Molecular Cancer,
Journal Year:
2020,
Volume and Issue:
19(1)
Published: Aug. 5, 2020
Abstract
Targeted
treatment,
which
can
specifically
kill
tumour
cells
without
affecting
normal
cells,
is
a
new
approach
for
therapy.
However,
tend
to
acquire
resistance
targeted
drugs
during
treatment.
Circular
RNAs
(circRNAs)
are
single-stranded
RNA
molecules
with
unique
structures
and
important
functions.
With
the
development
of
sequencing
technology,
circRNAs
have
been
found
be
widespread
in
tumour-resistant
play
regulatory
roles.
In
this
review,
we
present
latest
advances
circRNA
research
summarize
various
mechanisms
underlying
their
regulation.
Moreover,
review
role
chemotherapeutic
tumours
explore
clinical
value
regulation
treating
resistance.
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2020,
Volume and Issue:
39(1)
Published: Sept. 30, 2020
Abstract
Tumor
angiogenesis
is
necessary
for
the
continued
survival
and
development
of
tumor
cells,
plays
an
important
role
in
their
growth,
invasion,
metastasis.
The
microenvironment—composed
surrounding
secreted
cytokines—provides
a
conducive
environment
growth
tumors.
Different
components
microenvironment
can
regulate
development.
In
this
review,
we
have
discussed
regulatory
angiogenesis.
High
expression
angiogenic
factors
inflammatory
cytokines
microenvironment,
as
well
hypoxia,
are
presumed
to
be
reasons
poor
therapeutic
efficacy
current
anti-angiogenic
drugs.
A
combination
drugs
antitumor
or
hypoxia
inhibitors
might
improve
outcome.
Molecular Cancer,
Journal Year:
2020,
Volume and Issue:
19(1)
Published: April 27, 2020
Abstract
Epigenetics
is
dynamic
and
heritable
modifications
to
the
genome
that
occur
independently
of
DNA
sequence.
It
requires
interactions
cohesively
with
various
enzymes
other
molecular
components.
Aberrant
epigenetic
alterations
can
lead
inappropriate
onset
genetic
expressions
promote
tumorigenesis.
As
modifiers
are
susceptible
extrinsic
factors
reversible,
they
becoming
promising
targets
in
multiple
cancer
therapies.
Recently,
epi-drugs
have
been
developed
implicated
clinical
use.
The
use
alone,
or
combination
chemotherapy
immunotherapy,
has
shown
compelling
outcomes,
including
augmentation
anti-tumoral
effects,
overcoming
drug
resistance,
activation
host
immune
response.
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: May 21, 2021
Abstract
Significant
progress
has
been
made
in
circular
RNA
(circRNA)
research
recent
years.
Increasing
evidence
suggests
that
circRNAs
play
important
roles
many
cellular
processes,
and
their
dysregulation
is
implicated
the
pathogenesis
of
various
diseases.
CircRNAs
are
highly
stable
usually
expressed
a
tissue-
or
cell
type-specific
manner.
Therefore,
they
currently
being
explored
as
potential
therapeutic
targets.
Gain-of-function
loss-of-function
approaches
typically
performed
using
circRNA
expression
plasmids
interference-based
strategies,
respectively.
These
strategies
have
limitations
can
be
mitigated
nanoparticle
exosome
delivery
systems.
Furthermore,
developments
show
cre-lox
system
used
to
knockdown
cell-specific
While
still
early
stages
development,
CRISPR/Cas13
shown
promise
knocking
down
with
high
specificity
efficiency.
In
this
review,
we
describe
properties
functions
highlight
significance
disease.
We
summarize
overexpress
approach.
Lastly,
discuss
major
challenges
propose
future
directions
for
development
circRNA-based
therapeutics.
Frontiers in Immunology,
Journal Year:
2020,
Volume and Issue:
11
Published: April 3, 2020
The
intestinal
tract
is
the
largest
digestive
organ
in
human
body.
