Association between triglyceride-glucose index and Helicobacter pylori infection: a cross-sectional study DOI Creative Commons

Dan Long,

Chenhan Mao, Yin Xu

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 22, 2025

Mounting research suggests that insulin resistance (IR) is associated with Helicobacter pylori (H. pylori) infection. The triglyceride-glucose (TyG) index has received widespread attention due to its high sensitivity in assessing IR. This study examined the association between H. infection and TyG index. cross-sectional used data from National Health Nutrition Examination Survey (NHANES) 1999 - 2000. Participants were categorized into quartile groups (Q1-Q4) based on their Weighted multivariable-adjusted logistic regression subgroup analysis explore correlation Furthermore, was conducted assess robustness of our findings. included 2,918 participants, 1,101 whom infected pylori. mean for all participants 8.56 ± 0.67. Patients who positive had higher levels compared seronegative (8.74 0.03 vs. 8.57 0.03, P < 0.05). fourth showed highest odds Q1 (OR = 2.37, 95%CI: 1.52 3.71, 0.001). Sensitivity indicated remained strong even after excluding cardiovascular diseases or taking lipid-lowering medications, as well patients diabetes glucose-lowering medications. In this study, a stable found IR may be significantly Further studies are necessary elucidate underlying mechanisms potential clinical implications these

Language: Английский

The neutrophil-to-lymphocyte ratio is associated with all-cause and cardiovascular mortality among individuals with hypertension DOI Creative Commons
Xuexue Zhang, Rui Wei, Xujie Wang

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 2, 2024

Abstract Background Identifying reliable prognostic markers is crucial for the effective management of hypertension. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a potential inflammatory marker linked to cardiovascular outcomes. This study aims investigate association NLR with all-cause and mortality among patients Methods analyzed data from 3067 hypertensive adults in National Health Nutritional Examination Surveys (NHANES) 2009 2014. Mortality details were obtained Death Index (NDI). Restricted cubic spline (RCS) was deployed visualize risk. Weighted Cox proportional hazards models employed assess independent Time-dependent receiver operating characteristic curve (ROC) analysis conducted access predictive ability survival. Mediation used explore indirect impact on mediated through eGFR. Results Over median 92.0-months follow-up, 538 deaths occurred, including 114 deaths. RCS revealed positive between both mortality. Participants stratified into higher (> 3.5) lower (≤ groups. demonstrated that individuals had significantly increased risk (HR 1.96, 95% confidence interval (CI) 1.52–2.52, p < 0.0001) 2.33, CI 1.54–3.51, 0.0001). Stratified interaction confirmed stability core results. Notably, eGFR partially by 5.4% 4.7% proportion, respectively. Additionally, areas under (AUC) 3-, 5- 10- year survival 0.68, 0.65 0.64 0.70 0.69 mortality, Conclusion Elevated independently confers an

Language: Английский

Citations

50
Prediabetes Increases the Risk of Frailty in Prefrail Older Adults With Hypertension: Beneficial Effects of Metformin DOI

Gaetano Santulli,

Valeria Visco, Fahimeh Varzideh

et al.

Hypertension, Journal Year: 2024, Volume and Issue: 81(7), P. 1637 - 1643

Published: May 16, 2024

Prediabetes has garnered increasing attention due to its association with cardiovascular conditions, especially hypertension, which heightens the risk of prefrailty and frailty among older individuals.

Language: Английский

Citations

35
Association between the triglyceride glucose-body mass index and future cardiovascular disease risk in a population with Cardiovascular-Kidney-Metabolic syndrome stage 0–3: a nationwide prospective cohort study DOI Creative Commons
Weipeng Li, Chaonan Shen,

Weiya Kong

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 7, 2024

The American Heart Association (AHA) has recently introduced the concept of Cardiovascular-Kidney-Metabolic (CKM) syndrome, which is result an increasing emphasis on interplay metabolic, renal and cardiovascular diseases (CVD). Furthermore, there substantial evidence a correlation between triglyceride glucose-body mass index (TyG-BMI ) CVD as assessment insulin resistance (IR). However, it remains unknown whether this exists in population with CKM syndrome.

Language: Английский

Citations

27
Association between atherogenic index of plasma and future risk of cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study DOI Creative Commons

Gaoshu Zheng,

Jian Jin, Fei Wang

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 18, 2025

Language: Английский

Citations

7
Associations between estimated glucose disposal rate and arterial stiffness and mortality among US adults with non-alcoholic fatty liver disease DOI Creative Commons

Junting Song,

Ruicong Ma,

Lin Yin

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: May 8, 2024

Background The estimated glucose disposal rate (eGDR), an effective indicator of insulin resistance, has been related to acute coronary syndrome, ischemic stroke and heart failure. This study aims explore the relationship between eGDR arterial stiffness, all-cause mortality cardiovascular in patients with non-alcoholic fatty liver disease (NAFLD). Methods Participants NAFLD were chosen from National Health Nutrition Examination Survey (NHANES) 1999 2018. main outcomes are stiffness (represented by pulse wave velocity, ePWV), mortality. Multiple cox regression models, restricted cubic spline, sensitivity analysis subgroup carried out investigate correlation resistance indicators stiffness. Furthermore, receiver operating characteristic curves used compare predictive value triglyceride-glucose (TyG) index homeostasis model assessment (HOMA-IR) for Results In this study, a total 4,861 participants included analysis. After adjusting confounding factors multivariate weighted model, was inversely associated (Q4 vs. Q1, HR =0.65 (0.48-0.89, P=0.01) =0.35 (0.19-0.65, P&lt;0.001). Compared TyG HOMA-IR, shows excellent (0.588 0.550 0.513, P &lt; 0.001) (0.625 0.553 0.537, 0.001). addition, we found significant negative (β=-0.13(-0.14–0.11, P&lt; However, HOMA-IR showed no Conclusions Low (an resistance) levels increased risk United States.

