Association of magnesium depletion score with serum anti-aging protein Klotho in the middle-aged and older populations DOI Creative Commons

Zhijie Zhuang,

Shan Huang,

Yingzhu Xiong

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 27, 2025

Background Magnesium deficiency and low levels of the anti-aging protein Klotho have been independently associated with various age-related diseases. The Depletion Score (MDS) is recognized as a more valuable reliable predictor body magnesium status than traditional clinical markers such serum urine magnesium. However, relationship between remains unexplored. This study aimed to investigate association depletion, quantified by MDS, in US adults. Methods We analyzed data from 11,387 participants aged 40–79 years National Health Nutrition Examination Survey (NHANES) 2007–2016. Participants were divided into three groups based on MDS: (0–1 points), middle (2 high (3–5 reflecting cumulative risks depletion derived diuretic use, proton pump inhibitors, renal function, alcohol intake. Serum measured using validated ELISA assay. Sample-weighted multivariable linear regression models used examine MDS levels, adjusting for age, sex, race, socioeconomic status, lifestyle factors (smoking, use), parameters (body mass index, blood pressure, lipid levels), energy Results weighted average concentrations decreased significantly across (low: 864.50, middle: 805.67, high: 755.02 pg./mL; p < 0.0001). After full adjustment, compared group, had lower ( β = −35.49, 95% CI: −62.29 −8.69; −64.82, −115.30 −14.34, respectively; trend 0.003). inverse remained consistent subgroups, particularly strong relationships observed individuals BMI <25, current smokers, those income. Conclusion provides novel evidence an new indicator large, representative sample These findings suggest that monitoring via could help identify at risk accelerated aging, prompting interventions dietary adjustments or supplementation high-risk populations. Further research warranted elucidate mechanisms underlying this its implications

Language: Английский

Magnesium and health outcomes: an umbrella review of systematic reviews and meta-analyses of observational and intervention studies DOI
Nicola Veronese, Jacopo Demurtas, Gabriella Pesolillo

et al.

European Journal of Nutrition, Journal Year: 2019, Volume and Issue: 59(1), P. 263 - 272

Published: Jan. 25, 2019

Language: Английский

Citations

75
The role of thiamine dependent enzymes in obesity and obesity related chronic disease states: A systematic review DOI
Donogh Maguire, Dinesh Talwar, Paul G. Shiels

et al.

Clinical Nutrition ESPEN, Journal Year: 2018, Volume and Issue: 25, P. 8 - 17

Published: March 15, 2018

Language: Английский

Citations

71
Diet and prevention of type 2 diabetes mellitus: beyond weight loss and exercise DOI

Orsolya M Palacios,

Melvyn W. Kramer,

Kevin C. Maki

et al.

Expert Review of Endocrinology & Metabolism, Journal Year: 2018, Volume and Issue: 14(1), P. 1 - 12

Published: Nov. 29, 2018

Insulin resistance (IR) and pancreatic beta-cell dysfunction are core pathophysiologic features of type 2 diabetes mellitus (T2DM). Select lifestyle pharmacologic interventions, including weight loss, physical activity, a Mediterranean diet intervention, hypoglycemic agents, have been shown to prevent or delay T2DM. However, dietary factors other than loss may also impact risk, mainly through effects enhance insulin sensitivity, although some directly indirectly function.A literature review observational studies randomized controlled trials (RCTs) was conducted, the research indicates showing promise for reducing T2DM risk include higher intakes cereal fibers, unsaturated fatty acids, magnesium, polyphenols (e.g. anthocyanins), while glycemic load, added sugars, high-sugar beverages.While these supported by evidence from RCTs surrogate markers T2DM, they consistent with current recommendations emphasize consumption whole grains, nuts, seeds, legumes, seafood, fruits, vegetables, limiting saturated refined carbohydrates, processed meats. Additional intervention needed assess efficacy promising interventions delaying preventing onset

Language: Английский

Citations

60
Remineralization of desalinated water: Methods and environmental impact DOI
Alain Lesimple, Farah Ejaz Ahmed, Nidal Hilal

et al.

