Immunotherapy resistance in non-small-cell lung cancer: From mechanism to clinical strategies DOI Creative Commons
Suna Zhou, Haihua Yang

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 6, 2023

The high primary resistance incidence and unavoidable secondary are the major clinical obstacle to lasting long-term benefits in Non-small-cell lung cancer (NSCLC) patients treated with immunotherapy. mechanisms of immunotherapy NSCLC complex, mainly involving tumor cells microenvironment (TME) infiltrating immune cells, including TAMs, B NK T cells. selection strategies for progression after should depend on progressive mode. pattern can be divided into oligo-progression systemic/multiple progression, which considered further treatment selection. In future, it needs explore how optimize combined therapy reprogram under various genetic backgrounds timely reshape TME during antitumor treatments.

Language: Английский

Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma DOI Creative Commons
Zongqiang Hu, Gang Chen,

Yingpeng Zhao

et al.

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: March 18, 2023

Abstract Background Circular RNAs (circRNAs) can be encapsulated into exosomes to participate in intercellular communication, affecting the malignant progression of a variety tumors. Dysfunction CD8 + T cells is main factor immune escape from hepatocellular carcinoma (HCC). Nevertheless, effect exosome-derived circRNAs on T-cell dysfunction needs further exploration. Methods The circCCAR1 tumorigenesis and metastasis HCC was assessed by vitro vivo functional experiments. function measured enzyme-linked immunosorbent assay (ELISA), western blotting flow cytometry. Chromatin immunoprecipitation, biotinylated RNA pull-down, MS2 pull-down assays were used exploration mechanism. A mouse model with reconstituted human system components (huNSG mice) constructed explore role exosomal resistance anti-PD1 therapy HCC. Results Increased levels existed tumor tissues plasma patients, culture supernatant cells. CircCCAR1 accelerated growth vivo. E1A binding protein p300 (EP300) eukaryotic translation initiation 4A3 (EIF4A3) promoted biogenesis circCCAR1, Wilms 1-associated (WTAP)-mediated m6A modification enhanced stability insulin-like 2 mRNA-binding 3 (IGF2BP3). acted as sponge for miR-127-5p upregulate its target WTAP feedback loop comprising circCCAR1/miR-127-5p/WTAP axis formed. secreted heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1)-dependent manner. Exosomal taken caused stabilizing PD-1 protein. immunotherapy. Furthermore, increased cell division cycle apoptosis regulator 1 (CCAR1) induced EP300 CCAR1 β-catenin protein, which transcription PD-L1. Conclusions enhances released contributes immunosuppression facilitating induces immunotherapy, providing potential therapeutic strategy patients.

Language: Английский

Citations

180
Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance DOI Creative Commons
Shujing Wang, Jingrui Wang, Zhiqiang Chen

et al.

npj Precision Oncology, Journal Year: 2024, Volume and Issue: 8(1)

Published: Feb. 10, 2024

Abstract Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular heterogeneity and immunosuppressive nature microenvironment (TME). Tumor-associated macrophages (TAMs) constitute essential components TME. M2-like TAMs are in facilitating metastasis as well augmenting tumors. This review encapsulates mechanisms that use to promote resistance. We also describe emerging therapeutic strategies currently targeting combination with other antitumor drugs, some still undergoing clinical trial evaluation. Furthermore, we summarize analyze various existing approaches for developing novel drugs target overcome resistance, highlighting how can effectively stop growth, metastasis,

Language: Английский

Citations

158
Exosomal circRNA: emerging insights into cancer progression and clinical application potential DOI Creative Commons
Fan Zhang, Jiajia Jiang, Hui Qian

et al.

Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)

Published: June 26, 2023

Abstract Exosomal circRNA serves a novel genetic information molecule, facilitating communication between tumor cells and microenvironmental cells, such as immune fibroblasts, other components, thereby regulating critical aspects of cancer progression including escape, angiogenesis, metabolism, drug resistance, proliferation metastasis. Interestingly, microenvironment have new findings in influencing escape mediated by the release exosomal circRNA. Given intrinsic stability, abundance, broad distribution circRNAs, they represent excellent diagnostic prognostic biomarkers for liquid biopsy. Moreover, artificially synthesized circRNAs may open up possibilities therapy, potentially bolstered nanoparticles or plant exosome delivery strategies. In this review, we summarize functions underlying mechanisms cell non-tumor cell-derived progression, with special focus on their roles immunity metabolism. Finally, examine potential application therapeutic targets, highlighting promise clinical use.

