Journal of Nanobiotechnology,
Journal Year:
2021,
Volume and Issue:
19(1)
Published: Dec. 13, 2021
Accurate
diagnosis
and
effective
treatment
of
primary
liver
tumors
are
great
significance,
optical
imaging
has
been
widely
employed
in
clinical
imaging-guided
surgery
for
tumors.
The
second
near-infrared
window
(NIR-II)
emissive
AIEgen
photosensitizers
have
attracted
a
lot
attention
with
higher-resolution
bioimaging
deeper
penetration.
NIR-II
aggregation-induced
emission-based
luminogen
(AIEgen)
better
phototherapeutic
effects
accuracy
the
image-guided
surgery/phototherapy.
Herein,
an
phototheranostic
dot
was
proposed
resection
phototherapy
orthotopic
hepatic
Compared
indocyanine
green
(ICG),
dots
showed
bright
sharp
emission
at
1250
nm,
which
extended
to
1600
nm
high
photostability.
Moreover,
efficiently
generated
reactive
oxygen
species
(ROS)
photodynamic
therapy.
Investigations
vitro
vivo
demonstrated
that
could
be
both
tumor
early-stage
'downstaging'
intention
reduce
size.
therapeutic
strategy
induced
complete
inhibition
without
recurrence
few
side
effects.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Oct. 15, 2022
Abstract
Advances
in
diagnostic
imaging
have
provided
unprecedented
opportunities
to
detect
diseases
at
early
stages
and
with
high
reliability.
Diagnostic
is
also
crucial
monitoring
the
progress
or
remission
of
disease
thus
often
central
basis
therapeutic
decision-making.
Currently,
several
modalities
(computed
tomography,
magnetic
resonance
imaging,
positron
emission
among
others)
are
routinely
used
clinics
present
their
own
advantages
limitations.
In
vivo
near-infrared
(NIR)
fluorescence
has
recently
emerged
as
an
attractive
modality
combining
low
cost,
sensitivity,
relative
safety.
As
a
preclinical
tool,
it
can
be
investigate
mechanisms
for
testing
novel
diagnostics
therapeutics
prior
clinical
use.
However,
limited
depth
tissue
penetration
major
challenge
efficient
Therefore,
current
use
few
applications
such
image-guided
surgery
on
tumors
retinal
angiography,
using
FDA-approved
dyes.
Progress
fluorophore
development
NIR
technologies
holds
promise
extend
application
oncology,
cardiovascular
diseases,
plastic
surgery,
brain
others.
Nanotechnology
expected
revolutionize
through
targeted
delivery
fluorescent
probes
antibody
conjugation.
this
review,
we
discuss
latest
advances
technologies,
probes,
future
applications.
Graphical
Small,
Journal Year:
2023,
Volume and Issue:
19(17)
Published: Jan. 24, 2023
Carbon-based
quantum
dots
(QDs)
have
emerged
as
a
fascinating
class
of
advanced
materials
with
unique
combination
optoelectronic,
biocompatible,
and
catalytic
characteristics,
apt
for
plethora
applications
ranging
from
electronic
to
photoelectrochemical
devices.
Recent
research
works
established
carbon-based
QDs
those
frontline
through
improvements
in
design,
processing,
device
stability.
This
review
broadly
presents
the
recent
progress
synthesis
QDs,
including
carbon
graphene
graphitic
nitride
their
heterostructures,
well
salient
applications.
The
methods
are
first
introduced,
followed
by
an
extensive
discussion
dependence
performance
on
intrinsic
properties
nanostructures
aiming
present
general
strategies
designing
optimal
performance.
Furthermore,
diverse
presented,
emphasis
relationship
between
band
alignment,
charge
transfer,
improvement.
Among
discussed
this
review,
much
focus
is
given
photo
electrocatalytic,
energy
storage
conversion,
bioapplications,
which
pose
grand
challenge
rational
designs.
Finally,
summary
existing
challenges
future
directions
elaborated.
