Alterations in Glutathione Redox Homeostasis in Metabolic Dysfunction-Associated Fatty Liver Disease: A Systematic Review DOI Creative Commons
Lucia Cesarini, Flavia Grignaffini, Anna Alisi

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1461 - 1461

Published: Nov. 28, 2024

Low molecular weight (LMW) thiols, particularly glutathione, play pathogenic roles in various multiorgan diseases. The liver is central for the production and systemic distribution of LMW thiols; thus, it susceptible to imbalance redox status that may determine increased oxidative stress trigger damage observed metabolic dysfunction-associated steatotic disease (MASLD) models humans. Indeed, thiols at cellular extracellular levels be associated with severity MASLD. Here, we present a systematic literature review recent studies assessing MASLD vivo vitro human subjects. Based on PRISMA 2020 criteria, search was conducted using PubMed Scopus by applying inclusion/exclusion filters. initial returned 1012 documents, from which 165 eligible were selected, further described, qualitatively analysed. Of these studies, most focused animal models, while minority used fluids. analysis revealed heterogeneity methods sample processing measurement thiol levels, hinder cut-off values diagnostic use. Standardisation measure necessary facilitate future studies.

Language: Английский

Esculin inhibits hepatic stellate cell activation and CCl4-induced liver fibrosis by activating the Nrf2/GPX4 signaling pathway DOI

Shuoxi Xu,

Yonger Chen,

Jindian Miao

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155465 - 155465

Published: Feb. 17, 2024

Language: Английский

Citations

22
Ferroptosis in ulcerative colitis: Potential mechanisms and promising therapeutic targets DOI Open Access

Dan Long,

Chenhan Mao,

Yingtao Huang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116722 - 116722

Published: May 9, 2024

Ulcerative colitis (UC) is a complex immune-mediated chronic inflammatory bowel disease. It mainly characterized by diffuse inflammation of the colonic and rectal mucosa with barrier function impairment. Identifying new biomarkers for development more effective UC therapies remains pressing task current research. Ferroptosis newly identified form regulated cell death iron-dependent lipid peroxidation. As research deepens, ferroptosis has been demonstrated to be involved in pathological processes numerous diseases. A growing body evidence suggests that pathogenesis associated ferroptosis, regulation provides opportunities treatment. However, specific mechanisms which participates remain fully thoroughly investigated. Therefore, this review, we focus on advances mechanism recent years describe potential role UC. In addition, explore underlying crosslinked pathway between other such as macrophages, neutrophils, autophagy, endoplasmic reticulum stress, gut microbiota Finally, also summarize compounds may act inhibitors future.

Language: Английский

Citations

16
Targeting the regulation of iron homeostasis as a potential therapeutic strategy for nonalcoholic fatty liver disease DOI
Yutong Sui,

Xue Geng,

Ziwei Wang

et al.

Metabolism, Journal Year: 2024, Volume and Issue: 157, P. 155953 - 155953

Published: June 15, 2024

Language: Английский

Citations

13
Targeting cell death in NAFLD: mechanisms and targeted therapies DOI Creative Commons

Huili Xu,

Shengrong Wan,

Ying An

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Sept. 7, 2024

Language: Английский

Citations

7
The interplay of miRNAs and ferroptosis in diseases related to iron overload DOI

Shikai Jin,

Po‐Tsun Liu,

Daheng Zheng

et al.

APOPTOSIS, Journal Year: 2023, Volume and Issue: 29(1-2), P. 45 - 65

Published: Sept. 27, 2023

Language: Английский

Citations

15
Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications DOI Creative Commons

Zhili Wu,

Yanru Zhu,

Wen‐Chao Liu

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 352 - 352

Published: March 15, 2024

Ferroptosis is an emerging type of regulated cell death usually accompanied by the accumulation ferrous ions (Fe2+) and lipid peroxides. As metabolic hub body, liver crucial for iron storage metabolism. The seems to be closely related ferroptosis through Liver disease greatly threatens host health, exploring effective interventions essential. Mounting studies have demonstrated that one possible pathogenic mechanisms involved in disease. Targeting may provide a promising opportunity treating However, drugs targeting are extremely limited. Therefore, it urgent need develop new safe regulators. Natural active compounds (NAC), especially those derived from traditional Chinese medicine, recently shown great therapeutic potential via modulating ferroptosis-related genes or pathways. Here, we outline molecular mechanism systematically summarize regulatory function NAC on Finally, discuss application prospects problems concerning as regulators managing

Language: Английский

Citations

5
Inflammatory liver diseases and susceptibility to sepsis DOI
Hong Lü

Clinical Science, Journal Year: 2024, Volume and Issue: 138(7), P. 435 - 487

Published: April 1, 2024

Abstract Patients with inflammatory liver diseases, particularly alcohol-associated disease and metabolic dysfunction-associated fatty (MAFLD), have higher incidence of infections mortality rate due to sepsis. The current focus in the development drugs for MAFLD is resolution non-alcoholic steatohepatitis prevention progression cirrhosis. In patients cirrhosis or alcoholic hepatitis, sepsis a major cause death. As center key immune tissue, guardian, modifier, target Septic dysfunction highest compared other organ dysfunctions. addition maintaining homeostasis, produces secretes hepatokines acute phase proteins (APPs) essential tissue protection, immunomodulation, coagulation. Inflammatory diseases profound disorder impairment energy metabolism, regeneration, production/secretion APPs hepatokines. Herein, author reviews roles (1) disorders metabolism glucose, acids, ketone bodies, amino acids as well clearance ammonia lactate pathogenesis sepsis; (2) cytokines/chemokines (3) protection against injury infections; (4) nuclear receptors/signaling pathways underlying injuries drug targets Approaches that on regeneration will not only treat but also prevent severe

