Food Reviews International,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 50
Published: Jan. 4, 2025
Cancer
is
the
world's
second
most
common
cause
of
death,
with
colon
cancer
(CC)
ranking
third
in
prevalence
and
cancer-related
fatalities.
CC
originates
or
rectum
influenced
by
genetic
mutations,
lifestyle,
diet.
Although
chemotherapy,
especially
5-fluorouracil
(5-FU),
fundamental
to
treatment
has
improved
patient
survival,
its
benefits
are
often
limited
significant
side
effects
emerging
drug
resistance.
Recently,
plant-based
foods
have
drawn
interest
research
for
their
natural
bioactive
compounds
relatively
low
toxicity.
Certain
plant
not
only
exhibit
anti-cancer
activity
but
may
also
boost
effectiveness
5-FU
while
reducing
adverse
effects.
Despite
evidence
suggesting
a
synergistic
effect
between
5-FU,
this
area
remains
fragmented.
This
review
consolidates
current
on
including
fruits,
vegetables,
legumes,
tea
bioactives
treatment.
Besides,
it
explores
mechanisms
through
which
these
enhance
efficacy
reduce
effects,
evaluates
clinical
application
prospects,
identifies
challenges
future
directions.
comprehensive
analysis
aims
provide
scientific
foundation
integrated
CC,
highlighting
potential
enhancing
chemotherapy
associated
toxicities.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(15), P. 4818 - 4818
Published: July 27, 2022
Cancer
is
the
second
leading
cause
of
death
after
cardiovascular
diseases.
Conventional
anticancer
therapies
are
associated
with
lack
selectivity
and
serious
side
effects.
hallmarks
biological
capabilities
acquired
by
cancer
cells
during
neoplastic
transformation.
Targeting
multiple
a
promising
strategy
to
treat
cancer.
The
diversity
in
chemical
structure
relatively
low
toxicity
make
plant-derived
natural
products
source
for
development
new
more
effective
that
have
capacity
target
In
this
review,
we
discussed
activities
ten
extracted
from
plants.
majority
these
inhibit
targeting
hallmarks,
many
chemicals
reached
clinical
applications.
Studies
review
provide
solid
ground
researchers
physicians
design
combination
using
products.
Cancer Cell International,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: May 10, 2023
Abstract
Purpose
Although
doxorubicin
chemotherapy
is
commonly
applied
for
treating
different
malignant
tumors,
cardiotoxicity
induced
by
this
chemotherapeutic
agent
restricts
its
clinical
use.
The
use
of
silymarin/silibinin
may
mitigate
the
doxorubicin-induced
cardiac
adverse
effects.
For
aim,
potential
cardioprotective
effects
against
were
systematically
reviewed.
Methods
In
study,
we
performed
a
systematic
search
in
accordance
with
PRISMA
guideline
identifying
all
relevant
studies
on
“the
role
cardiotoxicity”
electronic
databases
up
to
June
2022.
Sixty-one
articles
obtained
and
screened
based
predefined
inclusion
exclusion
criteria.
Thirteen
eligible
papers
finally
included
review.
Results
According
echocardiographic
electrocardiographic
findings,
doxorubicin-treated
groups
presented
significant
reduction
ejection
fraction,
tissue
Doppler
peak
mitral
annulus
systolic
velocity,
fractional
shortening
as
well
bradycardia,
prolongation
QT
QRS
interval.
However,
these
abnormalities
obviously
improved
silymarin
plus
groups.
As
well,
administration
led
induce
histopathological
biochemical
changes
cells/tissue;
contrast,
co-administration
could
alterations
(for
most
cases).
Conclusion
it
was
found
that
alleviates
Silymarin/silibinin
exerts
via
antioxidant,
anti-inflammatory,
anti-apoptotic
activities,
other
mechanisms.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(9), P. 3746 - 3746
Published: April 26, 2023
This
review
article
describes
studies
published
over
the
past
five
years
on
combination
of
polyphenols,
which
are
most
studied
in
field
anticancer
effects
(curcumin,
quercetin,
resveratrol,
epigallocatechin
gallate,
and
apigenin)
chemotherapeutics
such
as
cisplatin,
5-fluorouracil,
oxaliplatin,
paclitaxel,
etc.