Exploration,
Journal Year:
2022,
Volume and Issue:
2(2)
Published: Feb. 19, 2022
Abstract
Illumination
of
biological
events
with
near‐infrared
II
sub‐channel
(NIR‐IIb,
1500–1700
nm)
enhances
the
transparency
tissues,
which
is
very
attractive
for
deep
imaging.
Due
to
long‐wavelength,
reduces
optical
damage,
suppresses
autofluorescence,
and
obviates
light
scattering,
NIR‐IIb
nanoprobes
afford
tissue
penetration
unprecedented
spatiotemporal
resolution.
Hence,
imaging
facilitates
learning
decipherment
proceedings
in
living
organisms
astounding
high
clarity.
In
comparison
its
predecessors
visible‐near‐infrared
spectrum,
has
shown
great
potential
extrapolating
applications
clinical
studies.
However,
use
organic
fluorescent
(OFNPs)
region
still
rare
since
it
early
stages.
Thus,
herein
we
aim
survey
recent
development
different
nanomaterials
characteristics,
their
unique
photophysical
properties,
utilization
animal
models.
Further,
practical
researches
on
emission
transition
are
highlighted.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(1)
Published: Jan. 11, 2023
Cancer
is
a
complex
disease
associated
with
combination
of
abnormal
physiological
process
and
exhibiting
dysfunctions
in
multiple
systems.
To
provide
effective
treatment
diagnosis
for
cancer,
current
strategies
simultaneously
focus
on
various
tumor
targets.
Based
the
rapid
development
nanotechnology,
nanocarriers
have
been
shown
to
exhibit
excellent
potential
cancer
therapy.
Compared
nanoparticles
single
functions,
multifunctional
are
believed
be
more
aggressive
potent
context
targeting.
However,
not
simply
an
upgraded
version
original
function,
but
involves
sophisticated
system
proper
backbone,
optimized
modification
sites,
simple
preparation
method,
efficient
function
integration.
Despite
this,
many
well-designed
promising
therapeutic
emerged
recently.
Here,
give
detailed
understanding
analyzation
currently
developed
nanoparticles,
their
platform
structures
organic
or
inorganic
backbones
were
systemically
generalized.
We
emphasized
functionalization
strategies,
which
additional
functions
nanoparticle.
also
discussed
application
that
involved
nanoformulations
functional
crosstalk.
This
review
thus
provides
overview
construction
advances
nanoparticles.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 3, 2024
Abstract
In
recent
years,
the
environmental
health
issue
of
microplastics
has
aroused
an
increasingly
significant
concern.
Some
studies
suggested
that
exposure
to
polystyrene
(PS-MPs)
may
lead
renal
inflammation
and
oxidative
stress
in
animals.
However,
little
is
known
about
essential
effects
PS-MPs
with
high-fat
diet
(HFD)
on
development
microenvironment.
this
study,
we
provided
single-cell
transcriptomic
landscape
kidney
microenvironment
induced
by
HFD
mouse
models
unbiased
RNA
sequencing
(scRNA-seq).
The
injury
cell
atlases
mice
were
evaluated
after
continued
exposure,
or
treated
for
35
days.
Results
showed
plus
treatment
aggravated
profibrotic
microenvironment,
reshaping
cellular
components.
First,
found
acted
extracellular
matrix
organization
epithelial
cells,
specifically
proximal
distal
convoluted
tubule
inhibit
induce
ROS-driven
carcinogenesis.
Second,
activated
PI3K-Akt,
MAPK,
IL-17
signaling
pathways
endothelial
cells.
Besides,
markedly
increased
proportions
CD8
+
effector
T
cells
proliferating
Notably,
mononuclear
phagocytes
exhibited
substantial
remodeling
enriched
phosphorylation
chemical
carcinogenesis
treatment,
typified
alterations
tissue-resident
M2-like
PF4
macrophages.
Multispectral
immunofluorescence
immunohistochemistry
identified
macrophages
clear
carcinoma
(ccRCC)
adjacent
normal
tissues,
indicating
activate
might
regulate
pro-tumorigenic
injury.
conclusion,
study
first
systematically
revealed
molecular
variation
immune
scRNA-seq
approach,
which
a
basis
decoding
genitourinary
understanding
their
potential
mammals.