Desalination, Journal Year: 2020, Volume and Issue: 496, P. 114692 - 114692

Published: Aug. 28, 2020

Language: Английский

Citations

50
The Effect of Electrolytes on Blood Pressure: A Brief Summary of Meta-Analyses DOI Open Access
Sehar Iqbal,

N Klammer,

Cem Ekmekçioğlu

et al.

Nutrients, Journal Year: 2019, Volume and Issue: 11(6), P. 1362 - 1362

Published: June 17, 2019

Nutrition is known to exert an undeniable impact on blood pressure with especially salt (sodium chloride), but also potassium, playing a prominent role. The aim of this review was summarize meta-analyses studying the effect different electrolytes or risk for hypertension, respectively. Overall, 32 evaluating sodium, calcium and magnesium human hypertension were included after literature search. Most showed beneficial lowering effects extent systolic reduction ranging between -0.7 (95% confidence interval: -2.6 1.2) -8.9 (-14.1 -3.7) mmHg sodium/salt reduction, -3.5 (-5.2 -1.8) -9.5 (-10.8 -8.1) -0.2 (-0.4 -0.03) -18.7 (-22.5 -15.0) magnesium. range diastolic 0.03 0.4) -5.9 (-9.7 -2.1) -2 (-3.1 -0.9) -6.4 (-7.3 -5.6) -0.3 (-0.5 -10.9 (-13.1 -8.7) Moreover, sufficient intake found reduce gestational hypertension.

Language: Английский

Citations

49
The effects of combined magnesium and zinc supplementation on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease DOI Creative Commons

Zahra Hamedifard,

Alireza Farrokhian, Željko Reiner

et al.

Lipids in Health and Disease, Journal Year: 2020, Volume and Issue: 19(1)

Published: May 28, 2020

Abstract Background The present research aimed to analyze the impacts of magnesium and zinc supplements on glycemic control, serum lipids, biomarkers oxidative stress inflammation in patients suffering from coronary heart disease (CHD) type 2 diabetes mellitus (T2DM). Methods According design, a randomized, double-blind, placebo-controlled trial has been implemented 60 subjects CHD T2DM. Therefore, participants have randomly divided into groups for taking placebo ( n = 30) or 250 mg oxide plus 150 sulfate 12 weeks. Results Magnesium significantly decreased fasting plasma glucose (FPG) (β − 9.44 mg/dL, 95% CI, 18.30, 0.57; P 0.03) insulin levels 1.37 μIU/mL, 2.57, 0.18; 0.02). Moreover, HDL-cholesterol enhanced 2.09 0.05, 4.13; 0.04) comparison placebo. There was an association between intake, significant decrease C-reactive protein (CRP) 0.85 mg/L, 1.26, 0.45; < 0.001), increase total nitrite 5.13 μmol/L, 1.85, 8.41; 0.003) antioxidant capacity (TAC) 43.44 mmol/L, 3.39, 83.50; when compared with Furthermore, reduced Beck Depression Inventory index (BDI) 1.66; 3.32, 0.009; Anxiety (BAI) 1.30; 2.43, 0.16; 0.02) Conclusions In T2DM CHD, 12-week intake had beneficial effects FPG, HDL-cholesterol, CRP, insulin, nitrite, TAC levels, BDI BAI score. This suggests that co-supplementation may be CHD. Further studies more lasting longer are needed determine safety co-supplementation. Trial registration Current Controlled Trials http://www.irct.ir: IRCT20130211012438N31 at 11 May 2019 registration. study retrospectively registered.

Language: Английский

Citations

48
Serum magnesium and calcium levels in relation to ischemic stroke DOI Creative Commons
Susanna C. Larsson, Matthew Traylor, Stephen Burgess

et al.

