Obesity and malnutrition in children and adults: A clinical review

Obesity Pillars, Journal Year: 2023, Volume and Issue: 8, P. 100087 - 100087

Published: Sept. 7, 2023

In the U.S., children and adults are consuming more low-nutrient foods with added sugar excess fats as compared to healthy, high-quality calories micronutrients. This diet is increasing prevalence of malnutrition nutritional deficiencies, despite high calorie intake. a review common micronutrient risk factors for malnutrition, dietary plans, health consequences in obesity U.S.

Language: Английский

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Intermittent fasting and protein pacing are superior to caloric restriction for weight and visceral fat loss

Obesity, Journal Year: 2022, Volume and Issue: 31(S1), P. 139 - 149

Published: Dec. 27, 2022

Abstract Objective This study compared intermittent fasting and protein pacing (IF‐P) versus a heart‐healthy caloric restriction (CR) diet, matched for energy intake physical activity expenditure, on body weight, total visceral fat mass, cardiometabolic health outcomes in adults with obesity. Methods IF‐P ( n = 21) CR 20) were assessed pre‐ (week 0), mid‐ 5), post‐ 9) intervention. Results Both groups reduced p < 0.05) blood pressure lipids, desire to eat food increased proportion of fat‐free mass. resulted greater reductions weight (−9% vs. −5%), (−16% −9%) (−33% −14%) (−17% 1%) mass percent (6% 3%) CR. These improvements despite similar weekly (IF‐P, 9470 ± 550 CR, 9095 608 kcal/wk; 0.90) expenditure 300 150 350 200 kcal/d; 0.79). Conclusions optimize loss, composition, health, hunger management, providing benefits.

Language: Английский

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Evaluation of the effectiveness of intermittent fasting versus caloric restriction in weight loss and improving cardiometabolic health: A systematic review and meta-analysis

Journal of Taibah University Medical Sciences, Journal Year: 2025, Volume and Issue: 20(2), P. 159 - 168

Published: March 7, 2025

Language: Английский

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Baicalin alleviates lipid accumulation in adipocytes via inducing metabolic reprogramming and targeting Adenosine A1 receptor

Toxicon, Journal Year: 2025, Volume and Issue: unknown, P. 108339 - 108339

Published: April 1, 2025

Language: Английский

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The metabolic effects of intermittent fasting in patients with type 2 diabetes exist in the short term but disappear after its discontinuation: a systematic review and meta-analysis of randomized controlled trials

Nutrition Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Exploratory analysis of one versus two-day intermittent fasting protocols on the gut microbiome and plasma metabolome in adults with overweight/obesity

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Oct. 26, 2022

Nutritional interventions are a promising therapeutic option for addressing obesity and cardiometabolic dysfunction. One such option, intermittent fasting (IF), has emerged as viable alternative to daily caloric restriction may beneficially modulate body weight regulation alter the gut microbiome (GM) plasma metabolome. This secondary analysis of larger, registered trial (ClinicalTrials.gov ID: NCT04327141) examined effect four-week intervention comparing one vs. two-consecutive days IF in combination with protein pacing (IF-P; 4-5 meals/day, >30% protein/day) on GM, metabolome, associated clinical outcomes overweight obese adults. Participants (n = 20) were randomly assigned either diet consisting day (total 36 h) six low-calorie P per week (IF1-P, n 10) or two (60 h total) five (IF2-P, 10). The fecal microbiome, outcomes, metabolome analyzed at baseline (week 0) after four weeks. There no significant time interaction effects alpha diversity; however, diversity was negatively correlated percent fat change (p 0.030). In addition, beta-diversity both groups altered significantly by 0.001), differences between groups. IF1-P group had increase abundance Ruminococcaceae Incertae Sedis Eubacterium fissicatena (q ≤ 0.007), while IF2-P decrease ventriosum 0.005). metabolite profile participants displayed increases serine, trimethylamine oxide (TMAO), levulinic acid, 3-aminobutyric citrate, isocitrate, glucuronic acid 0.049) compared IF1-P. Fecal short-chain fatty concentrations did not differ ≥ 0.126). Interestingly, gastrointestinal symptoms reduced but group. Our results demonstrate that short-term modestly influenced GM community structure suggesting these protocols could be certain nutritional strategies.

