Nanomaterials, Journal Year: 2024, Volume and Issue: 14(15), P. 1254 - 1254
Published: July 26, 2024
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Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 100, P. 102450 - 102450
Published: Aug. 10, 2024
Language: Английский
Citations
6
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(6), P. 1750 - 1750
Published: June 16, 2023
Neural tissue engineering presents a compelling technological breakthrough in restoring brain function, holding immense promise. However, the quest to develop implantable scaffolds for neural culture that fulfill all necessary criteria poses remarkable challenge material science. These materials must possess host of desirable characteristics, including support cellular survival, proliferation, and neuronal migration minimization inflammatory responses. Moreover, they should facilitate electrochemical cell communication, display mechanical properties akin brain, emulate intricate architecture extracellular matrix, ideally allow controlled release substances. This comprehensive review delves into primary requisites, limitations, prospective avenues scaffold design engineering. By offering panoramic overview, our work aims serve as an essential resource, guiding creation endowed with bio-mimetic properties, ultimately revolutionizing treatment neurological disorders by developing brain-implantable scaffolds.
Language: Английский
Citations
13
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12
Published: July 18, 2024
Treating brain diseases presents significant challenges due to neuronal degeneration, inflammation, and the intricate nature of brain. Stimuli-responsive hydrogels, designed closely resemble brain’s extracellular matrix, have emerged as promising candidates for controlled drug delivery tissue engineering. These hydrogels unique ability encapsulate therapeutic agents release them in a manner when triggered by environmental stimuli. This property makes particularly suitable delivering drugs precisely targeted areas brain, while minimizing collateral damage healthy tissue. Their preclinical success treating various animal studies underscores their translational potential human disease treatment. However, deeper understanding long-term behavior, biodistribution, biocompatibility within remains crucial. Furthermore, exploring novel hydrogel systems combinations is paramount advancing towards more effective treatments. review summarizes latest advancements this field over past 5 years, specifically highlighting progress with stimuli-responsive diseases.
Language: Английский
Citations
5
OBM Neurobiology, Journal Year: 2024, Volume and Issue: 08(01), P. 1 - 22
Published: Jan. 11, 2024
In the last decade, development in nanotechnology has been used intensively. By studying and nanomaterials, we can generate excellent responses healthcare related to neurological disorders. It also includes easy diagnosis of diseases their early stages, delivery genes, many more. Neurological disorders are one most sensitive topics. Therefore, nanomaterials promise treat as they highly efficient. Nanomaterials will significantly expand our knowledge how disease originates nervous system so that diagnose its stages. This review describe an overview paper present utilization with help recent data current research. focus on significant importance toxicology neurology. deal different applications studies impact developing new types treatment for Lastly, this discuss all challenges face promises future vast field.
Language: Английский
Citations
4
Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 30, 2024
Abstract The incidence of nerve tissue injuries, such as peripheral injury, spinal cord traumatic brain and various neurodegenerative diseases (NDs), is continuously increasing because stress, physical chemical trauma, the aging population worldwide. Restoration damaged nervous system challenging its structural functional complexity limited regenerative ability. Additionally, there no cure available for NDs except medications that provide symptomatic relief. Stem cells offer an alternative approach promoting damage repair, but their efficacy by a compromised survival rate neurogenesis process. To address these challenges, neural engineering has emerged promising strategy in which stem are seeded or encapsulated within suitable biomaterial construct, cell neurogenesis. Numerous biomaterials utilized to create different types constructs this purpose. Researchers trying develop ideal scaffolds combine biomaterials, cells, molecules exactly mimic biological mechanical properties achieve recovery associated with neurological dysfunction. This review focuses on exploring development applications potential use diagnosis, therapy, regeneration, treatment disorders.
Language: Английский
Citations
4
Neuroscience, Journal Year: 2024, Volume and Issue: 562, P. 106 - 124
Published: Oct. 28, 2024
Language: Английский
Citations
4
Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 29, 2025
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 189 - 210
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Pharmacology and Experimental Therapeutics, Journal Year: 2025, Volume and Issue: 392(4), P. 103522 - 103522
Published: Feb. 25, 2025
Approved therapies for managing opioid addiction involve intensive treatment regimens which remain both costly and ineffective. As pharmaceutical interventions have achieved variable success treating substance use disorders (SUD), alternative therapeutics must be considered. Antidrug antibodies induced by vaccination or introduced as monoclonal antibody formulations can neutralize destroy opioids in circulation before they reach their central nervous system targets act enzymes to deactivate receptors, preventing the physiologic psychoactive effects of substance. A lack "reward" those suffering from SUD has been shown result cessation promote long-term abstinence. Decreased production costs advent novel gene that stimulate vivo renewed interest this strategy. Furthermore, advances understanding immunopathogenesis revealed distinct mechanisms neuroimmune dysregulation underlying disorder. Beyond assisting with drug use, could treat reverse pathophysiologic hallmarks contribute cause chronic cognitive defects resulting use. In review, we synthesize key current literature regarding efficacy immunotherapies SUD. We will explore neuropharmacology these treatments relating evidence studies on counteract various behaviors drawing parallels similar immunopathology observed neurodegenerative disorders. Finally, discuss implications immunization technologies application computational methods developing personalized treatments. SIGNIFICANCE STATEMENT: Significant new contributing our recently emerged leading a paradigm shift concerning role immunology neuropathogenesis Concurrently, immunotherapeutic such advanced capabilities applications take advantage principles. This article reviews antibody-based being studied highlights directions further research may management
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 352 - 352
Published: March 9, 2025
Pharmaceutical 3D printing, combined with nanomaterials and nanodevices, presents a transformative approach to precision medicine for treating neurological diseases. This technology enables the creation of tailored dosage forms controlled release profiles, enhancing drug delivery across blood−brain barrier (BBB). The integration nanoparticles, such as poly lactic-co-glycolic acid (PLGA), chitosan, metallic nanomaterials, into 3D-printed scaffolds improves treatment efficacy by providing targeted prolonged release. Recent advances have demonstrated potential these systems in conditions like Parkinson’s disease, epilepsy, brain tumors. Moreover, printing allows multi-drug combinations personalized formulations that adapt individual patient needs. Novel approaches, including stimuli-responsive systems, on-demand dosing, theragnostics, provide new possibilities real-time monitoring disorders. Despite innovations, challenges remain terms scalability, regulatory approval, long-term safety. future perspectives this suggest its revolutionize treatments offering patient-specific therapies, improved penetration, enhanced outcomes. review discusses current state, applications, nanotechnology treatment, highlighting need further research overcome existing challenges.
Language: Английский
Citations
0