Graphical
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
34(7)
Published: Nov. 25, 2021
To
promote
the
clinical
theranostic
performances
of
platinum-based
anticancer
drugs,
imaging
capability
is
urgently
desired,
and
their
chemotherapeutic
efficacy
needs
to
be
upgraded.
Herein,
a
metallacycle
(M)
developed
for
imaging-guided
cancer
radio-chemotherapy
using
perylene
bisimide
fluorophore
(PPy)
tetraphenylethylene-based
di-Pt(II)
organometallic
precursor
(TPE-Pt)
as
building
blocks.
The
formation
this
discrete
supramolecular
coordination
complex
facilitates
encapsulation
M
by
glutathione
(GSH)-responsive
amphiphilic
block
copolymer
prepare
M-loaded
nanoparticles
(MNPs).
TPE-Pt
acts
drug
also
an
excellent
radiosensitizer,
thus
incorporating
radiotherapy
into
nanomedicine
accelerate
therapeutic
overcome
resistance.
NIR-emission
PPy
employed
detect
intracellular
delivery
tissue
distribution
MNPs
in
real
time.
In
vitro
vivo
investigations
demonstrate
combining
chemotherapy
radiotherapy;
administration
effectively
inhibits
tumor
growth
greatly
extends
survival
rate
cisplatin-resistant
A2780CIS-tumor-bearing
mice.
Guided
fluorescence
imaging,
precisely
carried
out,
which
boosting
outcomes
minimizing
undesired
side
effects.
success
system
brings
new
hope
nanomedicines
potential
translations.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Sept. 24, 2022
Abstract
Sentinel
lymph
node
imaging
and
biopsy
is
important
to
clinical
assessment
of
cancer
metastasis,
novel
non-radioactive
lymphographic
tracers
have
been
actively
pursued
over
the
years.
Here,
we
develop
gold
molecular
clusters
(Au
25
)
functionalized
by
phosphorylcholine
(PC)
ligands
for
NIR-II
(1000–3000
nm)
fluorescence
draining
nodes
in
4T1
murine
breast
CT26
colon
tumor
mouse
models.
The
Au-phosphorylcholine
(Au-PC)
probes
exhibit
‘super-stealth’
behavior
with
little
interactions
serum
proteins,
cells
tissues
vivo,
which
differs
from
indocyanine
green
(ICG)
dye.
Subcutaneous
injection
Au-PC
allows
mapping
at
an
optimal
time
~
0.5
−
1
hour
postinjection
followed
rapid
renal
clearance.
Preclinical
LN
affords
high
signal
background
ratios
safety
biocompatibility,
promising
future
translation.
Advanced Optical Materials,
Journal Year:
2022,
Volume and Issue:
11(11)
Published: Dec. 19, 2022
Abstract
The
importance
and
practicality
of
near‐infrared
(NIR)
light
for
the
biomedical
field
has
attached
to
academe
industry
with
development
technology.
Luminescent
materials
different
doping
strategies
are
promising
candidates
covering
biological
windows
from
700
nm
1
nm.
relationship
between
NIR
light,
nanophosphors,
tissue
towards
function
diagnostic
therapy
in
is
explored
clearly,
which
corresponds
diffuse
reflection
spectroscopy
bioimaging
light‐emitting
diode
(LED)
photobiomodulation.
diseases
can
be
monitored
specific
chromophore
absorption
under
source,
also
traced
dynamic
change
environment
by
luminescent
materials.
Especially
brain
diseases,
cytochrome
c
oxidase
mitochondria
as
crucial
photoreceptor
activated
irradiation
achieve
non‐invasive
treatment
neuron
protection
recovery.
attributed
LED
or
nanophosphors
show
potential
theranostic
approaches
Cr
3+
‐
Ni
2+
‐activated
phosphors
I
II
presented
optical
properties
explore
feasibility
practicability
precise
medical
future.