Language: Английский

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A detective story of intermittent fasting effect on immunity

Immunology, Journal Year: 2024, Volume and Issue: 173(2), P. 227 - 247

Published: June 25, 2024

Abstract Intermittent fasting (IF) refers to periodic routines, that caloric intake is minimized not by meal portion size reduction but intermittently eliminating ingestion of one or several consecutive meals. IF can instigate comprehensive and multifaceted alterations in energy metabolism, these metabolic channels may aboundingly function as primordial mechanisms interface with the immune system, instigating intricate transformations. This review delivers a understanding IF, paying particular attention its influence on thus seeking bridge two research domains. We explore how effects lipid hormonal levels, circadian rhythm, autophagy, oxidative stress, gut microbiota, intestinal barrier integrity, conjecture about orchestrating intersect between factors system. Moreover, includes findings implications system patients burdened autoimmune diseases.

Language: Английский

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Role of Ketogenic Diets and Intermittent Fasting in Neurologic Diseases, Cancers, and Obesity: A Systematic Review of Human Studies

Journal of Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 14(3), P. 103 - 127

Published: June 1, 2024

Ketogenic diet (KD) and intermittent fasting (IF) are non-pharmacologic nutritional therapies with modest side effects such gastrointestinal discomfort, dyslipidemia, hypomagnesemia for various medical conditions. KD IF may help weight loss, diabetes, cardiovascular disease, polycystic ovarian syndrome, cancer, chronic neurological illnesses. We studied IFs impact on obesity, neurodegenerative advised evidence-based safety. is hard to maintain despite benefits. Thus, occasional adoption newly diagnosed overweight or obese type 2 diabetics lose control blood glucose lipids. a high-fat, low-carbohydrate 4:1 3:1 fat carbohydrates protein, thus peripheral tissues the brain need fatty acids energy. Most energy comes from ketones. has been reliably used treat refractory epilepsy since 1920s. prevents epilepsy, stroke, severe injury, Alzheimers, other obesity 1960s. Combining chemotherapy radiation increase tumor cell sensitivity. can be disease without medicine effects. As an adjuvant therapy, offer new neuroprotection neuroscience treatments. Antioxidant defense inflammation reduction alleviate Alzheimers Parkinsons risk. By targeting cancer metabolism, cancer. Radiation intensified when in conjunction KD. In aggressive glioblastoma, most promising. Ketosis suppresses hunger, aiding loss patients. Among diabetes patients, it helps manage cholesterol, but long-term adherence difficult. If paired exercise, more effective than calorie restriction loss. Further prospective human trials needed assess therapeutic efficacy J Endocrinol Metab. 2024;14(3):103-127 doi: https://doi.org/10.14740/jem944

Language: Английский

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Sex-specific effects of intermittent fasting on hippocampal neurogenesis via the gut-brain axis

Food & Function, Journal Year: 2024, Volume and Issue: 15(16), P. 8432 - 8447

Published: Jan. 1, 2024

IF promotes neurogenesis in the hippocampal DG region. alters gut microbiota, decrease F-1-P, with sex-specific differences.

Language: Английский

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Is Intermittent Fasting Better Than Continuous Energy Restriction for Adults with Overweight and Obesity?

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2022, Volume and Issue: Volume 15, P. 2813 - 2826

Published: Sept. 1, 2022

Abstract: As a popular weight management intervention, intermittent fasting (IF) has been widely applied to the treatment of overweight and obesity in adults. This review describes different forms implementation protocols IF their effects on body weight, composition, cardiometabolic risk factors other diseases. The existing evidence suggests that is as effective continuous energy restriction may be feasible approach loss. Keywords: overweight, obesity, fasting, restriction,

Language: Английский

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