Language: Английский

Citations

99
Current understanding of plant-derived exosome-like nanoparticles in regulating the inflammatory response and immune system microenvironment DOI Creative Commons

Qiaoli Yi,

Zhijie Xu, Abhimanyu Thakur

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 190, P. 106733 - 106733

Published: March 15, 2023

Natural compounds are widely used to prevent and treat various diseases due their antioxidant anti-inflammatory effects. As a kind of promising natural compound, plant-derived exosome-like nanoparticles (PELNs) extracted from multivesicular bodies edible plants, including vegetables, foods, fruits, mainly regulate the cellular immune response pathogen attacks. Moreover, PELNs could remarkably interfere with dynamic imbalance between pro-inflammatory effects, facilitating maintain homeostasis microenvironment. may serve as better alternative animal-derived exosomes (ADEs) owing widespread sources, cost-effectiveness, easy accessibility. can mediate interspecies communication by transferring cargoes such proteins, lipids, nucleic acids plant cells mammalian cells. This review summarizes biogenesis, composition, classification exosomes; common separation, purification, characterization methods PELNs, potential advantages over ADEs; immunomodulatory functions in colitis, cancer, inflammation-associated metabolic diseases. Additionally, future perspectives challenges associated clinical application discussed.

Language: Английский

Citations

95
Extracellular Vesicles in Cancer Drug Resistance: Roles, Mechanisms, and Implications DOI Creative Commons

Yang Qiu-rong,

Jing Xu, Jianmei Gu

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(34)

Published: Oct. 17, 2022

Abstract Extracellular vesicles (EVs) are cell‐derived nanosized that mediate cell‐to‐cell communication via transporting bioactive molecules and thus critically involved in various physiological pathological conditions. EVs contribute to different aspects of cancer progression, such as growth, angiogenesis, metastasis, immune evasion, drug resistance. induce the resistance cells chemotherapy, radiotherapy, targeted therapy, antiangiogenesis immunotherapy by transferring specific cargos affect efflux regulate signaling pathways associated with epithelial‐mesenchymal transition, autophagy, metabolism, stemness. In addition, modulate reciprocal interaction between noncancer tumor microenvironment (TME) develop therapy detectable many biofluids patients, regarded novel biomarkers for monitoring response predicting prognosis. Moreover, suggested promising targets engineered nanovehicles deliver drugs overcoming therapy. this review, biological roles their mechanisms action summarized. The preclinical studies on using also discussed.

Language: Английский

Citations

86
Non-coding RNA in cancer drug resistance: Underlying mechanisms and clinical applications DOI Creative Commons

Xuehao Zhou,

Xiang Ao,

Zhaojun Jia

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: Aug. 17, 2022

Cancer is one of the most frequently diagnosed malignant diseases worldwide, posing a serious, long-term threat to patients’ health and life. Systemic chemotherapy remains first-line therapeutic approach for recurrent or metastatic cancer patients after surgery, with potential effectively extend patient survival. However, development drug resistance seriously limits clinical efficiency ultimately results in treatment failure death. A large number studies have shown that non-coding RNAs (ncRNAs), particularly microRNAs, long RNAs, circular are widely involved regulation resistance. Their dysregulation contributes by modulating expression specific target genes cellular apoptosis, autophagy, efflux, epithelial-to-mesenchymal transition (EMT), stem cells (CSCs). Moreover, some ncRNAs also possess great as efficient, biomarkers diagnosis prognosis well targets patients. In this review, we summarize recent findings on emerging role underlying mechanisms focus their applications treatment. This information will be benefit early prognostic assessments ncRNA-based strategies

Language: Английский

Citations

79
A comprehensive review of SHP2 and its role in cancer DOI
Moges Dessale Asmamaw,

Xiaojing Shi,

Lirong Zhang

et al.

Cellular Oncology, Journal Year: 2022, Volume and Issue: 45(5), P. 729 - 753

Published: Sept. 6, 2022

Language: Английский

Citations

76
Current Landscape of Therapeutic Resistance in Lung Cancer and Promising Strategies to Overcome Resistance DOI Open Access
Adnin Ashrafi, Zakia Akter, Pouya Modareszadeh

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(19), P. 4562 - 4562

Published: Sept. 20, 2022

Lung cancer is one of the leading causes cancer-related deaths worldwide with a 5-year survival rate less than 18%. Current treatment modalities include surgery, chemotherapy, radiation therapy, targeted and immunotherapy. Despite advances in therapeutic options, resistance to therapy remains major obstacle effectiveness long-term treatment, eventually insensitivity, poor progression-free survival, disease relapse. Resistance mechanisms stem from genetic mutations and/or epigenetic changes, unregulated drug efflux, tumor hypoxia, alterations microenvironment, several other cellular molecular alterations. A better understanding these crucial for targeting factors involved resistance, establishing novel antitumor targets, developing strategies resensitize cells towards treatment. In this review, we summarize diverse driving radiotherapy, immunotherapy, promising help overcome resistance.

Language: Английский

Citations

75
USP7 - a crucial regulator of cancer hallmarks DOI
Gouranga Saha, Srija Roy, Malini Basu

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(3), P. 188903 - 188903

Published: April 30, 2023

Language: Английский

Citations

47
The interactions of docetaxel with tumor microenvironment DOI
Reena Gupta, Mustafa M. Kadhim, Abduladheem Turki Jalil

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 119, P. 110214 - 110214

Published: April 29, 2023

Language: Английский

Citations

44