucial note not observed indicating utility be more pronounced prediction. conclusion could serve reliable managing long term is preliminary. To confirm universal applicability prognostic tool, it conduct rigorously designed research

Language: Английский

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Investigation of the connection between triglyceride-glucose (TyG) index and the risk of acute kidney injury in septic patients - a retrospective analysis utilizing the MIMIC-IV database

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: Jan. 6, 2025

The TyG index serves as a valuable tool for evaluating insulin resistance. An elevated has shown strong association with the occurrence of acute kidney injury (AKI). Nevertheless, existing literature does not address relationship between and in patients sepsis. Sepsis were identified from MIMIC-IV database categorized into four groups according to quadrilles their values. primary outcome this study was incidence AKI. risk AKI septic evaluated using Cox proportional hazards restricted cubic spline models. Subgroup analyses conducted investigate prognostic value different subgroups. A total 2,616 sepsis (57% whom male) included study. found be 78%. analysis revealed significant correlation patients. Furthermore, model an approximately linear higher trend hazard ratio (HR) remained consistent across various These findings emphasize reliability independent predictor unfavorable renal outcomes establishing causal two requires demonstration through larger prospective studies.

Language: Английский

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Association of TyG index with mortality at 28 days in sepsis patients in intensive care from MIMIC IV database

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 17, 2025

The relationship between the triglyceride‒glucose (TyG) index and clinical prognosis of septic patients in intensive care units (ICUs) remains unclear. This study aimed to explore correlation TyG 28-day all-cause mortality patients. A retrospective observational cohort was conducted, including 8955 from MIMIC IV 2.2 database. primary outcome mortality. Multivariate logistic regression analysis restricted cubic spline were used assess Subgroup analyses sensitivity performed further validate robustness results. total included, 5219 (58.3%) whom male, with a mean age 66.3 (15.8) years an average 9.08 (0.70) number deaths within 28 days 1639 (18.3%). RCS curve demonstrated U-shaped (nonlinear P value = 0.0003). risk negatively associated until it decreased 9.03 (adjusted odds ratio [OR] 0.727, 95% confidence interval [CI] 0.577–0.915). However, when exceeded 9.03, for significantly increased OR 1.185, CI 1.001–1.404). These findings consistent across subgroups various analyses. Our revealed nonlinear mortality, critical point at 9.03. results suggest that may be novel important factor short-term critically ill

Language: Английский

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Triglyceride–glucose index and the risk of in-hospital and ICU all-cause mortality: a systematic review and meta-analysis of observational studies

Nutrition and Diabetes, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 22, 2025

Several studies have illustrated the association of triglyceride glucose (TyG) index with in-hospital and intensive care unit (ICU) mortality. However, no compiled this evidence reached a conclusion. This study aimed to quantify TYG risk ICU An extensive search databases including PubMed, Scopus, Web Science, was performed up 21 Jan 2024. Nineteen were included in meta-analysis. The outcomes mortality 18 8 studies. Among 42,525 participants, 5233 1754 cases reported. pooled analysis revealed that each increase associated 33% 45% (RR = 1.33; 95% CI: 1.23, 1.43; I squared 90.3%) (RR: 1.45; 1.25, 1.67; 44.8%) mortality, respectively. Subgroup stronger between patients cardiovascular diseases than those cerebrovascular (Pheterogeneity Groups 0.014). findings showed positive TyG (PROSPERO registration ID: CRD420245414390).