According
to
WHO
data,
research
has
been
limited
cancers
with
highest
morbidity
rate
(lung,
colorectal,
liver,
gastric,
breast
cancer).
A
systematic
articles
(from
January
2018
2023)
was
carried
out
help
all
Web
Science
databases
available
base
clinical
studies.
Based
preclinical
presented
this
review,
polyphenols
can
enhance
drug
efficacy
reduce
chemoresistance
through
different
molecular
mechanisms.
Considering
large
number
studies,
curcumin
could
be
a
molecule
future
chemotherapy
cocktails.
One
main
problems
is
related
bioavailability
polyphenols.
The
design
new
co-delivery
system
for
drugs
essential
research.
Some
work
synergy
chemotherapeutic
drugs,
but
some
act
antagonistically,
so
caution
always
required.
Cancer and Metastasis Reviews,
Journal Year:
2023,
Volume and Issue:
43(1), P. 55 - 85
Published: July 29, 2023
Abstract
Despite
tremendous
medical
treatment
successes,
colorectal
cancer
(CRC)
remains
a
leading
cause
of
deaths
worldwide.
Chemotherapy
as
monotherapy
can
lead
to
significant
side
effects
and
chemoresistance
that
be
linked
several
resistance-activating
biological
processes,
including
an
increase
in
inflammation,
cellular
plasticity,
multidrug
resistance
(MDR),
inhibition
the
sentinel
gene
p53,
apoptosis.
As
consequence,
tumor
cells
escape
effectiveness
chemotherapeutic
agents.
This
underscores
need
for
cross-target
therapeutic
approaches
are
not
only
pharmacologically
safe
but
also
modulate
multiple
potent
signaling
pathways
sensitize
overcome
standard
drugs.
In
recent
years,
scientists
have
been
searching
natural
compounds
used
chemosensitizers
addition
conventional
medications
synergistic
CRC.
Resveratrol,
polyphenolic
phytoalexin
found
various
fruits
vegetables
such
peanuts,
berries,
red
grapes,
is
one
most
effective
chemopreventive
Abundant
vitro
vivo
studies
shown
resveratrol,
interaction
with
drugs,
chemosensitizer
CRC
agents
thus
prevents
drug
by
modulating
pathways,
transcription
factors,
epithelial-to-mesenchymal
transition-plasticity,
proliferation,
metastasis,
angiogenesis,
cell
cycle,
The
ability
resveratrol
modify
subcellular
may
suppress
plasticity
reversal
critical
parameters
understanding
its
anti-cancer
effects.
this
review,
we
focus
on
chemosensitizing
properties
and,
thus,
potential
importance
additive
ongoing
treatments.
Graphical
abstract
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Nov. 10, 2023
One
of
the
primary
diseases
that
cause
death
worldwide
is
cancer.
Cancer
cells
can
be
intrinsically
resistant
or
acquire
resistance
to
therapies
and
drugs
used
for
cancer
treatment
through
multiple
mechanisms
action
favor
cell
survival
proliferation,
becoming
one
leading
causes
failure
against
A
promising
strategy
overcome
chemoresistance
radioresistance
co-administration
anticancer
agents
natural
compounds
with
properties,
such
as
polyphenolic
compound
resveratrol
(RSV).
RSV
has
been
reported
able
sensitize
chemotherapeutic
radiotherapy,
promoting
death.
This
review
describes
molecular
by
which
sensitizes
tumor
radiotherapy
chemotherapy
treatment.
Review of Clinical Pharmacology and Pharmacokinetics - International Edition,
Journal Year:
2024,
Volume and Issue:
38(2), P. 187 - 196
Published: July 4, 2024
For
many
years,
natural
bioactives
have
been
used
to
treat,
cure,
and
prevent
diseases.
Crude
extracts
from
fruit
seeds
demonstrated
possess
a
range
of
advantageous
biological
properties,
including
anti-inflammatory,
antioxidant,
anti-tumorous
effects.
In
this
study,
the
Garden
Cress
(Lepidium
sativum,
Cr)
were
extracted
using
ethanol
as
solvent
two
extraction
techniques.