It
colonized
by,
and
consistently
exposed
to,
a
myriad
of
microorganisms,
including
bifidobacteria,
lactobacillus,
Escherichia
coli,
enterococcus,
clostridium
perfringens,
pseudomonas.
To
protect
body
from
potential
pathogens,
has
evolved
regional
immune
characteristics.
These
characteristics
are
defined
by
its
unique
structure,
function,
microenvironment,
which
differ
drastically
those
common
central
peripheral
organs.
microenvironment
created
flora
products
significantly
affects
function
region.
In
turn,
specific
diseases
regulate
influence
composition
flora.
A
constant
interplay
occurs
between
system.
Further,
can
be
reconstructed
probiotic
use
or
microbiota
transplantation,
functioning
to
recalibrate
homeostasis,
while
also
contributing
treatment
amelioration
diseases.
this
review,
we
summarize
relationship
occurrence
development
as
an
in-turn
effect
on
immunity.
We
discuss
improved
it
relates
non-specific
proliferation,
differentiation
secretion
cells,
within
region
following
remodeling
means
ameliorate
treat
Finally,
suggest
strategies
for
utilization
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: Nov. 10, 2021
Exosomes
play
a
role
as
mediators
of
cell-to-cell
communication,
thus
exhibiting
pleiotropic
activities
to
homeostasis
regulation.
Exosomal
non-coding
RNAs
(ncRNAs),
mainly
microRNAs
(miRNAs),
long
(lncRNAs),
and
circular
(circRNAs),
are
closely
related
variety
biological
functional
aspects
human
health.
When
the
exosomal
ncRNAs
undergo
tissue-specific
changes
due
diverse
internal
or
external
disorders,
they
can
cause
tissue
dysfunction,
aging,
diseases.
In
this
review,
we
comprehensively
discuss
underlying
regulatory
mechanisms
exosomes
in
addition,
explore
current
knowledge
on
roles
miRNAs,
lncRNAs,
circRNAs
health
diseases,
including
cancers,
metabolic
neurodegenerative
cardiovascular
autoimmune
infectious
determine
their
potential
implication
biomarker
identification
therapeutic
exploration.
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2021,
Volume and Issue:
40(1)
Published: March 1, 2021
Abstract
Single-cell
RNA
sequencing
(scRNA-seq),
a
technology
that
analyzes
transcriptomes
of
complex
tissues
at
single-cell
levels,
can
identify
differential
gene
expression
and
epigenetic
factors
caused
by
mutations
in
unicellular
genomes,
as
well
new
cell-specific
markers
cell
types.
scRNA-seq
plays
an
important
role
various
aspects
tumor
research.
It
reveals
the
heterogeneity
cells
monitors
progress
development,
thereby
preventing
further
cellular
deterioration.
Furthermore,
transcriptome
analysis
immune
tissue
be
used
to
classify
cells,
their
escape
mechanisms
drug
resistance
mechanisms,
develop
effective
clinical
targeted
therapies
combined
with
immunotherapy.
Moreover,
this
method
enables
study
intercellular
communication
interaction
non-malignant
reveal
carcinogenesis.
provides
technical
means
for
development
research
is
expected
make
significant
breakthroughs
field.
This
review
focuses
on
principles
scRNA-seq,
emphasis
application
heterogeneity,
pathogenesis,
treatment.
Briefings in Bioinformatics,
Journal Year:
2018,
Volume and Issue:
20(5), P. 1853 - 1864
Published: May 31, 2018
Abstract
Long
noncoding
RNAs
(lncRNAs)
are
a
group
of
transcripts
that
longer
than
200
nucleotides
(nt)
without
coding
potential.
Over
the
past
decade,
tens
thousands
novel
lncRNAs
have
been
annotated
in
animal
and
plant
genomes
because
advanced
high-throughput
RNA
sequencing
technologies
with
aid
transcript
classifiers.
Further,
considerable
number
reports
revealed
existence
stable,
functional
small
peptides
(also
known
as
micropeptides),
translated
from
lncRNAs.
In
this
review,
we
discuss
methods
lncRNA
classification,
investigations
regarding
their
potential
significance
they
encode.