Language: Английский

Citations

15
Associations of thyroid feedback quantile-based index with diabetes in euthyroid adults in the United States and China DOI Creative Commons
Heng Wan,

Genfeng Yu,

Yajun He

et al.

Annals of Medicine, Journal Year: 2024, Volume and Issue: 56(1)

Published: Feb. 21, 2024

Background We aimed to investigate the associations between thyroid hormone sensitivity indices and diabetes in euthyroid adults United States China.

Language: Английский

Citations

10
The association between helicobacter pylori infection and Triglyceride-Glucose (TyG) index in US adults: A retrospective cross-sectional study DOI Creative Commons
Wei Fu, Junlong Zhao,

GuoBin Chen

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0295888 - e0295888

Published: Jan. 3, 2025

Background The Triglyceride-glucose (TyG) index is a marker for insulin resistance and metabolic syndrome, while Helicobacter pylori linked to gastrointestinal diseases may affect risks. This study examined the association between TyG H. infection in adults. Methods Data from 3797 participants NHANES 1999–2000 cycle were analyzed. relationship was assessed using multivariate logistic regression two-piecewise model explore non-linear effects. Subgroup analyses conducted based on age, sex, glucose levels, BMI, CKD. Results A linear found. revealed significant interactions with few variables. Conclusions indicates infection, suggesting influences potential targeted interventions at-risk groups.

Language: Английский

Citations

1
Association of different insulin resistance surrogates with all-cause and cardiovascular mortality among the population with cardiometabolic multimorbidity DOI Creative Commons
Hongqiang Zhang, Zhixin Tu,

Si-hua Liu

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 22, 2025

Language: Английский

Citations

1
Correlation between neutrophil percentage-to-albumin ratio and all-cause and cerebrovascular mortality among hypertension patients DOI Creative Commons
You Li, Cheng Yu

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 23, 2025

Neutrophil percentage-to-albumin ratio (NPAR) is a novel inflammatory biomarker and correlated with the progression clinical outcomes of many diseases. This investigation aimed to clarified association between NPAR mortality risk among hypertension patients. The database National Health Nutrition Examination Survey provided patient data for hypertension. Using restricted cubic spline (RCS), was investigated. In order assess independent contribution in all-cause cerebrovascular mortality, weighted Cox proportional hazards models were employed. Concordance index receiver operating characteristic (ROC) curve employed how effectively predicted at different times. A total 6,866 cases included this investigation. During follow-up, 2,757 (40%) patients have died, 582 (8.5%) them from disease. RCS regression analysis found positive nonlinear correlation High indicated higher risks (HR = 1.81, 95% CI 1.52–2.37) 2.21, 1.67–2.88) patients, these results remained after adjusting certain parameters. areas under 5-year, 10-year 15-year ROC 0.720, 0.703 0.634, those 0.705, 0.706 0.699, respectively. served as s Higher mortality.

Language: Английский

Citations

1
Elevated Platelet‐to‐Lymphocyte Ratio as a Predictor of All‐Cause and Cardiovascular Mortality in Hypertensive Individuals DOI Creative Commons
Rui Xu, Ling Chen,

Changshun Yan

et al.

Journal of Clinical Hypertension, Journal Year: 2025, Volume and Issue: 27(1)

Published: Jan. 1, 2025

The platelet-to-lymphocyte ratio (PLR) has been proposed as a promising inflammatory biomarker, with potential implications for cardiovascular prognosis. However, its association mortality outcomes in hypertensive individuals is not fully elucidated. This investigation sought to clarify the linkage between PLR and both overall individuals. Data from 15 483 adults NHANES (2005-2018) were analyzed. Mortality data, including all-cause deaths, sourced National Death Index (NDI) up December 31, 2019. risk was depicted using restricted cubic spline (RCS) models. Cox proportional hazards regression models assessed independent of risk, adjustments incrementally applied: Model 1 without adjustments; 2 adjusted age sex; 3 further age, gender, race, marital status, diabetes, alcohol intake, smoking body mass index (BMI), history disease (CVD), high-density lipoprotein cholesterol (HDL), low-density (LDL), total (TC), triglyceride (TG), creatinine (CR). Over median follow-up 79 months, there 2820 deaths 758 deaths. multivariate analysis showed that those highest quartile had significantly elevated risks (Model 1: HR = 1.28, 95% CI 1.16-1.42, p < 0.001; 2: 1.14, 1.03-1.26, 0.014; 3: 1.16, 1.05-1.29, 0.004)and 1.59, 1.30-1.94, 1.38, 1.13-1.68, 1.47, 1.20-1.80, 0.001). study reveals U-shaped relationship mortality, alongside linear mortality. A threshold 118.83 identified indicative an adverse prognosis Elevated independently predicts heightened among patients.

Language: Английский

Citations

1