Journal of Food Composition and Analysis, Journal Year: 2024, Volume and Issue: 136, P. 106700 - 106700
Published: Aug. 30, 2024
Language: Английский
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(8), P. 672 - 672
Published: April 12, 2024
Curcumin, an organic phenolic molecule that is extracted from the rhizomes of Curcuma longa Linn, has undergone extensive evaluation for its diverse biological activities in both animals and humans. Despite favorable characteristics, curcumin encounters various formulation challenges stability issues can be effectively addressed through application nanotechnology. Nano-based techniques specifically focused on enhancing solubility, bioavailability, therapeutic efficacy while mitigating toxicity, have been explored curcumin. This review systematically presents information improvement curcumin’s beneficial properties when incorporated, either individually or conjunction with other drugs, into nanosystems such as liposomes, nanoemulsions, polymeric micelles, dendrimers, nanoparticles, solid-lipid nanostructured lipid carriers. Additionally, examines ongoing clinical trials recently granted patents, offering a thorough overview dynamic landscape delivery. Researchers are currently exploring nanocarriers crucial features surface modification, substantial loading capacity, biodegradability, compatibility, autonomous targeting specificity selectivity. Nevertheless, utilization delivery still initial phases, regulatory approval pending persistent safety concerns surrounding their use.
Language: Английский
Citations
24
ACS Omega, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
Curcumin (cur) possesses excellent therapeutic properties, including anti-inflammatory, antioxidant, and healing-promoting effects. However, its biomedical application is impeded by rapid degradation, limited bioavailability, poor aqueous solubility. Zeolitic imidazole framework (ZIF-8), with a high surface area tunable pore size, designed used as cur delivery carrier to overcome these limitations. The synthesis of cur-loaded ZIF-8 involves solvothermal method, followed encapsulation within the porous structure ZIF-8. amount was varied synthesize series panel 0.5 mg/mL cur@ZIF-8 that showed higher drug loading efficiency (85.91 ± 1.26%) capability (12.93 0.19%) without changes in shape, crystallinity, chemical composition, thermal stability original exhibited (1591.02 m2/g) micropore volume (0.54 cm3/g). Cur@ZIF-8 demonstrated superior outstanding antibacterial achieving 99% compared free cur. It less cytotoxicity against human fibroblast cells better antioxidant properties than Furthermore, release rate under acidic conditions, which promotes wound healing due microenvironment skin. biocompatibility nanoparticles highlight their potential promising candidates for diverse applications.
Language: Английский
Citations
5
Nutrients, Journal Year: 2023, Volume and Issue: 15(24), P. 5116 - 5116
Published: Dec. 15, 2023
Cognitive impairment and dementia are burgeoning public health concerns, especially given the increasing longevity of global population. These conditions not only affect quality life individuals their families, but also pose significant economic burdens on healthcare systems. In this context, our comprehensive narrative review critically examines role nutritional supplements in mitigating cognitive decline. Amidst growing interest non-pharmacological interventions for enhancement, delves into efficacy vitamins, minerals, antioxidants, other dietary supplements. Through a systematic evaluation randomized controlled trials, observational studies, meta-analysis, focuses outcomes such as memory attention improvement, executive function support, neuroprotection. The findings suggest complex interplay between supplementation health, with some showing promising results others displaying limited or context-dependent effectiveness. highlights importance dosage, bioavailability, individual differences response to supplementation. Additionally, it addresses safety concerns potential interactions conventional treatments. By providing clear overview current scientific knowledge, aims guide professionals researchers making informed decisions about use health.
Language: Английский
Citations
27
Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14
Published: June 6, 2023
Curcumin is well known as a potent antioxidant and free radical scavenger has great potential for anti-aging applications. In this study, we investigate the molecular mechanism of curcumin in prolonging lifespan
Language: Английский
Citations
25
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(2), P. 164 - 164
Published: Jan. 28, 2024
Curcumin is a natural compound found in turmeric that exhibits diverse biological activities. However, its poor bioavailability limits therapeutic application, which has led to the development of various bioavailability-improved formulations. In this methodological study, we analyzed whether systematic reviews on curcumin considered systemic oral formulations when synthesizing evidence from human clinical trials. A total 171 published between 2003 and 2022 were included study. From studies, extracted data study characteristics; type curcumin; methods; reporting regarding bioavailability, funding, conflict interest. Our results show rarely consider variable tested Relevant statistical subgroup and/or sensitivity analyses reported methods only 3.5% 6.4% reviews, respectively. more mentioned their discussion (57%) or conclusion (13%). The detailed analysis suggests there broad recognition product as crucial factor affecting health effects curcumin, not accompanied by adequate synthesis. Therefore, most orally administered should be taken with caution.