Language: Английский

Citations

4
Exploring the Role of Metabolic Hyperferritinaemia (MHF) in Steatotic Liver Disease (SLD) and Hepatocellular Carcinoma (HCC) DOI Open Access
Nikolaos-Andreas Anastasopoulos, Alexandra Barbouti, Anna Goussia

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 842 - 842

Published: Feb. 28, 2025

The increasing prevalence of the spectrum Steatotic Liver Disease (SLD), including Metabolic-Associated (MASLD), Steatohepatitis (MASH), and progression to Cirrhosis Hepatocellular Carcinoma (HCC) has led intense research in disease pathophysiology, with many studies focusing on role iron. Iron overload, which is often observed patients SLD as a part metabolic hyperferritinaemia (MHF), particularly reticuloendothelial system (RES), can exacerbate steatosis. This imbalance iron distribution, coupled high-fat diet, further promote by means oxidative stress triggering inflammation activating hepatic stellate cells (HSCs), therefore leading fibrosis simple steatosis more severe MASH. influence overload also been shown complex ferroptosis, type cell death driven iron-dependent lipid peroxidation. Ferroptosis depletes liver's antioxidant capacity, contributing development MASH, while its MASH-related HCC potentially linked alternations tumour microenvironment, well ferroptosis resistance. iron-rich steatotic environment becomes prone hepatocarcinogenesis activation several pro-carcinogenic mechanisms epithelial-to-mesenchymal transition deactivation DNA damage repair. Biochemical markers deranged metabolism have all stages associated multiple patient cohorts diverse genetic backgrounds, enhancing our daily clinical understanding this interaction. Further could lead enhanced therapies for management prevention.

Language: Английский

Citations

0
Multi-approach analysis reveals the mechanism by which Shugan Xiaozhi decoction protects against metabolic dysfunction-associated steatohepatitis DOI Creative Commons
Shuai Wang,

Ruili Du,

Jiahui Liu

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 141, P. 156712 - 156712

Published: April 2, 2025

Metabolic dysfunction-associated steatohepatitis (MASH) is a human health-threatening hepatic disease with limited treatment strategies. As clinical Traditional Chinese Medicine compound for MASH, Shugan Xiaozhi (SGXZ) decoction has definite effect, but its mechanism in treating MASH still not very clear. Exploring the potential of SGXZ through multiomics and animal experimental validation. UPLC-ESI-MS method was used to identify main components decoction. Periodic acid-schiff (PAS), picrosirius red (PSR), oil o staining were assess effect on MCD-induced mouse model. The analyzed using techniques. TUNEL staining, western blot (WB), immunohistochemistry (IHC), kits, transmission electron microscopy (TEM), immunofluorescence (IF) validate MASH. Finally, molecular docking dynamics simulation verify targeting between key important targets intervention. Through analysis, 30 active ingredients obtained from improved as evidenced by improvement histopathology, function indexes, lipid fibrosis indicators. Both proteomic transcriptomic results suggested an role ferroptosis intervention ferroptosis-related pathways significant these analyses. In addition, reduced cell death, inflammation, oxidative stress levels restored impaired mitochondrial morphology mice. Furthermore, Mechanism experiments proved that iron metabolism peroxidation imbalance activated Xc- system does have therapeutic may be related regulation p53/ SLC7A11/GPX4 pathway reduce ferroptosis.

Language: Английский

Citations

0
The NRF-2/HO-1 Signaling Pathway: A Promising Therapeutic Target for Metabolic Dysfunction-Associated Steatotic Liver Disease DOI Creative Commons
Na Li, Liyuan Hao, Shenghao Li

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 8061 - 8083

Published: Nov. 1, 2024

Abstract: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive disorder with rising prevalence. It begins lipid accumulation in hepatocytes and gradually progresses to Metabolic-associated steatohepatitis (MASH), fibrosis, cirrhosis, potentially hepatocellular carcinoma (HCC). The pathophysiology of MASLD complex involves multiple factors, oxidative stress playing crucial role. Oxidative drives the progression by causing cellular damage, inflammatory responses, making it key pathogenic mechanism. Nuclear Factor Erythroid 2-Related 2 / Heme Oxygenase-1 (Nrf2/HO-1) signaling axis provides robust multi-organ protection against spectrum endogenous exogenous insults, particularly stress. plays pivotal role mediating antioxidant, anti-inflammatory, anti-apoptotic responses. Many studies indicate that activating Nrf2/HO-1 pathway can significantly mitigate MASLD. This article examines highlights natural compounds protect targeting activation. findings holds great promise as therapeutic target for Keywords: NRF-2/HO-1 pathway, antioxidants, compounds, non-alcoholic fatty

Language: Английский

Citations

2