These
methods
are
microwave-facilitated
successive
microwave-ultrasound-assisted
extraction,
resulting
in
Cr-1
Cr-2,
respectively.
ethanolic
investigated
for
several
biochemical
characteristics,
flavonoid
content,
phenolic
cytotoxic,
cytoprotective
The
first
second
characteristics
computed
colorimetric
AlCl3
Folin-Ciocalteu
methods,
antioxidant
char¬acteristic
was
against
reactive
species,
named
hydroxyl
DPPH.
Also,
total
reducing
power
calculated
regard.
anti-inflammatory-reducing
evaluated
employing
three
inflammation-progressing
enzymes.
last
assessed
MTT-based
methodology
malignant
one
healthy
cellular
population,
outcomes
that
extract
microwave-facilitation
(Cr-1)
has
highest
contents,
well
best
activity.
Furthermore,
when
compared
other
one,
showed
greater
inhibitory
effect
on
enzymes
selectivity
COX2.
At
applied
concentrations,
neither
extract,
however,
had
any
antiprolifer¬ative
or
lines.
Moreover,
no
additional
influence
ability
5-fluorouracil
(5-FU)
stop
proliferation
cells.
However,
individually
with
5-FU,
cytotoxic
capability
drug
populations
substantially
lowered.
Given
these
findings,
authors
concluded
together
5-FU
may
serve
measure
normal
protection.
Arabian Journal of Chemistry,
Journal Year:
2022,
Volume and Issue:
15(8), P. 103966 - 103966
Published: May 20, 2022
Intrinsic
enzyme-mimic
activity
of
inorganic
nanoparticles
has
been
widely
used
for
nanozymatic
anticancer
and
antibacterial
treatment.
However,
the
relatively
low
peroxidase-mimic
(PMA)
catalse-mimic
(CMA)
nanozymes
in
tumor
microenvironment
hampered
their
potential
application
cancer
therapy.
Therefore,
this
study,
we
aimed
to
fabricate
platinum
(Pt)
dispersed
on
surface
iron
oxide
(Fe3O4)
nanosphere
that,
addition
boosting
PMA
CMA,
resulted
formation
a
pH-sensitive
nano-platform
drug
delivery
breast
After
development
Fe3O4
nanospheres
containing
Pt
loading
5-fluorouracil
(abbreviated
as:
Fe3O4/[email
protected]
nanospheres),
physicochemical
properties
were
examined
by
electron
microscopy,
dynamic
light
scattering,
zeta
potential,
X-ray
diffraction,
thermogravimetric,
BET
surface,
PMA/CMA
analyses.
Then,
cytotoxicity
against
4T1
cells
was
investigated
cell
counting
kit-8
assay
flow
cytometry.
Also,
effect
fabricated
nanoplatform
assessed
mouse
bearing
tumors,
vivo.
The
results
showed
that
provide
platform
optimal
FLU
loading,
continuous
release,
CMA
increase
level
ROS
O2,
respectively.
Cytotoxicity
outputs
mitigate
proliferation
mediated
apoptosis
intracellular
generation
reactive
oxygen
species
(ROS).
Furthermore,
vivo
assays
indicated
significant
reduction
size
overcoming
hypoxia.
Overall,
believe
developed
with
dual
can
be
ROS/chemotherapy
double-modality
antitumor
Gels,
Journal Year:
2022,
Volume and Issue:
8(10), P. 649 - 649
Published: Oct. 12, 2022
The
incorporation
of
graphene
oxide
(GO)
into
a
polymeric
drug
carrier
can
not
only
enhance
the
loading
efficiency
but
also
reduce
initial
burst
and
consequently
improve
controllability
release.
Firstly,
5-fluorouracil
(5-Fu)-loaded
hydroxypropyl
cellulose/chitosan
(HPC/CS@5-Fu)
GO/HPC/CS@5-Fu
aerogels
were
successfully
fabricated
through
chemical
cross-linking
with
glutaraldehyde.
Then,
obtained
characterized
using
scanning
electron
microscopy
(SEM),
Fourier
transform
infrared
(FITR),
X-ray
diffraction
(XRD),
differential
calorimetry
(DSC),
thermogravimetry
(TG),
effect
HPC
GO
content
on
(DL)
encapsulation
(EE)
for
two
investigated,
respectively.
Finally,
release
behavior
different
was
evaluated
at
pH
values,
four
kinds
kinetic
models
used
to
evaluate
behavior.