Neurology, Journal Year: 2019, Volume and Issue: 92(9)

Published: Jan. 26, 2019

ObjectiveTo determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach. MethodsAnalyses were conducted summary statistics data for 13 single-nucleotide polymorphisms robustly (n = 6) 7) concentrations.The corresponding obtained from MEGASTROKE consortium (34,217 cases 404,630 noncases). ResultsIn standard analysis, odds ratios each 0.1 mmol/L (about 1 SD) increase in genetically predicted 0.78 (95% confidence interval [CI] 0.69-0.89;p 1.3 × 10 -4 ) all stroke, 0.63 CI 0.50-0.80;p 1.6 cardioembolic 0.60 0.44-0.82;p 0.001) large artery stroke; there was no association small vessel (odds ratio 0.90, 95% 0.67-1.20;p 0.46).Only robust sensitivity analyses.There (per 0.5 mg/dL [about SD] calcium: 1.03, 0.88-1.21)or subtype. ConclusionsThis study found that higher a reduced risk but significant

Language: Английский

Citations

47
Sex-specific associations of plasma metals and metal mixtures with glucose metabolism: An occupational population-based study in China DOI

Xiaoting Ge,

Aimin Yang,

Sifang Huang

et al.

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 760, P. 143906 - 143906

Published: Dec. 4, 2020

Language: Английский

Citations

45
Identifying novel risk genes in intracranial aneurysm by integrating human proteomes and genetics DOI
Congyan Wu, Hanchen Liu, Qiao Zuo

et al.

Brain, Journal Year: 2024, Volume and Issue: 147(8), P. 2817 - 2825

Published: Aug. 1, 2024

Abstract Genome-wide association studies (GWAS) have become increasingly popular for detecting numerous loci associated with intracranial aneurysm (IA), but how these function remains unclear. In this study, we employed an integrative analytical pipeline to efficiently transform genetic associations and identify novel genes IA. Using multidimensional high-throughput data, integrated proteome-wide (PWAS), transcriptome-wide (TWAS), Mendelian randomization (MR) Bayesian co-localization analyses prioritize that can increase IA risk by altering their expression protein abundances in the brain blood. Moreover, single-cell RNA sequencing (scRNA-seq) of circle Willis was performed enrich filtered cells, gene set enrichment analysis (GSEA) conducted each using bulk RNA-seq data No significant cis-regulated plasma levels were proven be The five found According cellular analysis, expressed mainly endothelium, fibroblasts vascular smooth muscle cells. Only three genes, CNNM2, GPRIN3 UFL1, passed MR analyses. While UFL1 not validated confirmation PWAS as it profiled, TWAS. GSEA suggested are cell cycle. addition, abundance CNNM2 rupture (based on PWAS, analyses). Our findings indicated (CNNM2 correlated rupture) potential may provide a broad hint future research possible mechanisms therapeutic targets

Language: Английский

Citations

4
Variations in Magnesium Concentration Are Associated with Increased Mortality: Study in an Unselected Population of Hospitalized Patients DOI Open Access
Justyna Malinowska,

Milena Małecka,

Olga Ciepiela

et al.

Nutrients, Journal Year: 2020, Volume and Issue: 12(6), P. 1836 - 1836

Published: June 19, 2020

Dysmagnesemia is a serious disturbance of microelement homeostasis. The aim this study was to analyze the distribution serum magnesium concentrations in hospitalized patients according gender, age, and result hospitalization. conducted from February 2018 January 2019 at Central Clinical Hospital Warsaw. Laboratory test results 20,438 were included retrospective analysis. When lower reference value 0.65 mmol/L applied, hypermagnesemia occurred 196 (1%), hypomagnesemia 1505 (7%), normomagnesemia 18,711 (92%). At 0.75 mmol/L, found 25% 74% patients. 0.85 60% 39% Either hypo- or hyper-magnesemia associated with increased risk in-hospital mortality. This highest (40.1% deaths), but also increases inversely concentration below mmol/L. Serum not gender-dependent, there slight positive correlation age (p < 0.0001, r = 0.07). Large fluctuations level mortality 0.0017). indicate that dysmagnesemia severe diseases generally conditions. To avoid misdiagnosis, an increase cut-off for least suggested.

Language: Английский

Citations

28