Language: Английский
Citations
12
Vegetos, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 23, 2024
Language: Английский
Citations
11
Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1298 - 1298
Published: April 26, 2024
Natural products from mushrooms, plants, microalgae, and cyanobacteria have been intensively explored studied for their preventive or therapeutic potential. Among age-related pathologies, neurodegenerative diseases (such as Alzheimer’s Parkinson’s diseases) represent a worldwide health social problem. Since several pathological mechanisms are associated with neurodegeneration, promising strategies against aimed to target multiple processes. These approaches usually avoid premature cell death the loss of function damaged neurons. This review focuses attention on potential compounds derived natural sources, which could be exploited neuroprotective effect. Curcumin, resveratrol, ergothioneine, phycocyanin presented examples successful approaches, special focus possible improve delivery brain.
Language: Английский
Citations
10
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 982 - 982
Published: July 25, 2024
This study explored the therapeutic efficacy of
Language: Английский
Citations
8
Drugs and Drug Candidates, Journal Year: 2025, Volume and Issue: 4(1), P. 4 - 4
Published: Feb. 5, 2025
Background/Objectives: The interaction of bioactive compounds derived from plants with drugs has become a significant area investigation due to its potential improve, reduce, or have no effect on therapeutic outcomes. Due the dual these interactions, elucidating underlying mechanisms is essential for establishing strategy. This study emphasizes findings, mechanisms, and clinical implications drug–plant interactions. It calls more studies seek safe effective incorporation into practice. Methods: To identify relevant studies, we performed systematic literature search based various scientific databases 11 August 2024 30 December 2024. will be keywords such as synergy, antagonism, plant compounds, drug interactions supplemented secondary terms phytochemicals, herb-drug pharmacokinetics, pharmacodynamics. Results: Plant bioactives, including polyphenols, flavonoids, alkaloids, terpenoids, display valuable biological activities that can interact medications in three principal ways: additive effects, antagonism. Synergy occurs when combined effects chemicals pharmaceuticals outweigh sum their separate increasing effectiveness allowing dosage decrease reduce adverse effects. Additive occur impact equals total individual resulting better outcomes without risk. Antagonism ingredient reduces counteracts medicine, thereby jeopardizing treatment. In addition, specific may discernible effect. chemical makeup chemicals, medication patient characteristics genetics metabolism all intricacy Conclusions: Pharmacokinetics pharmacodynamics considerably modulated through components, which cause efficacy increase toxicity agents. More are needed clarify action, prove relevance, create guidelines co-administration. integrative approach mitigate those risks allow optimization by introducing pharmacogenomics personalized medicine approaches.
Language: Английский
Citations
1
Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 454 - 454
Published: Feb. 12, 2025
Conditions like diabetes mellitus (DM), cancer, infections, inflammation, cardiovascular diseases (CVDs), and gastrointestinal (GI) disorders continue to have a major global impact on mortality morbidity. Medicinal plants been used since ancient times in ethnomedicine (e.g., Ayurveda, Unani, Traditional Chinese Medicine, European Medicine) for the treatment of wide range disorders. Plants are rich source diverse phytoconstituents with antidiabetic, anticancer, antimicrobial, antihypertensive, antioxidant, antihyperlipidemic, cardioprotective, immunomodulatory, and/or anti-inflammatory activities. This review focuses 35 most commonly reported these disorders, particular emphasis their traditional uses, phytoconstituent contents, pharmacological properties, modes action. Active phytomolecules therapeutic potential include cucurbitane triterpenoids, diosgenin, limonoids (azadiradione gedunin), which exhibit antidiabetic triterpenoids specifically activating Glucose Transporter Type 4 (GLUT4) translocation. Capsaicin curcumin demonstrate anticancer activity by deactivating NF-κB arresting cell cycle G2 phase. Antimicrobial activities observed piperine, reserpine, berberine, dictamnine, chelerythrine, allitridin, latter two triggering bacterial lysis. Quercetin, catechin, genistein suppressing CD8+ cytotoxic T function. Ginsenoside Rg1 ginsenoside Rg3 treating diseases, PPARα promoter, PI3K/Akt pathway. In contrast, ternatin, tannins, quercitrin regulating arachidonic acid metabolism cyclooxygenase (COX) lipoxygenase activity. Further studies warranted fully investigate clinical benefits phytoconstituents, as well elucidate underlying molecular mechanisms
Language: Английский
Citations
1