Plant Foods and Their Bioactives as Dietary Enhancers for Colon Cancer Treatment with 5-Fluorouracil

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 50

Published: Jan. 4, 2025

Cancer is the world's second most common cause of death, with colon cancer (CC) ranking third in prevalence and cancer-related fatalities. CC originates or rectum influenced by genetic mutations, lifestyle, diet. Although chemotherapy, especially 5-fluorouracil (5-FU), fundamental to treatment has improved patient survival, its benefits are often limited significant side effects emerging drug resistance. Recently, plant-based foods have drawn interest research for their natural bioactive compounds relatively low toxicity. Certain plant not only exhibit anti-cancer activity but may also boost effectiveness 5-FU while reducing adverse effects. Despite evidence suggesting a synergistic effect between 5-FU, this area remains fragmented. This review consolidates current on including fruits, vegetables, legumes, tea bioactives treatment. Besides, it explores mechanisms through which these enhance efficacy reduce effects, evaluates clinical application prospects, identifies challenges future directions. comprehensive analysis aims provide scientific foundation integrated CC, highlighting potential enhancing chemotherapy associated toxicities.

Language: Английский

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Plants as a Source of Anticancer Agents: From Bench to Bedside

Molecules, Journal Year: 2022, Volume and Issue: 27(15), P. 4818 - 4818

Published: July 27, 2022

Cancer is the second leading cause of death after cardiovascular diseases. Conventional anticancer therapies are associated with lack selectivity and serious side effects. hallmarks biological capabilities acquired by cancer cells during neoplastic transformation. Targeting multiple a promising strategy to treat cancer. The diversity in chemical structure relatively low toxicity make plant-derived natural products source for development new more effective that have capacity target In this review, we discussed activities ten extracted from plants. majority these inhibit targeting hallmarks, many chemicals reached clinical applications. Studies review provide solid ground researchers physicians design combination using products.

Language: Английский

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A systematic review of the protective effects of silymarin/silibinin against doxorubicin-induced cardiotoxicity

Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)

Published: May 10, 2023

Abstract Purpose Although doxorubicin chemotherapy is commonly applied for treating different malignant tumors, cardiotoxicity induced by this chemotherapeutic agent restricts its clinical use. The use of silymarin/silibinin may mitigate the doxorubicin-induced cardiac adverse effects. For aim, potential cardioprotective effects against were systematically reviewed. Methods In study, we performed a systematic search in accordance with PRISMA guideline identifying all relevant studies on “the role cardiotoxicity” electronic databases up to June 2022. Sixty-one articles obtained and screened based predefined inclusion exclusion criteria. Thirteen eligible papers finally included review. Results According echocardiographic electrocardiographic findings, doxorubicin-treated groups presented significant reduction ejection fraction, tissue Doppler peak mitral annulus systolic velocity, fractional shortening as well bradycardia, prolongation QT QRS interval. However, these abnormalities obviously improved silymarin plus groups. As well, administration led induce histopathological biochemical changes cells/tissue; contrast, co-administration could alterations (for most cases). Conclusion it was found that alleviates Silymarin/silibinin exerts via antioxidant, anti-inflammatory, anti-apoptotic activities, other mechanisms.

Language: Английский

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Combination Chemotherapy with Selected Polyphenols in Preclinical and Clinical Studies—An Update Overview

Molecules, Journal Year: 2023, Volume and Issue: 28(9), P. 3746 - 3746

Published: April 26, 2023

This review article describes studies published over the past five years on combination of polyphenols, which are most studied in field anticancer effects (curcumin, quercetin, resveratrol, epigallocatechin gallate, and apigenin) chemotherapeutics such as cisplatin, 5-fluorouracil, oxaliplatin, paclitaxel, etc. According to WHO data, research has been limited cancers with highest morbidity rate (lung, colorectal, liver, gastric, breast cancer). A systematic articles (from January 2018 2023) was carried out help all Web Science databases available base clinical studies. Based preclinical presented this review, polyphenols can enhance drug efficacy reduce chemoresistance through different molecular mechanisms. Considering large number studies, curcumin could be a molecule future chemotherapy cocktails. One main problems is related bioavailability polyphenols. The design new co-delivery system for drugs essential research. Some work synergy chemotherapeutic drugs, but some act antagonistically, so caution always required.

Language: Английский

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Resveratrol as sensitizer in colorectal cancer plasticity

Cancer and Metastasis Reviews, Journal Year: 2023, Volume and Issue: 43(1), P. 55 - 85

Published: July 29, 2023

Abstract Despite tremendous medical treatment successes, colorectal cancer (CRC) remains a leading cause of deaths worldwide. Chemotherapy as monotherapy can lead to significant side effects and chemoresistance that be linked several resistance-activating biological processes, including an increase in inflammation, cellular plasticity, multidrug resistance (MDR), inhibition the sentinel gene p53, apoptosis. As consequence, tumor cells escape effectiveness chemotherapeutic agents. This underscores need for cross-target therapeutic approaches are not only pharmacologically safe but also modulate multiple potent signaling pathways sensitize overcome standard drugs. In recent years, scientists have been searching natural compounds used chemosensitizers addition conventional medications synergistic CRC. Resveratrol, polyphenolic phytoalexin found various fruits vegetables such peanuts, berries, red grapes, is one most effective chemopreventive Abundant vitro vivo studies shown resveratrol, interaction with drugs, chemosensitizer CRC agents thus prevents drug by modulating pathways, transcription factors, epithelial-to-mesenchymal transition-plasticity, proliferation, metastasis, angiogenesis, cell cycle, The ability resveratrol modify subcellular may suppress plasticity reversal critical parameters understanding its anti-cancer effects. this review, we focus on chemosensitizing properties and, thus, potential importance additive ongoing treatments. Graphical abstract

Language: Английский

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Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 10, 2023

One of the primary diseases that cause death worldwide is cancer. Cancer cells can be intrinsically resistant or acquire resistance to therapies and drugs used for cancer treatment through multiple mechanisms action favor cell survival proliferation, becoming one leading causes failure against A promising strategy overcome chemoresistance radioresistance co-administration anticancer agents natural compounds with properties, such as polyphenolic compound resveratrol (RSV). RSV has been reported able sensitize chemotherapeutic radiotherapy, promoting death. This review describes molecular by which sensitizes tumor radiotherapy chemotherapy treatment.