Language: Английский

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The triglyceride glucose index as a sensitive predictor for the risk of MACCEs in patients with diabetic foot ulcers: An ambispective longitudinal cohort study

International Wound Journal, Journal Year: 2024, Volume and Issue: 21(4)

Published: April 1, 2024

Abstract The triglyceride glucose (TyG) index has been confirmed a predictive value for type 2 diabetes mellitus (T2DM). However, no research yet whether there is linear correlation between the TyG and MACCEs in DFUs. present study aimed to delve into association risk of patients with A total 960 inpatients DFUs were recruited. All participants followed up every 6 months 11 years median 83 months. According cut‐off acquired from receiver operating characteristic (ROC) analysis, subjects divided two groups: low‐level (<9.12, n = 480) high‐level (≥9.12, 480). relationship was evaluated by multivariable Cox regression model, restricted cubic spline (RCS) stratified analysis Kaplan–Meier survival analysis. Out participants, 271 experienced (28.22%), whom 79 (29.15%) died. ROC got optimal 9.12. Multivariable combined RCS model showed that positively associated an S‐shaped non‐linear dose‐dependent manner within range 7.5–9.5 ( p < 0.001). indicated higher index, greater cumulative incidence (log‐rank, first positive Consequently, lowering level aids improving prognosis

Language: Английский

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Association of triglyceride glucose-body mass index with Alzheimer’s disease pathology, cognition and brain structure in non-demented people

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 12, 2024

Abstract The relationship between the triglyceride glucose-body mass index (TyG-BMI) and Alzheimer’s disease (AD) pathology, cognition, brain structure remains unclear. This study aimed to investigate these associations, focusing on cerebrospinal fluid (CSF) biomarkers, cognitive measures, imaging data. Eight hundred fifty-five non-demented participants were included. Linear regression was used explore associations TyG-BMI AD structure. association risk assessed using Kaplan–Meier Cox proportional hazards models. Longitudinal relationships linear mixed-effects Mediation analyses conducted examine pathology’s potential mediating role cognition as well In analyses, higher levels associated with increased Aβ 42 decreased Tau, pTau, Tau/Aβ , pTau/Aβ pTau/Tau. Positive correlations observed mini-mental state examination (MMSE), memory (MEM), executive function (EF), volumes of hippocampus, entorhinal cortex, middle temporal regions, while negative found Disease Assessment Scale (ADAS). Longitudinally, inversely ADAS, positively MMSE, MEM, EF, entorhinal, temporal. High correlated lower (HR 0.996 [0.994, 0.999]). revealed pathology mediated Additionally, could mediate changes by influencing is

Language: Английский

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Triglyceride-glucose index and mortality risk in individuals with or without chronic kidney disease: Insights from a national survey of United States adults, 1999–2018

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: 34(8), P. 1994 - 2001

Published: April 11, 2024

Background and AimsThe Triglyceride-Glucose Index (TyG) has been proposed as a predictor to mortality, yet its association remains incompletely understood for individuals with or without chronic kidney disease (CKD). Methods ResultsWe analyzed data from the National Health Nutrition Examination Survey spanning years 1999 2018.CKD was defined eGFR level < 60 ml/min/1.73m 2 urinary albumin creatinine ratio ≥ 30 mg/g.We employed Cox proportionalhazards model evaluate incident risk of mortality associated TyG among both non-CKD CKD individuals.In current analysis, 19,426 were CKD, while 2,975 had CKD.The overall mean 8.65, significant difference between (8.60 vs 8.95, P 0.001).The index exhibited linear associations cardiovascular (CVD) all-cause individuals, respectively.A per-unit increase in significantly CVD (HR =1.24, 95%CI = 1.09 -1.41) participants 1.19, 1.04 -1.36), no two groups (P 0.091).For participants, those age 65, J o u r n l e -p f 4 but not 65. ConclusionsOur findings underscore index's valuable predictive tool assessing CKD.

Language: Английский

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U-shaped association between triglyceride-glucose index and all-cause mortality among critically ill pediatrics: a population-based retrospective cohort study

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 26, 2024

Previous studies have shown that an elevated triglyceride-glucose (TyG) index was associated with all-cause mortality in both general adult individuals and critically ill patients. However, the relationship between TyG clinical prognosis pediatric patients admitted to intensive care unit (ICU) remains unknown. We aimed investigate association of in-hospital

Language: Английский

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