Language: Английский

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Unrevealing the total phenols, total flavonoids, antioxidant, anti-inflammatory, and cytotoxic effects of Garden Cress seed ethanolic extracts

Review of Clinical Pharmacology and Pharmacokinetics - International Edition, Journal Year: 2024, Volume and Issue: 38(2), P. 187 - 196

Published: July 4, 2024

For many years, natural bioactives have been used to treat, cure, and prevent diseases. Crude extracts from fruit seeds demonstrated possess a range of advantageous biological properties, including anti-inflammatory, antioxidant, anti-tumorous effects. In this study, the Garden Cress (Lepidium sativum, Cr) were extracted using ethanol as solvent two extraction techniques. These methods are microwave-facilitated successive microwave-ultrasound-assisted extraction, resulting in Cr-1 Cr-2, respectively. ethanolic investigated for several biochemical characteristics, flavonoid content, phenolic cytotoxic, cytoprotective The first second characteristics computed colorimetric AlCl3 Folin-Ciocalteu methods, antioxidant char¬acteristic was against reactive species, named hydroxyl DPPH. Also, total reducing power calculated regard. anti-inflammatory-reducing evaluated employing three inflammation-progressing enzymes. last assessed MTT-based methodology malignant one healthy cellular population, outcomes that extract microwave-facilitation (Cr-1) has highest contents, well best activity. Furthermore, when compared other one, showed greater inhibitory effect on enzymes selectivity COX2. At applied concentrations, neither extract, however, had any antiprolifer¬ative or lines. Moreover, no additional influence ability 5-fluorouracil (5-FU) stop proliferation cells. However, individually with 5-FU, cytotoxic capability drug populations substantially lowered. Given these findings, authors concluded together 5-FU may serve measure normal protection.

Language: Английский

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Magnetic stirring hydroxylation for fabrication of a highly modulated Cu-intercalated 3D titanium aluminum carbide MXene network for efficient electrochemical detection of fluorouracil

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151818 - 151818

Published: April 30, 2024

Language: Английский

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5-Fluorouracil-containing inorganic iron oxide/platinum nanozymes with dual drug delivery and enzyme-like activity for the treatment of breast cancer

Arabian Journal of Chemistry, Journal Year: 2022, Volume and Issue: 15(8), P. 103966 - 103966

Published: May 20, 2022

Intrinsic enzyme-mimic activity of inorganic nanoparticles has been widely used for nanozymatic anticancer and antibacterial treatment. However, the relatively low peroxidase-mimic (PMA) catalse-mimic (CMA) nanozymes in tumor microenvironment hampered their potential application cancer therapy. Therefore, this study, we aimed to fabricate platinum (Pt) dispersed on surface iron oxide (Fe3O4) nanosphere that, addition boosting PMA CMA, resulted formation a pH-sensitive nano-platform drug delivery breast After development Fe3O4 nanospheres containing Pt loading 5-fluorouracil (abbreviated as: Fe3O4/[email protected] nanospheres), physicochemical properties were examined by electron microscopy, dynamic light scattering, zeta potential, X-ray diffraction, thermogravimetric, BET surface, PMA/CMA analyses. Then, cytotoxicity against 4T1 cells was investigated cell counting kit-8 assay flow cytometry. Also, effect fabricated nanoplatform assessed mouse bearing tumors, vivo. The results showed that provide platform optimal FLU loading, continuous release, CMA increase level ROS O2, respectively. Cytotoxicity outputs mitigate proliferation mediated apoptosis intracellular generation reactive oxygen species (ROS). Furthermore, vivo assays indicated significant reduction size overcoming hypoxia. Overall, believe developed with dual can be ROS/chemotherapy double-modality antitumor

Language: Английский

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Fabrication and Evaluation of Graphene Oxide/Hydroxypropyl Cellulose/Chitosan Hybrid Aerogel for 5-Fluorouracil Release

Gels, Journal Year: 2022, Volume and Issue: 8(10), P. 649 - 649

Published: Oct. 12, 2022

The incorporation of graphene oxide (GO) into a polymeric drug carrier can not only enhance the loading efficiency but also reduce initial burst and consequently improve controllability release. Firstly, 5-fluorouracil (5-Fu)-loaded hydroxypropyl cellulose/chitosan (HPC/CS@5-Fu) GO/HPC/CS@5-Fu aerogels were successfully fabricated through chemical cross-linking with glutaraldehyde. Then, obtained characterized using scanning electron microscopy (SEM), Fourier transform infrared (FITR), X-ray diffraction (XRD), differential calorimetry (DSC), thermogravimetry (TG), effect HPC GO content on (DL) encapsulation (EE) for two investigated, respectively. Finally, release behavior different was evaluated at pH values, four kinds kinetic models used to evaluate behavior.

Language: Английский

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